Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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John Tentler

Concepts (390)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Pyrimidines
8
2020
520
1.380
Why?
Xenograft Model Antitumor Assays
22
2025
929
1.250
Why?
Antineoplastic Agents
19
2025
2207
1.210
Why?
Triple Negative Breast Neoplasms
5
2020
218
1.210
Why?
Protein Kinase Inhibitors
15
2020
980
1.170
Why?
Proto-Oncogene Proteins
10
2018
620
0.910
Why?
Colorectal Neoplasms
11
2018
866
0.910
Why?
Azepines
4
2020
106
0.810
Why?
Piperazines
4
2020
378
0.800
Why?
Quinoxalines
2
2020
64
0.780
Why?
Melanoma
10
2018
759
0.750
Why?
Pyrazoles
4
2018
517
0.720
Why?
Gene Expression Regulation, Neoplastic
9
2020
1439
0.710
Why?
Mice, Nude
16
2020
678
0.650
Why?
Cell Proliferation
22
2025
2499
0.640
Why?
Lymphocytes, Tumor-Infiltrating
1
2020
153
0.590
Why?
beta Catenin
2
2020
253
0.590
Why?
Enoyl-CoA Hydratase
1
2018
12
0.570
Why?
Cell Line, Tumor
25
2025
3537
0.530
Why?
DNA-Binding Proteins
8
2015
1487
0.520
Why?
Benzimidazoles
4
2013
187
0.480
Why?
Tumor Microenvironment
1
2020
737
0.470
Why?
Mutation
11
2018
4093
0.460
Why?
Cardiomyopathy, Dilated
1
2018
356
0.450
Why?
Tumor Suppressor Proteins
2
2015
320
0.450
Why?
Tumor Suppressor Protein p53
4
2016
536
0.440
Why?
ras Proteins
3
2013
151
0.410
Why?
Apoptosis
14
2025
2411
0.400
Why?
Pyrazines
5
2013
93
0.390
Why?
Genomics
1
2018
834
0.390
Why?
Proto-Oncogene Proteins B-raf
4
2018
224
0.370
Why?
Oncogene Proteins, Fusion
3
2018
212
0.340
Why?
Drug Design
1
2012
176
0.330
Why?
Mice
22
2025
18338
0.320
Why?
Prolactin
7
2004
87
0.320
Why?
Biomarkers, Tumor
3
2017
1321
0.320
Why?
Mitogen-Activated Protein Kinase Kinases
1
2010
126
0.310
Why?
Histone Deacetylase Inhibitors
3
2022
218
0.310
Why?
Nuclear Proteins
1
2015
743
0.310
Why?
Aurora Kinase A
4
2020
61
0.300
Why?
Drug Resistance, Neoplasm
8
2020
881
0.290
Why?
Animals
45
2025
38141
0.270
Why?
Cell Transformation, Neoplastic
4
2013
337
0.260
Why?
Pituitary Gland
7
2003
148
0.260
Why?
Imidazoles
4
2013
246
0.260
Why?
Neoplasms
4
2022
2897
0.240
Why?
Hydroxamic Acids
3
2011
94
0.240
Why?
Ethanol
11
1997
632
0.230
Why?
Gene Expression Profiling
6
2018
1769
0.230
Why?
Exome
2
2017
227
0.230
Why?
Protein Synthesis Inhibitors
1
2025
48
0.220
Why?
Ubiquitin-Activating Enzymes
2
2016
20
0.220
Why?
Transcription Factors
4
2011
1733
0.210
Why?
Pyrimidinones
2
2015
125
0.210
Why?
Breast Neoplasms
3
2012
2373
0.200
Why?
Antineoplastic Combined Chemotherapy Protocols
6
2020
1965
0.200
Why?
Protein Biosynthesis
2
2025
455
0.200
Why?
Receptor, IGF Type 1
3
2013
63
0.200
Why?
Pyridones
2
2015
208
0.190
Why?
Hematologic Neoplasms
1
2025
168
0.190
Why?
Cell Cycle Proteins
3
2018
631
0.180
Why?
Hypothalamus
12
1997
161
0.180
Why?
Humans
45
2025
145491
0.180
Why?
Immunoblotting
5
2015
294
0.180
Why?
Tumor Cells, Cultured
3
2020
883
0.170
Why?
Drug Synergism
4
2018
353
0.170
Why?
c-Mer Tyrosine Kinase
2
2018
38
0.170
Why?
G2 Phase Cell Cycle Checkpoints
3
2018
44
0.160
Why?
Benzoxazoles
1
2020
20
0.160
Why?
Transcription, Genetic
4
2013
1468
0.160
Why?
Breast
3
2018
157
0.160
Why?
Boronic Acids
2
2011
36
0.160
Why?
Growth Hormone
3
1997
91
0.150
Why?
Signal Transduction
10
2018
5202
0.150
Why?
Adenine
2
2020
338
0.150
Why?
eIF-2 Kinase
1
2019
29
0.150
Why?
Wnt Signaling Pathway
2
2019
210
0.150
Why?
Female
27
2020
78763
0.150
Why?
Sequence Analysis, RNA
2
2018
443
0.150
Why?
Epithelial Cells
4
2011
1112
0.150
Why?
Proto-Oncogene Proteins p21(ras)
4
2016
254
0.140
Why?
Phosphorylation
6
2025
1707
0.140
Why?
Breast Neoplasms, Male
1
2018
29
0.140
Why?
Cell Cycle
7
2018
595
0.140
Why?
Linkage Disequilibrium
1
2018
249
0.140
Why?
MAP Kinase Kinase Kinases
2
2015
70
0.140
Why?
Septins
1
2018
43
0.140
Why?
Cytochrome P-450 Enzyme System
1
2018
161
0.130
Why?
Mice, Inbred BALB C
1
2020
1261
0.130
Why?
Drug Therapy, Combination
1
2020
1046
0.130
Why?
Genetics, Population
1
2018
217
0.130
Why?
Cytoskeleton
1
2018
198
0.130
Why?
Neurofibromin 1
1
2017
26
0.130
Why?
Somatostatin
1
1997
53
0.130
Why?
Gonadotropin-Releasing Hormone
8
1993
212
0.130
Why?
Armadillo Domain Proteins
1
2017
6
0.130
Why?
Sexual Maturation
1
1997
48
0.120
Why?
Proto-Oncogene Proteins c-kit
1
2017
72
0.120
Why?
Testis
2
1997
162
0.120
Why?
RNA Splicing Factors
1
2017
66
0.120
Why?
Cyclopentanes
1
2016
18
0.120
Why?
Inhibitory Concentration 50
2
2016
90
0.120
Why?
Proto-Oncogene Proteins c-ret
1
2017
41
0.120
Why?
Cyclic AMP Response Element-Binding Protein
1
1997
145
0.120
Why?
Cyclic AMP-Dependent Protein Kinases
1
1997
125
0.120
Why?
Mucous Membrane
1
2017
128
0.120
Why?
Genes, erbB-1
1
2016
21
0.120
Why?
Gene Regulatory Networks
1
2018
320
0.120
Why?
Oligonucleotide Array Sequence Analysis
3
2015
751
0.120
Why?
Education, Graduate
1
2015
36
0.110
Why?
Skin Neoplasms
2
2013
850
0.110
Why?
HT29 Cells
2
2018
37
0.110
Why?
RNA, Messenger
10
2003
2820
0.110
Why?
Peptides, Cyclic
1
1997
275
0.110
Why?
Drug Discovery
1
2016
154
0.110
Why?
Tumor Protein p73
1
2015
18
0.110
Why?
Mitogen-Activated Protein Kinases
2
2014
287
0.110
Why?
Neoplasm Invasiveness
3
2018
505
0.110
Why?
Phosphoproteins
1
2017
339
0.110
Why?
Proteasome Endopeptidase Complex
2
2013
153
0.110
Why?
Luteinizing Hormone
8
1993
190
0.100
Why?
Cluster Analysis
2
2012
517
0.100
Why?
Computational Biology
2
2016
687
0.100
Why?
Case-Control Studies
2
2018
3619
0.100
Why?
Protein Kinases
1
2015
314
0.100
Why?
Testosterone
2
1997
413
0.100
Why?
Protein-Tyrosine Kinases
1
2017
431
0.100
Why?
Genotype
1
2018
1853
0.100
Why?
Receptor, Insulin
1
2013
93
0.100
Why?
Phenotype
3
2018
3157
0.100
Why?
Cell Survival
4
2019
1094
0.100
Why?
Ubiquitin-Conjugating Enzymes
1
2013
17
0.100
Why?
Tumor Stem Cell Assay
1
2012
34
0.090
Why?
Aurora Kinases
1
2012
28
0.090
Why?
Cyclin-Dependent Kinase Inhibitor p16
1
2013
72
0.090
Why?
Proto-Oncogene Proteins c-ets
4
2011
56
0.090
Why?
BRCA1 Protein
1
2013
82
0.090
Why?
Alcohol Oxidoreductases
1
2013
62
0.090
Why?
Rats
21
2004
5581
0.090
Why?
MicroRNAs
1
2018
689
0.090
Why?
Genes, p53
1
2012
67
0.090
Why?
Cyclosporine
1
2013
256
0.090
Why?
Mitochondria
1
2018
990
0.090
Why?
Positron-Emission Tomography
2
2011
343
0.090
Why?
Proto-Oncogene Proteins c-met
1
2012
76
0.090
Why?
Drug Screening Assays, Antitumor
4
2016
191
0.080
Why?
Ubiquitin-Protein Ligases
1
2013
191
0.080
Why?
TOR Serine-Threonine Kinases
1
2014
452
0.080
Why?
Proteasome Inhibitors
1
2011
38
0.080
Why?
Receptor Protein-Tyrosine Kinases
1
2013
230
0.080
Why?
Polymorphism, Single Nucleotide
1
2018
2146
0.080
Why?
Mammary Glands, Human
1
2011
68
0.080
Why?
Transcriptional Activation
2
2003
372
0.080
Why?
Cytoplasm
1
2011
257
0.080
Why?
Protease Inhibitors
1
2011
101
0.080
Why?
Recombinant Fusion Proteins
2
2011
667
0.080
Why?
Cell Movement
3
2011
961
0.080
Why?
Cellular Senescence
1
2012
225
0.080
Why?
Vascular Endothelial Growth Factor Receptor-3
1
2009
7
0.080
Why?
Neoplasm Transplantation
3
2016
246
0.080
Why?
Ki-67 Antigen
1
2010
117
0.080
Why?
Capillary Permeability
1
2010
132
0.080
Why?
Vascular Endothelial Growth Factor Receptor-1
1
2009
74
0.070
Why?
Gastrointestinal Neoplasms
1
2009
71
0.070
Why?
Adenocarcinoma
1
2016
923
0.070
Why?
Cell Line
4
2012
2823
0.070
Why?
Quinazolines
1
2009
266
0.070
Why?
Promoter Regions, Genetic
3
2004
1247
0.070
Why?
Peptide Fragments
1
2011
693
0.070
Why?
Carcinoma, Hepatocellular
1
2011
372
0.060
Why?
Pituitary Gland, Anterior
4
1992
37
0.060
Why?
Enzyme Inhibitors
3
2013
821
0.060
Why?
Algorithms
2
2015
1855
0.060
Why?
Drug Delivery Systems
1
2010
382
0.060
Why?
Colonic Neoplasms
1
2009
257
0.060
Why?
Prognosis
2
2017
4323
0.060
Why?
Proto-Oncogene Protein c-ets-1
2
2003
26
0.060
Why?
Disease Models, Animal
2
2014
4559
0.060
Why?
Reproducibility of Results
2
2010
3424
0.060
Why?
Growth Hormone-Releasing Hormone
2
1997
19
0.060
Why?
Rats, Inbred Strains
12
1992
320
0.060
Why?
Transplantation, Heterologous
2
2016
169
0.050
Why?
Oncogene Protein p65(gag-jun)
1
2004
2
0.050
Why?
Proto-Oncogene Proteins c-jun
1
2004
54
0.050
Why?
Gene Expression Regulation
2
2004
2594
0.050
Why?
Proto-Oncogene Proteins c-myc
1
2025
167
0.050
Why?
Transfection
2
2003
925
0.050
Why?
Male
25
2020
72817
0.050
Why?
High-Throughput Nucleotide Sequencing
2
2017
553
0.050
Why?
Transcription Factor Pit-1
1
2003
26
0.050
Why?
Suppression, Genetic
1
2003
25
0.050
Why?
Mesoderm
1
2004
147
0.050
Why?
Genes, Dominant
1
2003
100
0.050
Why?
Disease Progression
3
2018
2862
0.050
Why?
Pancreatic Neoplasms
1
2011
928
0.050
Why?
Lung Neoplasms
1
2016
2664
0.050
Why?
Histone Deacetylase 1
1
2022
23
0.040
Why?
Caspase 3
2
2013
234
0.040
Why?
Blotting, Northern
3
1997
203
0.040
Why?
Acetylation
1
2022
250
0.040
Why?
DNA Repair
2
2013
256
0.040
Why?
DNA Damage
2
2013
434
0.040
Why?
Middle Aged
6
2020
36176
0.040
Why?
Repressor Proteins
1
2004
430
0.040
Why?
Radioimmunoassay
8
1993
165
0.040
Why?
Histone Deacetylases
1
2022
207
0.040
Why?
Bortezomib
2
2011
54
0.040
Why?
Aged
5
2020
26125
0.040
Why?
Mechanistic Target of Rapamycin Complex 2
1
2020
62
0.040
Why?
Maximum Tolerated Dose
1
2020
211
0.040
Why?
Myeloid Cell Leukemia Sequence 1 Protein
1
2019
39
0.040
Why?
Mechanistic Target of Rapamycin Complex 1
1
2020
138
0.040
Why?
Blotting, Western
3
2010
1162
0.040
Why?
Gene Expression
3
1993
1478
0.040
Why?
M Phase Cell Cycle Checkpoints
1
2018
23
0.040
Why?
Azetidines
1
2018
45
0.040
Why?
Lymphocytes
2
1991
379
0.030
Why?
Spleen
2
1991
511
0.030
Why?
GTP Phosphohydrolases
1
2018
93
0.030
Why?
4-Aminobenzoic Acid
1
2018
8
0.030
Why?
Nausea
1
2018
113
0.030
Why?
HCT116 Cells
1
2018
78
0.030
Why?
Enzyme-Linked Immunosorbent Assay
2
2010
839
0.030
Why?
Okadaic Acid
1
1997
15
0.030
Why?
Orchiectomy
4
1994
73
0.030
Why?
Colforsin
1
1997
47
0.030
Why?
Mutagenesis, Site-Directed
2
2011
374
0.030
Why?
Dose-Response Relationship, Drug
3
1997
2030
0.030
Why?
Diarrhea
1
2018
194
0.030
Why?
Piperidines
1
2018
221
0.030
Why?
Angiogenesis Inhibitors
1
2018
238
0.030
Why?
Cells, Cultured
4
2013
4127
0.030
Why?
Tumor Burden
1
2018
324
0.030
Why?
Histones
1
2022
663
0.030
Why?
Ubiquitination
1
2016
118
0.030
Why?
Heterografts
1
2016
143
0.030
Why?
Cyclin-Dependent Kinase Inhibitor p21
1
2016
106
0.030
Why?
Protein Isoforms
1
2017
396
0.030
Why?
Cetuximab
1
2016
111
0.030
Why?
Cell Differentiation
1
2004
2045
0.030
Why?
Fatigue
1
2018
364
0.030
Why?
Gene Rearrangement
1
2017
156
0.030
Why?
Camptothecin
1
2016
138
0.030
Why?
Administration, Oral
1
2018
863
0.030
Why?
Models, Educational
1
2015
89
0.030
Why?
Treatment Outcome
1
2010
11831
0.030
Why?
Polymerase Chain Reaction
3
1993
1049
0.030
Why?
Capacity Building
1
2015
62
0.030
Why?
DNA Copy Number Variations
1
2016
184
0.030
Why?
Diphenylamine
1
2014
8
0.030
Why?
DNA Mutational Analysis
1
2016
409
0.030
Why?
Biopsy
1
2018
1081
0.030
Why?
Follicle Stimulating Hormone
2
1993
250
0.030
Why?
Databases, Genetic
1
2015
248
0.030
Why?
Interdisciplinary Communication
1
2015
200
0.030
Why?
Aged, 80 and over
2
2017
8326
0.030
Why?
Guanine
1
1994
85
0.030
Why?
Analysis of Variance
1
1997
1304
0.030
Why?
Methyltransferases
1
1994
75
0.030
Why?
Gonadotropins
1
1993
39
0.030
Why?
Neoplasm Metastasis
1
2016
691
0.030
Why?
Caspase 7
1
2013
22
0.030
Why?
MAP Kinase Kinase 2
1
2013
28
0.020
Why?
Butadienes
1
2013
36
0.020
Why?
Benzamides
1
2014
224
0.020
Why?
Research Personnel
1
2015
187
0.020
Why?
Program Development
1
2015
369
0.020
Why?
MAP Kinase Kinase 1
1
2013
70
0.020
Why?
Mentors
1
2015
218
0.020
Why?
Kinetics
2
2014
1605
0.020
Why?
Molecular Sequence Data
3
2011
2910
0.020
Why?
Cell Cycle Checkpoints
1
2013
98
0.020
Why?
Oncogene Proteins, Viral
1
2013
20
0.020
Why?
Cyclin-Dependent Kinase Inhibitor p27
1
2013
64
0.020
Why?
Adult
4
2018
40707
0.020
Why?
Melanocytes
1
2013
65
0.020
Why?
Cooperative Behavior
1
2015
464
0.020
Why?
Genes, Synthetic
1
2012
14
0.020
Why?
Proto-Oncogene Proteins c-mdm2
1
2013
67
0.020
Why?
Genes, Lethal
1
2012
30
0.020
Why?
Phosphatidylinositol 3-Kinases
1
2014
380
0.020
Why?
Drug Hypersensitivity
1
1993
90
0.020
Why?
DNA, Neoplasm
1
2013
158
0.020
Why?
Nitriles
1
2013
205
0.020
Why?
Mice, SCID
1
2013
369
0.020
Why?
Ataxia Telangiectasia Mutated Proteins
1
2012
68
0.020
Why?
Membrane Proteins
1
2018
1164
0.020
Why?
Nuclear Export Signals
1
2011
4
0.020
Why?
Nuclear Localization Signals
1
2011
16
0.020
Why?
Glycoprotein Hormones, alpha Subunit
1
1991
23
0.020
Why?
Precision Medicine
1
2016
456
0.020
Why?
Microscopy, Fluorescence
1
2013
407
0.020
Why?
Peptide Mapping
1
2011
62
0.020
Why?
Intercellular Signaling Peptides and Proteins
1
2013
376
0.020
Why?
Alcoholic Intoxication
1
1992
77
0.020
Why?
Calcium Signaling
1
2013
244
0.020
Why?
Amino Acid Motifs
1
2011
220
0.020
Why?
Colony-Forming Units Assay
1
2010
95
0.020
Why?
Amino Acid Substitution
1
2011
303
0.020
Why?
Culture Media, Conditioned
1
2010
112
0.020
Why?
Genes, ras
1
2010
96
0.020
Why?
Protein Transport
1
2011
438
0.020
Why?
Gene Dosage
1
2010
148
0.020
Why?
Ligands
1
2011
667
0.020
Why?
Hypertension
1
2018
1273
0.020
Why?
Nuclear Magnetic Resonance, Biomolecular
1
2011
346
0.020
Why?
Structure-Activity Relationship
1
2010
567
0.020
Why?
Gene Knockdown Techniques
1
2010
335
0.020
Why?
Drug Combinations
1
2010
397
0.020
Why?
Serum Albumin
1
1990
144
0.020
Why?
Prolactinoma
1
1989
13
0.020
Why?
Protein Structure, Tertiary
1
2011
850
0.020
Why?
Immunohistochemistry
1
2013
1710
0.020
Why?
Transcriptome
1
2015
1038
0.020
Why?
Curriculum
1
2015
1068
0.020
Why?
Magnetic Resonance Spectroscopy
1
2011
625
0.020
Why?
Cell Communication
1
2010
326
0.020
Why?
Proto-Oncogene Proteins c-akt
1
2010
436
0.020
Why?
Pregnanediones
1
1987
12
0.020
Why?
Rats, Sprague-Dawley
4
1994
2526
0.020
Why?
Follow-Up Studies
1
2017
5426
0.020
Why?
Amino Acid Sequence
1
2011
2137
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2009
975
0.020
Why?
Brain Chemistry
1
1987
117
0.020
Why?
Calcium
1
2013
1190
0.020
Why?
Sulfonamides
1
2011
581
0.020
Why?
Pituitary Neoplasms
1
1989
190
0.020
Why?
Anesthetics
1
1987
99
0.020
Why?
Estrogens
1
1989
364
0.010
Why?
Feasibility Studies
1
2010
1119
0.010
Why?
Flow Cytometry
1
2009
1156
0.010
Why?
Prostatic Neoplasms
1
2013
978
0.010
Why?
Indoles
1
2009
508
0.010
Why?
Models, Biological
1
2013
1815
0.010
Why?
Metabolomics
1
2011
729
0.010
Why?
Liver Neoplasms
1
2011
779
0.010
Why?
Proto-Oncogene Protein c-ets-2
1
2004
4
0.010
Why?
Contact Inhibition
1
2004
5
0.010
Why?
Oncogene Protein p21(ras)
1
2004
15
0.010
Why?
Epidermal Growth Factor
1
2004
161
0.010
Why?
Antisense Elements (Genetics)
1
2003
3
0.010
Why?
Collagenases
1
2003
22
0.010
Why?
Matrix Metalloproteinase 3
1
2003
27
0.010
Why?
Genetic Vectors
1
2004
335
0.010
Why?
Cell Adhesion
1
2004
452
0.010
Why?
Cytokines
1
2010
2054
0.010
Why?
Cell Division
1
2004
753
0.010
Why?
Trans-Activators
1
2004
397
0.010
Why?
HeLa Cells
1
2003
633
0.010
Why?
Brain
1
1992
2944
0.010
Why?
Potassium
2
1990
153
0.010
Why?
Base Sequence
2
1993
2180
0.010
Why?
Biological Assay
2
1990
129
0.010
Why?
Hypophysectomy
2
1987
12
0.010
Why?
O(6)-Methylguanine-DNA Methyltransferase
1
1994
6
0.010
Why?
Cocarcinogenesis
1
1994
13
0.010
Why?
Injections, Intraperitoneal
1
1994
115
0.010
Why?
Rats, Mutant Strains
1
1993
19
0.010
Why?
Thyrotropin
1
1994
119
0.010
Why?
RNA-Directed DNA Polymerase
1
1993
35
0.010
Why?
Stress, Physiological
2
1987
452
0.010
Why?
Adrenocorticotropic Hormone
1
1994
147
0.010
Why?
Blotting, Southern
1
1992
84
0.010
Why?
Cyclic AMP
1
1992
207
0.010
Why?
Protein Kinase C
1
1992
250
0.010
Why?
Enzyme Activation
1
1992
762
0.010
Why?
RNA Splicing
1
1992
286
0.000
Why?
Cross Reactions
1
1990
130
0.000
Why?
Dinoprostone
1
1990
180
0.000
Why?
Bromocriptine
1
1989
31
0.000
Why?
Norepinephrine
1
1990
200
0.000
Why?
Naloxone
1
1990
132
0.000
Why?
Perfusion
1
1990
249
0.000
Why?
Rats, Inbred F344
1
1989
268
0.000
Why?
In Vitro Techniques
1
1990
1047
0.000
Why?
Depression, Chemical
1
1987
16
0.000
Why?
Chromatography, High Pressure Liquid
1
1990
581
0.000
Why?
Urethane
1
1987
43
0.000
Why?
Molecular Weight
1
1987
312
0.000
Why?
Pancreas
1
1990
341
0.000
Why?
Dopamine
1
1990
295
0.000
Why?
Drug Administration Schedule
1
1989
782
0.000
Why?
Cerebral Cortex
1
1990
471
0.000
Why?
Ketamine
1
1987
137
0.000
Why?
Restraint, Physical
1
1986
75
0.000
Why?
Alcoholism
1
1992
821
0.000
Why?
DNA
1
1991
1451
0.000
Why?
Kidney
1
1990
1498
0.000
Why?
Liver
1
1990
1895
0.000
Why?
Lung
1
1990
4103
0.000
Why?
Tentler's Networks
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