 Epidermal Growth Factor
"Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
| Descriptor ID |
D004815
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| MeSH Number(s) |
D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500
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| Concept/Terms |
Epidermal Growth Factor- Epidermal Growth Factor
- Growth Factor, Epidermal
- Urogastrone
- Epidermal Growth Factor-Urogastrone
- Growth Factor-Urogastrone, Epidermal
- Human Urinary Gastric Inhibitor
- beta-Urogastrone
- beta Urogastrone
- EGF
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Below are MeSH descriptors whose meaning is more general than "Epidermal Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Epidermal Growth Factor".
This graph shows the total number of publications written about "Epidermal Growth Factor" by people in this website by year, and whether "Epidermal Growth Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 1 | 4 | | 1996 | 1 | 2 | 3 | | 1997 | 2 | 2 | 4 | | 1998 | 4 | 1 | 5 | | 1999 | 2 | 2 | 4 | | 2000 | 0 | 3 | 3 | | 2003 | 4 | 5 | 9 | | 2004 | 1 | 5 | 6 | | 2005 | 2 | 2 | 4 | | 2006 | 3 | 3 | 6 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 2 | 0 | 2 | | 2010 | 2 | 1 | 3 | | 2011 | 0 | 3 | 3 | | 2012 | 0 | 3 | 3 | | 2013 | 0 | 5 | 5 | | 2014 | 1 | 2 | 3 | | 2015 | 1 | 2 | 3 | | 2016 | 2 | 3 | 5 | | 2017 | 1 | 0 | 1 | | 2020 | 0 | 2 | 2 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Epidermal Growth Factor" by people in Profiles.
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Sen T, Ju W, Nair V, Ladd P, Menon R, Otto EA, Pyle L, Vigers T, Nelson RG, Arnott C, Neal B, Hansen MK, Kretzler M, Bjornstad P, Heerspink HJL. Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes. Kidney Int. 2023 10; 104(4):828-839.
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Qi Z, Qiu Y, Wang Z, Zhang H, Lu L, Liu Y, Mathes D, Pomfret EA, Gao D, Lu SL, Wang Z. A novel diphtheria toxin-based bivalent human EGF fusion toxin for treatment of head and neck squamous cell carcinoma. Mol Oncol. 2021 04; 15(4):1054-1068.
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Bunker EN, Wheeler GE, Chapnick DA, Liu X. Suppression of a-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-a autocrine/paracrine signaling. Mol Biol Cell. 2021 02 15; 32(4):348-361.
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Lkhagvadorj K, Zeng Z, Song J, Reinders-Luinge M, Kooistra W, Song S, Krauss-Etschmann S, Melgert BN, Cao J, Hylkema MN. Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring: role for AREG-induced EGFR signaling. Am J Physiol Lung Cell Mol Physiol. 2020 10 01; 319(4):L742-L751.
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Astashchanka A, Shroka TM, Jacobsen BM. Mucin 2 (MUC2) modulates the aggressiveness of breast cancer. Breast Cancer Res Treat. 2019 Jan; 173(2):289-299.
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Beswick DM, Santa Maria C, Ayoub NF, Capasso R, Santa Maria PL. Epithelial separation theory for post-tonsillectomy secondary hemorrhage: evidence in a mouse model and potential heparin-binding epidermal growth factor-like growth factor therapy. Eur Arch Otorhinolaryngol. 2018 Feb; 275(2):569-578.
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Holtan SG, Newell LF, Cutler C, Verneris MR, DeFor TE, Wu J, Howard A, MacMillan ML, Antin JH, Blazar BR, Weisdorf DJ, Panoskaltsis-Mortari A. Low EGF in myeloablative allotransplantation: association with severe acute GvHD in BMT CTN 0402. Bone Marrow Transplant. 2017 Sep; 52(9):1300-1303.
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He F, Verneris MR, Cooley S, Blazar BR, MacMillan ML, Newell LF, Panoskaltsis-Mortari A, DeFor T, Weisdorf DJ, Holtan SG. Low day +100 serum epidermal growth factor levels are associated with acute GvHD after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2017 02; 52(2):301-303.
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Thorburn J, Staskiewicz L, Goodall ML, Dimberg L, Frankel AE, Ford HL, Thorburn A. Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells. Mol Pharmacol. 2017 Jan; 91(1):58-64.
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Thongkittidilok C, Wildt DE, Songsasen N. Responsiveness of intraovarian dog follicles in vitro to epidermal growth factor and vascular endothelial growth factor depends on ovarian donor age. Reprod Domest Anim. 2017 Apr; 52 Suppl 2:114-122.
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