 Transfection
"Transfection" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
| Descriptor ID |
D014162
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| MeSH Number(s) |
E05.393.350.810 G05.728.860
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Transfection".
Below are MeSH descriptors whose meaning is more specific than "Transfection".
This graph shows the total number of publications written about "Transfection" by people in this website by year, and whether "Transfection" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 16 | 16 | | 1996 | 0 | 18 | 18 | | 1997 | 1 | 17 | 18 | | 1998 | 2 | 20 | 22 | | 1999 | 1 | 20 | 21 | | 2000 | 0 | 45 | 45 | | 2001 | 3 | 43 | 46 | | 2002 | 1 | 34 | 35 | | 2003 | 6 | 44 | 50 | | 2004 | 3 | 32 | 35 | | 2005 | 1 | 34 | 35 | | 2006 | 0 | 41 | 41 | | 2007 | 0 | 22 | 22 | | 2008 | 4 | 25 | 29 | | 2009 | 2 | 34 | 36 | | 2010 | 2 | 22 | 24 | | 2011 | 2 | 17 | 19 | | 2012 | 1 | 31 | 32 | | 2013 | 4 | 15 | 19 | | 2014 | 5 | 13 | 18 | | 2015 | 3 | 15 | 18 | | 2016 | 1 | 15 | 16 | | 2017 | 1 | 14 | 15 | | 2018 | 1 | 7 | 8 | | 2019 | 0 | 10 | 10 | | 2020 | 0 | 5 | 5 | | 2021 | 0 | 6 | 6 | | 2022 | 0 | 2 | 2 | | 2023 | 0 | 1 | 1 | | 2024 | 1 | 5 | 6 | | 2025 | 0 | 3 | 3 |
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Below are the most recent publications written about "Transfection" by people in Profiles.
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Sekar RP, Lawson JL, McGrath C, Wheeler G, Moreau G, Johansen CG, Farnsworth NL, Kumar R. Tuning DLVO Interactions Alters Polymer-Mediated pDNA Delivery in a Cell Type-Dependent Manner. Langmuir. 2025 Jul 15; 41(27):17426-17438.
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Shin JE, Won EJ, Xu J, Lee JC, Bang JK, Mitchell MJ, Cha-Molstad H. Transition Temperature-Guided Design of Lipid Nanoparticles for Effective mRNA Delivery. ACS Appl Mater Interfaces. 2025 May 14; 17(19):28012-28024.
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Padilla MS, Mrksich K, Wang Y, Haley RM, Li JJ, Han EL, El-Mayta R, Kim EH, Dias S, Gong N, Teerdhala SV, Han X, Chowdhary V, Xue L, Siddiqui Z, Yamagata HM, Kim D, Yoon IC, Wilson JM, Radhakrishnan R, Mitchell MJ. Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Nat Commun. 2025 Jan 24; 16(1):996.
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Han EL, Tang S, Kim D, Murray AM, Swingle KL, Hamilton AG, Mrksich K, Padilla MS, Palanki R, Li JJ, Mitchell MJ. Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain. Nano Lett. 2025 01 15; 25(2):800-810.
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Nunes LGA, Rosario FJ, Urschitz J. In vivo placental gene modulation via sonoporation. Placenta. 2025 Jun 13; 166:109-116.
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Lawson JL, Sekar RP, Wright ARE, Wheeler G, Yanes J, Estridge J, Johansen CG, Farnsworth NL, Kumar P, Tay JW, Kumar R. The Spatial Distribution of Lipophilic Cations in Gradient Copolymers Regulates Polymer-pDNA Complexation, Polyplex Aggregation, and Intracellular pDNA Delivery. Biomacromolecules. 2024 10 14; 25(10):6855-6870.
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Mrksich K, Padilla MS, Joseph RA, Han EL, Kim D, Palanki R, Xu J, Mitchell MJ. Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. J Biomed Mater Res A. 2024 09; 112(9):1494-1505.
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Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Adv Mater. 2024 Jun; 36(26):e2313226.
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Han EL, Padilla MS, Palanki R, Kim D, Mrksich K, Li JJ, Tang S, Yoon IC, Mitchell MJ. Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing. Nano Lett. 2024 02 07; 24(5):1477-1486.
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Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, Weissman D, Mitchell MJ. In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism. Small. 2024 03; 20(11):e2304378.
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