 Pregnanediones
"Pregnanediones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Pregnane derivatives in which two side-chain methyl groups or two methylene groups in the ring skeleton (or a combination thereof) have been oxidized to keto groups.
| Descriptor ID |
D011277
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| MeSH Number(s) |
D04.210.500.745.558
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pregnanediones".
Below are MeSH descriptors whose meaning is more specific than "Pregnanediones".
This graph shows the total number of publications written about "Pregnanediones" by people in this website by year, and whether "Pregnanediones" was a major or minor topic of these publications.
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Below are the most recent publications written about "Pregnanediones" by people in Profiles.
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Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells. 2020 12 12; 9(12).
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Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain. Br J Anaesth. 2020 05; 124(5):603-613.
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Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain. 2005 Oct; 117(3):326-339.
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Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, Mennerick S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain. 2005 Apr; 114(3):429-443.
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Todorovic SM, Prakriya M, Nakashima YM, Nilsson KR, Han M, Zorumski CF, Covey DF, Lingle CJ. Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity. Mol Pharmacol. 1998 Nov; 54(5):918-27.
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Emanuele MA, Tentler J, Kirsteins L, Reda D, Emanuele NV, Lawrence AM. Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. J Endocrinol. 1987 Nov; 115(2):221-3.
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