 Amino Acid Substitution
"Amino Acid Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
| Descriptor ID |
D019943
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| MeSH Number(s) |
E05.393.420.601.035 G05.558.109
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| Concept/Terms |
Amino Acid Substitution- Amino Acid Substitution
- Amino Acid Substitutions
- Substitution, Amino Acid
- Substitutions, Amino Acid
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Below are MeSH descriptors whose meaning is more general than "Amino Acid Substitution".
Below are MeSH descriptors whose meaning is more specific than "Amino Acid Substitution".
This graph shows the total number of publications written about "Amino Acid Substitution" by people in this website by year, and whether "Amino Acid Substitution" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 | | 1998 | 0 | 3 | 3 | | 1999 | 1 | 5 | 6 | | 2000 | 0 | 9 | 9 | | 2001 | 1 | 5 | 6 | | 2002 | 0 | 4 | 4 | | 2003 | 1 | 15 | 16 | | 2004 | 1 | 10 | 11 | | 2005 | 1 | 10 | 11 | | 2006 | 4 | 10 | 14 | | 2007 | 0 | 12 | 12 | | 2008 | 1 | 17 | 18 | | 2009 | 3 | 8 | 11 | | 2010 | 1 | 9 | 10 | | 2011 | 0 | 8 | 8 | | 2012 | 1 | 12 | 13 | | 2013 | 3 | 15 | 18 | | 2014 | 1 | 10 | 11 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 7 | 8 | | 2017 | 1 | 5 | 6 | | 2018 | 0 | 7 | 7 | | 2019 | 1 | 7 | 8 | | 2020 | 0 | 10 | 10 | | 2021 | 0 | 6 | 6 |
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Below are the most recent publications written about "Amino Acid Substitution" by people in Profiles.
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Showers WM, Leach SM, Kechris K, Strong M. Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations. Infect Genet Evol. 2022 01; 97:105153.
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Wozniak T, Sajek M, Jaruzelska J, Sajek MP. RNAlign2D: a rapid method for combined RNA structure and sequence-based alignment using a pseudo-amino acid substitution matrix. BMC Bioinformatics. 2021 Oct 16; 22(1):504.
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Alam M, Arunagiri A, Haataja L, Torres M, Larkin D, Kappler J, Jin N, Arvan P. Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes. Diabetes. 2021 11; 70(11):2580-2594.
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Shen H, Gonskikh Y, Stoute J, Liu KF. Human DIMT1 generates N26,6A-dimethylation-containing small RNAs. J Biol Chem. 2021 10; 297(4):101146.
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Tomer Y, Wambach J, Knudsen L, Zhao M, Rodriguez LR, Murthy A, White FV, Venosa A, Katzen J, Ochs M, Hamvas A, Beers MF, Mulugeta S. The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling. Am J Physiol Lung Cell Mol Physiol. 2021 08 01; 321(2):L291-L307.
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Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T, Lutz KA, Martin JM, Treacy CM, Rosenzweig EB, Krishnan U, Coleman AW, Gonzaga-Jauregui C, Lawrie A, Trembath RC, Wilkins MR, Morrell NW, Shen Y, Gr?f S, Nichols WC, Chung WK. Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome Med. 2021 05 10; 13(1):80.
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Jacobson DR, Perkins TT. Free-energy changes of bacteriorhodopsin point mutants measured by single-molecule force spectroscopy. Proc Natl Acad Sci U S A. 2021 03 30; 118(13).
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Cast TP, Boesch DJ, Smyth K, Shaw AE, Ghebrial M, Chanda S. An Autism-Associated Mutation Impairs Neuroligin-4 Glycosylation and Enhances Excitatory Synaptic Transmission in Human Neurons. J Neurosci. 2021 01 20; 41(3):392-407.
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Ilaslan E, Markosyan R, Sproll P, Stevenson BJ, Sajek M, Sajek MP, Hayrapetyan H, Sarkisian T, Livshits L, Nef S, Jaruzelska J, Kusz-Zamelczyk K. The FKBP4 Gene, Encoding a Regulator of the Androgen Receptor Signaling Pathway, Is a Novel Candidate Gene for Androgen Insensitivity Syndrome. Int J Mol Sci. 2020 Nov 09; 21(21).
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Gaullier G, Roberts G, Muthurajan UM, Bowerman S, Rudolph J, Mahadevan J, Jha A, Rae PS, Luger K. Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1. PLoS One. 2020; 15(11):e0240932.
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