 Melanoma
"Melanoma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Descriptor ID |
D008545
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| MeSH Number(s) |
C04.557.465.625.650.510 C04.557.580.625.650.510 C04.557.665.510
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| Concept/Terms |
Melanoma- Melanoma
- Melanomas
- Malignant Melanoma
- Malignant Melanomas
- Melanoma, Malignant
- Melanomas, Malignant
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Below are MeSH descriptors whose meaning is more general than "Melanoma".
Below are MeSH descriptors whose meaning is more specific than "Melanoma".
This graph shows the total number of publications written about "Melanoma" by people in this website by year, and whether "Melanoma" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 6 | 0 | 6 | | 1996 | 3 | 1 | 4 | | 1997 | 5 | 1 | 6 | | 1998 | 4 | 0 | 4 | | 1999 | 4 | 0 | 4 | | 2000 | 4 | 2 | 6 | | 2001 | 5 | 1 | 6 | | 2002 | 5 | 2 | 7 | | 2003 | 5 | 2 | 7 | | 2004 | 4 | 1 | 5 | | 2005 | 13 | 1 | 14 | | 2006 | 12 | 1 | 13 | | 2007 | 6 | 1 | 7 | | 2008 | 13 | 2 | 15 | | 2009 | 15 | 1 | 16 | | 2010 | 6 | 2 | 8 | | 2011 | 13 | 2 | 15 | | 2012 | 16 | 2 | 18 | | 2013 | 22 | 5 | 27 | | 2014 | 23 | 2 | 25 | | 2015 | 13 | 6 | 19 | | 2016 | 24 | 3 | 27 | | 2017 | 35 | 0 | 35 | | 2018 | 23 | 2 | 25 | | 2019 | 19 | 4 | 23 | | 2020 | 26 | 2 | 28 | | 2021 | 23 | 0 | 23 | | 2022 | 16 | 0 | 16 | | 2023 | 18 | 1 | 19 | | 2024 | 23 | 3 | 26 | | 2025 | 9 | 0 | 9 |
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Below are the most recent publications written about "Melanoma" by people in Profiles.
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Neff C, Price M, Ballard CAP, Cioffi G, Liu Z, Walsh R, Barnholtz-Sloan JS, Walsh KM, Salama AKS, Anders CK, Fecci PE, Ostrom QT. Atopy Improves Survival and Decreases Risk of Brain Metastasis in Cutaneous Melanoma. Cancer Epidemiol Biomarkers Prev. 2025 Sep 02; 34(9):1600-1608.
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Nangia V, Ashraf H, Marikar N, Passanisi VJ, Ill CR, Spencer SL. MAPK and mTORC1 signaling converge to drive cyclin D1 protein production to enable cell cycle reentry in melanoma persister cells. Sci Signal. 2025 Sep 02; 18(902):eadw3231.
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Tiago M, Purwin TJ, Stefanski CD, da Silva RO, Fane ME, Chhabra Y, Haj JI, Teh JL, Kadamb R, Cai W, Rosenbaum SR, Chua V, Hacohen N, Davies MA, Villanueva J, Chervoneva I, Weeraratna AT, Erkes DA, Capparelli C, Aguirre-Ghiso JA, Aplin AE. Elevated NR2F1 underlies the persistence of invasive disease after treatment of BRAF-mutant melanoma. J Clin Invest. 2025 Sep 16; 135(18).
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Seidel JA, Alder L, Salama AKS, Anders CK, Komisarow J, Fecci PE, Sperduto P, Mullikin T, Kirkpatrick JP, Floyd SR, Reitman ZJ, Vaios EJ. Management outcomes for biopsy-proven radiation necrosis in patients with brain metastases in the era of immune-checkpoint blockade. J Neurooncol. 2025 Oct; 175(1):199-208.
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Monson KR, Ferguson R, Handzlik JE, Morales L, Xiong J, Chat V, Dagayev S, Khodadadi-Jamayran A, Simpson D, Kazlow E, Bunis A, Sreenivasaiah C, Ibrahim M, Voloshyna I, Ouwerkerk W, Luiten RM, Capone M, Madonna G, Lu Y, Shao Y, Pavlick A, Krogsgaard M, Mehnert J, Tang H, Dolfi S, Tenney D, Haanen JBAG, Gajewski TF, Hodi FS, Flaherty KT, Couts K, Robinson W, Puzanov I, Ernstoff MS, Rahma O, Postow M, Sullivan RJ, Luke JJ, Ascierto PA, Osman I, Kirchhoff T. Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma. Nat Med. 2025 Jul; 31(7):2385-2396.
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Gouda MA, Voss MH, Tawbi H, Gordon M, Tykodi SS, Lam ET, Vaishampayan U, Tannir NM, Chaves J, Nikolinakos P, Fan A, Lee R, McDermott D, Shapiro GI, Gandhi L, Bhatia S, Katragadda V, Meric-Bernstam F. A phase I/II study of the safety and efficacy of telaglenastat (CB-839) in combination with nivolumab in patients with metastatic melanoma, renal cell carcinoma, and non-small-cell lung cancer. ESMO Open. 2025 May; 10(5):104536.
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Horton L, Fakhoury JW, Manwar R, Rajabi-Estarabadi A, Turk D, O'Leary S, Fotouhi A, Daveluy S, Jain M, Nouri K, Mehregan D, Avanaki K. Review of Non-Invasive Imaging Technologies for Cutaneous Melanoma. Biosensors (Basel). 2025 May 07; 15(5).
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Guenther JM, Ward A, Martin BJ, Cripe M, Beard T, Wisco O, Sharma R, Leong SP, Essner R, Clark JI, Hamner J, Sickle-Santanello B, Yamamoto M. A Prospective, Multicenter Analysis of Recurrence-Free Survival After Sentinel Lymph Node Biopsy Decisions Influenced by the 31-GEP. Cancer Med. 2025 Apr; 14(7):e70839.
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Borgers JSW, Lenkala D, Kohler V, Jackson EK, Linssen MD, Hymson S, McCarthy B, O'Reilly Cosgrove E, Balogh KN, Esaulova E, Starr K, Ware Y, Klobuch S, Sciuto T, Chen X, Mahimkar G, Sheen JHF, Ramesh S, Wilgenhof S, van Thienen JV, Scheiner KC, Jedema I, Rooney M, Dong JZ, Srouji JR, Juneja VR, Arieta CM, Nuijen B, Gottstein C, Finney OC, Manson K, Nijenhuis CM, Gaynor RB, DeMario M, Haanen JB, van Buuren MM. Personalized, autologous neoantigen-specific T cell therapy in metastatic melanoma: a phase 1 trial. Nat Med. 2025 Mar; 31(3):881-893.
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Zhang Z, Langenbach M, Sagar S, Fetsch V, Stritzker J, Severa E, Meng K, Winkler F, Rana N, Zoldan K, Godbole I, Solis S, Weber JS, Rafei-Shamsabadi D, Lehr S, Diehl R, Venhoff AC, Voll RE, Buettner N, Neumann-Haefelin C, Boettler T, Hofmann M, Boerries M, Meiss F, Zeiser R, Thimme R, Herati RS, Bengsch B. Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells. Nat Immunol. 2025 Jan; 26(1):92-104.
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