 Ubiquitin-Protein Ligases
"Ubiquitin-Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
| Descriptor ID |
D044767
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| MeSH Number(s) |
D08.811.464.938.750
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| Concept/Terms |
Ubiquitin-Protein Ligases- Ubiquitin-Protein Ligases
- Ligases, Ubiquitin-Protein
- Ubiquitin Protein Ligases
- E3 Ubiquitin Ligase
- Ligase, E3 Ubiquitin
- Ubiquitin Ligase, E3
- Ubiquitin-Protein Ligase E3
- Ligase E3, Ubiquitin-Protein
- Ubiquitin Protein Ligase E3
- Ubiquitin Ligase E3
- Ligase E3, Ubiquitin
- Ubiquitin-Protein Ligase
- Ligase, Ubiquitin-Protein
- Ubiquitin Protein Ligase
- E3 Ligase
- Ligase, E3
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Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligases".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligases".
This graph shows the total number of publications written about "Ubiquitin-Protein Ligases" by people in this website by year, and whether "Ubiquitin-Protein Ligases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 4 | 4 | | 2006 | 1 | 4 | 5 | | 2007 | 2 | 3 | 5 | | 2008 | 5 | 0 | 5 | | 2009 | 1 | 5 | 6 | | 2010 | 1 | 3 | 4 | | 2011 | 1 | 3 | 4 | | 2012 | 5 | 2 | 7 | | 2013 | 3 | 7 | 10 | | 2014 | 6 | 5 | 11 | | 2015 | 8 | 3 | 11 | | 2016 | 6 | 2 | 8 | | 2017 | 7 | 5 | 12 | | 2018 | 1 | 1 | 2 | | 2019 | 1 | 4 | 5 | | 2020 | 8 | 1 | 9 | | 2021 | 4 | 5 | 9 | | 2022 | 1 | 3 | 4 | | 2023 | 2 | 3 | 5 | | 2024 | 3 | 3 | 6 | | 2025 | 2 | 5 | 7 |
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Below are the most recent publications written about "Ubiquitin-Protein Ligases" by people in Profiles.
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Thorne AJ, Gao A, Necker-Brown A, Bansal A, Kalyanaraman K, Chandramohan P, Sasse SK, Gerber AN, Mostafa MM, Newton R. Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid. Mol Pharmacol. 2025 Oct; 107(10):100073.
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Livingston PD, Labbate Bonaldo AL, Jamnick NA, Weinzierl NM, Gammon CJ, Callaway CS, Lee S, Gao B, Goodspeed A, Carvalho RF, Young CD, Orlicky DJ, Adams DJ, Novinger LJ, Bonetto A. B0092 tumor-bearing mice are a new model for the study of cachexia in head and neck cancer. Am J Physiol Cell Physiol. 2025 Aug 01; 329(2):C646-C658.
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Sargen MR, Fitzhugh MH, Ko JS, Close AG, Horton SC, Malik F, Furtado LV, Bahrami A, Seynnaeve BKN, Pappo AS, Liu V, Cheung K, Pack SD, Xi L, Raffeld M, Lee I, Gagan J, Aldape K, Barr FG, Hewitt SM, Ferrone CK, Hayden A, Hatton JN, Goldstein AM, Pfeiffer RM, Widemann B, Malone MFW, Gross AM, Kaplan R, Yohe ME, Berrebi KG. Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series. Pediatr Blood Cancer. 2025 Aug; 72(8):e31814.
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Sampath R, Vaeth K, Mikalayeva V, Skeberdis VA, Prekeris R, Han KJ. Rab40 GTPases regulate AMBRA1-mediated transcription and cell migration. J Cell Sci. 2025 Apr 01; 138(7).
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Fogo GM, Raghunayakula S, Emaus KJ, Torres Torres FJ, Shangguan G, Wider JM, Hüttemann M, Sanderson TH. Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion. Autophagy. 2025 07; 21(7):1492-1506.
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Briney CA, Henriksen JC, Lin C, Jones LA, Benner L, Rains AB, Gutierrez R, Gafken PR, Rissland OS. Muskelin is a substrate adaptor of the highly regulated Drosophila embryonic CTLH E3 ligase. EMBO Rep. 2025 Mar; 26(6):1647-1669.
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Oguh AU, Haemmerle MW, Sen S, Rozo AV, Shrestha S, Cartailler JP, Fazelinia H, Ding H, Preza S, Yang J, Yang X, Sussel L, Alvarez-Dominguez JR, Doliba N, Spruce LA, Arrojo E Drigo R, Stoffers DA. E3 ligase substrate adaptor SPOP fine-tunes the UPR of pancreatic ß cells. Genes Dev. 2025 Feb 03; 39(3-4):261-279.
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Blears D, Lou J, Fong N, Mitter R, Sheridan RM, He D, Dirac-Svejstrup AB, Bentley D, Svejstrup JQ. Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint. Mol Cell. 2024 Dec 19; 84(24):4790-4807.e11.
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Bricelj A, Dora Ng YL, Gobec M, Kuchta R, Hu W, Javornik ?, Ro?ic M, Gütschow M, Zheng G, Krönke J, Steinebach C, Sosic I. Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs. Chemistry. 2024 Aug 12; 30(45):e202400430.
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Broderick A, Pan E, Li J, Chu A, Hwang C, Barata PC, Cackowski FC, Labriola M, Ghose A, Bilen MA, Kilari D, Thapa B, Piero M, Graham L, Tripathi A, Garje R, Koshkin VS, Hernandez E, Dorff TB, Schweizer MT, Alva AS, McKay RR, Armstrong AJ. Clinical implications of Wnt pathway genetic alterations in men with advanced prostate cancer. Prostate Cancer Prostatic Dis. 2025 Jun; 28(2):419-426.
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