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Tatiana Grigori Kutateladze

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations
Phone303/724-3593

    Collapse Research 
    Collapse research activities and funding
    R01AG067664     (KUTATELADZE, TATIANA G)May 1, 2021 - Feb 28, 2027
    NIH
    Targeting acetylated histone H4 by MLL4
    Role: Principal Investigator
    R56AG067664     (KUTATELADZE, TATIANA G)Sep 15, 2020 - Aug 31, 2021
    NIH
    Targeting acetylated histone H4 by MLL4
    Role: Principal Investigator
    R01CA252707     (KUTATELADZE, TATIANA G)Jul 1, 2020 - Jun 30, 2026
    NIH
    Molecular analysis of ASH1L
    Role: Principal Investigator
    R01HL151334     (KUTATELADZE, TATIANA G)May 15, 2020 - Apr 30, 2025
    NIH
    The role of JADE in HBO complexes
    Role: Principal Investigator
    R01GM135671     (KUTATELADZE, TATIANA G)Jan 1, 2020 - Nov 30, 2024
    NIH
    Epigenetic mechanisms for regulation of p300
    Role: Principal Investigator
    R01GM125195     (KUTATELADZE, TATIANA G)Sep 1, 2017 - Jun 30, 2022
    NIH
    Interdomain crosstalk in MORC3
    Role: Principal Investigator
    R01GM106416     (KUTATELADZE, TATIANA G)May 1, 2015 - Mar 31, 2020
    NIH
    Epigenetic regulation by PHF1
    Role: Principal Investigator
    R01GM100907     (KUTATELADZE, TATIANA G)Feb 1, 2015 - Jan 31, 2020
    NIH
    Molecular mechanism of chromatin targeting by BRPF1
    Role: Principal Investigator
    R01GM101664     (KUTATELADZE, TATIANA G)Aug 1, 2013 - Jul 31, 2018
    NIH
    Molecular analysis of methylated p53
    Role: Principal Investigator
    R01GM096863     (KUTATELADZE, TATIANA G)Aug 2, 2011 - Apr 30, 2015
    NIH
    Molecular analysis of CHD4
    Role: Principal Investigator
    R01CA113472     (KUTATELADZE, TATIANA G)Sep 6, 2006 - Jul 31, 2012
    NIH
    Structural basis of signaling by ING2 PHD
    Role: Principal Investigator
    R01GM071424     (KUTATELADZE, TATIANA G)Sep 1, 2006 - Aug 31, 2011
    NIH
    Membrane Targeting by PI-binding Domains
    Role: Principal Investigator
    R01CA095144     (KUTATELADZE, TATIANA G)Apr 1, 2002 - Mar 31, 2006
    NIH
    Structure and Function of the Phox Domain
    Role: Principal Investigator
    R01CA085716     (KUTATELADZE, TATIANA G)Apr 1, 2000 - Mar 31, 2006
    NIH
    STRUCTURE AND FUNCTION OF FYVE DOMAINS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Brown K, Chew PY, Ingersoll S, Espinosa JR, Aguirre A, Espinoza A, Wen J, Astatike K, Kutateladze TG, Collepardo-Guevara R, Ren X. Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation. Cell Rep. 2023 10 31; 42(10):113136. PMID: 37756159.
      View in: PubMed
    2. Smith AL, Pal D, Martinez-Rico R, Eiken AP, Durden DL, Kutateladze TG, El-Gamal D. Preclinical activity of a novel multi-axis inhibitor in aggressive and indolent B-cell malignancies. Leuk Lymphoma. 2023 12; 64(14):2333-2337. PMID: 37706519.
      View in: PubMed
    3. Tencer AH, Yu Y, Causse SZ, Campbell GR, Klein BJ, Xuan H, Cartier J, Miles MA, Gaurav N, Zadoroznyj A, Holt TA, Wen H, Hawkins CJ, Spector SA, Dubrez L, Shi X, Kutateladze TG. Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2. Nat Struct Mol Biol. 2023 09; 30(9):1265-1274. PMID: 37524969.
      View in: PubMed
    4. Nguyen MC, Wang D, Klein BJ, Chen Y, Kutateladze TG. Differences and similarities in recognition of co-factors by Taf14. Biochim Biophys Acta Gene Regul Mech. 2023 09; 1866(3):194961. PMID: 37482120.
      View in: PubMed
    5. Kumar Sinha V, Zhang Y, Xu L, Chen YW, Picaud S, Zandian M, Biswas S, Filippakopoulos P, Wang SP, Shi X, Kutateladze TG. Histone H4K16ac Binding Function of the Triple PHD Finger Cassette of MLL4. J Mol Biol. 2024 Apr 01; 436(7):168212. PMID: 37481158.
      View in: PubMed
    6. Gaurav N, Kutateladze TG. Non-histone binding functions of PHD fingers. Trends Biochem Sci. 2023 07; 48(7):610-617. PMID: 37061424.
      View in: PubMed
    7. Lee E, Redzic JS, Saviola AJ, Li X, Ebmeier CC, Kutateladze TG, Hansen KC, Zhao R, Ahn N, Sluchanko NN, Eisenmesser E. Molecular insight into the specific interactions of the SARS-Coronavirus-2 nucleocapsid with RNA and host protein. Protein Sci. 2023 04; 32(4):e4603. PMID: 36807437.
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    8. Liu J, Chaves-Arquero B, Wei P, Tencer AH, Ruiz-Albor A, Zhang G, Blanco FJ, Kutateladze TG. Molecular insight into the PCNA-binding mode of FBH1. Structure. 2023 05 04; 31(5):511-517.e3. PMID: 36990095.
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    9. Ortiz G, Kutateladze TG, Fujimori DG. Chemical tools targeting readers of lysine methylation. Curr Opin Chem Biol. 2023 06; 74:102286. PMID: 36948085.
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    10. Black JC, Kutateladze TG. Atypical histone targets of PHD fingers. J Biol Chem. 2023 04; 299(4):104601. PMID: 36907441.
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    11. Becht DC, Klein BJ, Kanai A, Jang SM, Cox KL, Zhou BR, Phanor SK, Zhang Y, Chen RW, Ebmeier CC, Lachance C, Galloy M, Fradet-Turcotte A, Bulyk ML, Bai Y, Poirier MG, C?t? J, Yokoyama A, Kutateladze TG. MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain. Nat Commun. 2023 02 08; 14(1):697. PMID: 36754959.
      View in: PubMed
    12. Nguyen MC, Strahl BD, Kutateladze TG. Engaging with benzoyllysine through a p-p-p mechanism. Curr Opin Chem Biol. 2023 Feb; 72:102252. PMID: 36566617.
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    13. Penumutchu S, Liu J, Singh UK, Kutateladze TG, Zhang Y. Protocol to identify drug-binding sites in proteins using solution NMR spectroscopy. STAR Protoc. 2022 12 16; 3(4):101842. PMID: 36595882.
      View in: PubMed
    14. Zandian M, Jang SM, Lachance C, Acharya A, Byrareddy SN, C?t? J, Kutateladze TG. Characterization of multiple interactions between the envelope E protein of SARS-CoV-2 and human BRD4. STAR Protoc. 2022 12 16; 3(4):101853. PMID: 36595918.
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    15. Liu J, Kutateladze TG. Dietary polyphenols link extracellular histones and nonhistone proteins. J Biol Chem. 2022 12; 298(12):102651. PMID: 36377105.
      View in: PubMed
    16. Zandian M, Chen IP, Byrareddy SN, Fujimori DG, Ott M, Kutateladze TG. Catching BETs by viruses. Biochim Biophys Acta Gene Regul Mech. 2022 10; 1865(7):194859. PMID: 35985635.
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    17. Vann KR, Acharya A, Jang SM, Lachance C, Zandian M, Holt TA, Smith AL, Pandey K, Durden DL, El-Gamal D, C?t? J, Byrareddy SN, Kutateladze TG. Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection. Structure. 2022 09 01; 30(9):1224-1232.e5. PMID: 35716662.
      View in: PubMed
    18. Smith AL, Eiken AP, Skupa SA, Moore DY, Umeta LT, Smith LM, Lyden ER, D'Angelo CR, Kallam A, Vose JM, Kutateladze TG, El-Gamal D. A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia. Int J Mol Sci. 2022 Jun 16; 23(12). PMID: 35743155.
      View in: PubMed
    19. Hatazawa S, Liu J, Takizawa Y, Zandian M, Negishi L, Kutateladze TG, Kurumizaka H. Structural basis for binding diversity of acetyltransferase p300 to the nucleosome. iScience. 2022 Jul 15; 25(7):104563. PMID: 35754730.
      View in: PubMed
    20. Klein BJ, Feigerle JT, Zhang J, Ebmeier CC, Fan L, Singh RK, Wang WW, Schmitt LR, Lee T, Hansen KC, Liu WR, Wang YX, Strahl BD, Anthony Weil P, Kutateladze TG. Taf2 mediates DNA binding of Taf14. Nat Commun. 2022 06 08; 13(1):3177. PMID: 35676274.
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    21. Zhang Y, Towers CG, Singh UK, Liu J, H?kansson M, Logan DT, Donini O, Kutateladze TG. Dusquetide modulates innate immune response through binding to p62. Structure. 2022 08 04; 30(8):1055-1061.e7. PMID: 35640615.
      View in: PubMed
    22. Acharya A, Kutateladze TG, Byrareddy SN. Combining antiviral drugs with BET inhibitors is beneficial in combatting SARS-CoV-2 infection. Clin Transl Discov. 2022 Jun; 2(2). PMID: 35633739.
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    23. Tencer AH, Liu J, Zhu J, Burkholder NT, Zhang Y, Wu W, Strahl BD, Ohta T, Kutateladze TG. The ZZ domain of HERC2 is a receptor of arginylated substrates. Sci Rep. 2022 04 11; 12(1):6063. PMID: 35411094.
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    24. Acharya A, Pathania AS, Pandey K, Thurman M, Vann KR, Kutateladze TG, Challagundala KB, Durden DL, Byrareddy SN. PI3K-a/mTOR/BRD4 inhibitor alone or in combination with other anti-virals blocks replication of SARS-CoV-2 and its variants of concern including Delta and Omicron. Clin Transl Med. 2022 04; 12(4):e806. PMID: 35390226.
      View in: PubMed
    25. Musselman CA, Kutateladze TG. Visualizing Conformational Ensembles of the Nucleosome by NMR. ACS Chem Biol. 2022 03 18; 17(3):495-502. PMID: 35196453.
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    26. Vann KR, Pal D, Smith AL, Sahar NE, Krishnaiah M, El-Gamal D, Kutateladze TG. Combinatorial inhibition of BTK, PI3K-AKT and BRD4-MYC as a strategy for treatment of mantle cell lymphoma. Mol Biomed. 2022 Jan 15; 3(1):2. PMID: 35031886.
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    27. Vann KR, Vishweshwaraiah YL, Dokholyan NV, Kutateladze TG. Searching for methyllysine-binding aromatic cages. Biochem J. 2021 10 15; 478(19):3613-3619. PMID: 34624071.
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    28. Pal D, Vann KR, Joshi S, Sahar NE, Morales GA, El-Gamal D, Kutateladze TG, Durden DL. The BTK/PI3K/BRD4 axis inhibitor SRX3262 overcomes Ibrutinib resistance in mantle cell lymphoma. iScience. 2021 Sep 24; 24(9):102931. PMID: 34557659.
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    29. Zhang Y, Brown K, Yu Y, Ibrahim Z, Zandian M, Xuan H, Ingersoll S, Lee T, Ebmeier CC, Liu J, Panne D, Shi X, Ren X, Kutateladze TG. Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity. Nat Commun. 2021 07 29; 12(1):4618. PMID: 34326347.
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    30. Ma XR, Xu L, Xu S, Klein BJ, Wang H, Das S, Li K, Yang KS, Sohail S, Chapman A, Kutateladze TG, Shi X, Liu WR, Wen H. Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain. J Med Chem. 2021 08 12; 64(15):10997-11013. PMID: 34279931.
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    31. Klein BJ, Deshpande A, Cox KL, Xuan F, Zandian M, Barbosa K, Khanal S, Tong Q, Zhang Y, Zhang P, Sinha A, Bohlander SK, Shi X, Wen H, Poirier MG, Deshpande AJ, Kutateladze TG. The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations. Nat Commun. 2021 07 05; 12(1):4130. PMID: 34226546.
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    32. Engelberg IA, Liu J, Norris-Drouin JL, Cholensky SH, Ottavi SA, Frye SV, Kutateladze TG, James LI. Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1). J Med Chem. 2021 06 24; 64(12):8510-8522. PMID: 33999620.
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    33. Vann KR, Klein BJ, Kutateladze TG. Mechanistic similarities in recognition of histone tails and DNA by epigenetic readers. Curr Opin Struct Biol. 2021 12; 71:1-6. PMID: 33993059.
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    34. le Paige UB, Xiang S, Hendrix MMRM, Zhang Y, Folkers GE, Weingarth M, Bonvin AMJJ, Kutateladze TG, Voets IK, Baldus M, van Ingen H. Characterization of nucleosome sediments for protein interaction studies by solid-state NMR spectroscopy. Magn Reson (Gott). 2021; 2(1):187-202. PMID: 35647606.
      View in: PubMed
    35. Klein BJ, Cox KL, Jang SM, Singh RK, C?t? J, Poirier MG, Kutateladze TG. Structural and biophysical characterization of the nucleosome-binding PZP domain. STAR Protoc. 2021 06 18; 2(2):100479. PMID: 33982013.
      View in: PubMed
    36. Acharya A, Pandey K, Thurman M, Challagundala KB, Vann KR, Kutateladze TG, Morales GA, Durden DL, Byrareddy SN. Blockade of SARS-CoV-2 infection in vitro by highly potent PI3K-a/mTOR/BRD4 inhibitor. bioRxiv. 2021 Mar 05. PMID: 33688653.
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    37. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-G?mez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, ?lvarez ?MC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Ant?n Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Ara?jo WL, Araya J, Arden C, Ar?valo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnaun?-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, ?valos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, B?nr?ti ?, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Baril? D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touz? N, Bellarosa C, Belleudi F, Bell? P?rez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Bur?n MI, Bustos V, B?ttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cair? M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cant? C, Cao B, Caraglia M, Caram?s B, Carchman EH, Cardenal-Mu?oz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. PMID: 33634751.
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    38. Musselman CA, Kutateladze TG. Characterization of functional disordered regions within chromatin-associated proteins. iScience. 2021 Feb 19; 24(2):102070. PMID: 33604523.
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    39. Riching AS, Danis E, Zhao Y, Cao Y, Chi C, Bagchi RA, Klein BJ, Xu H, Kutateladze TG, McKinsey TA, Buttrick PM, Song K. Suppression of canonical TGF-? signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis. J Mol Cell Cardiol. 2021 04; 153:44-59. PMID: 33359755.
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    40. Yu Y, Tencer A, Xuan H, Kutateladze TG, Shi X. ZZEF1 is a Histone Reader and Transcriptional Coregulator of Kr?ppel-Like Factors. J Mol Biol. 2021 01 22; 433(2):166722. PMID: 33227311.
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    41. Tencer AH, Cox KL, Wright GM, Zhang Y, Petell CJ, Klein BJ, Strahl BD, Black JC, Poirier MG, Kutateladze TG. Molecular mechanism of the MORC4 ATPase activation. Nat Commun. 2020 10 29; 11(1):5466. PMID: 33122719.
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    42. Liu J, Xue Z, Vann KR, Shi X, Kutateladze TG. Protocol for Biochemical Analysis and Structure Determination of the ZZ Domain of the E3?Ubiquitin Ligase HERC2. STAR Protoc. 2020 12 18; 1(3):100155. PMID: 33377049.
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    43. Vann KR, Tencer AH, Kutateladze TG. Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2. Signal Transduct Target Ther. 2020 10 09; 5(1):234. PMID: 33037187.
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    44. Zhang Y, Narlikar GJ, Kutateladze TG. Enzymatic Reactions inside Biological Condensates. J Mol Biol. 2021 06 11; 433(12):166624. PMID: 32805219.
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    45. Liu J, Xue Z, Zhang Y, Vann KR, Shi X, Kutateladze TG. Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1. Structure. 2020 11 03; 28(11):1225-1230.e3. PMID: 32726574.
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    46. Burgoyne AM, Vann KR, Joshi S, Morales GA, Vega FM, Singh A, Pal D, Merati AB, Kutateladze TG, Durden DL. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020; 6(1):49. PMID: 32793389.
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    47. Vann KR, Pal D, Morales GA, Burgoyne AM, Durden DL, Kutateladze TG. Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets. Sci Rep. 2020 07 21; 10(1):12027. PMID: 32694708.
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    48. Zhang Y, Guo Y, Gough SM, Zhang J, Vann KR, Li K, Cai L, Shi X, Aplan PD, Wang GG, Kutateladze TG. Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun. 2020 07 03; 11(1):3339. PMID: 32620764.
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    49. Zhang Y, Kutateladze TG. Molecular structure analyses suggest strategies to therapeutically target SARS-CoV-2. Nat Commun. 2020 06 10; 11(1):2920. PMID: 32523109.
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    50. Zhang Y, Kutateladze TG. Exploring epigenetics with chemical tools. Nat Chem. 2020 06; 12(6):506-508. PMID: 32472102.
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    51. Bacon CW, Challa A, Hyder U, Shukla A, Borkar AN, Bayo J, Liu J, Wu SY, Chiang CM, Kutateladze TG, D'Orso I. KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs. Mol Cell. 2020 06 18; 78(6):1133-1151.e14. PMID: 32402252.
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    52. Mondal P, Sen S, Klein BJ, Tiwary N, Gadad SS, Kutateladze TG, Roy S, Das C. TCF19 Promotes Cell Proliferation through Binding to the Histone H3K4me3 Mark. Biochemistry. 2020 02 04; 59(4):389-399. PMID: 31746185.
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    53. Zhang Y, Kutateladze TG. Liquid-liquid phase separation is an intrinsic physicochemical property of chromatin. Nat Struct Mol Biol. 2019 12; 26(12):1085-1086. PMID: 31695191.
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    54. Klein BJ, Cox KL, Jang SM, C?t? J, Poirier MG, Kutateladze TG. Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin. Structure. 2020 01 07; 28(1):105-110.e3. PMID: 31711755.
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    55. Manickavinayaham S, V?lez-Cruz R, Biswas AK, Bedford E, Klein BJ, Kutateladze TG, Liu B, Bedford MT, Johnson DG. E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair. Nat Commun. 2019 10 30; 10(1):4951. PMID: 31666529.
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    56. Klein BJ, Jang SM, Lachance C, Mi W, Lyu J, Sakuraba S, Krajewski K, Wang WW, Sidoli S, Liu J, Zhang Y, Wang X, Warfield BM, Kueh AJ, Voss AK, Thomas T, Garcia BA, Liu WR, Strahl BD, Kono H, Li W, Shi X, C?t? J, Kutateladze TG. Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation. Nat Commun. 2019 10 17; 10(1):4724. PMID: 31624313.
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    57. Musselman CA, Kutateladze TG. The PHD finger of Spp1 mediates histone modification cross-talk. Biochem J. 2019 08 28; 476(16):2351-2354. PMID: 31462441.
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    58. Zhang Y, Bertulat B, Tencer AH, Ren X, Wright GM, Black J, Cardoso MC, Kutateladze TG. MORC3 Forms Nuclear Condensates through Phase Separation. iScience. 2019 Jul 26; 17:182-189. PMID: 31284181.
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    59. Zhang Y, Kutateladze TG. Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome. Mol Cell. 2019 06 06; 74(5):862-863. PMID: 31173720.
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    60. Zhang Y, Jang Y, Lee JE, Ahn J, Xu L, Holden MR, Cornett EM, Krajewski K, Klein BJ, Wang SP, Dou Y, Roeder RG, Strahl BD, Rothbart SB, Shi X, Ge K, Kutateladze TG. Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF. Nat Commun. 2019 05 24; 10(1):2314. PMID: 31127101.
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    147. Musselman CA, Mansfield RE, Garske AL, Davrazou F, Kwan AH, Oliver SS, O'Leary H, Denu JM, Mackay JP, Kutateladze TG. Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. Biochem J. 2009 Sep 25; 423(2):179-87. PMID: 19624289.
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    148. He J, Vora M, Haney RM, Filonov GS, Musselman CA, Burd CG, Kutateladze AG, Verkhusha VV, Stahelin RV, Kutateladze TG. Membrane insertion of the FYVE domain is modulated by pH. Proteins. 2009 Sep; 76(4):852-60. PMID: 19296456.
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    149. Champagne KS, Kutateladze TG. Structural insight into histone recognition by the ING PHD fingers. Curr Drug Targets. 2009 May; 10(5):432-41. PMID: 19442115.
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    150. Kutateladze TG. ING family of tumor suppressors. Curr Drug Targets. 2009 May; 10(5):384. PMID: 19442110.
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    151. Pe?a PV, Musselman CA, Kuo AJ, Gozani O, Kutateladze TG. NMR assignments and histone specificity of the ING2 PHD finger. Magn Reson Chem. 2009 Apr; 47(4):352-8. PMID: 19184981.
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    152. Saksouk N, Avvakumov N, Champagne KS, Hung T, Doyon Y, Cayrou C, Paquet E, Ullah M, Landry AJ, C?t? V, Yang XJ, Gozani O, Kutateladze TG, C?t? J. HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail. Mol Cell. 2009 Jan 30; 33(2):257-65. PMID: 19187766.
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    153. Hung T, Binda O, Champagne KS, Kuo AJ, Johnson K, Chang HY, Simon MD, Kutateladze TG, Gozani O. ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation. Mol Cell. 2009 Jan 30; 33(2):248-56. PMID: 19187765.
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    154. Champagne KS, Saksouk N, Pe?a PV, Johnson K, Ullah M, Yang XJ, C?t? J, Kutateladze TG. The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide. Proteins. 2008 Sep; 72(4):1371-6. PMID: 18623064.
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    155. He J, Kutateladze TG. Sequence-specific 1H, 13C, and 15N resonance assignments of GRP1 PH domain. Biomol NMR Assign. 2008 Dec; 2(2):97-9. PMID: 19636878.
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    156. He J, Haney RM, Vora M, Verkhusha VV, Stahelin RV, Kutateladze TG. Molecular mechanism of membrane targeting by the GRP1 PH domain. J Lipid Res. 2008 Aug; 49(8):1807-15. PMID: 18469301.
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    157. Pe?a PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, Kutateladze TG. Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biol. 2008 Jul 04; 380(2):303-12. PMID: 18533182.
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    158. Matthews AG, Kuo AJ, Ram?n-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 2007 Dec 13; 450(7172):1106-10. PMID: 18033247.
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    159. Hom RA, Vora M, Regner M, Subach OM, Cho W, Verkhusha VV, Stahelin RV, Kutateladze TG. pH-dependent binding of the Epsin ENTH domain and the AP180 ANTH domain to PI(4,5)P2-containing bilayers. J Mol Biol. 2007 Oct 19; 373(2):412-23. PMID: 17825837.
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    160. Kutateladze TG. Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes. Prog Lipid Res. 2007 Nov; 46(6):315-27. PMID: 17707914.
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    161. Huang W, Zhang H, Davrazou F, Kutateladze TG, Shi X, Gozani O, Prestwich GD. Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. J Am Chem Soc. 2007 May 23; 129(20):6498-506. PMID: 17469822.
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    162. Shi X, Kachirskaia I, Walter KL, Kuo JH, Lake A, Davrazou F, Chan SM, Martin DG, Fingerman IM, Briggs SD, Howe L, Utz PJ, Kutateladze TG, Lugovskoy AA, Bedford MT, Gozani O. Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. J Biol Chem. 2007 Jan 26; 282(4):2450-5. PMID: 17142463.
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    163. Lee SA, Kovacs J, Stahelin RV, Cheever ML, Overduin M, Setty TG, Burd CG, Cho W, Kutateladze TG. Molecular mechanism of membrane docking by the Vam7p PX domain. J Biol Chem. 2006 Dec 01; 281(48):37091-101. PMID: 16984909.
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    164. Cheever ML, Kutateladze TG, Overduin M. Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphate. Protein Sci. 2006 Aug; 15(8):1873-82. PMID: 16877709.
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    165. Gajewiak J, Xu Y, Lee SA, Kutateladze TG, Prestwich GD. Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate. Org Lett. 2006 Jun 22; 8(13):2811-3. PMID: 16774263.
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    166. Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Pe?a P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, C?t? J, Chua KF, Gozani O. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature. 2006 Jul 06; 442(7098):96-9. PMID: 16728974.
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    167. Pe?a PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O, Zhao R, Kutateladze TG. Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature. 2006 Jul 06; 442(7098):100-3. PMID: 16728977.
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    168. Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G. Structural insights into histone demethylation by JMJD2 family members. Cell. 2006 May 19; 125(4):691-702. PMID: 16677698.
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    169. Kutateladze TG. Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain. Biochim Biophys Acta. 2006 Aug; 1761(8):868-77. PMID: 16644267.
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    170. Tokonzaba E, Capelluto DG, Kutateladze TG, Overduin M. Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain. Chem Biol Drug Des. 2006 Mar; 67(3):230-7. PMID: 16611216.
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    171. Xu Y, Lee SA, Kutateladze TG, Sbrissa D, Shisheva A, Prestwich GD. Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate. J Am Chem Soc. 2006 Jan 25; 128(3):885-97. PMID: 16417379.
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    172. Brunecky R, Lee S, Rzepecki PW, Overduin M, Prestwich GD, Kutateladze AG, Kutateladze TG. Investigation of the binding geometry of a peripheral membrane protein. Biochemistry. 2005 Dec 13; 44(49):16064-71. PMID: 16331966.
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    173. Lee SA, Eyeson R, Cheever ML, Geng J, Verkhusha VV, Burd C, Overduin M, Kutateladze TG. Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13052-7. PMID: 16141328.
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    174. Zoetewey DL, Tripet BP, Kutateladze TG, Overduin MJ, Wood JM, Hodges RS. Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProP. J Mol Biol. 2003 Dec 12; 334(5):1063-76. PMID: 14643666.
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    175. Kutateladze TG, Capelluto DG, Ferguson CG, Cheever ML, Kutateladze AG, Prestwich GD, Overduin M. Multivalent mechanism of membrane insertion by the FYVE domain. J Biol Chem. 2004 Jan 23; 279(4):3050-7. PMID: 14578346.
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    176. Storey MK, Clay KL, Kutateladze T, Murphy RC, Overduin M, Voelker DR. Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures. J Biol Chem. 2001 Dec 21; 276(51):48539-48. PMID: 11602607.
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    177. Overduin M, Cheever ML, Kutateladze TG. Signaling with phosphoinositides: better than binary. Mol Interv. 2001 Aug; 1(3):150-9. PMID: 14993348.
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    178. Cheever ML, Sato TK, de Beer T, Kutateladze TG, Emr SD, Overduin M. Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol. 2001 Jul; 3(7):613-8. PMID: 11433291.
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    179. Kutateladze TG, Overduin M. Structural mechanism of endosome docking by the FYVE domain. Science. 2001 03 02; 291(5509):1793-6. PMID: 11230696.
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    180. Kutateladze TG, Overduin M. Sequence-specific 1H, 15N and 13C resonance assignments of the EEA1 FYVE domain. J Biomol NMR. 2000 May; 17(1):89-90. PMID: 10909872.
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    181. Schneider R, Travers A, Kutateladze T, Muskhelishvili G. A DNA architectural protein couples cellular physiology and DNA topology in Escherichia coli. Mol Microbiol. 1999 Dec; 34(5):953-64. PMID: 10594821.
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    182. Kutateladze TG, Ogburn KD, Watson WT, de Beer T, Emr SD, Burd CG, Overduin M. Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Mol Cell. 1999 Jun; 3(6):805-11. PMID: 10394369.
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    183. Thompson JE, Kutateladze TG, Schuster MC, Venegas FD, Messmore JM, Raines RT. Limits to Catalysis by Ribonuclease A. Bioorg Chem. 1995 Dec; 23(4):471-481. PMID: 21799547.
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