Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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John Tentler

Concepts (390)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Pyrimidines
8
2020
530
1.370
Why?
Xenograft Model Antitumor Assays
22
2025
936
1.240
Why?
Antineoplastic Agents
19
2025
2219
1.210
Why?
Triple Negative Breast Neoplasms
5
2020
218
1.200
Why?
Protein Kinase Inhibitors
15
2020
981
1.170
Why?
Proto-Oncogene Proteins
10
2018
625
0.910
Why?
Colorectal Neoplasms
11
2018
868
0.900
Why?
Azepines
4
2020
105
0.810
Why?
Piperazines
4
2020
375
0.790
Why?
Quinoxalines
2
2020
65
0.770
Why?
Melanoma
10
2018
762
0.750
Why?
Pyrazoles
4
2018
517
0.720
Why?
Gene Expression Regulation, Neoplastic
9
2020
1450
0.710
Why?
Mice, Nude
16
2020
680
0.650
Why?
Cell Proliferation
22
2025
2514
0.640
Why?
Lymphocytes, Tumor-Infiltrating
1
2020
154
0.590
Why?
beta Catenin
2
2020
254
0.580
Why?
Enoyl-CoA Hydratase
1
2018
12
0.570
Why?
Cell Line, Tumor
25
2025
3551
0.520
Why?
DNA-Binding Proteins
8
2015
1482
0.520
Why?
Benzimidazoles
4
2013
189
0.480
Why?
Tumor Microenvironment
1
2020
735
0.470
Why?
Mutation
11
2018
4090
0.460
Why?
Cardiomyopathy, Dilated
1
2018
356
0.450
Why?
Tumor Suppressor Proteins
2
2015
322
0.440
Why?
Tumor Suppressor Protein p53
4
2016
534
0.440
Why?
ras Proteins
3
2013
150
0.400
Why?
Apoptosis
14
2025
2444
0.400
Why?
Genomics
1
2018
830
0.390
Why?
Pyrazines
5
2013
94
0.390
Why?
Proto-Oncogene Proteins B-raf
4
2018
224
0.370
Why?
Oncogene Proteins, Fusion
3
2018
212
0.340
Why?
Drug Design
1
2012
175
0.330
Why?
Mice
22
2025
18355
0.320
Why?
Prolactin
7
2004
87
0.320
Why?
Biomarkers, Tumor
3
2017
1329
0.320
Why?
Mitogen-Activated Protein Kinase Kinases
1
2010
126
0.310
Why?
Histone Deacetylase Inhibitors
3
2022
218
0.310
Why?
Nuclear Proteins
1
2015
740
0.300
Why?
Aurora Kinase A
4
2020
61
0.300
Why?
Drug Resistance, Neoplasm
8
2020
883
0.290
Why?
Animals
45
2025
38101
0.270
Why?
Cell Transformation, Neoplastic
4
2013
337
0.260
Why?
Pituitary Gland
7
2003
149
0.260
Why?
Imidazoles
4
2013
247
0.250
Why?
Neoplasms
4
2022
2913
0.240
Why?
Hydroxamic Acids
3
2011
94
0.240
Why?
Ethanol
11
1997
631
0.230
Why?
Gene Expression Profiling
6
2018
1777
0.230
Why?
Exome
2
2017
229
0.220
Why?
Protein Synthesis Inhibitors
1
2025
48
0.220
Why?
Ubiquitin-Activating Enzymes
2
2016
20
0.220
Why?
Transcription Factors
4
2011
1736
0.210
Why?
Pyrimidinones
2
2015
125
0.210
Why?
Breast Neoplasms
3
2012
2393
0.200
Why?
Protein Biosynthesis
2
2025
452
0.200
Why?
Antineoplastic Combined Chemotherapy Protocols
6
2020
1969
0.200
Why?
Receptor, IGF Type 1
3
2013
64
0.200
Why?
Pyridones
2
2015
209
0.190
Why?
Hematologic Neoplasms
1
2025
168
0.190
Why?
Cell Cycle Proteins
3
2018
630
0.180
Why?
Humans
45
2025
145783
0.180
Why?
Hypothalamus
12
1997
163
0.180
Why?
Immunoblotting
5
2015
295
0.180
Why?
Tumor Cells, Cultured
3
2020
887
0.170
Why?
Drug Synergism
4
2018
354
0.170
Why?
c-Mer Tyrosine Kinase
2
2018
39
0.160
Why?
G2 Phase Cell Cycle Checkpoints
3
2018
44
0.160
Why?
Transcription, Genetic
4
2013
1454
0.160
Why?
Benzoxazoles
1
2020
20
0.160
Why?
Breast
3
2018
156
0.150
Why?
Boronic Acids
2
2011
36
0.150
Why?
Growth Hormone
3
1997
91
0.150
Why?
Signal Transduction
10
2018
5224
0.150
Why?
Adenine
2
2020
339
0.150
Why?
eIF-2 Kinase
1
2019
28
0.150
Why?
Wnt Signaling Pathway
2
2019
212
0.150
Why?
Female
27
2020
79045
0.150
Why?
Sequence Analysis, RNA
2
2018
442
0.150
Why?
Epithelial Cells
4
2011
1134
0.140
Why?
Proto-Oncogene Proteins p21(ras)
4
2016
254
0.140
Why?
Phosphorylation
6
2025
1708
0.140
Why?
Breast Neoplasms, Male
1
2018
29
0.140
Why?
Cell Cycle
7
2018
598
0.140
Why?
Linkage Disequilibrium
1
2018
255
0.140
Why?
MAP Kinase Kinase Kinases
2
2015
70
0.140
Why?
Septins
1
2018
43
0.130
Why?
Cytochrome P-450 Enzyme System
1
2018
162
0.130
Why?
Mice, Inbred BALB C
1
2020
1261
0.130
Why?
Drug Therapy, Combination
1
2020
1043
0.130
Why?
Cytoskeleton
1
2018
192
0.130
Why?
Genetics, Population
1
2018
217
0.130
Why?
Neurofibromin 1
1
2017
26
0.130
Why?
Somatostatin
1
1997
53
0.130
Why?
Gonadotropin-Releasing Hormone
8
1993
217
0.130
Why?
Armadillo Domain Proteins
1
2017
6
0.130
Why?
Sexual Maturation
1
1997
48
0.120
Why?
Proto-Oncogene Proteins c-kit
1
2017
72
0.120
Why?
Testis
2
1997
162
0.120
Why?
RNA Splicing Factors
1
2017
66
0.120
Why?
Cyclopentanes
1
2016
17
0.120
Why?
Inhibitory Concentration 50
2
2016
91
0.120
Why?
Proto-Oncogene Proteins c-ret
1
2017
41
0.120
Why?
Cyclic AMP-Dependent Protein Kinases
1
1997
125
0.120
Why?
Cyclic AMP Response Element-Binding Protein
1
1997
146
0.120
Why?
Mucous Membrane
1
2017
128
0.120
Why?
Genes, erbB-1
1
2016
21
0.120
Why?
Gene Regulatory Networks
1
2018
318
0.120
Why?
Oligonucleotide Array Sequence Analysis
3
2015
751
0.110
Why?
RNA, Messenger
10
2003
2805
0.110
Why?
Education, Graduate
1
2015
35
0.110
Why?
Skin Neoplasms
2
2013
853
0.110
Why?
HT29 Cells
2
2018
37
0.110
Why?
Peptides, Cyclic
1
1997
273
0.110
Why?
Drug Discovery
1
2016
153
0.110
Why?
Tumor Protein p73
1
2015
18
0.110
Why?
Mitogen-Activated Protein Kinases
2
2014
288
0.110
Why?
Phosphoproteins
1
2017
337
0.110
Why?
Neoplasm Invasiveness
3
2018
508
0.110
Why?
Proteasome Endopeptidase Complex
2
2013
155
0.110
Why?
Cluster Analysis
2
2012
501
0.100
Why?
Luteinizing Hormone
8
1993
207
0.100
Why?
Computational Biology
2
2016
669
0.100
Why?
Case-Control Studies
2
2018
3634
0.100
Why?
Protein Kinases
1
2015
312
0.100
Why?
Testosterone
2
1997
416
0.100
Why?
Genotype
1
2018
1857
0.100
Why?
Protein-Tyrosine Kinases
1
2017
431
0.100
Why?
Receptor, Insulin
1
2013
93
0.100
Why?
Phenotype
3
2018
3170
0.100
Why?
Cell Survival
4
2019
1104
0.100
Why?
Ubiquitin-Conjugating Enzymes
1
2013
17
0.100
Why?
Tumor Stem Cell Assay
1
2012
34
0.090
Why?
Aurora Kinases
1
2012
28
0.090
Why?
Cyclin-Dependent Kinase Inhibitor p16
1
2013
72
0.090
Why?
Proto-Oncogene Proteins c-ets
4
2011
56
0.090
Why?
BRCA1 Protein
1
2013
82
0.090
Why?
Alcohol Oxidoreductases
1
2013
61
0.090
Why?
Rats
21
2004
5585
0.090
Why?
MicroRNAs
1
2018
686
0.090
Why?
Genes, p53
1
2012
67
0.090
Why?
Cyclosporine
1
2013
256
0.090
Why?
Mitochondria
1
2018
993
0.090
Why?
Positron-Emission Tomography
2
2011
343
0.090
Why?
Proto-Oncogene Proteins c-met
1
2012
76
0.090
Why?
Drug Screening Assays, Antitumor
4
2016
194
0.080
Why?
Ubiquitin-Protein Ligases
1
2013
194
0.080
Why?
TOR Serine-Threonine Kinases
1
2014
456
0.080
Why?
Proteasome Inhibitors
1
2011
41
0.080
Why?
Receptor Protein-Tyrosine Kinases
1
2013
231
0.080
Why?
Polymorphism, Single Nucleotide
1
2018
2181
0.080
Why?
Mammary Glands, Human
1
2011
68
0.080
Why?
Transcriptional Activation
2
2003
372
0.080
Why?
Cytoplasm
1
2011
254
0.080
Why?
Protease Inhibitors
1
2011
102
0.080
Why?
Recombinant Fusion Proteins
2
2011
666
0.080
Why?
Cell Movement
3
2011
963
0.080
Why?
Cellular Senescence
1
2012
226
0.080
Why?
Vascular Endothelial Growth Factor Receptor-3
1
2009
7
0.080
Why?
Neoplasm Transplantation
3
2016
246
0.080
Why?
Ki-67 Antigen
1
2010
118
0.080
Why?
Capillary Permeability
1
2010
132
0.070
Why?
Vascular Endothelial Growth Factor Receptor-1
1
2009
74
0.070
Why?
Gastrointestinal Neoplasms
1
2009
73
0.070
Why?
Adenocarcinoma
1
2016
926
0.070
Why?
Cell Line
4
2012
2823
0.070
Why?
Quinazolines
1
2009
266
0.070
Why?
Promoter Regions, Genetic
3
2004
1247
0.070
Why?
Peptide Fragments
1
2011
697
0.060
Why?
Carcinoma, Hepatocellular
1
2011
373
0.060
Why?
Pituitary Gland, Anterior
4
1992
37
0.060
Why?
Enzyme Inhibitors
3
2013
821
0.060
Why?
Algorithms
2
2015
1851
0.060
Why?
Drug Delivery Systems
1
2010
381
0.060
Why?
Colonic Neoplasms
1
2009
258
0.060
Why?
Prognosis
2
2017
4330
0.060
Why?
Proto-Oncogene Protein c-ets-1
2
2003
26
0.060
Why?
Reproducibility of Results
2
2010
3418
0.060
Why?
Disease Models, Animal
2
2014
4568
0.060
Why?
Growth Hormone-Releasing Hormone
2
1997
19
0.060
Why?
Rats, Inbred Strains
12
1992
321
0.060
Why?
Transplantation, Heterologous
2
2016
170
0.050
Why?
Oncogene Protein p65(gag-jun)
1
2004
2
0.050
Why?
Proto-Oncogene Proteins c-jun
1
2004
54
0.050
Why?
Gene Expression Regulation
2
2004
2601
0.050
Why?
Proto-Oncogene Proteins c-myc
1
2025
169
0.050
Why?
Transfection
2
2003
927
0.050
Why?
High-Throughput Nucleotide Sequencing
2
2017
534
0.050
Why?
Male
25
2020
73010
0.050
Why?
Transcription Factor Pit-1
1
2003
26
0.050
Why?
Suppression, Genetic
1
2003
25
0.050
Why?
Mesoderm
1
2004
147
0.050
Why?
Genes, Dominant
1
2003
100
0.050
Why?
Disease Progression
3
2018
2865
0.050
Why?
Pancreatic Neoplasms
1
2011
928
0.050
Why?
Lung Neoplasms
1
2016
2668
0.050
Why?
Histone Deacetylase 1
1
2022
23
0.040
Why?
Caspase 3
2
2013
242
0.040
Why?
Blotting, Northern
3
1997
203
0.040
Why?
DNA Repair
2
2013
255
0.040
Why?
Acetylation
1
2022
259
0.040
Why?
Middle Aged
6
2020
36309
0.040
Why?
DNA Damage
2
2013
437
0.040
Why?
Repressor Proteins
1
2004
429
0.040
Why?
Radioimmunoassay
8
1993
165
0.040
Why?
Histone Deacetylases
1
2022
207
0.040
Why?
Bortezomib
2
2011
54
0.040
Why?
Aged
5
2020
26217
0.040
Why?
Mechanistic Target of Rapamycin Complex 2
1
2020
62
0.040
Why?
Maximum Tolerated Dose
1
2020
211
0.040
Why?
Myeloid Cell Leukemia Sequence 1 Protein
1
2019
39
0.040
Why?
Mechanistic Target of Rapamycin Complex 1
1
2020
138
0.040
Why?
Blotting, Western
3
2010
1184
0.040
Why?
Gene Expression
3
1993
1478
0.040
Why?
M Phase Cell Cycle Checkpoints
1
2018
23
0.040
Why?
Azetidines
1
2018
45
0.040
Why?
Lymphocytes
2
1991
376
0.030
Why?
Spleen
2
1991
508
0.030
Why?
GTP Phosphohydrolases
1
2018
93
0.030
Why?
4-Aminobenzoic Acid
1
2018
8
0.030
Why?
Nausea
1
2018
112
0.030
Why?
HCT116 Cells
1
2018
76
0.030
Why?
Enzyme-Linked Immunosorbent Assay
2
2010
849
0.030
Why?
Okadaic Acid
1
1997
15
0.030
Why?
Orchiectomy
4
1994
72
0.030
Why?
Colforsin
1
1997
47
0.030
Why?
Mutagenesis, Site-Directed
2
2011
376
0.030
Why?
Dose-Response Relationship, Drug
3
1997
2028
0.030
Why?
Diarrhea
1
2018
193
0.030
Why?
Piperidines
1
2018
222
0.030
Why?
Angiogenesis Inhibitors
1
2018
239
0.030
Why?
Cells, Cultured
4
2013
4151
0.030
Why?
Tumor Burden
1
2018
325
0.030
Why?
Histones
1
2022
666
0.030
Why?
Ubiquitination
1
2016
119
0.030
Why?
Cyclin-Dependent Kinase Inhibitor p21
1
2016
106
0.030
Why?
Heterografts
1
2016
143
0.030
Why?
Protein Isoforms
1
2017
399
0.030
Why?
Cell Differentiation
1
2004
2050
0.030
Why?
Cetuximab
1
2016
111
0.030
Why?
Fatigue
1
2018
366
0.030
Why?
Gene Rearrangement
1
2017
156
0.030
Why?
Camptothecin
1
2016
138
0.030
Why?
Administration, Oral
1
2018
867
0.030
Why?
Polymerase Chain Reaction
3
1993
1043
0.030
Why?
Models, Educational
1
2015
90
0.030
Why?
Treatment Outcome
1
2010
11794
0.030
Why?
Capacity Building
1
2015
62
0.030
Why?
DNA Copy Number Variations
1
2016
188
0.030
Why?
Diphenylamine
1
2014
7
0.030
Why?
DNA Mutational Analysis
1
2016
410
0.030
Why?
Biopsy
1
2018
1082
0.030
Why?
Databases, Genetic
1
2015
238
0.030
Why?
Aged, 80 and over
2
2017
8347
0.030
Why?
Interdisciplinary Communication
1
2015
201
0.030
Why?
Guanine
1
1994
85
0.030
Why?
Follicle Stimulating Hormone
2
1993
266
0.030
Why?
Analysis of Variance
1
1997
1300
0.030
Why?
Methyltransferases
1
1994
75
0.030
Why?
Neoplasm Metastasis
1
2016
688
0.030
Why?
Caspase 7
1
2013
22
0.030
Why?
Butadienes
1
2013
33
0.020
Why?
Research Personnel
1
2015
185
0.020
Why?
MAP Kinase Kinase 2
1
2013
28
0.020
Why?
Gonadotropins
1
1993
44
0.020
Why?
Benzamides
1
2014
226
0.020
Why?
Kinetics
2
2014
1568
0.020
Why?
Program Development
1
2015
368
0.020
Why?
Mentors
1
2015
217
0.020
Why?
MAP Kinase Kinase 1
1
2013
70
0.020
Why?
Molecular Sequence Data
3
2011
2883
0.020
Why?
Cell Cycle Checkpoints
1
2013
97
0.020
Why?
Oncogene Proteins, Viral
1
2013
20
0.020
Why?
Cyclin-Dependent Kinase Inhibitor p27
1
2013
64
0.020
Why?
Adult
4
2018
40881
0.020
Why?
Melanocytes
1
2013
65
0.020
Why?
Cooperative Behavior
1
2015
463
0.020
Why?
Genes, Synthetic
1
2012
13
0.020
Why?
Proto-Oncogene Proteins c-mdm2
1
2013
67
0.020
Why?
Genes, Lethal
1
2012
30
0.020
Why?
Phosphatidylinositol 3-Kinases
1
2014
383
0.020
Why?
Drug Hypersensitivity
1
1993
90
0.020
Why?
DNA, Neoplasm
1
2013
160
0.020
Why?
Mice, SCID
1
2013
369
0.020
Why?
Nitriles
1
2013
211
0.020
Why?
Ataxia Telangiectasia Mutated Proteins
1
2012
69
0.020
Why?
Membrane Proteins
1
2018
1166
0.020
Why?
Nuclear Export Signals
1
2011
4
0.020
Why?
Nuclear Localization Signals
1
2011
16
0.020
Why?
Glycoprotein Hormones, alpha Subunit
1
1991
23
0.020
Why?
Precision Medicine
1
2016
461
0.020
Why?
Microscopy, Fluorescence
1
2013
408
0.020
Why?
Peptide Mapping
1
2011
62
0.020
Why?
Intercellular Signaling Peptides and Proteins
1
2013
376
0.020
Why?
Alcoholic Intoxication
1
1992
76
0.020
Why?
Calcium Signaling
1
2013
245
0.020
Why?
Amino Acid Motifs
1
2011
219
0.020
Why?
Colony-Forming Units Assay
1
2010
95
0.020
Why?
Amino Acid Substitution
1
2011
302
0.020
Why?
Culture Media, Conditioned
1
2010
112
0.020
Why?
Genes, ras
1
2010
96
0.020
Why?
Protein Transport
1
2011
442
0.020
Why?
Gene Dosage
1
2010
145
0.020
Why?
Ligands
1
2011
668
0.020
Why?
Hypertension
1
2018
1276
0.020
Why?
Nuclear Magnetic Resonance, Biomolecular
1
2011
347
0.020
Why?
Structure-Activity Relationship
1
2010
563
0.020
Why?
Gene Knockdown Techniques
1
2010
334
0.020
Why?
Drug Combinations
1
2010
396
0.020
Why?
Prolactinoma
1
1989
13
0.020
Why?
Serum Albumin
1
1990
147
0.020
Why?
Protein Structure, Tertiary
1
2011
855
0.020
Why?
Transcriptome
1
2015
1042
0.020
Why?
Immunohistochemistry
1
2013
1723
0.020
Why?
Curriculum
1
2015
1074
0.020
Why?
Magnetic Resonance Spectroscopy
1
2011
627
0.020
Why?
Cell Communication
1
2010
327
0.020
Why?
Proto-Oncogene Proteins c-akt
1
2010
440
0.020
Why?
Pregnanediones
1
1987
12
0.020
Why?
Rats, Sprague-Dawley
4
1994
2525
0.020
Why?
Follow-Up Studies
1
2017
5428
0.020
Why?
Amino Acid Sequence
1
2011
2131
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2009
979
0.020
Why?
Brain Chemistry
1
1987
120
0.020
Why?
Calcium
1
2013
1191
0.020
Why?
Sulfonamides
1
2011
583
0.020
Why?
Pituitary Neoplasms
1
1989
190
0.020
Why?
Anesthetics
1
1987
100
0.020
Why?
Estrogens
1
1989
367
0.010
Why?
Models, Biological
1
2013
1764
0.010
Why?
Feasibility Studies
1
2010
1115
0.010
Why?
Flow Cytometry
1
2009
1165
0.010
Why?
Prostatic Neoplasms
1
2013
981
0.010
Why?
Indoles
1
2009
507
0.010
Why?
Metabolomics
1
2011
733
0.010
Why?
Liver Neoplasms
1
2011
777
0.010
Why?
Proto-Oncogene Protein c-ets-2
1
2004
4
0.010
Why?
Contact Inhibition
1
2004
5
0.010
Why?
Oncogene Protein p21(ras)
1
2004
15
0.010
Why?
Epidermal Growth Factor
1
2004
162
0.010
Why?
Antisense Elements (Genetics)
1
2003
3
0.010
Why?
Collagenases
1
2003
22
0.010
Why?
Matrix Metalloproteinase 3
1
2003
27
0.010
Why?
Genetic Vectors
1
2004
335
0.010
Why?
Cell Adhesion
1
2004
451
0.010
Why?
Cytokines
1
2010
2069
0.010
Why?
Cell Division
1
2004
757
0.010
Why?
Trans-Activators
1
2004
396
0.010
Why?
HeLa Cells
1
2003
632
0.010
Why?
Brain
1
1992
2969
0.010
Why?
Potassium
2
1990
152
0.010
Why?
Base Sequence
2
1993
2171
0.010
Why?
Biological Assay
2
1990
132
0.010
Why?
Hypophysectomy
2
1987
12
0.010
Why?
O(6)-Methylguanine-DNA Methyltransferase
1
1994
6
0.010
Why?
Cocarcinogenesis
1
1994
13
0.010
Why?
Injections, Intraperitoneal
1
1994
116
0.010
Why?
Rats, Mutant Strains
1
1993
19
0.010
Why?
Stress, Physiological
2
1987
443
0.010
Why?
Thyrotropin
1
1994
120
0.010
Why?
RNA-Directed DNA Polymerase
1
1993
35
0.010
Why?
Adrenocorticotropic Hormone
1
1994
147
0.010
Why?
Blotting, Southern
1
1992
85
0.010
Why?
Cyclic AMP
1
1992
208
0.010
Why?
Protein Kinase C
1
1992
251
0.010
Why?
Enzyme Activation
1
1992
762
0.010
Why?
RNA Splicing
1
1992
284
0.000
Why?
Cross Reactions
1
1990
130
0.000
Why?
Dinoprostone
1
1990
180
0.000
Why?
Bromocriptine
1
1989
31
0.000
Why?
Norepinephrine
1
1990
201
0.000
Why?
Naloxone
1
1990
132
0.000
Why?
Rats, Inbred F344
1
1989
268
0.000
Why?
Perfusion
1
1990
251
0.000
Why?
In Vitro Techniques
1
1990
1049
0.000
Why?
Depression, Chemical
1
1987
16
0.000
Why?
Chromatography, High Pressure Liquid
1
1990
592
0.000
Why?
Urethane
1
1987
43
0.000
Why?
Molecular Weight
1
1987
312
0.000
Why?
Pancreas
1
1990
341
0.000
Why?
Dopamine
1
1990
295
0.000
Why?
Drug Administration Schedule
1
1989
782
0.000
Why?
Cerebral Cortex
1
1990
474
0.000
Why?
Ketamine
1
1987
137
0.000
Why?
Restraint, Physical
1
1986
75
0.000
Why?
Alcoholism
1
1992
826
0.000
Why?
DNA
1
1991
1437
0.000
Why?
Kidney
1
1990
1497
0.000
Why?
Liver
1
1990
1899
0.000
Why?
Lung
1
1990
4116
0.000
Why?
Tentler's Networks
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