 Wnt Signaling Pathway
"Wnt Signaling Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.
| Descriptor ID |
D060449
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| MeSH Number(s) |
G02.111.820.925 G04.835.925
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| Concept/Terms |
Wnt Signaling Pathway- Wnt Signaling Pathway
- Pathway, Wnt Signaling
- Pathways, Wnt Signaling
- Signaling Pathway, Wnt
- Signaling Pathways, Wnt
- Wnt Signaling Pathways
- Wnt Pathway
- Pathway, Wnt
- Pathways, Wnt
- Wnt Pathways
Wnt beta-Catenin Signaling Pathway- Wnt beta-Catenin Signaling Pathway
- Wnt beta Catenin Signaling Pathway
- Wnt Pathway, Canonical
- Canonical Wnt Pathway
- Canonical Wnt Pathways
- Pathway, Canonical Wnt
- Pathways, Canonical Wnt
- Wnt Pathways, Canonical
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Below are MeSH descriptors whose meaning is more general than "Wnt Signaling Pathway".
Below are MeSH descriptors whose meaning is more specific than "Wnt Signaling Pathway".
This graph shows the total number of publications written about "Wnt Signaling Pathway" by people in this website by year, and whether "Wnt Signaling Pathway" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 2 | 2 | 4 | | 2012 | 2 | 2 | 4 | | 2013 | 4 | 3 | 7 | | 2014 | 4 | 2 | 6 | | 2015 | 7 | 5 | 12 | | 2016 | 2 | 6 | 8 | | 2017 | 7 | 5 | 12 | | 2018 | 8 | 2 | 10 | | 2019 | 8 | 3 | 11 | | 2020 | 8 | 6 | 14 | | 2021 | 4 | 3 | 7 | | 2022 | 1 | 1 | 2 | | 2023 | 2 | 2 | 4 | | 2024 | 3 | 6 | 9 | | 2025 | 2 | 4 | 6 | | 2026 | 3 | 0 | 3 |
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Below are the most recent publications written about "Wnt Signaling Pathway" by people in Profiles.
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Figueroa V, Coianis MI, Sahores A, Pataccini G, Abba MC, Elía A, May M, Vanzulli SI, Martínez Vázquez P, Burruchaga J, Torres F, Sartorius CA, Lanari C, Lamb CA. Nuclear FGF2, androgen receptor and Wnt pathway activation define a targetable subset of antiprogestin-resistant luminal breast cancer. Br J Cancer. 2026 Jun; 134(11):1671-1682.
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Matthias J, David MA, Buckley SE, Stark SD, Austin NA, Zona NE, Zuscik MJ, Hunt KJ. The Synovial Fingerprint of Ankle Fractures: A Central Role for WNT Pathway Activation in Posttraumatic Ankle Osteoarthritis. Foot Ankle Int. 2026 May; 47(5):662-673.
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Torborg SR, Kim JY, Singhal A, Grbovic-Huezo O, Holm M, Wu K, Han X, Ho YJ, Haglund C, Mitchell MJ, Lowe SW, Dow LE, Pitter KL, Sanchez-Rivera FJ, Levchenko A, Tammela T. Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states. Dev Cell. 2026 May 13; 61(5):1012-1027.e8.
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Corr BR, Woodruff ER, Yamamoto TM, Jordan KR, Danhorn T, Bossard C, Nguyen LL, Chuong EB, Wick L, Young A, Kusumoto S, Orsulic S, Barroilhet L, Bitler BG. SM08502-Mediated ß-Catenin Repression Synergizes with Olaparib to Inhibit Tumor Progression. Cancer Res Commun. 2025 Dec 01; 5(12):2112-2126.
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Lieu CH, Lenz HJ, Benson AB, Meng X, Kim UI, Kim SH, Kim K, Sung MJ. A First-In-Human Dose-Escalation Phase I Study of Basroparib, a Tankyrase Inhibitor, in Patients with Advanced-Stage Solid Tumors. Cancer Res Commun. 2025 Oct 01; 5(10):1771-1778.
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Moran HR, Nyarko OO, Garfield AL, O'Rourke R, Ching RK, Gray R, Cobb TM, Riemslagh FW, Lovely CB, Peña B, Burger A, Sucharov CC, Mosimann C. The pericardium forms as a distinct structure during heart formation. Nat Commun. 2025 Sep 29; 16(1):8566.
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Kocere A, Chiavacci E, Soneson C, Jacobson ST, Harrison EN, Méndez-Acevedo KM, MacGowan JS, Wells HH, Hiltabidle MS, Raghunath A, Shavit JA, Panáková D, Williams MLK, Robinson MD, Mosimann C, Burger A. Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signaling. Dev Biol. 2025 Dec; 528:34-56.
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Liu J, Mosti F, Zhao HT, Lollis D, Sotelo-Fonseca JE, Escobar-Tomlienovich CF, Musso CM, Mao Y, Massri AJ, Doll HM, Moss ND, Sousa AMM, Wray GA, Schmidt ERE, Silver DL. A human-specific enhancer fine-tunes radial glia potency and corticogenesis. Nature. 2025 07; 643(8074):1321-1332.
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Hartman GD, Sishtla K, Kpenu EK, Mijit M, Muniyandi A, Jo HN, Junge HJ, Shaw A, Bischof D, Liu S, Wan J, Kelley MR, Corson TW. Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells. Redox Biol. 2025 06; 83:103646.
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Rutt LN, Orlicky DJ, McCullough RL. Investigating the role of Wnt3a and Wnt5a as critical factors of hepatic stellate cell activation in acute toxicant-induced liver injury. Cell Biol Toxicol. 2024 12 21; 41(1):5.
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