 Cyclin-Dependent Kinase Inhibitor p27
"Cyclin-Dependent Kinase Inhibitor p27" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
| Descriptor ID |
D050760
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| MeSH Number(s) |
D12.644.360.225.600 D12.776.167.187.600 D12.776.476.225.600 D12.776.624.776.355.600
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| Concept/Terms |
Cyclin-Dependent Kinase Inhibitor p27- Cyclin-Dependent Kinase Inhibitor p27
- Cyclin Dependent Kinase Inhibitor p27
- CDKN4 Protein
- p27 CDK Inhibitor
- CDK Inhibitor, p27
- p27 Kip1 Protein
- Kip1 Protein, p27
- CDKN1B Protein
- p27Kip1 Protein
- CDK Inhibitor p27
- p27, CDK Inhibitor
- Cyclin-Dependent Kinase Inhibitor 1B
- Cyclin Dependent Kinase Inhibitor 1B
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Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor p27".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor p27".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor p27" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor p27" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 | | 1999 | 0 | 2 | 2 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 3 | 3 | | 2003 | 0 | 3 | 3 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 4 | 5 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 2 | 3 | | 2008 | 1 | 3 | 4 | | 2009 | 0 | 3 | 3 | | 2010 | 0 | 3 | 3 | | 2011 | 0 | 1 | 1 | | 2012 | 2 | 4 | 6 | | 2013 | 0 | 4 | 4 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 1 | 2 | | 2018 | 0 | 2 | 2 | | 2019 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 | | 2023 | 0 | 1 | 1 | | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor p27" by people in Profiles.
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Yadav M, Kandhari K, Mathan SV, Ali M, Singh RP. Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC. Mol Carcinog. 2024 Sep; 63(9):1697-1711.
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Rong Y, Darnell AM, Sapp KM, Vander Heiden MG, Spencer SL. Cells use multiple mechanisms for cell-cycle arrest upon withdrawal of individual amino acids. Cell Rep. 2023 12 26; 42(12):113539.
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Witkiewicz AK, Kumarasamy V, Sanidas I, Knudsen ES. Cancer cell cycle dystopia: heterogeneity, plasticity, and therapy. Trends Cancer. 2022 09; 8(9):711-725.
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Knudsen ES, Kumarasamy V, Nambiar R, Pearson JD, Vail P, Rosenheck H, Wang J, Eng K, Bremner R, Schramek D, Rubin SM, Welm AL, Witkiewicz AK. CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities. Cell Rep. 2022 03 01; 38(9):110448.
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Hoxha S, Shepard A, Troutman S, Diao H, Doherty JR, Janiszewska M, Witwicki RM, Pipkin ME, Ja WW, Kareta MS, Kissil JL. YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators. Cancer Res. 2020 06 15; 80(12):2512-2522.
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Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 12 13; 366(6471).
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Mishra SK, Stephenson DJ, Chalfant CE, Brown RE. Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 02; 1864(2):158-167.
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White JP, Billin AN, Campbell ME, Russell AJ, Huffman KM, Kraus WE. The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells. Stem Cell Reports. 2018 08 14; 11(2):425-439.
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Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami-Nishida S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E. Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis. Arterioscler Thromb Vasc Biol. 2018 05; 38(5):994-1006.
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Kiseljak-Vassiliades K, Xu M, Mills TS, Smith EE, Silveira LJ, Lillehei KO, Kerr JM, Kleinschmidt-DeMasters BK, Wierman ME. Differential somatostatin receptor (SSTR) 1-5 expression and downstream effectors in histologic subtypes of growth hormone pituitary tumors. Mol Cell Endocrinol. 2015 Dec 05; 417:73-83.
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