Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

John Tentler

Concepts (390)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Pyrimidines
8
2020
472
1.480
Why?
Xenograft Model Antitumor Assays
22
2025
868
1.340
Why?
Triple Negative Breast Neoplasms
5
2020
202
1.290
Why?
Antineoplastic Agents
19
2025
2145
1.290
Why?
Protein Kinase Inhibitors
15
2020
920
1.280
Why?
Colorectal Neoplasms
11
2018
799
1.000
Why?
Proto-Oncogene Proteins
10
2018
646
0.960
Why?
Azepines
4
2020
90
0.880
Why?
Piperazines
4
2020
351
0.860
Why?
Quinoxalines
2
2020
66
0.820
Why?
Pyrazoles
4
2018
427
0.800
Why?
Melanoma
10
2018
758
0.780
Why?
Gene Expression Regulation, Neoplastic
9
2020
1402
0.760
Why?
Mice, Nude
16
2020
696
0.690
Why?
Cell Proliferation
22
2025
2482
0.670
Why?
beta Catenin
2
2020
251
0.620
Why?
Enoyl-CoA Hydratase
1
2018
12
0.610
Why?
Lymphocytes, Tumor-Infiltrating
1
2020
210
0.600
Why?
Cell Line, Tumor
25
2025
3420
0.560
Why?
DNA-Binding Proteins
8
2015
1507
0.550
Why?
Benzimidazoles
4
2013
169
0.520
Why?
Tumor Microenvironment
1
2020
682
0.510
Why?
Mutation
11
2018
3964
0.480
Why?
Cardiomyopathy, Dilated
1
2018
383
0.480
Why?
Tumor Suppressor Proteins
2
2015
328
0.470
Why?
Tumor Suppressor Protein p53
4
2016
531
0.460
Why?
ras Proteins
3
2013
151
0.430
Why?
Pyrazines
5
2013
92
0.410
Why?
Genomics
1
2018
793
0.410
Why?
Apoptosis
14
2025
2557
0.410
Why?
Proto-Oncogene Proteins B-raf
4
2018
227
0.390
Why?
Oncogene Proteins, Fusion
3
2018
215
0.360
Why?
Drug Design
1
2012
170
0.350
Why?
Mice
22
2025
17843
0.350
Why?
Biomarkers, Tumor
3
2017
1279
0.340
Why?
Prolactin
7
2004
100
0.340
Why?
Mitogen-Activated Protein Kinase Kinases
1
2010
134
0.330
Why?
Histone Deacetylase Inhibitors
3
2022
211
0.330
Why?
Nuclear Proteins
1
2015
710
0.330
Why?
Aurora Kinase A
4
2020
56
0.320
Why?
Drug Resistance, Neoplasm
8
2020
806
0.310
Why?
Animals
45
2025
37011
0.290
Why?
Cell Transformation, Neoplastic
4
2013
328
0.280
Why?
Imidazoles
4
2013
244
0.270
Why?
Pituitary Gland
7
2003
149
0.270
Why?
Neoplasms
4
2022
2666
0.270
Why?
Hydroxamic Acids
3
2011
89
0.250
Why?
Ethanol
11
1997
608
0.250
Why?
Gene Expression Profiling
6
2018
1770
0.240
Why?
Exome
2
2017
231
0.240
Why?
Protein Synthesis Inhibitors
1
2025
46
0.240
Why?
Ubiquitin-Activating Enzymes
2
2016
17
0.230
Why?
Pyrimidinones
2
2015
114
0.220
Why?
Transcription Factors
4
2011
1717
0.220
Why?
Antineoplastic Combined Chemotherapy Protocols
6
2020
1695
0.220
Why?
Breast Neoplasms
3
2012
2249
0.220
Why?
Protein Biosynthesis
2
2025
434
0.220
Why?
Pyridones
2
2015
168
0.210
Why?
Receptor, IGF Type 1
3
2013
65
0.210
Why?
Hematologic Neoplasms
1
2025
158
0.200
Why?
Cell Cycle Proteins
3
2018
614
0.190
Why?
Humans
45
2025
137514
0.190
Why?
Hypothalamus
12
1997
153
0.190
Why?
Immunoblotting
5
2015
307
0.190
Why?
Drug Synergism
4
2018
379
0.180
Why?
Tumor Cells, Cultured
3
2020
957
0.180
Why?
c-Mer Tyrosine Kinase
2
2018
45
0.180
Why?
G2 Phase Cell Cycle Checkpoints
3
2018
45
0.170
Why?
Benzoxazoles
1
2020
20
0.170
Why?
Transcription, Genetic
4
2013
1458
0.170
Why?
Breast
3
2018
153
0.160
Why?
Female
27
2020
73162
0.160
Why?
Boronic Acids
2
2011
38
0.160
Why?
Growth Hormone
3
1997
101
0.160
Why?
Signal Transduction
10
2018
5096
0.160
Why?
Wnt Signaling Pathway
2
2019
193
0.160
Why?
eIF-2 Kinase
1
2019
31
0.160
Why?
Sequence Analysis, RNA
2
2018
451
0.160
Why?
Epithelial Cells
4
2011
1099
0.150
Why?
Proto-Oncogene Proteins p21(ras)
4
2016
270
0.150
Why?
Phosphorylation
6
2025
1762
0.150
Why?
Breast Neoplasms, Male
1
2018
28
0.150
Why?
Cell Cycle
7
2018
604
0.150
Why?
Linkage Disequilibrium
1
2018
268
0.140
Why?
MAP Kinase Kinase Kinases
2
2015
73
0.140
Why?
Cytochrome P-450 Enzyme System
1
2018
158
0.140
Why?
Septins
1
2018
43
0.140
Why?
Mice, Inbred BALB C
1
2020
1271
0.140
Why?
Drug Therapy, Combination
1
2020
1060
0.140
Why?
Cytoskeleton
1
2018
186
0.140
Why?
Genetics, Population
1
2018
210
0.140
Why?
Neurofibromin 1
1
2017
26
0.140
Why?
Somatostatin
1
1997
62
0.140
Why?
Gonadotropin-Releasing Hormone
8
1993
208
0.140
Why?
Armadillo Domain Proteins
1
2017
6
0.130
Why?
Proto-Oncogene Proteins c-kit
1
2017
67
0.130
Why?
RNA Splicing Factors
1
2017
53
0.130
Why?
Testis
2
1997
150
0.130
Why?
Proto-Oncogene Proteins c-ret
1
2017
31
0.130
Why?
Sexual Maturation
1
1997
55
0.130
Why?
Inhibitory Concentration 50
2
2016
90
0.130
Why?
Cyclopentanes
1
2016
20
0.130
Why?
Adenine
1
2018
268
0.130
Why?
Mucous Membrane
1
2017
125
0.130
Why?
Cyclic AMP Response Element-Binding Protein
1
1997
145
0.130
Why?
Cyclic AMP-Dependent Protein Kinases
1
1997
136
0.130
Why?
Genes, erbB-1
1
2016
17
0.130
Why?
Gene Regulatory Networks
1
2018
308
0.130
Why?
Oligonucleotide Array Sequence Analysis
3
2015
765
0.120
Why?
Education, Graduate
1
2015
34
0.120
Why?
RNA, Messenger
10
2003
2838
0.120
Why?
Peptides, Cyclic
1
1997
260
0.120
Why?
Drug Discovery
1
2016
141
0.120
Why?
HT29 Cells
2
2018
40
0.120
Why?
Tumor Protein p73
1
2015
14
0.120
Why?
Skin Neoplasms
2
2013
853
0.120
Why?
Neoplasm Invasiveness
3
2018
510
0.120
Why?
Proteasome Endopeptidase Complex
2
2013
156
0.110
Why?
Phosphoproteins
1
2017
338
0.110
Why?
Mitogen-Activated Protein Kinases
2
2014
316
0.110
Why?
Luteinizing Hormone
8
1993
185
0.110
Why?
Computational Biology
2
2016
645
0.110
Why?
Cluster Analysis
2
2012
502
0.110
Why?
Testosterone
2
1997
399
0.110
Why?
Case-Control Studies
2
2018
3546
0.110
Why?
Protein Kinases
1
2015
319
0.110
Why?
Genotype
1
2018
1920
0.100
Why?
Protein-Tyrosine Kinases
1
2017
434
0.100
Why?
Receptor, Insulin
1
2013
105
0.100
Why?
Ubiquitin-Conjugating Enzymes
1
2013
13
0.100
Why?
Phenotype
3
2018
3205
0.100
Why?
Cell Survival
4
2019
1122
0.100
Why?
Tumor Stem Cell Assay
1
2012
34
0.100
Why?
Aurora Kinases
1
2012
27
0.100
Why?
Cyclin-Dependent Kinase Inhibitor p16
1
2013
69
0.100
Why?
Proto-Oncogene Proteins c-ets
4
2011
56
0.100
Why?
BRCA1 Protein
1
2013
76
0.100
Why?
Alcohol Oxidoreductases
1
2013
62
0.100
Why?
Rats
21
2004
5676
0.100
Why?
Genes, p53
1
2012
72
0.100
Why?
Mitochondria
1
2018
947
0.090
Why?
Cyclosporine
1
2013
268
0.090
Why?
Positron-Emission Tomography
2
2011
299
0.090
Why?
MicroRNAs
1
2018
704
0.090
Why?
Receptor, ErbB-2
2
2012
342
0.090
Why?
Proto-Oncogene Proteins c-met
1
2012
75
0.090
Why?
TOR Serine-Threonine Kinases
1
2014
414
0.090
Why?
Ubiquitin-Protein Ligases
1
2013
179
0.090
Why?
Drug Screening Assays, Antitumor
4
2016
196
0.090
Why?
Proteasome Inhibitors
1
2011
45
0.090
Why?
Mammary Glands, Human
1
2011
64
0.090
Why?
Receptor Protein-Tyrosine Kinases
1
2013
235
0.090
Why?
Polymorphism, Single Nucleotide
1
2018
2193
0.090
Why?
Cellular Senescence
1
2012
188
0.090
Why?
Transcriptional Activation
2
2003
379
0.090
Why?
Cytoplasm
1
2011
274
0.090
Why?
Recombinant Fusion Proteins
2
2011
665
0.090
Why?
Protease Inhibitors
1
2011
107
0.080
Why?
Cell Movement
3
2011
972
0.080
Why?
Vascular Endothelial Growth Factor Receptor-3
1
2009
7
0.080
Why?
Ki-67 Antigen
1
2010
112
0.080
Why?
Neoplasm Transplantation
3
2016
256
0.080
Why?
Capillary Permeability
1
2010
144
0.080
Why?
Vascular Endothelial Growth Factor Receptor-1
1
2009
71
0.080
Why?
Adenocarcinoma
1
2016
937
0.080
Why?
Gastrointestinal Neoplasms
1
2009
79
0.070
Why?
Cell Line
4
2012
2852
0.070
Why?
Quinazolines
1
2009
249
0.070
Why?
Promoter Regions, Genetic
3
2004
1255
0.070
Why?
Carcinoma, Hepatocellular
1
2011
360
0.070
Why?
Peptide Fragments
1
2011
708
0.070
Why?
Algorithms
2
2015
1702
0.070
Why?
Pituitary Gland, Anterior
4
1992
39
0.070
Why?
Enzyme Inhibitors
3
2013
845
0.070
Why?
Drug Delivery Systems
1
2010
363
0.070
Why?
Prognosis
2
2017
4031
0.070
Why?
Colonic Neoplasms
1
2009
258
0.060
Why?
Proto-Oncogene Protein c-ets-1
2
2003
25
0.060
Why?
Disease Models, Animal
2
2014
4295
0.060
Why?
Reproducibility of Results
2
2010
3292
0.060
Why?
Growth Hormone-Releasing Hormone
2
1997
24
0.060
Why?
Rats, Inbred Strains
12
1992
369
0.060
Why?
Transplantation, Heterologous
2
2016
195
0.060
Why?
Oncogene Protein p65(gag-jun)
1
2004
2
0.060
Why?
Proto-Oncogene Proteins c-jun
1
2004
55
0.060
Why?
Proto-Oncogene Proteins c-myc
1
2025
141
0.050
Why?
Male
25
2020
67718
0.050
Why?
Gene Expression Regulation
2
2004
2615
0.050
Why?
Transfection
2
2003
948
0.050
Why?
Transcription Factor Pit-1
1
2003
27
0.050
Why?
High-Throughput Nucleotide Sequencing
2
2017
538
0.050
Why?
Suppression, Genetic
1
2003
25
0.050
Why?
Genes, Dominant
1
2003
95
0.050
Why?
Mesoderm
1
2004
144
0.050
Why?
Disease Progression
3
2018
2755
0.050
Why?
Pancreatic Neoplasms
1
2011
943
0.050
Why?
Lung Neoplasms
1
2016
2494
0.050
Why?
Histone Deacetylase 1
1
2022
26
0.050
Why?
DNA Repair
2
2013
230
0.050
Why?
Caspase 3
2
2013
246
0.050
Why?
Middle Aged
6
2020
33355
0.040
Why?
Blotting, Northern
3
1997
199
0.040
Why?
Acetylation
1
2022
254
0.040
Why?
DNA Damage
2
2013
420
0.040
Why?
Aged
5
2020
23798
0.040
Why?
Repressor Proteins
1
2004
425
0.040
Why?
Radioimmunoassay
8
1993
174
0.040
Why?
Histone Deacetylases
1
2022
215
0.040
Why?
Bortezomib
2
2011
54
0.040
Why?
Mechanistic Target of Rapamycin Complex 2
1
2020
62
0.040
Why?
Maximum Tolerated Dose
1
2020
199
0.040
Why?
Myeloid Cell Leukemia Sequence 1 Protein
1
2019
40
0.040
Why?
Mechanistic Target of Rapamycin Complex 1
1
2020
125
0.040
Why?
Blotting, Western
3
2010
1227
0.040
Why?
M Phase Cell Cycle Checkpoints
1
2018
24
0.040
Why?
Gene Expression
3
1993
1505
0.040
Why?
Azetidines
1
2018
43
0.040
Why?
Spleen
2
1991
516
0.040
Why?
4-Aminobenzoic Acid
1
2018
7
0.040
Why?
GTP Phosphohydrolases
1
2018
91
0.040
Why?
Lymphocytes
2
1991
395
0.040
Why?
Nausea
1
2018
115
0.040
Why?
HCT116 Cells
1
2018
80
0.040
Why?
Okadaic Acid
1
1997
14
0.030
Why?
Orchiectomy
4
1994
71
0.030
Why?
Enzyme-Linked Immunosorbent Assay
2
2010
849
0.030
Why?
Colforsin
1
1997
54
0.030
Why?
Mutagenesis, Site-Directed
2
2011
377
0.030
Why?
Diarrhea
1
2018
183
0.030
Why?
Dose-Response Relationship, Drug
3
1997
2066
0.030
Why?
Piperidines
1
2018
208
0.030
Why?
Angiogenesis Inhibitors
1
2018
226
0.030
Why?
Tumor Burden
1
2018
311
0.030
Why?
Cells, Cultured
4
2013
4206
0.030
Why?
Ubiquitination
1
2016
104
0.030
Why?
Histones
1
2022
641
0.030
Why?
Fatigue
1
2018
329
0.030
Why?
Cell Differentiation
1
2004
1979
0.030
Why?
Heterografts
1
2016
139
0.030
Why?
Cetuximab
1
2016
95
0.030
Why?
Protein Isoforms
1
2017
403
0.030
Why?
Administration, Oral
1
2018
814
0.030
Why?
Cyclin-Dependent Kinase Inhibitor p21
1
2016
121
0.030
Why?
Gene Rearrangement
1
2017
151
0.030
Why?
Camptothecin
1
2016
116
0.030
Why?
Treatment Outcome
1
2010
10821
0.030
Why?
Models, Educational
1
2015
93
0.030
Why?
Polymerase Chain Reaction
3
1993
1061
0.030
Why?
Capacity Building
1
2015
62
0.030
Why?
Diphenylamine
1
2014
9
0.030
Why?
DNA Copy Number Variations
1
2016
185
0.030
Why?
DNA Mutational Analysis
1
2016
401
0.030
Why?
Aged, 80 and over
2
2017
7593
0.030
Why?
Biopsy
1
2018
1132
0.030
Why?
Interdisciplinary Communication
1
2015
192
0.030
Why?
Databases, Genetic
1
2015
237
0.030
Why?
Follicle Stimulating Hormone
2
1993
244
0.030
Why?
Guanine
1
1994
79
0.030
Why?
Analysis of Variance
1
1997
1324
0.030
Why?
Methyltransferases
1
1994
78
0.030
Why?
Research Personnel
1
2015
170
0.030
Why?
Gonadotropins
1
1993
40
0.030
Why?
Neoplasm Metastasis
1
2016
659
0.030
Why?
Caspase 7
1
2013
22
0.030
Why?
Benzamides
1
2014
218
0.030
Why?
MAP Kinase Kinase 2
1
2013
28
0.030
Why?
Butadienes
1
2013
37
0.030
Why?
Mentors
1
2015
197
0.030
Why?
Program Development
1
2015
366
0.030
Why?
Adult
4
2018
37821
0.030
Why?
MAP Kinase Kinase 1
1
2013
75
0.030
Why?
Kinetics
2
2014
1679
0.030
Why?
Cell Cycle Checkpoints
1
2013
98
0.030
Why?
Oncogene Proteins, Viral
1
2013
23
0.030
Why?
Molecular Sequence Data
3
2011
2901
0.030
Why?
Cyclin-Dependent Kinase Inhibitor p27
1
2013
75
0.030
Why?
Melanocytes
1
2013
66
0.020
Why?
Cooperative Behavior
1
2015
447
0.020
Why?
Nitriles
1
2013
175
0.020
Why?
Genes, Synthetic
1
2012
15
0.020
Why?
Phosphatidylinositol 3-Kinases
1
2014
366
0.020
Why?
Genes, Lethal
1
2012
30
0.020
Why?
Proto-Oncogene Proteins c-mdm2
1
2013
66
0.020
Why?
Drug Hypersensitivity
1
1993
89
0.020
Why?
DNA, Neoplasm
1
2013
165
0.020
Why?
Ataxia Telangiectasia Mutated Proteins
1
2012
67
0.020
Why?
Mice, SCID
1
2013
367
0.020
Why?
Membrane Proteins
1
2018
1167
0.020
Why?
Precision Medicine
1
2016
426
0.020
Why?
Nuclear Export Signals
1
2011
4
0.020
Why?
Glycoprotein Hormones, alpha Subunit
1
1991
23
0.020
Why?
Nuclear Localization Signals
1
2011
18
0.020
Why?
Peptide Mapping
1
2011
64
0.020
Why?
Alcoholic Intoxication
1
1992
66
0.020
Why?
Microscopy, Fluorescence
1
2013
402
0.020
Why?
Intercellular Signaling Peptides and Proteins
1
2013
379
0.020
Why?
Calcium Signaling
1
2013
253
0.020
Why?
Amino Acid Motifs
1
2011
225
0.020
Why?
Colony-Forming Units Assay
1
2010
91
0.020
Why?
Amino Acid Substitution
1
2011
309
0.020
Why?
Culture Media, Conditioned
1
2010
111
0.020
Why?
Genes, ras
1
2010
96
0.020
Why?
Protein Transport
1
2011
443
0.020
Why?
Gene Dosage
1
2010
148
0.020
Why?
Ligands
1
2011
665
0.020
Why?
Drug Combinations
1
2010
344
0.020
Why?
Nuclear Magnetic Resonance, Biomolecular
1
2011
340
0.020
Why?
Structure-Activity Relationship
1
2010
586
0.020
Why?
Gene Knockdown Techniques
1
2010
329
0.020
Why?
Transcriptome
1
2015
974
0.020
Why?
Prolactinoma
1
1989
13
0.020
Why?
Hypertension
1
2018
1293
0.020
Why?
Serum Albumin
1
1990
150
0.020
Why?
Protein Structure, Tertiary
1
2011
869
0.020
Why?
Curriculum
1
2015
980
0.020
Why?
Immunohistochemistry
1
2013
1740
0.020
Why?
Cell Communication
1
2010
313
0.020
Why?
Magnetic Resonance Spectroscopy
1
2011
619
0.020
Why?
Proto-Oncogene Proteins c-akt
1
2010
437
0.020
Why?
Pregnanediones
1
1987
9
0.020
Why?
Rats, Sprague-Dawley
4
1994
2501
0.020
Why?
Follow-Up Studies
1
2017
5139
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2009
974
0.020
Why?
Amino Acid Sequence
1
2011
2146
0.020
Why?
Brain Chemistry
1
1987
120
0.020
Why?
Sulfonamides
1
2011
513
0.020
Why?
Calcium
1
2013
1233
0.020
Why?
Anesthetics
1
1987
81
0.020
Why?
Pituitary Neoplasms
1
1989
190
0.020
Why?
Feasibility Studies
1
2010
950
0.020
Why?
Estrogens
1
1989
361
0.020
Why?
Models, Biological
1
2013
1775
0.020
Why?
Flow Cytometry
1
2009
1185
0.020
Why?
Metabolomics
1
2011
679
0.020
Why?
Prostatic Neoplasms
1
2013
1034
0.010
Why?
Liver Neoplasms
1
2011
786
0.010
Why?
Proto-Oncogene Protein c-ets-2
1
2004
4
0.010
Why?
Contact Inhibition
1
2004
5
0.010
Why?
Oncogene Protein p21(ras)
1
2004
16
0.010
Why?
Epidermal Growth Factor
1
2004
174
0.010
Why?
Antisense Elements (Genetics)
1
2003
4
0.010
Why?
Collagenases
1
2003
25
0.010
Why?
Matrix Metalloproteinase 3
1
2003
28
0.010
Why?
Genetic Vectors
1
2004
322
0.010
Why?
Cell Adhesion
1
2004
467
0.010
Why?
Cell Division
1
2004
795
0.010
Why?
Cytokines
1
2010
2095
0.010
Why?
Trans-Activators
1
2004
399
0.010
Why?
HeLa Cells
1
2003
640
0.010
Why?
Brain
1
1992
2831
0.010
Why?
Potassium
2
1990
151
0.010
Why?
Base Sequence
2
1993
2180
0.010
Why?
Biological Assay
2
1990
123
0.010
Why?
Hypophysectomy
2
1987
15
0.010
Why?
O(6)-Methylguanine-DNA Methyltransferase
1
1994
6
0.010
Why?
Cocarcinogenesis
1
1994
14
0.010
Why?
Injections, Intraperitoneal
1
1994
115
0.010
Why?
Rats, Mutant Strains
1
1993
25
0.010
Why?
Thyrotropin
1
1994
114
0.010
Why?
RNA-Directed DNA Polymerase
1
1993
34
0.010
Why?
Adrenocorticotropic Hormone
1
1994
142
0.010
Why?
Stress, Physiological
2
1987
445
0.010
Why?
Blotting, Southern
1
1992
72
0.010
Why?
Cyclic AMP
1
1992
243
0.010
Why?
Protein Kinase C
1
1992
265
0.010
Why?
Enzyme Activation
1
1992
816
0.010
Why?
RNA Splicing
1
1992
268
0.010
Why?
Cross Reactions
1
1990
133
0.010
Why?
Dinoprostone
1
1990
191
0.000
Why?
Bromocriptine
1
1989
29
0.000
Why?
Norepinephrine
1
1990
212
0.000
Why?
Naloxone
1
1990
120
0.000
Why?
Perfusion
1
1990
212
0.000
Why?
Rats, Inbred F344
1
1989
264
0.000
Why?
Depression, Chemical
1
1987
23
0.000
Why?
Chromatography, High Pressure Liquid
1
1990
595
0.000
Why?
In Vitro Techniques
1
1990
1108
0.000
Why?
Urethane
1
1987
43
0.000
Why?
Pancreas
1
1990
328
0.000
Why?
Molecular Weight
1
1987
332
0.000
Why?
Drug Administration Schedule
1
1989
784
0.000
Why?
Dopamine
1
1990
301
0.000
Why?
Ketamine
1
1987
93
0.000
Why?
Cerebral Cortex
1
1990
459
0.000
Why?
Restraint, Physical
1
1986
72
0.000
Why?
Alcoholism
1
1992
805
0.000
Why?
DNA
1
1991
1460
0.000
Why?
Kidney
1
1990
1472
0.000
Why?
Liver
1
1990
1940
0.000
Why?
Lung
1
1990
4066
0.000
Why?
Tentler's Networks
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