 Electron Transport Complex I
"Electron Transport Complex I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UBIQUINONE to ubiquinol. In MITOCHONDRIA the complex also couples its reaction to the transport of PROTONS across the internal mitochondrial membrane. The NADH DEHYDROGENASE component of the complex can be isolated and is listed as EC 1.6.99.3.
| Descriptor ID |
D042967
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| MeSH Number(s) |
D05.500.562.249 D08.811.600.250.500.500 D08.811.682.608.504 D12.776.157.427.374.375.863 D12.776.157.530.450.250.875.300 D12.776.331.199.500 D12.776.543.277.500.500 D12.776.543.585.450.250.875.437 D12.776.556.579.374.375.140
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| Concept/Terms |
NADH Dehydrogenase (Ubiquinone)- NADH Dehydrogenase (Ubiquinone)
- NADH Dehydrogenase Complex 1
- NADH Dehydrogenase I
- NADH DH I
- Ubiquinone Reductase
- NADH-Coenzyme Q Reductase
- NADH Coenzyme Q Reductase
- NADH-CoQ Reductase
- NADH CoQ Reductase
- NADH-Ubiquinone Oxidoreductase
- NADH Ubiquinone Oxidoreductase
- Oxidoreductase, NADH-Ubiquinone
- NADH-Ubiquinone Reductase
- NADH Ubiquinone Reductase
- Reductase, NADH-Ubiquinone
- Rotenone-Sensitive Mitochondrial NADH-Ubiquinone Oxidoreductase
- Rotenone Sensitive Mitochondrial NADH Ubiquinone Oxidoreductase
- Complex I Dehydrogenase
- Dehydrogenase, Complex I
- NADH Q1 Oxidoreductase
- Oxidoreductase, NADH Q1
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Below are MeSH descriptors whose meaning is more general than "Electron Transport Complex I".
Below are MeSH descriptors whose meaning is more specific than "Electron Transport Complex I".
This graph shows the total number of publications written about "Electron Transport Complex I" by people in this website by year, and whether "Electron Transport Complex I" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 2 | 3 | | 2016 | 0 | 2 | 2 | | 2017 | 1 | 0 | 1 | | 2019 | 2 | 0 | 2 | | 2020 | 0 | 2 | 2 | | 2021 | 1 | 1 | 2 | | 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Electron Transport Complex I" by people in Profiles.
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Ojha R, Tantray I, Rimal S, Mitra S, Cheshier S, Lu B. Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells. Dev Cell. 2022 01 24; 57(2):260-276.e9.
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Yang JH, Friederich MW, Ellsworth KA, Frederick A, Foreman E, Malicki D, Dimmock D, Lenberg J, Prasad C, Yu AC, Anthony Rupar C, Hegele RA, Manickam K, Koboldt DC, Crist E, Choi SS, Farhan SMK, Harvey H, Sattar S, Karp N, Wong T, Haas R, Van Hove JLK, Wigby K. Expanding the phenotypic and molecular spectrum of NFS1-related disorders that cause functional deficiencies in mitochondrial and cytosolic iron-sulfur cluster containing enzymes. Hum Mutat. 2022 03; 43(3):305-315.
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Thandapani P, Kloetgen A, Witkowski MT, Glytsou C, Lee AK, Wang E, Wang J, LeBoeuf SE, Avrampou K, Papagiannakopoulos T, Tsirigos A, Aifantis I. Valine tRNA levels and availability regulate complex I assembly in leukaemia. Nature. 2022 01; 601(7893):428-433.
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Chatfield KC, Sparagna GC, Specht KS, Whitcomb LA, Omar AK, Miyamoto SD, Wolfe LM, Chicco AJ. Long-chain fatty acid oxidation and respiratory complex I deficiencies distinguish Barth Syndrome from idiopathic pediatric cardiomyopathy. J Inherit Metab Dis. 2022 01; 45(1):111-124.
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Keller A, Hull SE, Elajaili H, Johnston A, Knaub LA, Chun JH, Walker L, Nozik-Grayck E, Reusch JEB. (-)-Epicatechin Modulates Mitochondrial Redox in Vascular Cell Models of Oxidative Stress. Oxid Med Cell Longev. 2020; 2020:6392629.
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Cole LK, Mejia EM, Sparagna GC, Vandel M, Xiang B, Han X, Dedousis N, Kaufman BA, Dolinsky VW, Hatch GM. Cardiolipin deficiency elevates susceptibility to a lipotoxic hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2020 07; 144:24-34.
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Friederich MW, Perez FA, Knight KM, Van Hove RA, Yang SP, Saneto RP, Van Hove JLK. Pathogenic variants in NUBPL result in failure to assemble the matrix arm of complex I and cause a complex leukoencephalopathy with thalamic involvement. Mol Genet Metab. 2020 03; 129(3):236-242.
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Janssen RC, Boyle KE. Microplate Assays for Spectrophotometric Measurement of Mitochondrial Enzyme Activity. Methods Mol Biol. 2019; 1978:355-368.
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Boehm E, Zaganelli S, Maundrell K, Jourdain AA, Thore S, Martinou JC. FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain. Nucleic Acids Res. 2017 Jun 02; 45(10):6135-6146.
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Friederich MW, Erdogan AJ, Coughlin CR, Elos MT, Jiang H, O'Rourke CP, Lovell MA, Wartchow E, Gowan K, Chatfield KC, Chick WS, Spector EB, Van Hove JLK, Riemer J. Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Hum Mol Genet. 2017 02 15; 26(4):702-716.
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