 Mitogen-Activated Protein Kinases
"Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
| Descriptor ID |
D020928
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| MeSH Number(s) |
D08.811.913.696.620.682.700.567 D12.644.360.450 D12.776.476.450
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| Concept/Terms |
Mitogen-Activated Protein Kinases- Mitogen-Activated Protein Kinases
- Kinases, Mitogen-Activated Protein
- Mitogen Activated Protein Kinases
- Protein Kinases, Mitogen-Activated
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Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinases".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinases".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinases" by people in this website by year, and whether "Mitogen-Activated Protein Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 1 | 0 | 1 | | 1996 | 4 | 0 | 4 | | 1997 | 7 | 0 | 7 | | 1998 | 10 | 0 | 10 | | 1999 | 9 | 5 | 14 | | 2000 | 16 | 5 | 21 | | 2001 | 9 | 2 | 11 | | 2002 | 8 | 15 | 23 | | 2003 | 16 | 26 | 42 | | 2004 | 15 | 17 | 32 | | 2005 | 0 | 3 | 3 | | 2006 | 1 | 4 | 5 | | 2007 | 1 | 3 | 4 | | 2008 | 1 | 5 | 6 | | 2009 | 1 | 3 | 4 | | 2010 | 2 | 3 | 5 | | 2011 | 1 | 4 | 5 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 3 | 4 | | 2014 | 3 | 1 | 4 | | 2015 | 3 | 0 | 3 | | 2016 | 4 | 0 | 4 | | 2017 | 2 | 1 | 3 | | 2019 | 1 | 1 | 2 | | 2020 | 4 | 0 | 4 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 3 | 3 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinases" by people in Profiles.
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Pearson AD, Allen C, Fangusaro J, Hutter C, Witt O, Weiner S, Reaman G, Russo M, Bandopadhayay P, Ahsan S, Barone A, Barry E, de Rojas T, Fisher M, Fox E, Bender JG, Gore L, Hargrave D, Hawkins D, Kreider B, Langseth AJ, Lesa G, Ligas F, Marotti M, Marshall LV, Nasri K, Norga K, Nysom K, Pappo A, Rossato G, Scobie N, Smith M, Stieglitz E, Weigel B, Weinstein A, Viana R, Karres D, Vassal G. Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration. Eur J Cancer. 2022 Dec; 177:120-142.
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Hazegh K, Fang F, Kelly K, Sinchar D, Wang L, Zuchelkowski BE, Ufelle AC, Esparza O, Davizon-Castillo P, Page GP, Kanias T. Erythrocyte mitogen-activated protein kinases mediate hemolytic events under osmotic and oxidative stress and in hemolytic diseases. Cell Signal. 2022 11; 99:110450.
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Kavran AJ, Stuart SA, Hayashi KR, Basken JM, Brandhuber BJ, Ahn NG. Intermittent treatment of BRAFV600E melanoma cells delays resistance by adaptive resensitization to drug rechallenge. Proc Natl Acad Sci U S A. 2022 03 22; 119(12):e2113535119.
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Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A. 2021 05 18; 118(20).
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Liao P, Song K, Zhu Z, Liu Z, Zhang W, Li W, Hu J, Hu Q, Chen C, Chen B, McLeod HL, Pei H, Chen L, He Y. Propranolol Suppresses the Growth of Colorectal Cancer Through Simultaneously Activating Autologous CD8+ T Cells and Inhibiting Tumor AKT/MAPK Pathway. Clin Pharmacol Ther. 2020 09; 108(3):606-615.
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Br?zman O, Nov?k J, Bauer AK, Babica P. Airborne PAHs inhibit gap junctional intercellular communication and activate MAPKs in human bronchial epithelial cell line. Environ Toxicol Pharmacol. 2020 Oct; 79:103422.
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Weaver BP, Weaver YM, Omi S, Yuan W, Ewbank JJ, Han M. Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development. Dev Cell. 2020 05 04; 53(3):358-369.e6.
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Anwar A, Anwar H, Yamauchi T, Tseng R, Agarwal R, Horwitz LD, Zhai Z, Fujita M. Bucillamine Inhibits UVB-Induced MAPK Activation and Apoptosis in Human HaCaT Keratinocytes and SKH-1 Hairless Mouse Skin. Photochem Photobiol. 2020 07; 96(4):870-876.
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Neuwelt AJ, Kimball AK, Johnson AM, Arnold BW, Bullock BL, Kaspar RE, Kleczko EK, Kwak JW, Wu MH, Heasley LE, Doebele RC, Li HY, Nemenoff RA, Clambey ET. Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms. J Immunother Cancer. 2020 04; 8(1).
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George TJ, Franke AJ, Chakravarthy AB, Das P, Dasari A, El-Rayes BF, Hong TS, Kinsella TJ, Landry JC, Lee JJ, Monjazeb AM, Jacobs SA, Raben D, Rahma OE, Williams TM, Wu C, Coleman CN, Vikram B, Ahmed MM. National Cancer Institute (NCI) state of the science: Targeted radiosensitizers in colorectal cancer. Cancer. 2019 08 15; 125(16):2732-2746.
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