Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Philip Reigan

Concepts (387)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Thymidine Phosphorylase
7
2022
12
2.450
Why?
Antineoplastic Agents
16
2020
1895
2.110
Why?
Ribosomal Protein S6 Kinases, 90-kDa
4
2021
13
2.040
Why?
Protein Kinase Inhibitors
8
2021
795
1.900
Why?
Pyrimidines
6
2021
378
1.830
Why?
Protein-Tyrosine Kinases
6
2019
398
1.620
Why?
Nuclear Proteins
6
2018
592
1.480
Why?
Cell Cycle Proteins
5
2018
552
1.450
Why?
Enzyme Inhibitors
9
2021
751
1.300
Why?
Glioblastoma
3
2022
253
1.170
Why?
STAT3 Transcription Factor
3
2022
173
1.130
Why?
Pyrazoles
4
2018
364
1.020
Why?
Neoplasms
5
2023
2105
1.020
Why?
Models, Molecular
25
2021
1378
1.010
Why?
Pyrroles
2
2021
183
0.910
Why?
Prodrugs
4
2007
42
0.820
Why?
Pyrimidinones
4
2018
88
0.770
Why?
NAD(P)H Dehydrogenase (Quinone)
8
2011
31
0.770
Why?
Purines
1
2021
159
0.700
Why?
Pteridines
1
2020
20
0.680
Why?
Cell Survival
8
2022
1021
0.670
Why?
Drug Resistance, Neoplasm
4
2021
642
0.660
Why?
Structure-Activity Relationship
10
2020
503
0.660
Why?
Small Molecule Libraries
2
2016
80
0.650
Why?
AMP-Activated Protein Kinases
1
2020
175
0.640
Why?
Indolequinones
5
2011
5
0.630
Why?
Aldehydes
8
2014
142
0.590
Why?
Protein Binding
12
2021
1897
0.580
Why?
HSP90 Heat-Shock Proteins
5
2011
43
0.580
Why?
Brain Neoplasms
3
2020
984
0.580
Why?
Medulloblastoma
2
2016
172
0.550
Why?
Cell Line, Tumor
18
2022
2725
0.550
Why?
Glutamate-Cysteine Ligase
2
2013
17
0.540
Why?
Xanthine Oxidase
2
2007
71
0.520
Why?
Protein Isoforms
1
2017
339
0.520
Why?
Benzoquinones
4
2011
44
0.510
Why?
Uracil
3
2021
28
0.490
Why?
Isoxazoles
5
2023
52
0.470
Why?
Cisplatin
1
2016
263
0.470
Why?
Hydroquinones
3
2011
27
0.450
Why?
Lactams, Macrocyclic
3
2011
46
0.440
Why?
Deoxyribose
1
2013
5
0.440
Why?
Drug Screening Assays, Antitumor
5
2020
180
0.420
Why?
Glutathione
2
2011
300
0.420
Why?
Humans
57
2024
114757
0.380
Why?
Molecular Structure
5
2020
438
0.370
Why?
Molecular Docking Simulation
6
2023
101
0.360
Why?
Protein Conformation
4
2021
811
0.330
Why?
Catalytic Domain
5
2021
197
0.330
Why?
Cell Line
5
2022
2639
0.330
Why?
Cell Proliferation
10
2020
2196
0.330
Why?
Glucose
2
2013
897
0.320
Why?
Imidazoles
3
2021
211
0.320
Why?
Molecular Targeted Therapy
3
2016
347
0.310
Why?
Aldehyde Dehydrogenase
3
2014
134
0.310
Why?
Proto-Oncogene Proteins B-raf
2
2021
193
0.300
Why?
Signal Transduction
6
2022
4522
0.300
Why?
Amides
2
2020
87
0.290
Why?
Growth Inhibitors
1
2007
43
0.290
Why?
Pancreatic Neoplasms
4
2009
732
0.280
Why?
Thyroid Neoplasms
2
2021
263
0.280
Why?
Proto-Oncogene Proteins c-akt
4
2013
399
0.270
Why?
src Homology Domains
2
2016
33
0.270
Why?
Tumor Suppressor Protein p53
2
2023
447
0.250
Why?
Binding Sites
6
2018
1176
0.240
Why?
Molecular Dynamics Simulation
3
2023
201
0.240
Why?
Animals
27
2022
31762
0.240
Why?
Pyrrolidines
1
2004
55
0.230
Why?
G-Quadruplexes
2
2022
15
0.230
Why?
Giardia lamblia
1
2024
21
0.220
Why?
Thymidine
2
2022
58
0.220
Why?
Rifabutin
3
2008
5
0.210
Why?
DNA
3
2016
1351
0.210
Why?
Polycomb Repressive Complex 1
1
2023
40
0.210
Why?
Liver Diseases, Alcoholic
2
2014
83
0.210
Why?
Ear Diseases
1
2022
13
0.200
Why?
Amino Acid Transport System ASC
1
2022
10
0.200
Why?
K562 Cells
2
2020
73
0.200
Why?
Virus Internalization
1
2022
40
0.200
Why?
Models, Chemical
1
2023
250
0.200
Why?
Minor Histocompatibility Antigens
1
2022
41
0.190
Why?
Drug Synergism
3
2021
316
0.190
Why?
Catalysis
3
2013
292
0.190
Why?
Quinone Reductases
2
2011
15
0.190
Why?
Fluorouracil
1
2022
152
0.190
Why?
Proto-Oncogene Proteins c-myc
1
2022
115
0.180
Why?
Maneb
1
2020
7
0.180
Why?
Receptors, Androgen
1
2022
131
0.180
Why?
Heterocyclic Compounds
1
2020
18
0.180
Why?
Dose-Response Relationship, Drug
3
2020
1846
0.180
Why?
Lipoprotein Lipase
1
2020
54
0.180
Why?
Mitogen-Activated Protein Kinase 3
1
2021
146
0.180
Why?
Mice
17
2022
14916
0.180
Why?
Mitogen-Activated Protein Kinase 1
1
2021
164
0.170
Why?
Polymorphism, Genetic
2
2014
612
0.170
Why?
Neovascularization, Pathologic
1
2022
283
0.170
Why?
Fluorescence
1
2020
148
0.170
Why?
Amino Acid Sequence
8
2014
1988
0.160
Why?
Adenocarcinoma, Follicular
1
2019
34
0.160
Why?
Chromatography, High Pressure Liquid
5
2013
472
0.160
Why?
Thyroid Carcinoma, Anaplastic
1
2019
34
0.160
Why?
Protein Carbonylation
3
2013
51
0.160
Why?
Enzyme Assays
1
2018
21
0.150
Why?
CDC2 Protein Kinase
1
2018
25
0.150
Why?
Neoplastic Stem Cells
1
2022
334
0.150
Why?
Receptors, Metabotropic Glutamate
1
2018
34
0.150
Why?
Escherichia coli
4
2006
722
0.150
Why?
Pyridazines
1
2018
49
0.150
Why?
Phosphorylation
3
2018
1571
0.150
Why?
Proto-Oncogene Proteins p21(ras)
1
2019
229
0.150
Why?
Antigens, Neoplasm
2
2011
222
0.150
Why?
Glucocorticoids
1
2022
532
0.150
Why?
Leukemia, Myeloid, Acute
2
2022
536
0.140
Why?
Dihydropyridines
1
2017
15
0.140
Why?
Glycoproteins
2
2011
304
0.140
Why?
Oncogene Proteins, Fusion
1
2019
179
0.140
Why?
Cyclic S-Oxides
1
2016
1
0.140
Why?
Niclosamide
1
2016
1
0.140
Why?
Lysine
2
2023
242
0.140
Why?
Fluorescence Polarization
1
2016
35
0.140
Why?
MicroRNAs
1
2023
601
0.140
Why?
Antioxidants
2
2011
530
0.140
Why?
G2 Phase Cell Cycle Checkpoints
1
2016
41
0.140
Why?
M Phase Cell Cycle Checkpoints
1
2016
23
0.130
Why?
Antiviral Agents
1
2022
646
0.130
Why?
Immunity, Innate
1
2022
723
0.130
Why?
Parkinson Disease
1
2020
345
0.130
Why?
Molecular Sequence Data
7
2014
2791
0.130
Why?
Quantitative Structure-Activity Relationship
1
2015
13
0.130
Why?
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
2
2013
138
0.130
Why?
Oxidation-Reduction
5
2020
927
0.130
Why?
Crystallography, X-Ray
5
2017
405
0.130
Why?
Alzheimer Disease
1
2020
443
0.130
Why?
Cells, Cultured
3
2020
3890
0.130
Why?
Small-Conductance Calcium-Activated Potassium Channels
1
2015
8
0.130
Why?
Drug Design
1
2016
151
0.130
Why?
HeLa Cells
1
2016
562
0.120
Why?
Membrane Proteins
2
2011
1022
0.120
Why?
Retinaldehyde
1
2014
6
0.120
Why?
Allosteric Regulation
3
2023
82
0.120
Why?
Acetaldehyde
1
2014
20
0.120
Why?
Drug Discovery
1
2016
124
0.120
Why?
Recombinant Proteins
5
2011
1233
0.120
Why?
Sulfhydryl Compounds
2
2020
177
0.120
Why?
Mass Spectrometry
4
2012
633
0.120
Why?
DNA Repair
1
2016
186
0.120
Why?
Enzyme-Linked Immunosorbent Assay
1
2016
797
0.120
Why?
Pituitary Neoplasms
1
2015
157
0.120
Why?
Computer Simulation
4
2014
878
0.120
Why?
Endoplasmic Reticulum Stress
1
2014
91
0.110
Why?
Heat-Shock Proteins
1
2014
113
0.110
Why?
Mammary Glands, Animal
2
2011
116
0.110
Why?
Fatty Liver, Alcoholic
1
2013
16
0.110
Why?
Inflammation
2
2022
2481
0.110
Why?
Protein Folding
2
2014
239
0.110
Why?
Adenosine Triphosphatases
1
2014
153
0.110
Why?
Lactation
2
2011
151
0.110
Why?
Antimetabolites, Antineoplastic
1
2013
82
0.110
Why?
Protein Tyrosine Phosphatases
1
2014
147
0.110
Why?
Antineoplastic Combined Chemotherapy Protocols
1
2021
1361
0.110
Why?
Cell Cycle
2
2014
543
0.110
Why?
Hypoxanthine Phosphoribosyltransferase
1
2013
25
0.110
Why?
Gene Expression Regulation
3
2013
2321
0.110
Why?
Electrophoresis, Polyacrylamide Gel
1
2013
319
0.100
Why?
Gout
1
2013
37
0.100
Why?
Electron Transport Complex I
1
2012
33
0.100
Why?
Status Epilepticus
1
2012
32
0.100
Why?
PTEN Phosphohydrolase
1
2013
140
0.100
Why?
Fatty Acid-Binding Proteins
1
2012
60
0.100
Why?
Apoptosis
6
2021
2369
0.100
Why?
Glutathione Reductase
1
2011
21
0.100
Why?
Acridines
1
2011
7
0.100
Why?
Glutathione Peroxidase
1
2011
41
0.100
Why?
DNA Topoisomerases, Type II
1
2011
44
0.100
Why?
Glutathione Transferase
1
2011
94
0.100
Why?
Intracellular Signaling Peptides and Proteins
1
2014
386
0.100
Why?
Flavoproteins
1
2011
7
0.100
Why?
Receptors, Cytoplasmic and Nuclear
1
2013
193
0.090
Why?
Xenograft Model Antitumor Assays
4
2021
706
0.090
Why?
Myocytes, Cardiac
1
2015
448
0.090
Why?
Glycolipids
1
2011
35
0.090
Why?
Transcriptional Activation
1
2013
337
0.090
Why?
Mitochondria, Liver
1
2011
67
0.090
Why?
Organelles
1
2011
51
0.090
Why?
Indoles
2
2015
306
0.090
Why?
Hydrogen Peroxide
1
2012
287
0.090
Why?
Histone-Lysine N-Methyltransferase
1
2011
95
0.090
Why?
Brain
2
2012
2374
0.090
Why?
Sirtuin 3
1
2011
52
0.090
Why?
Superoxide Dismutase
1
2012
305
0.090
Why?
Carcinoma, Hepatocellular
1
2012
211
0.090
Why?
Breast Neoplasms
2
2020
1868
0.090
Why?
Milk
1
2011
124
0.090
Why?
Enzyme Activation
2
2013
787
0.090
Why?
Protein Processing, Post-Translational
1
2012
399
0.090
Why?
Oxidative Stress
2
2014
1084
0.090
Why?
Cell Movement
1
2014
867
0.090
Why?
Kinetics
1
2013
1550
0.080
Why?
Phospholipids
1
2011
197
0.080
Why?
Adenosine Triphosphate
1
2011
431
0.080
Why?
Thioredoxin-Disulfide Reductase
1
2009
14
0.080
Why?
Peroxiredoxin VI
1
2008
5
0.080
Why?
Tumor Cells, Cultured
3
2022
854
0.080
Why?
Protein Structure, Tertiary
4
2014
797
0.080
Why?
Down-Regulation
1
2011
596
0.080
Why?
DNA-Binding Proteins
2
2013
1314
0.080
Why?
Mutation
4
2021
3350
0.080
Why?
Lipid Metabolism
1
2011
446
0.080
Why?
Protein Interaction Domains and Motifs
3
2013
132
0.070
Why?
Cross-Linking Reagents
1
2008
181
0.070
Why?
Quinones
1
2007
10
0.070
Why?
Spectrophotometry, Infrared
1
2007
43
0.070
Why?
Acrolein
1
2007
23
0.070
Why?
NF-kappa B p50 Subunit
1
2007
25
0.070
Why?
Cell Membrane
1
2011
680
0.070
Why?
Energy Metabolism
1
2012
729
0.070
Why?
Anti-Bacterial Agents
2
2024
1477
0.070
Why?
Galactosides
1
2006
3
0.070
Why?
beta-Galactosidase
1
2006
62
0.070
Why?
RNA, Messenger
2
2024
2557
0.070
Why?
Substrate Specificity
3
2014
354
0.070
Why?
Arginine
3
2013
236
0.060
Why?
Carcinoma
1
2007
198
0.060
Why?
Magnetic Resonance Spectroscopy
1
2007
473
0.060
Why?
Nitroimidazoles
1
2005
6
0.060
Why?
Computational Biology
1
2008
530
0.060
Why?
Spectrometry, Mass, Electrospray Ionization
3
2011
162
0.060
Why?
Biological Availability
1
2005
119
0.060
Why?
Emetine
1
2024
7
0.060
Why?
Aldehyde Dehydrogenase, Mitochondrial
2
2014
33
0.060
Why?
Mice, Nude
2
2021
635
0.060
Why?
Mice, Inbred C57BL
4
2014
4710
0.050
Why?
Polycomb-Group Proteins
1
2023
29
0.050
Why?
Peptides
2
2023
849
0.050
Why?
Cryoelectron Microscopy
1
2024
144
0.050
Why?
Insulin Resistance
1
2011
1072
0.050
Why?
Disease Models, Animal
3
2022
3542
0.050
Why?
Benzamides
1
2023
169
0.050
Why?
Ribosomes
1
2024
148
0.050
Why?
Exoribonucleases
1
2023
40
0.050
Why?
Stress, Physiological
2
2015
379
0.050
Why?
Molecular Conformation
2
2015
138
0.050
Why?
Alcohols
1
2022
28
0.050
Why?
Ethanol
3
2012
548
0.050
Why?
Phospholipase C beta
1
2022
25
0.050
Why?
Mesocricetus
1
2022
30
0.050
Why?
Hep G2 Cells
2
2013
61
0.050
Why?
Ear
1
2022
32
0.050
Why?
Peptide Mapping
2
2012
60
0.050
Why?
High-Throughput Screening Assays
1
2023
123
0.050
Why?
Serine Endopeptidases
1
2022
102
0.050
Why?
Sequence Alignment
2
2012
325
0.050
Why?
Oximes
1
2021
19
0.050
Why?
Perilipin-2
2
2011
36
0.050
Why?
Oxidative Phosphorylation
1
2022
156
0.050
Why?
Angiogenesis Inhibitors
1
2003
215
0.050
Why?
Spike Glycoprotein, Coronavirus
1
2022
92
0.050
Why?
Neural Crest
1
2022
117
0.050
Why?
Indazoles
1
2021
58
0.050
Why?
Cell-Free System
2
2011
47
0.040
Why?
Antibodies, Monoclonal
1
2006
1270
0.040
Why?
Viral Load
1
2022
405
0.040
Why?
HEK293 Cells
2
2013
594
0.040
Why?
Blotting, Western
2
2013
1151
0.040
Why?
Lipoproteins
1
2020
160
0.040
Why?
Carbon
1
2020
157
0.040
Why?
T-Lymphocytes
1
2007
1745
0.040
Why?
MAP Kinase Signaling System
1
2021
276
0.040
Why?
Female
8
2022
59507
0.040
Why?
Microglia
1
2020
202
0.040
Why?
Tandem Mass Spectrometry
2
2013
413
0.040
Why?
Genomics
2
2014
639
0.040
Why?
Piperazines
1
2021
311
0.040
Why?
Triglycerides
1
2020
470
0.040
Why?
Neoplasm Transplantation
1
2019
232
0.040
Why?
Amyloid beta-Peptides
1
2020
189
0.040
Why?
Child
1
2016
18352
0.040
Why?
Drug Resistance, Multiple
1
2017
19
0.040
Why?
Dimerization
1
2017
176
0.030
Why?
Models, Biological
2
2014
1630
0.030
Why?
Rats, Sprague-Dawley
2
2012
2209
0.030
Why?
Adult
1
2016
30548
0.030
Why?
Nitroglycerin
1
2014
21
0.030
Why?
Circular Dichroism
1
2015
135
0.030
Why?
Male
6
2022
55579
0.030
Why?
Phenotype
1
2022
2812
0.030
Why?
Spectrophotometry, Ultraviolet
1
2014
73
0.030
Why?
Unfolded Protein Response
1
2014
43
0.030
Why?
Calorimetry
1
2014
60
0.030
Why?
Lung
2
2022
3546
0.030
Why?
Macrophages
1
2020
1261
0.030
Why?
Magnesium
1
2014
145
0.030
Why?
Sequence Homology, Amino Acid
1
2014
353
0.030
Why?
Cell Cycle Checkpoints
1
2013
85
0.030
Why?
Retinoid X Receptors
1
2013
39
0.030
Why?
Caco-2 Cells
1
2013
66
0.030
Why?
RNA Splice Sites
1
2013
34
0.030
Why?
Tumor Microenvironment
1
2015
433
0.030
Why?
Telomere
1
2015
202
0.030
Why?
Hyperuricemia
1
2013
44
0.030
Why?
Synaptosomes
1
2012
12
0.030
Why?
Biotinylation
1
2012
27
0.030
Why?
Kainic Acid
1
2012
31
0.030
Why?
Fishes
1
2013
81
0.030
Why?
Anilino Naphthalenesulfonates
1
2012
10
0.030
Why?
Excitatory Amino Acid Agonists
1
2012
37
0.030
Why?
Rats
2
2012
4943
0.030
Why?
Methyltransferases
1
2013
61
0.030
Why?
Nuclear Magnetic Resonance, Biomolecular
1
2014
238
0.030
Why?
Electron Transport Complex IV
1
2012
53
0.030
Why?
Sulfonamides
1
2015
445
0.030
Why?
Anura
1
2012
42
0.030
Why?
Electrophoresis, Gel, Two-Dimensional
1
2012
101
0.030
Why?
Cysteine Proteinase Inhibitors
1
2012
45
0.030
Why?
ATP-Binding Cassette Transporters
1
2013
123
0.030
Why?
Endoplasmic Reticulum
1
2014
234
0.030
Why?
Molecular Weight
1
2012
331
0.020
Why?
Ubiquitination
1
2012
86
0.020
Why?
Gene Knockout Techniques
1
2012
99
0.020
Why?
Genome, Human
1
2014
351
0.020
Why?
Immunoprecipitation
1
2012
152
0.020
Why?
Inhibitory Concentration 50
1
2011
74
0.020
Why?
Amination
1
2011
2
0.020
Why?
Chromatography, Liquid
1
2013
348
0.020
Why?
Alkylation
1
2011
18
0.020
Why?
Nucleic Acid Conformation
1
2015
669
0.020
Why?
Oxidants
1
2012
112
0.020
Why?
Embryo, Mammalian
1
2012
214
0.020
Why?
Immunohistochemistry
1
2015
1635
0.020
Why?
Protein Subunits
1
2012
201
0.020
Why?
Histone Deacetylase Inhibitors
1
2013
198
0.020
Why?
Lipid Droplets
1
2011
21
0.020
Why?
Binding, Competitive
1
2011
193
0.020
Why?
Metabolic Networks and Pathways
1
2012
168
0.020
Why?
Glycogen Synthase Kinase 3 beta
1
2011
60
0.020
Why?
Cloning, Molecular
1
2012
524
0.020
Why?
DNA Primers
1
2012
514
0.020
Why?
Ligands
1
2013
565
0.020
Why?
Mammary Glands, Human
1
2011
60
0.020
Why?
NAD
1
2011
64
0.020
Why?
Glycogen Synthase Kinase 3
1
2011
77
0.020
Why?
Lipid Peroxidation
1
2011
139
0.020
Why?
Membranes, Artificial
1
2011
65
0.020
Why?
Acetylation
1
2011
211
0.020
Why?
Mammals
1
2012
245
0.020
Why?
Phosphatidylinositol 3-Kinases
1
2012
330
0.020
Why?
Protein Structure, Secondary
1
2011
325
0.020
Why?
Transfection
1
2012
870
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2012
928
0.020
Why?
In Vitro Techniques
1
2011
1013
0.020
Why?
Hypoxia
1
2015
957
0.020
Why?
Analysis of Variance
1
2012
1226
0.020
Why?
DNA Breaks, Single-Stranded
1
2009
5
0.020
Why?
Phylogeny
1
2012
794
0.020
Why?
Evolution, Molecular
1
2012
437
0.020
Why?
Animal Feed
1
2008
49
0.020
Why?
Gene Expression Regulation, Neoplastic
1
2014
1147
0.020
Why?
NADPH-Ferrihemoprotein Reductase
1
2008
10
0.020
Why?
Promoter Regions, Genetic
1
2013
1133
0.020
Why?
Microsomes, Liver
1
2008
57
0.020
Why?
Liver Neoplasms
1
2012
507
0.020
Why?
Caspases
1
2009
245
0.020
Why?
Oxygen
1
2012
853
0.020
Why?
Transcription Factor AP-1
1
2007
80
0.020
Why?
Mitochondria
1
2012
751
0.020
Why?
Tetrazolium Salts
1
2006
18
0.020
Why?
NFATC Transcription Factors
1
2007
78
0.020
Why?
Indicators and Reagents
1
2006
99
0.020
Why?
Proteomics
1
2012
843
0.020
Why?
Cell Respiration
1
2006
75
0.020
Why?
Thiazoles
1
2006
110
0.020
Why?
Deoxyuridine
1
2006
6
0.020
Why?
Cysteine
1
2007
171
0.020
Why?
Smoke
1
2007
123
0.020
Why?
Drug Carriers
1
2006
112
0.020
Why?
Superoxides
1
2006
214
0.020
Why?
Drug Interactions
1
2006
340
0.020
Why?
Colonic Neoplasms
1
2006
221
0.010
Why?
Drug Delivery Systems
1
2006
296
0.010
Why?
Oxygen Consumption
1
2006
588
0.010
Why?
Respiratory Tract Infections
1
2007
319
0.010
Why?
Time Factors
1
2012
6124
0.010
Why?
Liver
1
2008
1631
0.010
Why?
Aged
1
2019
19094
0.010
Why?
Child, Preschool
1
2014
9079
0.010
Why?
Cytokines
1
2007
1843
0.010
Why?
Middle Aged
1
2019
26757
0.010
Why?
Reigan's Networks
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