 High-Throughput Nucleotide Sequencing
"High-Throughput Nucleotide Sequencing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.
| Descriptor ID |
D059014
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| MeSH Number(s) |
E05.393.760.319
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| Concept/Terms |
High-Throughput Nucleotide Sequencing- High-Throughput Nucleotide Sequencing
- High Throughput Nucleotide Sequencing
- Nucleotide Sequencing, High-Throughput
- Sequencing, High-Throughput Nucleotide
Massively-Parallel Sequencing- Massively-Parallel Sequencing
- Massively Parallel Sequencing
- Sequencing, Massively-Parallel
- Sequencings, Massively-Parallel
High-Throughput RNA Sequencing- High-Throughput RNA Sequencing
- High Throughput RNA Sequencing
- RNA Sequencing, High-Throughput
- Sequencing, High-Throughput RNA
Deep Sequencing- Deep Sequencing
- Deep Sequencings
- Sequencing, Deep
- Sequencings, Deep
High-Throughput DNA Sequencing- High-Throughput DNA Sequencing
- DNA Sequencing, High-Throughput
- High Throughput DNA Sequencing
- High-Throughput DNA Sequencings
- Sequencing, High-Throughput DNA
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Below are MeSH descriptors whose meaning is more general than "High-Throughput Nucleotide Sequencing".
Below are MeSH descriptors whose meaning is more specific than "High-Throughput Nucleotide Sequencing".
This graph shows the total number of publications written about "High-Throughput Nucleotide Sequencing" by people in this website by year, and whether "High-Throughput Nucleotide Sequencing" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2008 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 3 | 6 | 9 | | 2012 | 5 | 6 | 11 | | 2013 | 10 | 17 | 27 | | 2014 | 11 | 18 | 29 | | 2015 | 7 | 33 | 40 | | 2016 | 8 | 34 | 42 | | 2017 | 9 | 20 | 29 | | 2018 | 22 | 26 | 48 | | 2019 | 11 | 18 | 29 | | 2020 | 2 | 17 | 19 | | 2021 | 6 | 21 | 27 | | 2022 | 5 | 14 | 19 | | 2023 | 1 | 14 | 15 | | 2024 | 6 | 8 | 14 | | 2025 | 4 | 20 | 24 | | 2026 | 0 | 3 | 3 |
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Below are the most recent publications written about "High-Throughput Nucleotide Sequencing" by people in Profiles.
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Hansen MS, Hill CJ, Sussel L, Wells KL. Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets. Diabetes. 2026 Apr 01; 75(4):606-616.
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Waliany S, Cooper AJ, Liu SV, Gautschi O, Rotow JK, Smith KER, Weber UM, Lee DH, Loong HHF, Patel JD, Pennell NA, Nagasaka M, Patel SA, Tan DSW, Solomon BJ, Kim TM, Pall G, Riess JW, Sun L, Früh M, Uy NF, Gadgeel S, Feng J, Do A, Falcon C, Leighl NB, Baik CS, Lai GGY, Ou SI, Cheung KSY, Patil T, Mansfield AS, Weiler D, Yeap BY, Wirth LJ, Gainor JF, Drilon A, Lin JJ. Landscape of Genomic Mechanisms of Resistance to Selective RET Inhibitors in RET-Altered Solid Tumors: Analysis of the RETgistry Global Consortium. Clin Cancer Res. 2026 Mar 16; 32(6):1157-1168.
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Chu VT, Spottiswoode N, Ward R, Yokoe DS, Ramirez-Avila L, Phelps MS, Glascock A, Crawford ED, Kamm J, Hao S, Li L, Dynerman D, Waltari E, Nafees S, Kalantar KL, Caldera S, Madera S, Guerrero ES, Ivashin D, Serpa PH, Love C, Mwakibete LL, Doernberg SB, Kistler A, Alvino R, Engel J, Chiu CY, Pak C, Cunningham G, Reyes H, Buie B, Messacar K, Leroue M, Prince BC, Detweiler AM, Stanley K, Caughell C, McNeil N, Neff N, Nichols A, Miller S, DeRisi JL, Tato CM, Langelier CR. Implementation and outcomes of a rapid response genomic hospital epidemiology programme at an academic medical centre over 7 years. Lancet Microbe. 2026 Feb; 7(2):101277.
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Russell JN, Kos D, Yacoub E, Sies AN, Warr B, Jelinski M, Ruzzini A, Cameron ADS. Enhanced metagenomic surveillance for bovine respiratory disease pathogens and antimicrobial resistance by hybridization capture sequencing. Appl Environ Microbiol. 2025 Oct 22; 91(10):e0097725.
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Pitsava G, Hawley M, Auriga L, de Dios I, Ko A, Marmolejos S, Almalvez M, Chen I, Scozzaro K, Zhao J, Barrick R, Ah Mew N, Fusaro VA, LoTempio J, Taylor M, Mestroni L, Graw S, Milewicz D, Guo D, Murdock DR, Bujakowska KM, Xiao C, Délot EC, Berger SI, Vilain E. Genome sequencing reveals the impact of pseudoexons in rare genetic disease. Genet Med. 2025 Nov; 27(11):101574.
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Liu X, Tang YH, Blachly J, Edge S, Jakubek YA, McCarter M, Naqash AR, Nepple KG, Osman A, Reilley MJ, Riedlinger G, Salhia B, Schneider BP, Shriver C, Churchman ML, Rounbehler RJ, Teer JK, Gillis N, Teng M. qcCHIP: an R package to identify clonal hematopoiesis variants using cohort-specific data characteristics. Bioinformatics. 2025 Sep 01; 41(9).
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Rizkalla CN, Tretiakova M, Suarez CJ, Williamson SR, Al-Obaidy KI, Acosta AM, Idrees MT, Chan E, Potterveld S, Sangoi AR. Urothelial carcinoma with osteoclast-like giant cells: An expanded immunohistochemical and molecular profile. Am J Clin Pathol. 2025 Aug 26; 164(2):257-264.
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Ungar WJ, Wu V, Marshall CR, Hwang J, Hayeems RZ, Tsiplova K, Gillespie MK, Szuto A, Chisholm C, Stavropoulos DJ, Venkataramanan V, Xiao B, Costain G, Bergeron MB, Sawyer S, Lau L, Huang L, Mendoza-Londono R, Somerville MJ, Boycott KM. A microcosting and cost consequence analysis from a randomized controlled trial comparing genome sequencing with exome sequencing for genetic diagnosis. Genet Med. 2026 Feb; 28(2):101561.
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Zane LK, Yee LM, Chang TC, Sklar J, Yang G, Wen JD, Li P, Harrington R, Sims DJ, Harper K, Trent JM, LoBello JR, Szelinger S, Benson K, Zeng J, Poorman K, Xu D, Frampton GM, Pavlick DC, Miller VA, Tandon B, Swat W, Weiss L, Funari VA, Conroy JM, Prescott JL, Chandra PK, Ma C, Champion KJ, Baschkopf GX, Fesko YA, Freitas TAK, Tomlins SA, Hovelson DH, White K, Sorrells S, Tell R, Beaubier N, King D, Li L, Kelly K, Uvalic J, Meyers B, Kolhe R, Lindeman NI, Baltay M, Sholl LM, Lopategui J, Vail E, Zhang W, Telatar M, Afkhami M, Hsiao SJ, Mansukhani MM, Adams E, Jiang L, Aldape KD, Raffeld M, Xi L, Stehr H, Segal JP, Aisner DL, Davies KD, Brown NA, Livingston RJ, Konnick EQ, Song W, Solomon JP, Walther Z, McShane LM, Harris LN, Chen AP, Tsongalis GJ, Hamilton SR, Flaherty KT, O'Dwyer PJ, Conley BA, Patton DR, Iafrate AJ, Williams PM, Tricoli JV, Karlovich C. A Concordance Study among 26 NGS Laboratories Participating in the NCI Molecular Analysis for Therapy Choice Clinical Trial. Clin Cancer Res. 2025 Aug 14; 31(16):3512-3525.
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Kronenberg Z, Nolan C, Porubsky D, Mokveld T, Rowell WJ, Lee S, Dolzhenko E, Chang PC, Holt JM, Saunders CT, Olson ND, Steely CJ, McGee S, Guarracino A, Koundinya N, Harvey WT, Watkins WS, Munson KM, Hoekzema K, Chua KP, Chen X, Fanslow C, Lambert C, Dashnow H, Garrison E, Smith JD, Lansdorp PM, Zook JM, Carroll A, Jorde LB, Neklason DW, Quinlan AR, Eichler EE, Eberle MA. The Platinum Pedigree: a long-read benchmark for genetic variants. Nat Methods. 2025 Aug; 22(8):1669-1676.
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