 Vascular Endothelial Growth Factor Receptor-1
"Vascular Endothelial Growth Factor Receptor-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
| Descriptor ID |
D040281
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.950.100 D12.776.543.750.630.750.100 D12.776.543.750.750.400.910.100
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| Concept/Terms |
Vascular Endothelial Growth Factor Receptor-1- Vascular Endothelial Growth Factor Receptor-1
- Vascular Endothelial Growth Factor Receptor 1
- FLT1 Receptor Tyrosine Kinase
- VEGF Receptor flt-1 Protein
- VEGF Receptor flt 1 Protein
- VEGFR-1
- fms-Like Tyrosine Kinase
- Tyrosine Kinase, fms-Like
- Proto-Oncogene Protein flt
- Proto Oncogene Protein flt
- FLT1 RTK
- VEGF Receptor, FLT
- FLT VEGF Receptor
- Receptor, FLT VEGF
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Below are MeSH descriptors whose meaning is more general than "Vascular Endothelial Growth Factor Receptor-1".
Below are MeSH descriptors whose meaning is more specific than "Vascular Endothelial Growth Factor Receptor-1".
This graph shows the total number of publications written about "Vascular Endothelial Growth Factor Receptor-1" by people in this website by year, and whether "Vascular Endothelial Growth Factor Receptor-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2009 | 2 | 2 | 4 | | 2010 | 2 | 3 | 5 | | 2011 | 1 | 2 | 3 | | 2012 | 1 | 2 | 3 | | 2013 | 2 | 3 | 5 | | 2014 | 2 | 1 | 3 | | 2015 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 0 | 2 | 2 | | 2020 | 1 | 0 | 1 | | 2022 | 1 | 2 | 3 |
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Below are the most recent publications written about "Vascular Endothelial Growth Factor Receptor-1" by people in Profiles.
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Mundo W, Toledo-Jaldin L, Heath-Freudenthal A, Huayacho J, Lazo-Vega L, Larrea-Alvarado A, Miranda-Garrido V, Mizutani R, Moore LG, Moreno-Aramayo A, Gomez R, Gutierrez P, Julian CG. Is Maternal Cardiovascular Performance Impaired in Altitude-Associated Fetal Growth Restriction? High Alt Med Biol. 2022 12; 23(4):352-360.
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Li A, Ambruso SL, Oto OA, Barry M, Edelstein CL. A case report of pre-eclampsia-like endothelial injury in the kidney of an 85-year-old man treated with ibrutinib. BMC Nephrol. 2022 07 23; 23(1):264.
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Heath-Freudenthal A, Toledo-Jaldin L, von Alvensleben I, Lazo-Vega L, Mizutani R, Stalker M, Yasini H, Mendizabal F, Dorado Madera J, Mundo W, Castro-Monrroy M, Houck JA, Moreno-Aramayo A, Miranda-Garrido V, Su EJ, Giussani DA, Abman SH, Moore LG, Julian CG. Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations. Hypertension. 2022 06; 79(6):1286-1296.
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Levine L, Arany Z, Kern-Goldberger A, Koelper N, Lewey J, Sammel MD, Elovitz MA, Ky B. Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia. Hypertens Pregnancy. 2021 Feb; 40(1):44-49.
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da Silva RF, Banzato TP, Alves LF, Carvalho JE, Agarwal R, Cagnon VHA. Antiangiogenic therapy with Nintedanib affects hypoxia, angiogenesis and apoptosis in the ventral prostate of TRAMP animals. Cell Tissue Res. 2020 Feb; 379(2):407-420.
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Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP. Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Crit Care. 2019 07 23; 23(1):259.
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Robertson SA. Preventing Preeclampsia by Silencing Soluble Flt-1? N Engl J Med. 2019 03 14; 380(11):1080-1082.
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Drilon A, Fu S, Patel MR, Fakih M, Wang D, Olszanski AJ, Morgensztern D, Liu SV, Cho BC, Bazhenova L, Rodriguez CP, Doebele RC, Wozniak A, Reckamp KL, Seery T, Nikolinakos P, Hu Z, Oliver JW, Trone D, McArthur K, Patel R, Multani PS, Ahn MJ. A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105. Cancer Discov. 2019 03; 9(3):384-395.
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Ji S, Xin H, Li Y, Su EJ. FMS-like tyrosine kinase 1 (FLT1) is a key regulator of fetoplacental endothelial cell migration and angiogenesis. Placenta. 2018 10; 70:7-14.
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Wallace B, Peisl A, Seedorf G, Nowlin T, Kim C, Bosco J, Kenniston J, Keefe D, Abman SH. Anti-sFlt-1 Therapy Preserves Lung Alveolar and Vascular Growth in Antenatal Models of Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2018 03 15; 197(6):776-787.
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