 Ketamine
"Ketamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
| Descriptor ID |
D007649
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| MeSH Number(s) |
D02.455.426.392.368.367.652
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| Concept/Terms |
Ketamine- Ketamine
- 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
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Below are MeSH descriptors whose meaning is more general than "Ketamine".
Below are MeSH descriptors whose meaning is more specific than "Ketamine".
This graph shows the total number of publications written about "Ketamine" by people in this website by year, and whether "Ketamine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 2 | 2 | | 1999 | 1 | 1 | 2 | | 2000 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 1 | 1 | 2 | | 2007 | 2 | 0 | 2 | | 2008 | 1 | 0 | 1 | | 2009 | 2 | 1 | 3 | | 2010 | 2 | 0 | 2 | | 2011 | 3 | 1 | 4 | | 2012 | 1 | 0 | 1 | | 2014 | 1 | 2 | 3 | | 2015 | 6 | 1 | 7 | | 2016 | 6 | 2 | 8 | | 2017 | 4 | 3 | 7 | | 2018 | 6 | 3 | 9 | | 2019 | 4 | 2 | 6 | | 2020 | 5 | 2 | 7 | | 2021 | 1 | 1 | 2 | | 2022 | 6 | 0 | 6 | | 2023 | 4 | 0 | 4 | | 2024 | 1 | 0 | 1 | | 2025 | 4 | 0 | 4 |
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Below are the most recent publications written about "Ketamine" by people in Profiles.
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Green SM, Tsze DS, Roback MG. Ketamine Procedural Sedation in 38,910 Children: Frequency and Predictors of Critical and High-Risk Events. Pediatr Crit Care Med. 2026 Feb 01; 27(2):207-217.
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Casey JD, Seitz KP, Driver BE, Gibbs KW, Ginde AA, Trent SA, Russell DW, Muhs AL, Prekker ME, Gaillard JP, Resnick-Ault D, Stewart LJ, Whitson MR, DeMasi SC, Robinson AE, Palakshappa JA, Aggarwal NR, Brainard JC, Douin DJ, Marvi TK, Scott BK, Alber SM, Lyle C, Gandotra S, Van Schaik GW, Lacy AJ, Sherlin KC, Erickson HL, Cain JM, Redman B, Beach LL, Gould B, McIntosh J, Lewis AA, Lloyd BD, Israel TL, Imhoff B, Wang L, Spicer AB, Churpek MM, Rice TW, Self WH, Han JH, Semler MW. Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults. N Engl J Med. 2026 Apr 23; 394(16):1608-1620.
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Green SM, Tsze DS, Roback MG. Emergency Department Ketamine Sedation: Frequency and Predictors of Critical and High-Risk Adverse Events. Ann Emerg Med. 2025 Dec; 86(6):600-605.
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Campbell K, Neul JL, Lieberman DN, Berry-Kravis E, Benke TA, Fu C, Percy A, Suter B, Morris D, Carpenter RL, Marsh ED, von Hehn J. A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome. J Neurodev Disord. 2025 Jan 24; 17(1):4.
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Fuller RG, Kikla EM, Fawcett APW, Hesling JD, Keenan S, Flarity KM, Patzkowski MS, April MD, Bebarta VS, Schauer SG. Low-dose ketamine for acute pain: A narrative review. Am J Emerg Med. 2024 12; 86:41-55.
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Niciu MJ, Meisner RC, Carr BR, Farooqui AA, Feifel D, Kaplin A, Kendrick EJ, Kim PM, Schneck CD, Vande Voort JL, Parikh SV. National Network of Depression Centers position statement: Insurance coverage for intravenous ketamine in treatment-resistant major depressive disorder. J Affect Disord. 2024 02 01; 346:221-222.
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Song R, Zhang J, Perszyk RE, Camp CR, Tang W, Kannan V, Li J, Xu Y, Chen J, Li Y, Liang SH, Traynelis SF, Yuan H. Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors. J Neurochem. 2024 Dec; 168(12):3936-3949.
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Schauer SG, April MD, Arana AA, Long BJ, Maddry JK. Ketamine during resuscitation - Is it as hemodynamically perfect as we think? Am J Emerg Med. 2023 11; 73:234.e3-234.e7.
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Driver BE, Trent SA, Prekker ME, Reardon RF, Brown CA. Sedative Dose for Rapid Sequence Intubation and Postintubation Hypotension: Is There an Association? Ann Emerg Med. 2023 10; 82(4):417-424.
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Freedman R. Ketamine and ECT in Depression - Risks and Rewards. N Engl J Med. 2023 06 22; 388(25):2389-2390.
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