Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

John Tentler

Concepts (390)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Pyrimidines
8
2020
470
1.480
Why?
Xenograft Model Antitumor Assays
22
2025
868
1.340
Why?
Antineoplastic Agents
19
2025
2122
1.290
Why?
Triple Negative Breast Neoplasms
5
2020
202
1.290
Why?
Protein Kinase Inhibitors
15
2020
916
1.270
Why?
Colorectal Neoplasms
11
2018
791
1.000
Why?
Proto-Oncogene Proteins
10
2018
647
0.950
Why?
Azepines
4
2020
90
0.870
Why?
Piperazines
4
2020
350
0.850
Why?
Quinoxalines
2
2020
66
0.820
Why?
Pyrazoles
4
2018
423
0.800
Why?
Melanoma
10
2018
757
0.770
Why?
Gene Expression Regulation, Neoplastic
9
2020
1396
0.750
Why?
Mice, Nude
16
2020
696
0.680
Why?
Cell Proliferation
22
2025
2475
0.670
Why?
beta Catenin
2
2020
253
0.620
Why?
Enoyl-CoA Hydratase
1
2018
12
0.610
Why?
Lymphocytes, Tumor-Infiltrating
1
2020
209
0.590
Why?
Cell Line, Tumor
25
2025
3405
0.560
Why?
DNA-Binding Proteins
8
2015
1501
0.550
Why?
Benzimidazoles
4
2013
170
0.520
Why?
Tumor Microenvironment
1
2020
672
0.510
Why?
Mutation
11
2018
3946
0.480
Why?
Cardiomyopathy, Dilated
1
2018
383
0.470
Why?
Tumor Suppressor Proteins
2
2015
327
0.470
Why?
Tumor Suppressor Protein p53
4
2016
528
0.460
Why?
ras Proteins
3
2013
153
0.430
Why?
Genomics
1
2018
790
0.410
Why?
Pyrazines
5
2013
90
0.410
Why?
Apoptosis
14
2025
2551
0.410
Why?
Proto-Oncogene Proteins B-raf
4
2018
224
0.390
Why?
Oncogene Proteins, Fusion
3
2018
214
0.360
Why?
Drug Design
1
2012
167
0.350
Why?
Mice
22
2025
17757
0.350
Why?
Biomarkers, Tumor
3
2017
1272
0.340
Why?
Prolactin
7
2004
97
0.340
Why?
Mitogen-Activated Protein Kinase Kinases
1
2010
134
0.330
Why?
Histone Deacetylase Inhibitors
3
2022
210
0.330
Why?
Nuclear Proteins
1
2015
712
0.330
Why?
Aurora Kinase A
4
2020
56
0.320
Why?
Drug Resistance, Neoplasm
8
2020
800
0.310
Why?
Animals
45
2025
36847
0.290
Why?
Cell Transformation, Neoplastic
4
2013
327
0.280
Why?
Pituitary Gland
7
2003
148
0.270
Why?
Imidazoles
4
2013
238
0.270
Why?
Neoplasms
4
2022
2643
0.270
Why?
Hydroxamic Acids
3
2011
89
0.250
Why?
Ethanol
11
1997
606
0.250
Why?
Gene Expression Profiling
6
2018
1772
0.240
Why?
Exome
2
2017
230
0.240
Why?
Protein Synthesis Inhibitors
1
2025
47
0.230
Why?
Ubiquitin-Activating Enzymes
2
2016
17
0.230
Why?
Pyrimidinones
2
2015
113
0.220
Why?
Antineoplastic Combined Chemotherapy Protocols
6
2020
1682
0.220
Why?
Breast Neoplasms
3
2012
2234
0.220
Why?
Transcription Factors
4
2011
1718
0.220
Why?
Protein Biosynthesis
2
2025
430
0.220
Why?
Pyridones
2
2015
168
0.210
Why?
Receptor, IGF Type 1
3
2013
65
0.210
Why?
Hematologic Neoplasms
1
2025
155
0.200
Why?
Humans
45
2025
136765
0.190
Why?
Cell Cycle Proteins
3
2018
613
0.190
Why?
Hypothalamus
12
1997
153
0.190
Why?
Immunoblotting
5
2015
306
0.190
Why?
Drug Synergism
4
2018
382
0.180
Why?
Tumor Cells, Cultured
3
2020
953
0.180
Why?
c-Mer Tyrosine Kinase
2
2018
45
0.170
Why?
G2 Phase Cell Cycle Checkpoints
3
2018
44
0.170
Why?
Benzoxazoles
1
2020
19
0.170
Why?
Transcription, Genetic
4
2013
1455
0.170
Why?
Breast
3
2018
149
0.160
Why?
Female
27
2020
72795
0.160
Why?
Boronic Acids
2
2011
37
0.160
Why?
Growth Hormone
3
1997
101
0.160
Why?
Signal Transduction
10
2018
5076
0.160
Why?
Wnt Signaling Pathway
2
2019
192
0.160
Why?
eIF-2 Kinase
1
2019
31
0.160
Why?
Sequence Analysis, RNA
2
2018
452
0.150
Why?
Epithelial Cells
4
2011
1094
0.150
Why?
Proto-Oncogene Proteins p21(ras)
4
2016
267
0.150
Why?
Phosphorylation
6
2025
1758
0.150
Why?
Breast Neoplasms, Male
1
2018
29
0.150
Why?
Cell Cycle
7
2018
601
0.150
Why?
Linkage Disequilibrium
1
2018
268
0.140
Why?
Cytochrome P-450 Enzyme System
1
2018
155
0.140
Why?
MAP Kinase Kinase Kinases
2
2015
73
0.140
Why?
Septins
1
2018
43
0.140
Why?
Mice, Inbred BALB C
1
2020
1269
0.140
Why?
Drug Therapy, Combination
1
2020
1062
0.140
Why?
Cytoskeleton
1
2018
188
0.140
Why?
Genetics, Population
1
2018
209
0.140
Why?
Neurofibromin 1
1
2017
26
0.140
Why?
Somatostatin
1
1997
61
0.140
Why?
Gonadotropin-Releasing Hormone
8
1993
212
0.130
Why?
Armadillo Domain Proteins
1
2017
6
0.130
Why?
Proto-Oncogene Proteins c-kit
1
2017
67
0.130
Why?
RNA Splicing Factors
1
2017
53
0.130
Why?
Testis
2
1997
151
0.130
Why?
Proto-Oncogene Proteins c-ret
1
2017
31
0.130
Why?
Sexual Maturation
1
1997
55
0.130
Why?
Cyclopentanes
1
2016
19
0.130
Why?
Inhibitory Concentration 50
2
2016
90
0.130
Why?
Adenine
1
2018
270
0.130
Why?
Mucous Membrane
1
2017
125
0.130
Why?
Cyclic AMP Response Element-Binding Protein
1
1997
145
0.130
Why?
Cyclic AMP-Dependent Protein Kinases
1
1997
135
0.130
Why?
Genes, erbB-1
1
2016
17
0.130
Why?
Gene Regulatory Networks
1
2018
304
0.130
Why?
RNA, Messenger
10
2003
2831
0.120
Why?
Education, Graduate
1
2015
34
0.120
Why?
Oligonucleotide Array Sequence Analysis
3
2015
766
0.120
Why?
Peptides, Cyclic
1
1997
259
0.120
Why?
Drug Discovery
1
2016
141
0.120
Why?
HT29 Cells
2
2018
40
0.120
Why?
Tumor Protein p73
1
2015
14
0.120
Why?
Skin Neoplasms
2
2013
852
0.120
Why?
Neoplasm Invasiveness
3
2018
507
0.110
Why?
Proteasome Endopeptidase Complex
2
2013
155
0.110
Why?
Phosphoproteins
1
2017
337
0.110
Why?
Mitogen-Activated Protein Kinases
2
2014
313
0.110
Why?
Luteinizing Hormone
8
1993
185
0.110
Why?
Computational Biology
2
2016
643
0.110
Why?
Cluster Analysis
2
2012
497
0.110
Why?
Testosterone
2
1997
401
0.110
Why?
Case-Control Studies
2
2018
3539
0.110
Why?
Protein Kinases
1
2015
319
0.110
Why?
Genotype
1
2018
1914
0.100
Why?
Protein-Tyrosine Kinases
1
2017
434
0.100
Why?
Receptor, Insulin
1
2013
105
0.100
Why?
Ubiquitin-Conjugating Enzymes
1
2013
13
0.100
Why?
Cell Survival
4
2019
1116
0.100
Why?
Phenotype
3
2018
3189
0.100
Why?
Tumor Stem Cell Assay
1
2012
34
0.100
Why?
Aurora Kinases
1
2012
27
0.100
Why?
Cyclin-Dependent Kinase Inhibitor p16
1
2013
69
0.100
Why?
Proto-Oncogene Proteins c-ets
4
2011
56
0.100
Why?
BRCA1 Protein
1
2013
76
0.100
Why?
Alcohol Oxidoreductases
1
2013
62
0.100
Why?
Rats
21
2004
5639
0.100
Why?
Genes, p53
1
2012
72
0.100
Why?
Mitochondria
1
2018
946
0.090
Why?
Cyclosporine
1
2013
268
0.090
Why?
Positron-Emission Tomography
2
2011
293
0.090
Why?
MicroRNAs
1
2018
692
0.090
Why?
Receptor, ErbB-2
2
2012
340
0.090
Why?
Proto-Oncogene Proteins c-met
1
2012
75
0.090
Why?
TOR Serine-Threonine Kinases
1
2014
412
0.090
Why?
Ubiquitin-Protein Ligases
1
2013
176
0.090
Why?
Drug Screening Assays, Antitumor
4
2016
194
0.090
Why?
Proteasome Inhibitors
1
2011
46
0.090
Why?
Mammary Glands, Human
1
2011
64
0.090
Why?
Receptor Protein-Tyrosine Kinases
1
2013
234
0.090
Why?
Polymorphism, Single Nucleotide
1
2018
2184
0.090
Why?
Cellular Senescence
1
2012
187
0.090
Why?
Transcriptional Activation
2
2003
378
0.090
Why?
Cytoplasm
1
2011
272
0.090
Why?
Recombinant Fusion Proteins
2
2011
664
0.080
Why?
Cell Movement
3
2011
968
0.080
Why?
Protease Inhibitors
1
2011
107
0.080
Why?
Vascular Endothelial Growth Factor Receptor-3
1
2009
7
0.080
Why?
Ki-67 Antigen
1
2010
111
0.080
Why?
Neoplasm Transplantation
3
2016
257
0.080
Why?
Capillary Permeability
1
2010
145
0.080
Why?
Vascular Endothelial Growth Factor Receptor-1
1
2009
71
0.080
Why?
Adenocarcinoma
1
2016
938
0.080
Why?
Gastrointestinal Neoplasms
1
2009
77
0.070
Why?
Cell Line
4
2012
2838
0.070
Why?
Quinazolines
1
2009
250
0.070
Why?
Promoter Regions, Genetic
3
2004
1249
0.070
Why?
Carcinoma, Hepatocellular
1
2011
361
0.070
Why?
Peptide Fragments
1
2011
705
0.070
Why?
Algorithms
2
2015
1689
0.070
Why?
Pituitary Gland, Anterior
4
1992
38
0.070
Why?
Enzyme Inhibitors
3
2013
839
0.070
Why?
Drug Delivery Systems
1
2010
362
0.070
Why?
Prognosis
2
2017
4013
0.070
Why?
Colonic Neoplasms
1
2009
254
0.060
Why?
Proto-Oncogene Protein c-ets-1
2
2003
25
0.060
Why?
Disease Models, Animal
2
2014
4282
0.060
Why?
Reproducibility of Results
2
2010
3265
0.060
Why?
Growth Hormone-Releasing Hormone
2
1997
24
0.060
Why?
Rats, Inbred Strains
12
1992
362
0.060
Why?
Transplantation, Heterologous
2
2016
194
0.060
Why?
Oncogene Protein p65(gag-jun)
1
2004
2
0.060
Why?
Proto-Oncogene Proteins c-jun
1
2004
55
0.060
Why?
Proto-Oncogene Proteins c-myc
1
2025
139
0.050
Why?
Male
25
2020
67311
0.050
Why?
Gene Expression Regulation
2
2004
2605
0.050
Why?
Transfection
2
2003
941
0.050
Why?
Transcription Factor Pit-1
1
2003
27
0.050
Why?
High-Throughput Nucleotide Sequencing
2
2017
535
0.050
Why?
Suppression, Genetic
1
2003
25
0.050
Why?
Genes, Dominant
1
2003
95
0.050
Why?
Mesoderm
1
2004
144
0.050
Why?
Disease Progression
3
2018
2750
0.050
Why?
Pancreatic Neoplasms
1
2011
935
0.050
Why?
Lung Neoplasms
1
2016
2489
0.050
Why?
Histone Deacetylase 1
1
2022
25
0.050
Why?
DNA Repair
2
2013
231
0.050
Why?
Middle Aged
6
2020
33228
0.040
Why?
Caspase 3
2
2013
246
0.040
Why?
Blotting, Northern
3
1997
200
0.040
Why?
Acetylation
1
2022
248
0.040
Why?
DNA Damage
2
2013
420
0.040
Why?
Aged
5
2020
23794
0.040
Why?
Repressor Proteins
1
2004
427
0.040
Why?
Radioimmunoassay
8
1993
173
0.040
Why?
Histone Deacetylases
1
2022
215
0.040
Why?
Bortezomib
2
2011
54
0.040
Why?
Mechanistic Target of Rapamycin Complex 2
1
2020
62
0.040
Why?
Maximum Tolerated Dose
1
2020
199
0.040
Why?
Mechanistic Target of Rapamycin Complex 1
1
2020
125
0.040
Why?
Myeloid Cell Leukemia Sequence 1 Protein
1
2019
41
0.040
Why?
Blotting, Western
3
2010
1225
0.040
Why?
Gene Expression
3
1993
1500
0.040
Why?
M Phase Cell Cycle Checkpoints
1
2018
24
0.040
Why?
Azetidines
1
2018
43
0.040
Why?
Spleen
2
1991
514
0.040
Why?
Lymphocytes
2
1991
393
0.040
Why?
4-Aminobenzoic Acid
1
2018
7
0.040
Why?
GTP Phosphohydrolases
1
2018
93
0.040
Why?
Nausea
1
2018
111
0.040
Why?
HCT116 Cells
1
2018
80
0.040
Why?
Okadaic Acid
1
1997
14
0.030
Why?
Orchiectomy
4
1994
71
0.030
Why?
Enzyme-Linked Immunosorbent Assay
2
2010
851
0.030
Why?
Colforsin
1
1997
53
0.030
Why?
Mutagenesis, Site-Directed
2
2011
374
0.030
Why?
Diarrhea
1
2018
183
0.030
Why?
Dose-Response Relationship, Drug
3
1997
2052
0.030
Why?
Piperidines
1
2018
206
0.030
Why?
Angiogenesis Inhibitors
1
2018
226
0.030
Why?
Tumor Burden
1
2018
309
0.030
Why?
Cells, Cultured
4
2013
4191
0.030
Why?
Histones
1
2022
636
0.030
Why?
Ubiquitination
1
2016
102
0.030
Why?
Fatigue
1
2018
327
0.030
Why?
Cell Differentiation
1
2004
1982
0.030
Why?
Heterografts
1
2016
138
0.030
Why?
Cetuximab
1
2016
95
0.030
Why?
Protein Isoforms
1
2017
403
0.030
Why?
Administration, Oral
1
2018
813
0.030
Why?
Cyclin-Dependent Kinase Inhibitor p21
1
2016
121
0.030
Why?
Gene Rearrangement
1
2017
149
0.030
Why?
Camptothecin
1
2016
115
0.030
Why?
Treatment Outcome
1
2010
10745
0.030
Why?
Models, Educational
1
2015
92
0.030
Why?
Polymerase Chain Reaction
3
1993
1059
0.030
Why?
Capacity Building
1
2015
63
0.030
Why?
DNA Copy Number Variations
1
2016
182
0.030
Why?
Diphenylamine
1
2014
9
0.030
Why?
DNA Mutational Analysis
1
2016
399
0.030
Why?
Aged, 80 and over
2
2017
7585
0.030
Why?
Biopsy
1
2018
1124
0.030
Why?
Interdisciplinary Communication
1
2015
191
0.030
Why?
Databases, Genetic
1
2015
237
0.030
Why?
Follicle Stimulating Hormone
2
1993
244
0.030
Why?
Guanine
1
1994
79
0.030
Why?
Analysis of Variance
1
1997
1316
0.030
Why?
Methyltransferases
1
1994
78
0.030
Why?
Research Personnel
1
2015
171
0.030
Why?
Gonadotropins
1
1993
40
0.030
Why?
Neoplasm Metastasis
1
2016
657
0.030
Why?
Caspase 7
1
2013
22
0.030
Why?
Benzamides
1
2014
216
0.030
Why?
Butadienes
1
2013
36
0.030
Why?
MAP Kinase Kinase 2
1
2013
28
0.030
Why?
Mentors
1
2015
200
0.030
Why?
Adult
4
2018
37631
0.030
Why?
Program Development
1
2015
364
0.030
Why?
MAP Kinase Kinase 1
1
2013
75
0.030
Why?
Kinetics
2
2014
1664
0.030
Why?
Cell Cycle Checkpoints
1
2013
98
0.030
Why?
Oncogene Proteins, Viral
1
2013
22
0.030
Why?
Molecular Sequence Data
3
2011
2894
0.030
Why?
Cyclin-Dependent Kinase Inhibitor p27
1
2013
75
0.020
Why?
Melanocytes
1
2013
65
0.020
Why?
Cooperative Behavior
1
2015
445
0.020
Why?
Nitriles
1
2013
172
0.020
Why?
Genes, Synthetic
1
2012
15
0.020
Why?
Phosphatidylinositol 3-Kinases
1
2014
366
0.020
Why?
Genes, Lethal
1
2012
30
0.020
Why?
Proto-Oncogene Proteins c-mdm2
1
2013
65
0.020
Why?
DNA, Neoplasm
1
2013
164
0.020
Why?
Drug Hypersensitivity
1
1993
90
0.020
Why?
Ataxia Telangiectasia Mutated Proteins
1
2012
66
0.020
Why?
Mice, SCID
1
2013
366
0.020
Why?
Membrane Proteins
1
2018
1163
0.020
Why?
Precision Medicine
1
2016
426
0.020
Why?
Nuclear Export Signals
1
2011
4
0.020
Why?
Glycoprotein Hormones, alpha Subunit
1
1991
23
0.020
Why?
Nuclear Localization Signals
1
2011
18
0.020
Why?
Peptide Mapping
1
2011
64
0.020
Why?
Microscopy, Fluorescence
1
2013
397
0.020
Why?
Alcoholic Intoxication
1
1992
68
0.020
Why?
Intercellular Signaling Peptides and Proteins
1
2013
382
0.020
Why?
Calcium Signaling
1
2013
249
0.020
Why?
Amino Acid Motifs
1
2011
225
0.020
Why?
Colony-Forming Units Assay
1
2010
91
0.020
Why?
Amino Acid Substitution
1
2011
306
0.020
Why?
Culture Media, Conditioned
1
2010
110
0.020
Why?
Genes, ras
1
2010
97
0.020
Why?
Protein Transport
1
2011
443
0.020
Why?
Gene Dosage
1
2010
140
0.020
Why?
Ligands
1
2011
661
0.020
Why?
Drug Combinations
1
2010
343
0.020
Why?
Nuclear Magnetic Resonance, Biomolecular
1
2011
340
0.020
Why?
Structure-Activity Relationship
1
2010
570
0.020
Why?
Transcriptome
1
2015
969
0.020
Why?
Gene Knockdown Techniques
1
2010
327
0.020
Why?
Hypertension
1
2018
1284
0.020
Why?
Prolactinoma
1
1989
13
0.020
Why?
Serum Albumin
1
1990
150
0.020
Why?
Curriculum
1
2015
975
0.020
Why?
Protein Structure, Tertiary
1
2011
860
0.020
Why?
Immunohistochemistry
1
2013
1733
0.020
Why?
Cell Communication
1
2010
315
0.020
Why?
Magnetic Resonance Spectroscopy
1
2011
610
0.020
Why?
Proto-Oncogene Proteins c-akt
1
2010
437
0.020
Why?
Pregnanediones
1
1987
9
0.020
Why?
Rats, Sprague-Dawley
4
1994
2486
0.020
Why?
Follow-Up Studies
1
2017
5106
0.020
Why?
Amino Acid Sequence
1
2011
2138
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2009
975
0.020
Why?
Brain Chemistry
1
1987
116
0.020
Why?
Sulfonamides
1
2011
513
0.020
Why?
Calcium
1
2013
1197
0.020
Why?
Anesthetics
1
1987
81
0.020
Why?
Pituitary Neoplasms
1
1989
190
0.020
Why?
Feasibility Studies
1
2010
951
0.020
Why?
Estrogens
1
1989
367
0.020
Why?
Models, Biological
1
2013
1773
0.020
Why?
Flow Cytometry
1
2009
1180
0.010
Why?
Metabolomics
1
2011
678
0.010
Why?
Prostatic Neoplasms
1
2013
1034
0.010
Why?
Liver Neoplasms
1
2011
785
0.010
Why?
Proto-Oncogene Protein c-ets-2
1
2004
4
0.010
Why?
Contact Inhibition
1
2004
5
0.010
Why?
Oncogene Protein p21(ras)
1
2004
16
0.010
Why?
Epidermal Growth Factor
1
2004
175
0.010
Why?
Antisense Elements (Genetics)
1
2003
4
0.010
Why?
Collagenases
1
2003
25
0.010
Why?
Matrix Metalloproteinase 3
1
2003
28
0.010
Why?
Genetic Vectors
1
2004
317
0.010
Why?
Cell Adhesion
1
2004
466
0.010
Why?
Cytokines
1
2010
2084
0.010
Why?
Cell Division
1
2004
796
0.010
Why?
Trans-Activators
1
2004
398
0.010
Why?
HeLa Cells
1
2003
633
0.010
Why?
Brain
1
1992
2664
0.010
Why?
Potassium
2
1990
147
0.010
Why?
Base Sequence
2
1993
2179
0.010
Why?
Biological Assay
2
1990
123
0.010
Why?
Hypophysectomy
2
1987
15
0.010
Why?
O(6)-Methylguanine-DNA Methyltransferase
1
1994
6
0.010
Why?
Cocarcinogenesis
1
1994
14
0.010
Why?
Injections, Intraperitoneal
1
1994
115
0.010
Why?
Rats, Mutant Strains
1
1993
25
0.010
Why?
Thyrotropin
1
1994
114
0.010
Why?
RNA-Directed DNA Polymerase
1
1993
34
0.010
Why?
Adrenocorticotropic Hormone
1
1994
142
0.010
Why?
Stress, Physiological
2
1987
441
0.010
Why?
Blotting, Southern
1
1992
72
0.010
Why?
Cyclic AMP
1
1992
234
0.010
Why?
Protein Kinase C
1
1992
261
0.010
Why?
Enzyme Activation
1
1992
810
0.010
Why?
RNA Splicing
1
1992
268
0.010
Why?
Cross Reactions
1
1990
133
0.010
Why?
Dinoprostone
1
1990
191
0.000
Why?
Bromocriptine
1
1989
29
0.000
Why?
Norepinephrine
1
1990
204
0.000
Why?
Naloxone
1
1990
121
0.000
Why?
Perfusion
1
1990
211
0.000
Why?
Rats, Inbred F344
1
1989
264
0.000
Why?
Depression, Chemical
1
1987
23
0.000
Why?
In Vitro Techniques
1
1990
1089
0.000
Why?
Chromatography, High Pressure Liquid
1
1990
597
0.000
Why?
Urethane
1
1987
43
0.000
Why?
Pancreas
1
1990
329
0.000
Why?
Molecular Weight
1
1987
335
0.000
Why?
Drug Administration Schedule
1
1989
785
0.000
Why?
Dopamine
1
1990
303
0.000
Why?
Ketamine
1
1987
93
0.000
Why?
Cerebral Cortex
1
1990
433
0.000
Why?
Restraint, Physical
1
1986
72
0.000
Why?
Alcoholism
1
1992
804
0.000
Why?
DNA
1
1991
1458
0.000
Why?
Kidney
1
1990
1467
0.000
Why?
Liver
1
1990
1940
0.000
Why?
Lung
1
1990
4062
0.000
Why?
Tentler's Networks
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