 Lipoprotein Lipase
"Lipoprotein Lipase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.
| Descriptor ID |
D008071
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| MeSH Number(s) |
D08.811.277.352.100.430
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| Concept/Terms |
Lipoprotein Lipase- Lipoprotein Lipase
- Lipase, Lipoprotein
- Diglyceride Lipase
- Lipase, Diglyceride
- Heparin-Clearing Factor
- Factor, Heparin-Clearing
- Heparin Clearing Factor
- Post-Heparin Lipase
- Lipase, Post-Heparin
- Post Heparin Lipase
- Postheparin Lipase
- Lipase, Postheparin
- Postheparin Lipoprotein Lipase
- Lipase, Postheparin Lipoprotein
- Lipoprotein Lipase, Postheparin
- Diacylglycerol Lipase
- Lipase, Diacylglycerol
- Lipemia-Clearing Factor
- Factor, Lipemia-Clearing
- Lipemia Clearing Factor
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Below are MeSH descriptors whose meaning is more general than "Lipoprotein Lipase".
Below are MeSH descriptors whose meaning is more specific than "Lipoprotein Lipase".
This graph shows the total number of publications written about "Lipoprotein Lipase" by people in this website by year, and whether "Lipoprotein Lipase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 1 | 3 | | 2006 | 4 | 1 | 5 | | 2007 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2010 | 2 | 1 | 3 | | 2011 | 1 | 0 | 1 | | 2013 | 0 | 2 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 2 | 1 | 3 | | 2016 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 1 | 3 | | 2020 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lipoprotein Lipase" by people in Profiles.
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Lightbourne M, Startzell M, Bruce KD, Brite B, Muniyappa R, Skarulis M, Shamburek R, Gharib AM, Ouwerkerk R, Walter M, Eckel RH, Brown RJ. Volanesorsen, an antisense oligonucleotide to apolipoprotein C-III, increases lipoprotein lipase activity and lowers triglycerides in partial lipodystrophy. J Clin Lipidol. 2022 Nov-Dec; 16(6):850-862.
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Presby DM, Rudolph MC, Sherk VD, Jackman MR, Foright RM, Jones KL, Houck JA, Johnson GC, Higgins JA, Neufer PD, Eckel RH, MacLean PS. Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure. Diabetes. 2021 04; 70(4):867-877.
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Loving BA, Tang M, Neal MC, Gorkhali S, Murphy R, Eckel RH, Bruce KD. Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation. Cells. 2021 01 20; 10(2).
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D Bruce K, Tang M, Reigan P, H Eckel R. Genetic Variants of Lipoprotein Lipase and Regulatory Factors Associated with Alzheimer's Disease Risk. Int J Mol Sci. 2020 Nov 06; 21(21).
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Chait A, Eckel RH. The Chylomicronemia Syndrome Is Most Often Multifactorial: A Narrative Review of Causes and Treatment. Ann Intern Med. 2019 05 07; 170(9):626-634.
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Roberts BS, Babilonia-Rosa MA, Broadwell LJ, Wu MJ, Neher SB. Lipase maturation factor 1 affects redox homeostasis in the endoplasmic reticulum. EMBO J. 2018 10 01; 37(19).
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Falko JM. Familial Chylomicronemia Syndrome: A Clinical Guide For Endocrinologists. Endocr Pract. 2018 08; 24(8):756-763.
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Heerwagen MJR, Gumina DL, Hernandez TL, Van Pelt RE, Kramer AW, Janssen RC, Jensen DR, Powell TL, Friedman JE, Winn VD, Barbour LA. Placental lipoprotein lipase activity is positively associated with newborn adiposity. Placenta. 2018 04; 64:53-60.
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Gadek KE, Wang H, Hall MN, Sungello M, Libby A, MacLaskey D, Eckel RH, Olwin BB. Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency. PLoS One. 2018; 13(1):e0190963.
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Gao Y, Vidal-Itriago A, Kalsbeek MJ, Layritz C, Garc?a-C?ceres C, Tom RZ, Eichmann TO, Vaz FM, Houtkooper RH, van der Wel N, Verhoeven AJ, Yan J, Kalsbeek A, Eckel RH, Hofmann SM, Yi CX. Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity. Cell Rep. 2017 Sep 26; 20(13):3034-3042.
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