 Ligands
"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
| Descriptor ID |
D008024
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| MeSH Number(s) |
D27.720.470.480
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ligands".
Below are MeSH descriptors whose meaning is more specific than "Ligands".
This graph shows the total number of publications written about "Ligands" by people in this website by year, and whether "Ligands" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 13 | 13 | | 1997 | 0 | 5 | 5 | | 1998 | 1 | 10 | 11 | | 1999 | 0 | 8 | 8 | | 2000 | 0 | 9 | 9 | | 2001 | 0 | 18 | 18 | | 2002 | 0 | 16 | 16 | | 2003 | 0 | 23 | 23 | | 2004 | 0 | 21 | 21 | | 2005 | 0 | 18 | 18 | | 2006 | 1 | 21 | 22 | | 2007 | 0 | 15 | 15 | | 2008 | 0 | 16 | 16 | | 2009 | 2 | 21 | 23 | | 2010 | 0 | 17 | 17 | | 2011 | 2 | 14 | 16 | | 2012 | 1 | 21 | 22 | | 2013 | 1 | 19 | 20 | | 2014 | 0 | 17 | 17 | | 2015 | 1 | 17 | 18 | | 2016 | 2 | 14 | 16 | | 2017 | 1 | 14 | 15 | | 2018 | 0 | 11 | 11 | | 2019 | 1 | 9 | 10 | | 2020 | 1 | 22 | 23 | | 2021 | 0 | 12 | 12 | | 2022 | 0 | 30 | 30 | | 2023 | 0 | 26 | 26 | | 2024 | 1 | 10 | 11 | | 2025 | 0 | 8 | 8 |
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Below are the most recent publications written about "Ligands" by people in Profiles.
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Tian H, Beltrán J, George W, Lenert-Mondou C, Seder N, Davis ZI, Swift SD, Girke T, Whitehead TA, Wheeldon I, Cutler SR. Unusually broad-spectrum small-molecule sensing using a single protein scaffold. Proc Natl Acad Sci U S A. 2025 Dec 23; 122(51):e2519924122.
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Spradlin SF, Dickerson KA, Batey RT. Structural and functional clues challenge the hypothesis that the yjdF riboswitch is natively regulated through broad recognition of azaaromatic compounds. Nucleic Acids Res. 2025 Nov 13; 53(21).
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Sardar M, Ahmad N, Mushtaq M, Heinz H, Nur-E-Alam M, Ul-Haq Z. Unveiling Ligand-Induced Conformational Changes in Mutant AR-LBD: Molecular Dynamics Insights into the Androgen Receptor-Coactivator Mechanism. J Chem Inf Model. 2025 Sep 08; 65(17):9154-9176.
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Yamada H, Yano H, Matsubara E, Zhao S, Shinchi Y, Pan C, Koga T, Fujino K, Fujiwara Y, Ikeda K, Komohara Y, Suzuki M. The expression of PD-1 ligands in the immune microenvironment was altered in TTF-1-negative lung adenocarcinoma. Hum Cell. 2025 Aug 18; 38(5):146.
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Adair L, Han R, Fulton R, Figueroa A, Patel M. A multielectrode array reveals therapeutic potential of translocator protein ligands in a zebrafish model of Dravet syndrome. J Pharmacol Exp Ther. 2025 Jul; 392(7):103614.
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Schlinsog M, Sattasathuchana T, Xu P, Guidez EB, Gilson MK, Potter MJ, Gordon MS, Webb SP. Computation of Protein-Ligand Binding Free Energies with a Quantum Mechanics-Based Mining Minima Algorithm. J Chem Theory Comput. 2025 Apr 22; 21(8):4236-4265.
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Patel M, Panja S, Zaman LA, Yeapuri P, Bhattarai S, Gorantla S, Chang L, Heredia A, Walczak P, Hanson B, Cohen SM, Kevadiya BD, Gendelman HE. CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses. Nat Commun. 2025 Jan 08; 16(1):513.
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Gurrea-Rubio M, Lin F, Wicha MS, Mao-Draayer Y, Fox DA. Ligands of CD6: roles in the pathogenesis and treatment of cancer. Front Immunol. 2024; 15:1528478.
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Karolczak J, Przybylowska A, Szewczyk K, Taisner W, Heumann JM, Stowell MHB, Nowicki M, Brzezinski D. Ligand identification in CryoEM and X-ray maps using deep learning. Bioinformatics. 2024 12 26; 41(1).
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Pacheco J, Peña KA, Savransky S, Gidon A, Hammond GRV, Janetzko J, Vilardaga JP. Fast-diffusing receptor collisions with slow-diffusing peptide ligand assemble the ternary parathyroid hormone-GPCR-arrestin complex. Nat Commun. 2024 12 03; 15(1):10499.
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