 O(6)-Methylguanine-DNA Methyltransferase
"O(6)-Methylguanine-DNA Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC 2.1.1.63.
| Descriptor ID |
D019853
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| MeSH Number(s) |
D08.811.913.555.500.800.650
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| Concept/Terms |
O(6)-Methylguanine-DNA Methyltransferase- O(6)-Methylguanine-DNA Methyltransferase
- Methylated-DNA-Protein-Cysteine S-Methyltransferase
- Methylated DNA Protein Cysteine S Methyltransferase
- S-Methyltransferase, Methylated-DNA-Protein-Cysteine
- O(6)-Methylguanine Methyltransferase
- O(6)-Alkylguanine-DNA Alkyltransferase
- O(6)-MeG-DNA Methyltransferase
- O(6)-Methylguanine DNA Transmethylase
- Guanine-O(6)-Alkyltransferase
- O(6)-AGT
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Below are MeSH descriptors whose meaning is more general than "O(6)-Methylguanine-DNA Methyltransferase".
Below are MeSH descriptors whose meaning is more specific than "O(6)-Methylguanine-DNA Methyltransferase".
This graph shows the total number of publications written about "O(6)-Methylguanine-DNA Methyltransferase" by people in this website by year, and whether "O(6)-Methylguanine-DNA Methyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "O(6)-Methylguanine-DNA Methyltransferase" by people in Profiles.
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Roth JC, Alberti MO, Ismail M, Lingas KT, Reese JS, Gerson SL. MGMT enrichment and second gene co-expression in hematopoietic progenitor cells using separate or dual-gene lentiviral vectors. Virus Res. 2015 Jan 22; 196:170-80.
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McMurray MA, Thorner J. Septin stability and recycling during dynamic structural transitions in cell division and development. Curr Biol. 2008 Aug 26; 18(16):1203-8.
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Tranah GJ, Bugni J, Giovannucci E, Ma J, Fuchs C, Hines L, Samson L, Hunter DJ. O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States). Cancer Causes Control. 2006 Jun; 17(5):721-31.
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Tserng KY, Ingalls ST, Boczko EM, Spiro TP, Li X, Majka S, Gerson SL, Willson JK, Hoppel CL. Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine. J Clin Pharmacol. 2003 Aug; 43(8):881-93.
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Wilson DM, Tentler JJ, Carney JP, Wilson TM, Kelley MR. Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats. Alcohol Clin Exp Res. 1994 Oct; 18(5):1267-71.
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