Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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John Tentler

Concepts (390)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Pyrimidines
8
2020
472
1.450
Why?
Xenograft Model Antitumor Assays
22
2025
870
1.310
Why?
Antineoplastic Agents
19
2025
2152
1.260
Why?
Triple Negative Breast Neoplasms
5
2020
203
1.260
Why?
Protein Kinase Inhibitors
15
2020
907
1.260
Why?
Colorectal Neoplasms
11
2018
792
0.970
Why?
Proto-Oncogene Proteins
10
2018
621
0.940
Why?
Azepines
4
2020
97
0.850
Why?
Piperazines
4
2020
345
0.840
Why?
Quinoxalines
2
2020
67
0.800
Why?
Pyrazoles
4
2018
425
0.780
Why?
Melanoma
10
2018
757
0.770
Why?
Gene Expression Regulation, Neoplastic
9
2020
1395
0.740
Why?
Mice, Nude
16
2020
688
0.670
Why?
Cell Proliferation
22
2025
2480
0.660
Why?
beta Catenin
2
2020
253
0.610
Why?
Enoyl-CoA Hydratase
1
2018
12
0.600
Why?
Lymphocytes, Tumor-Infiltrating
1
2020
205
0.580
Why?
Cell Line, Tumor
25
2025
3397
0.550
Why?
DNA-Binding Proteins
8
2015
1473
0.540
Why?
Benzimidazoles
4
2013
177
0.500
Why?
Tumor Microenvironment
1
2020
668
0.500
Why?
Mutation
11
2018
3984
0.480
Why?
Cardiomyopathy, Dilated
1
2018
334
0.470
Why?
Tumor Suppressor Proteins
2
2015
322
0.460
Why?
Tumor Suppressor Protein p53
4
2016
527
0.450
Why?
ras Proteins
3
2013
148
0.420
Why?
Genomics
1
2018
797
0.410
Why?
Pyrazines
5
2013
86
0.410
Why?
Apoptosis
14
2025
2551
0.400
Why?
Proto-Oncogene Proteins B-raf
4
2018
221
0.380
Why?
Oncogene Proteins, Fusion
3
2018
206
0.360
Why?
Drug Design
1
2012
165
0.350
Why?
Mice
22
2025
17828
0.340
Why?
Biomarkers, Tumor
3
2017
1229
0.340
Why?
Prolactin
7
2004
95
0.330
Why?
Mitogen-Activated Protein Kinase Kinases
1
2010
132
0.330
Why?
Nuclear Proteins
1
2015
707
0.320
Why?
Histone Deacetylase Inhibitors
3
2022
209
0.320
Why?
Aurora Kinase A
4
2020
55
0.320
Why?
Drug Resistance, Neoplasm
8
2020
801
0.310
Why?
Animals
45
2025
37243
0.290
Why?
Cell Transformation, Neoplastic
4
2013
333
0.270
Why?
Imidazoles
4
2013
239
0.270
Why?
Pituitary Gland
7
2003
150
0.270
Why?
Neoplasms
4
2022
2687
0.260
Why?
Hydroxamic Acids
3
2011
90
0.250
Why?
Ethanol
11
1997
615
0.240
Why?
Gene Expression Profiling
6
2018
1746
0.240
Why?
Exome
2
2017
237
0.230
Why?
Protein Synthesis Inhibitors
1
2025
47
0.230
Why?
Ubiquitin-Activating Enzymes
2
2016
17
0.230
Why?
Transcription Factors
4
2011
1701
0.220
Why?
Pyrimidinones
2
2015
114
0.220
Why?
Breast Neoplasms
3
2012
2283
0.220
Why?
Antineoplastic Combined Chemotherapy Protocols
6
2020
1742
0.220
Why?
Protein Biosynthesis
2
2025
434
0.210
Why?
Pyridones
2
2015
170
0.200
Why?
Receptor, IGF Type 1
3
2013
64
0.200
Why?
Hematologic Neoplasms
1
2025
159
0.200
Why?
Cell Cycle Proteins
3
2018
617
0.190
Why?
Humans
45
2025
138972
0.190
Why?
Hypothalamus
12
1997
153
0.190
Why?
Immunoblotting
5
2015
309
0.180
Why?
Drug Synergism
4
2018
367
0.180
Why?
Tumor Cells, Cultured
3
2020
956
0.180
Why?
c-Mer Tyrosine Kinase
2
2018
41
0.170
Why?
G2 Phase Cell Cycle Checkpoints
3
2018
44
0.170
Why?
Benzoxazoles
1
2020
19
0.160
Why?
Transcription, Genetic
4
2013
1471
0.160
Why?
Breast
3
2018
158
0.160
Why?
Boronic Acids
2
2011
35
0.160
Why?
Female
27
2020
74016
0.160
Why?
Signal Transduction
10
2018
5092
0.160
Why?
Growth Hormone
3
1997
102
0.160
Why?
Wnt Signaling Pathway
2
2019
197
0.160
Why?
eIF-2 Kinase
1
2019
31
0.160
Why?
Sequence Analysis, RNA
2
2018
449
0.150
Why?
Epithelial Cells
4
2011
1103
0.150
Why?
Proto-Oncogene Proteins p21(ras)
4
2016
262
0.150
Why?
Phosphorylation
6
2025
1767
0.150
Why?
Breast Neoplasms, Male
1
2018
29
0.140
Why?
Cell Cycle
7
2018
593
0.140
Why?
Linkage Disequilibrium
1
2018
258
0.140
Why?
MAP Kinase Kinase Kinases
2
2015
72
0.140
Why?
Septins
1
2018
43
0.140
Why?
Cytochrome P-450 Enzyme System
1
2018
158
0.140
Why?
Mice, Inbred BALB C
1
2020
1261
0.140
Why?
Drug Therapy, Combination
1
2020
1031
0.140
Why?
Genetics, Population
1
2018
207
0.130
Why?
Cytoskeleton
1
2018
194
0.130
Why?
Neurofibromin 1
1
2017
25
0.130
Why?
Somatostatin
1
1997
58
0.130
Why?
Gonadotropin-Releasing Hormone
8
1993
212
0.130
Why?
Armadillo Domain Proteins
1
2017
6
0.130
Why?
Proto-Oncogene Proteins c-kit
1
2017
67
0.130
Why?
RNA Splicing Factors
1
2017
56
0.130
Why?
Testis
2
1997
157
0.130
Why?
Proto-Oncogene Proteins c-ret
1
2017
33
0.130
Why?
Sexual Maturation
1
1997
55
0.130
Why?
Inhibitory Concentration 50
2
2016
89
0.130
Why?
Cyclopentanes
1
2016
19
0.130
Why?
Cyclic AMP-Dependent Protein Kinases
1
1997
129
0.130
Why?
Cyclic AMP Response Element-Binding Protein
1
1997
145
0.130
Why?
Mucous Membrane
1
2017
126
0.130
Why?
Genes, erbB-1
1
2016
18
0.120
Why?
Gene Regulatory Networks
1
2018
310
0.120
Why?
Adenine
1
2018
301
0.120
Why?
RNA, Messenger
10
2003
2815
0.120
Why?
Education, Graduate
1
2015
33
0.120
Why?
Oligonucleotide Array Sequence Analysis
3
2015
761
0.120
Why?
Drug Discovery
1
2016
144
0.120
Why?
Skin Neoplasms
2
2013
837
0.120
Why?
HT29 Cells
2
2018
41
0.120
Why?
Peptides, Cyclic
1
1997
265
0.120
Why?
Tumor Protein p73
1
2015
14
0.120
Why?
Neoplasm Invasiveness
3
2018
501
0.110
Why?
Phosphoproteins
1
2017
340
0.110
Why?
Proteasome Endopeptidase Complex
2
2013
159
0.110
Why?
Mitogen-Activated Protein Kinases
2
2014
316
0.110
Why?
Luteinizing Hormone
8
1993
183
0.110
Why?
Computational Biology
2
2016
650
0.110
Why?
Cluster Analysis
2
2012
517
0.110
Why?
Testosterone
2
1997
402
0.100
Why?
Case-Control Studies
2
2018
3574
0.100
Why?
Protein Kinases
1
2015
308
0.100
Why?
Genotype
1
2018
1849
0.100
Why?
Protein-Tyrosine Kinases
1
2017
431
0.100
Why?
Receptor, Insulin
1
2013
100
0.100
Why?
Phenotype
3
2018
3143
0.100
Why?
Ubiquitin-Conjugating Enzymes
1
2013
13
0.100
Why?
Cell Survival
4
2019
1126
0.100
Why?
Tumor Stem Cell Assay
1
2012
34
0.100
Why?
Aurora Kinases
1
2012
28
0.100
Why?
Cyclin-Dependent Kinase Inhibitor p16
1
2013
68
0.100
Why?
Proto-Oncogene Proteins c-ets
4
2011
56
0.100
Why?
BRCA1 Protein
1
2013
77
0.100
Why?
Alcohol Oxidoreductases
1
2013
61
0.100
Why?
Rats
21
2004
5591
0.090
Why?
Genes, p53
1
2012
68
0.090
Why?
MicroRNAs
1
2018
676
0.090
Why?
Mitochondria
1
2018
958
0.090
Why?
Positron-Emission Tomography
2
2011
304
0.090
Why?
Cyclosporine
1
2013
266
0.090
Why?
Receptor, ErbB-2
2
2012
349
0.090
Why?
Proto-Oncogene Proteins c-met
1
2012
72
0.090
Why?
TOR Serine-Threonine Kinases
1
2014
416
0.090
Why?
Ubiquitin-Protein Ligases
1
2013
174
0.090
Why?
Drug Screening Assays, Antitumor
4
2016
193
0.090
Why?
Proteasome Inhibitors
1
2011
43
0.090
Why?
Receptor Protein-Tyrosine Kinases
1
2013
231
0.090
Why?
Polymorphism, Single Nucleotide
1
2018
2138
0.090
Why?
Mammary Glands, Human
1
2011
65
0.090
Why?
Transcriptional Activation
2
2003
376
0.080
Why?
Cellular Senescence
1
2012
190
0.080
Why?
Cytoplasm
1
2011
270
0.080
Why?
Recombinant Fusion Proteins
2
2011
663
0.080
Why?
Protease Inhibitors
1
2011
104
0.080
Why?
Cell Movement
3
2011
969
0.080
Why?
Vascular Endothelial Growth Factor Receptor-3
1
2009
7
0.080
Why?
Ki-67 Antigen
1
2010
111
0.080
Why?
Neoplasm Transplantation
3
2016
249
0.080
Why?
Capillary Permeability
1
2010
147
0.080
Why?
Vascular Endothelial Growth Factor Receptor-1
1
2009
72
0.080
Why?
Adenocarcinoma
1
2016
882
0.070
Why?
Gastrointestinal Neoplasms
1
2009
75
0.070
Why?
Cell Line
4
2012
2879
0.070
Why?
Quinazolines
1
2009
249
0.070
Why?
Promoter Regions, Genetic
3
2004
1235
0.070
Why?
Carcinoma, Hepatocellular
1
2011
339
0.070
Why?
Peptide Fragments
1
2011
694
0.070
Why?
Algorithms
2
2015
1730
0.070
Why?
Pituitary Gland, Anterior
4
1992
38
0.070
Why?
Enzyme Inhibitors
3
2013
850
0.060
Why?
Drug Delivery Systems
1
2010
359
0.060
Why?
Prognosis
2
2017
3995
0.060
Why?
Colonic Neoplasms
1
2009
247
0.060
Why?
Proto-Oncogene Protein c-ets-1
2
2003
25
0.060
Why?
Disease Models, Animal
2
2014
4316
0.060
Why?
Reproducibility of Results
2
2010
3313
0.060
Why?
Growth Hormone-Releasing Hormone
2
1997
25
0.060
Why?
Rats, Inbred Strains
12
1992
345
0.060
Why?
Transplantation, Heterologous
2
2016
193
0.060
Why?
Oncogene Protein p65(gag-jun)
1
2004
2
0.060
Why?
Proto-Oncogene Proteins c-jun
1
2004
57
0.050
Why?
Gene Expression Regulation
2
2004
2591
0.050
Why?
Male
25
2020
68250
0.050
Why?
Proto-Oncogene Proteins c-myc
1
2025
147
0.050
Why?
Transfection
2
2003
942
0.050
Why?
High-Throughput Nucleotide Sequencing
2
2017
543
0.050
Why?
Transcription Factor Pit-1
1
2003
27
0.050
Why?
Suppression, Genetic
1
2003
24
0.050
Why?
Disease Progression
3
2018
2752
0.050
Why?
Mesoderm
1
2004
144
0.050
Why?
Genes, Dominant
1
2003
97
0.050
Why?
Pancreatic Neoplasms
1
2011
859
0.050
Why?
Lung Neoplasms
1
2016
2533
0.050
Why?
Histone Deacetylase 1
1
2022
20
0.050
Why?
DNA Repair
2
2013
229
0.050
Why?
Caspase 3
2
2013
251
0.040
Why?
Middle Aged
6
2020
33782
0.040
Why?
Blotting, Northern
3
1997
198
0.040
Why?
Acetylation
1
2022
244
0.040
Why?
DNA Damage
2
2013
422
0.040
Why?
Aged
5
2020
24172
0.040
Why?
Repressor Proteins
1
2004
423
0.040
Why?
Radioimmunoassay
8
1993
169
0.040
Why?
Histone Deacetylases
1
2022
209
0.040
Why?
Bortezomib
2
2011
53
0.040
Why?
Mechanistic Target of Rapamycin Complex 2
1
2020
62
0.040
Why?
Maximum Tolerated Dose
1
2020
204
0.040
Why?
Myeloid Cell Leukemia Sequence 1 Protein
1
2019
40
0.040
Why?
Mechanistic Target of Rapamycin Complex 1
1
2020
129
0.040
Why?
Blotting, Western
3
2010
1232
0.040
Why?
Gene Expression
3
1993
1487
0.040
Why?
M Phase Cell Cycle Checkpoints
1
2018
24
0.040
Why?
Azetidines
1
2018
44
0.040
Why?
Spleen
2
1991
524
0.040
Why?
Lymphocytes
2
1991
395
0.040
Why?
GTP Phosphohydrolases
1
2018
93
0.040
Why?
4-Aminobenzoic Acid
1
2018
8
0.040
Why?
Nausea
1
2018
111
0.030
Why?
HCT116 Cells
1
2018
80
0.030
Why?
Enzyme-Linked Immunosorbent Assay
2
2010
850
0.030
Why?
Okadaic Acid
1
1997
15
0.030
Why?
Orchiectomy
4
1994
75
0.030
Why?
Colforsin
1
1997
48
0.030
Why?
Mutagenesis, Site-Directed
2
2011
376
0.030
Why?
Diarrhea
1
2018
182
0.030
Why?
Dose-Response Relationship, Drug
3
1997
2047
0.030
Why?
Piperidines
1
2018
216
0.030
Why?
Angiogenesis Inhibitors
1
2018
230
0.030
Why?
Tumor Burden
1
2018
307
0.030
Why?
Cells, Cultured
4
2013
4182
0.030
Why?
Histones
1
2022
632
0.030
Why?
Ubiquitination
1
2016
105
0.030
Why?
Fatigue
1
2018
337
0.030
Why?
Cell Differentiation
1
2004
1994
0.030
Why?
Heterografts
1
2016
135
0.030
Why?
Cetuximab
1
2016
98
0.030
Why?
Protein Isoforms
1
2017
397
0.030
Why?
Administration, Oral
1
2018
787
0.030
Why?
Cyclin-Dependent Kinase Inhibitor p21
1
2016
122
0.030
Why?
Gene Rearrangement
1
2017
151
0.030
Why?
Treatment Outcome
1
2010
10921
0.030
Why?
Camptothecin
1
2016
122
0.030
Why?
Polymerase Chain Reaction
3
1993
1047
0.030
Why?
Models, Educational
1
2015
95
0.030
Why?
Capacity Building
1
2015
62
0.030
Why?
DNA Copy Number Variations
1
2016
179
0.030
Why?
Diphenylamine
1
2014
9
0.030
Why?
DNA Mutational Analysis
1
2016
397
0.030
Why?
Biopsy
1
2018
1072
0.030
Why?
Aged, 80 and over
2
2017
7685
0.030
Why?
Interdisciplinary Communication
1
2015
191
0.030
Why?
Follicle Stimulating Hormone
2
1993
243
0.030
Why?
Databases, Genetic
1
2015
241
0.030
Why?
Guanine
1
1994
81
0.030
Why?
Analysis of Variance
1
1997
1317
0.030
Why?
Methyltransferases
1
1994
72
0.030
Why?
Gonadotropins
1
1993
40
0.030
Why?
Neoplasm Metastasis
1
2016
667
0.030
Why?
Caspase 7
1
2013
22
0.030
Why?
Research Personnel
1
2015
183
0.030
Why?
Benzamides
1
2014
213
0.030
Why?
Butadienes
1
2013
37
0.030
Why?
MAP Kinase Kinase 2
1
2013
28
0.030
Why?
Program Development
1
2015
362
0.030
Why?
Mentors
1
2015
209
0.030
Why?
MAP Kinase Kinase 1
1
2013
75
0.030
Why?
Adult
4
2018
38393
0.030
Why?
Kinetics
2
2014
1649
0.030
Why?
Cell Cycle Checkpoints
1
2013
97
0.020
Why?
Oncogene Proteins, Viral
1
2013
22
0.020
Why?
Molecular Sequence Data
3
2011
2925
0.020
Why?
Cyclin-Dependent Kinase Inhibitor p27
1
2013
74
0.020
Why?
Melanocytes
1
2013
65
0.020
Why?
Cooperative Behavior
1
2015
457
0.020
Why?
Phosphatidylinositol 3-Kinases
1
2014
368
0.020
Why?
Genes, Synthetic
1
2012
14
0.020
Why?
Nitriles
1
2013
176
0.020
Why?
Genes, Lethal
1
2012
30
0.020
Why?
Proto-Oncogene Proteins c-mdm2
1
2013
66
0.020
Why?
DNA, Neoplasm
1
2013
158
0.020
Why?
Drug Hypersensitivity
1
1993
95
0.020
Why?
Mice, SCID
1
2013
368
0.020
Why?
Ataxia Telangiectasia Mutated Proteins
1
2012
65
0.020
Why?
Membrane Proteins
1
2018
1149
0.020
Why?
Precision Medicine
1
2016
421
0.020
Why?
Nuclear Export Signals
1
2011
4
0.020
Why?
Glycoprotein Hormones, alpha Subunit
1
1991
23
0.020
Why?
Nuclear Localization Signals
1
2011
18
0.020
Why?
Peptide Mapping
1
2011
65
0.020
Why?
Alcoholic Intoxication
1
1992
70
0.020
Why?
Microscopy, Fluorescence
1
2013
413
0.020
Why?
Intercellular Signaling Peptides and Proteins
1
2013
385
0.020
Why?
Calcium Signaling
1
2013
250
0.020
Why?
Amino Acid Motifs
1
2011
225
0.020
Why?
Colony-Forming Units Assay
1
2010
96
0.020
Why?
Amino Acid Substitution
1
2011
310
0.020
Why?
Culture Media, Conditioned
1
2010
112
0.020
Why?
Genes, ras
1
2010
94
0.020
Why?
Protein Transport
1
2011
443
0.020
Why?
Gene Dosage
1
2010
141
0.020
Why?
Ligands
1
2011
666
0.020
Why?
Hypertension
1
2018
1249
0.020
Why?
Drug Combinations
1
2010
346
0.020
Why?
Nuclear Magnetic Resonance, Biomolecular
1
2011
342
0.020
Why?
Structure-Activity Relationship
1
2010
570
0.020
Why?
Transcriptome
1
2015
966
0.020
Why?
Gene Knockdown Techniques
1
2010
329
0.020
Why?
Prolactinoma
1
1989
14
0.020
Why?
Serum Albumin
1
1990
151
0.020
Why?
Protein Structure, Tertiary
1
2011
862
0.020
Why?
Curriculum
1
2015
1008
0.020
Why?
Immunohistochemistry
1
2013
1730
0.020
Why?
Cell Communication
1
2010
316
0.020
Why?
Magnetic Resonance Spectroscopy
1
2011
611
0.020
Why?
Proto-Oncogene Proteins c-akt
1
2010
442
0.020
Why?
Pregnanediones
1
1987
9
0.020
Why?
Rats, Sprague-Dawley
4
1994
2497
0.020
Why?
Follow-Up Studies
1
2017
5152
0.020
Why?
Amino Acid Sequence
1
2011
2159
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2009
984
0.020
Why?
Brain Chemistry
1
1987
118
0.020
Why?
Sulfonamides
1
2011
505
0.020
Why?
Calcium
1
2013
1188
0.020
Why?
Pituitary Neoplasms
1
1989
191
0.020
Why?
Anesthetics
1
1987
98
0.020
Why?
Feasibility Studies
1
2010
980
0.020
Why?
Estrogens
1
1989
370
0.010
Why?
Models, Biological
1
2013
1810
0.010
Why?
Metabolomics
1
2011
689
0.010
Why?
Flow Cytometry
1
2009
1192
0.010
Why?
Prostatic Neoplasms
1
2013
1046
0.010
Why?
Liver Neoplasms
1
2011
719
0.010
Why?
Proto-Oncogene Protein c-ets-2
1
2004
4
0.010
Why?
Contact Inhibition
1
2004
5
0.010
Why?
Oncogene Protein p21(ras)
1
2004
16
0.010
Why?
Epidermal Growth Factor
1
2004
176
0.010
Why?
Antisense Elements (Genetics)
1
2003
3
0.010
Why?
Collagenases
1
2003
24
0.010
Why?
Matrix Metalloproteinase 3
1
2003
28
0.010
Why?
Genetic Vectors
1
2004
336
0.010
Why?
Cell Adhesion
1
2004
466
0.010
Why?
Cytokines
1
2010
2083
0.010
Why?
Cell Division
1
2004
794
0.010
Why?
Trans-Activators
1
2004
391
0.010
Why?
HeLa Cells
1
2003
638
0.010
Why?
Brain
1
1992
2791
0.010
Why?
Potassium
2
1990
147
0.010
Why?
Base Sequence
2
1993
2176
0.010
Why?
Biological Assay
2
1990
129
0.010
Why?
Hypophysectomy
2
1987
15
0.010
Why?
O(6)-Methylguanine-DNA Methyltransferase
1
1994
6
0.010
Why?
Cocarcinogenesis
1
1994
13
0.010
Why?
Injections, Intraperitoneal
1
1994
114
0.010
Why?
Rats, Mutant Strains
1
1993
24
0.010
Why?
Thyrotropin
1
1994
117
0.010
Why?
RNA-Directed DNA Polymerase
1
1993
34
0.010
Why?
Stress, Physiological
2
1987
450
0.010
Why?
Adrenocorticotropic Hormone
1
1994
148
0.010
Why?
Blotting, Southern
1
1992
75
0.010
Why?
Cyclic AMP
1
1992
219
0.010
Why?
Protein Kinase C
1
1992
252
0.010
Why?
Enzyme Activation
1
1992
819
0.010
Why?
RNA Splicing
1
1992
270
0.010
Why?
Cross Reactions
1
1990
130
0.000
Why?
Dinoprostone
1
1990
192
0.000
Why?
Norepinephrine
1
1990
192
0.000
Why?
Bromocriptine
1
1989
31
0.000
Why?
Naloxone
1
1990
123
0.000
Why?
Perfusion
1
1990
225
0.000
Why?
Rats, Inbred F344
1
1989
267
0.000
Why?
Depression, Chemical
1
1987
20
0.000
Why?
In Vitro Techniques
1
1990
1090
0.000
Why?
Chromatography, High Pressure Liquid
1
1990
590
0.000
Why?
Urethane
1
1987
43
0.000
Why?
Pancreas
1
1990
322
0.000
Why?
Molecular Weight
1
1987
326
0.000
Why?
Drug Administration Schedule
1
1989
769
0.000
Why?
Dopamine
1
1990
308
0.000
Why?
Ketamine
1
1987
110
0.000
Why?
Cerebral Cortex
1
1990
452
0.000
Why?
Restraint, Physical
1
1986
73
0.000
Why?
Alcoholism
1
1992
818
0.000
Why?
DNA
1
1991
1441
0.000
Why?
Kidney
1
1990
1467
0.000
Why?
Liver
1
1990
1807
0.000
Why?
Lung
1
1990
4103
0.000
Why?
Tentler's Networks
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