Amino Acid Substitution
"Amino Acid Substitution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Descriptor ID |
D019943
|
MeSH Number(s) |
E05.393.420.601.035 G05.558.109
|
Concept/Terms |
Amino Acid Substitution- Amino Acid Substitution
- Amino Acid Substitutions
- Substitution, Amino Acid
- Substitutions, Amino Acid
|
Below are MeSH descriptors whose meaning is more general than "Amino Acid Substitution".
Below are MeSH descriptors whose meaning is more specific than "Amino Acid Substitution".
This graph shows the total number of publications written about "Amino Acid Substitution" by people in this website by year, and whether "Amino Acid Substitution" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
---|
1997 | 0 | 1 | 1 | 1998 | 0 | 2 | 2 | 1999 | 1 | 5 | 6 | 2000 | 0 | 8 | 8 | 2001 | 2 | 5 | 7 | 2002 | 0 | 7 | 7 | 2003 | 1 | 14 | 15 | 2004 | 1 | 8 | 9 | 2005 | 1 | 9 | 10 | 2006 | 4 | 11 | 15 | 2007 | 0 | 13 | 13 | 2008 | 1 | 18 | 19 | 2009 | 2 | 9 | 11 | 2010 | 0 | 9 | 9 | 2011 | 1 | 8 | 9 | 2012 | 1 | 12 | 13 | 2013 | 3 | 15 | 18 | 2014 | 1 | 9 | 10 | 2015 | 0 | 1 | 1 | 2016 | 1 | 8 | 9 | 2017 | 1 | 6 | 7 | 2018 | 0 | 6 | 6 | 2019 | 1 | 7 | 8 | 2020 | 0 | 9 | 9 | 2021 | 0 | 5 | 5 | 2024 | 1 | 1 | 2 | 2025 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Amino Acid Substitution" by people in Profiles.
-
Jha V, Freed BM, Sunderhaus ER, Lee JE, Prage EB, Miglani M, Rosloniec EF, Matsuda JL, Coulombe MG, McKee AS, Roark CL. Substitution of Glutamic Acid at Position 71 of DR?1*04:01 and Collagen-Specific Tolerance Without Alloreactivity. Arthritis Rheumatol. 2025 May; 77(5):526-535.
-
Buvoli M, Wilson GC, Buvoli A, Gugel JF, Hau A, B?nnemann CG, Paradas C, Ryba DM, Woulfe KC, Walker LA, Buvoli T, Ochala J, Leinwand LA. A Laing distal myopathy-associated proline substitution in the ?-myosin rod perturbs myosin cross-bridging activity. J Clin Invest. 2024 May 01; 134(9).
-
Daffern N, Johansson KE, Baumer ZT, Robertson NR, Woojuh J, Bedewitz MA, Davis Z, Wheeldon I, Cutler SR, Lindorff-Larsen K, Whitehead TA. GMMA Can Stabilize Proteins Across Different Functional Constraints. J Mol Biol. 2024 Jun 01; 436(11):168586.
-
Showers WM, Leach SM, Kechris K, Strong M. Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations. Infect Genet Evol. 2022 01; 97:105153.
-
Wozniak T, Sajek M, Jaruzelska J, Sajek MP. RNAlign2D: a rapid method for combined RNA structure and sequence-based alignment using a pseudo-amino acid substitution matrix. BMC Bioinformatics. 2021 Oct 16; 22(1):504.
-
Alam M, Arunagiri A, Haataja L, Torres M, Larkin D, Kappler J, Jin N, Arvan P. Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes. Diabetes. 2021 11; 70(11):2580-2594.
-
Shen H, Gonskikh Y, Stoute J, Liu KF. Human DIMT1 generates N26,6A-dimethylation-containing small RNAs. J Biol Chem. 2021 10; 297(4):101146.
-
Tomer Y, Wambach J, Knudsen L, Zhao M, Rodriguez LR, Murthy A, White FV, Venosa A, Katzen J, Ochs M, Hamvas A, Beers MF, Mulugeta S. The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling. Am J Physiol Lung Cell Mol Physiol. 2021 08 01; 321(2):L291-L307.
-
Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T, Lutz KA, Martin JM, Treacy CM, Rosenzweig EB, Krishnan U, Coleman AW, Gonzaga-Jauregui C, Lawrie A, Trembath RC, Wilkins MR, Morrell NW, Shen Y, Gr?f S, Nichols WC, Chung WK. Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome Med. 2021 05 10; 13(1):80.
-
Jacobson DR, Perkins TT. Free-energy changes of bacteriorhodopsin point mutants measured by single-molecule force spectroscopy. Proc Natl Acad Sci U S A. 2021 03 30; 118(13).
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|