 Enzyme Inhibitors
"Enzyme Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
| Descriptor ID |
D004791
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| MeSH Number(s) |
D27.505.519.389
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Enzyme Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Enzyme Inhibitors".
This graph shows the total number of publications written about "Enzyme Inhibitors" by people in this website by year, and whether "Enzyme Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 4 | 6 | | 1996 | 5 | 12 | 17 | | 1997 | 5 | 20 | 25 | | 1998 | 3 | 12 | 15 | | 1999 | 8 | 16 | 24 | | 2000 | 5 | 24 | 29 | | 2001 | 6 | 21 | 27 | | 2002 | 8 | 29 | 37 | | 2003 | 11 | 29 | 40 | | 2004 | 8 | 33 | 41 | | 2005 | 9 | 16 | 25 | | 2006 | 8 | 20 | 28 | | 2007 | 14 | 15 | 29 | | 2008 | 12 | 20 | 32 | | 2009 | 7 | 23 | 30 | | 2010 | 7 | 14 | 21 | | 2011 | 11 | 9 | 20 | | 2012 | 12 | 18 | 30 | | 2013 | 4 | 19 | 23 | | 2014 | 10 | 14 | 24 | | 2015 | 6 | 10 | 16 | | 2016 | 7 | 7 | 14 | | 2017 | 6 | 4 | 10 | | 2018 | 9 | 6 | 15 | | 2019 | 2 | 10 | 12 | | 2020 | 6 | 2 | 8 | | 2021 | 7 | 1 | 8 | | 2022 | 0 | 5 | 5 | | 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Enzyme Inhibitors" by people in Profiles.
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Friedman AJ, Padgette HM, Kramer L, Liechty ET, Donovan GW, Fox JM, Shirts MR. Biophysical Rationale for the Selective Inhibition of PTP1B over TCPTP by Nonpolar Terpenoids. J Phys Chem B. 2023 10 05; 127(39):8305-8316.
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Derry JMJ, Burns C, Frazier JP, Beirne E, Grenley M, DuFort CC, Killingbeck E, Leon M, Williams C, Gregory M, Houlton J, Clayburgh D, Swiecicki P, Huszar D, Berger A, Klinghoffer RA. Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment. Clin Cancer Res. 2023 09 15; 29(18):3813-3825.
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Pizzolato Umeton R, Waltz M, Aaen GS, Benson L, Gorman M, Goyal M, Graves JS, Harris Y, Krupp L, Lotze TE, Shukla NM, Mar S, Ness J, Rensel M, Schreiner T, Tillema JM, Roalstad S, Rodriguez M, Rose J, Waubant E, Weinstock-Guttman B, Casper C, Chitnis T. Therapeutic Response in Pediatric Neuromyelitis Optica Spectrum Disorder. Neurology. 2023 02 28; 100(9):e985-e994.
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Friedman AJ, Liechty ET, Kramer L, Sarkar A, Fox JM, Shirts MR. Allosteric Inhibition of PTP1B by a Nonpolar Terpenoid. J Phys Chem B. 2022 10 27; 126(42):8427-8438.
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Dwyer-Nield L, Keith RL, Tennis MA. Protocol for intranasal chemoprevention delivery in a urethane mouse lung cancer model. STAR Protoc. 2022 12 16; 3(4):101750.
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Crawley WT, Jungels CG, Stenmark KR, Fini MA. U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia. Redox Biol. 2022 05; 51:102271.
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Tian D, Han M. Bacterial peptidoglycan muropeptides benefit mitochondrial homeostasis and animal physiology by acting as ATP synthase agonists. Dev Cell. 2022 02 07; 57(3):361-372.e5.
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Hongdusit A, Liechty ET, Fox JM. Analysis of Three Architectures for Controlling PTP1B with Light. ACS Synth Biol. 2022 01 21; 11(1):61-68.
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Qi L, Lindsay H, Kogiso M, Du Y, Braun FK, Zhang H, Guo L, Zhao S, Injac SG, Baxter PA, Su JM, Xiao S, Erickson SW, Earley EJ, Teicher B, Smith MA, Li XN. Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies. Lab Invest. 2022 02; 102(2):185-193.
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Anantharajan J, Baburajendran N, Lin G, Loh YY, Xu W, Ahmad NHB, Liu S, Jansson AE, Kuan JWL, Ng EY, Yeo YK, Hung AW, Joy J, Hill J, Ford HL, Zhao R, Keller TH, Kang C. Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase. Protein Sci. 2022 02; 31(2):422-431.
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