 Ligands
"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
| Descriptor ID |
D008024
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| MeSH Number(s) |
D27.720.470.480
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ligands".
Below are MeSH descriptors whose meaning is more specific than "Ligands".
This graph shows the total number of publications written about "Ligands" by people in this website by year, and whether "Ligands" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 8 | 8 | | 1996 | 0 | 13 | 13 | | 1997 | 0 | 4 | 4 | | 1998 | 1 | 9 | 10 | | 1999 | 0 | 8 | 8 | | 2000 | 0 | 10 | 10 | | 2001 | 0 | 16 | 16 | | 2002 | 0 | 15 | 15 | | 2003 | 0 | 24 | 24 | | 2004 | 0 | 17 | 17 | | 2005 | 0 | 18 | 18 | | 2006 | 1 | 20 | 21 | | 2007 | 0 | 14 | 14 | | 2008 | 0 | 16 | 16 | | 2009 | 2 | 20 | 22 | | 2010 | 0 | 16 | 16 | | 2011 | 2 | 13 | 15 | | 2012 | 1 | 20 | 21 | | 2013 | 1 | 16 | 17 | | 2014 | 0 | 14 | 14 | | 2015 | 1 | 14 | 15 | | 2016 | 2 | 11 | 13 | | 2017 | 1 | 11 | 12 | | 2018 | 1 | 12 | 13 | | 2019 | 1 | 9 | 10 | | 2020 | 1 | 20 | 21 | | 2021 | 0 | 11 | 11 | | 2022 | 0 | 27 | 27 | | 2023 | 0 | 23 | 23 | | 2024 | 1 | 8 | 9 | | 2025 | 0 | 2 | 2 |
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Below are the most recent publications written about "Ligands" by people in Profiles.
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Schlinsog M, Sattasathuchana T, Xu P, Guidez EB, Gilson MK, Potter MJ, Gordon MS, Webb SP. Computation of Protein-Ligand Binding Free Energies with a Quantum Mechanics-Based Mining Minima Algorithm. J Chem Theory Comput. 2025 Apr 22; 21(8):4236-4265.
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Patel M, Panja S, Zaman LA, Yeapuri P, Bhattarai S, Gorantla S, Chang L, Heredia A, Walczak P, Hanson B, Cohen SM, Kevadiya BD, Gendelman HE. CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses. Nat Commun. 2025 Jan 08; 16(1):513.
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Karolczak J, Przybylowska A, Szewczyk K, Taisner W, Heumann JM, Stowell MHB, Nowicki M, Brzezinski D. Ligand identification in CryoEM and X-ray maps using deep learning. Bioinformatics. 2024 12 26; 41(1).
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Pacheco J, Pe?a KA, Savransky S, Gidon A, Hammond GRV, Janetzko J, Vilardaga JP. Fast-diffusing receptor collisions with slow-diffusing peptide ligand assemble the ternary parathyroid hormone-GPCR-arrestin complex. Nat Commun. 2024 12 03; 15(1):10499.
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Leonard AC, Friedman AJ, Chayer R, Petersen BM, Woojuh J, Xing Z, Cutler SR, Kaar JL, Shirts MR, Whitehead TA. Rationalizing Diverse Binding Mechanisms to the Same Protein Fold: Insights for Ligand Recognition and Biosensor Design. ACS Chem Biol. 2024 08 16; 19(8):1757-1772.
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Daffern N, Johansson KE, Baumer ZT, Robertson NR, Woojuh J, Bedewitz MA, Davis Z, Wheeldon I, Cutler SR, Lindorff-Larsen K, Whitehead TA. GMMA Can Stabilize Proteins Across Different Functional Constraints. J Mol Biol. 2024 Jun 01; 436(11):168586.
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Olenginski LT, Spradlin SF, Batey RT. Flipping the script: Understanding riboswitches from an alternative perspective. J Biol Chem. 2024 03; 300(3):105730.
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Jacobson DR, Perkins TT. Quantifying a light-induced energetic change in bacteriorhodopsin by force spectroscopy. Proc Natl Acad Sci U S A. 2024 Feb 13; 121(7):e2313818121.
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Patel SP, Alonso-Gordoa T, Banerjee S, Wang D, Naidoo J, Standifer NE, Palmer DC, Cheng LY, Kourtesis P, Ascierto ML, Das M, Diamond JR, Hellmann MD, Carneiro BA. Phase 1/2 study of monalizumab plus durvalumab in patients with advanced solid tumors. J Immunother Cancer. 2024 02 02; 12(2).
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Mishra N, Kant R, Kandhari K, Ammar DA, Tewari-Singh N, Pantcheva MB, Petrash JM, Agarwal C, Agarwal R. Nitrogen Mustard-Induced Ex Vivo Human Cornea Injury Model and Therapeutic Intervention by Dexamethasone. J Pharmacol Exp Ther. 2024 01 17; 388(2):484-494.
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