 Substantia Nigra
"Substantia Nigra" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.
| Descriptor ID |
D013378
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| MeSH Number(s) |
A08.186.211.132.659.413.656
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| Concept/Terms |
Substantia Nigra- Substantia Nigra
- Nigra, Substantia
- Nigras, Substantia
- Substantia Nigras
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Below are MeSH descriptors whose meaning is more general than "Substantia Nigra".
Below are MeSH descriptors whose meaning is more specific than "Substantia Nigra".
This graph shows the total number of publications written about "Substantia Nigra" by people in this website by year, and whether "Substantia Nigra" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2017 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 1 | 2 | | 2021 | 2 | 0 | 2 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Substantia Nigra" by people in Profiles.
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Barcomb K, Ford CP. Alterations in neurotransmitter co-release in Parkinson's disease. Exp Neurol. 2023 12; 370:114562.
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Bortz DM, Feistritzer CM, Power CC, Grace AA. Medial septum activation improves strategy switching once strategies are well-learned via bidirectional regulation of dopamine neuron population activity. Neuropsychopharmacology. 2022 11; 47(12):2090-2100.
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Zych SM, Ford CP. Divergent properties and independent regulation of striatal dopamine and GABA co-transmission. Cell Rep. 2022 05 17; 39(7):110823.
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Tekriwal A, Felsen G, Ojemann SG, Abosch A, Thompson JA. Motor context modulates substantia nigra pars reticulata spike activity in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 2022 04; 93(4):386-394.
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Gordi?n-V?lez WJ, Chouhan D, Espa?a RA, Chen HI, Burdick JA, Duda JE, Cullen DK. Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria. Brain Res Bull. 2021 10; 175:168-185.
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Cai Y, Nielsen BE, Boxer EE, Aoto J, Ford CP. Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments. Neuron. 2021 04 07; 109(7):1137-1149.e5.
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Bantle CM, French CT, Cummings JE, Sadasivan S, Tran K, Slayden RA, Smeyne RJ, Tjalkens RB. Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus. PLoS One. 2021; 16(1):e0245171.
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McGregor MM, McKinsey GL, Girasole AE, Bair-Marshall CJ, Rubenstein JLR, Nelson AB. Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons. Cell Rep. 2019 11 05; 29(6):1419-1428.e5.
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Bortz DM, Gazo KL, Grace AA. The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons. Neuropsychopharmacology. 2019 12; 44(13):2186-2194.
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Kirkley KS, Popichak KA, Hammond SL, Davies C, Hunt L, Tjalkens RB. Genetic suppression of IKK2/NF-?B in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease. Neurobiol Dis. 2019 07; 127:193-209.
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