 Substantia Nigra
"Substantia Nigra" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.
| Descriptor ID |
D013378
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| MeSH Number(s) |
A08.186.211.132.659.413.656
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| Concept/Terms |
Substantia Nigra- Substantia Nigra
- Nigra, Substantia
- Nigras, Substantia
- Substantia Nigras
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Below are MeSH descriptors whose meaning is more general than "Substantia Nigra".
Below are MeSH descriptors whose meaning is more specific than "Substantia Nigra".
This graph shows the total number of publications written about "Substantia Nigra" by people in this website by year, and whether "Substantia Nigra" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 3 | 0 | 3 | | 2002 | 1 | 1 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 2 | 1 | 3 | | 2008 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 1 | 2 | 3 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2017 | 3 | 0 | 3 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 1 | 2 | | 2021 | 2 | 0 | 2 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 1 | 1 | | 2024 | 1 | 3 | 4 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Substantia Nigra" by people in Profiles.
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Hohorst AA, Tanner MK, Han R, Korth KM, Westerman JD, Mendoza CS, Dryden MQ, Alvarez LA, Abdul RA, Loetz EC, Oleson EB, Greenwood BN. High ovarian hormones present during fear extinction reduce fear relapse through a nigrostriatal dopamine pathway. Biol Sex Differ. 2025 Jun 01; 16(1):38.
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Gordi?n-V?lez WJ, Browne KD, Galarraga JH, Chouhan D, Duda JE, Espa?a RA, Chen HI, Burdick JA, Cullen DK. Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway. Adv Healthc Mater. 2025 Jan; 14(2):e2402997.
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Latham AS, Rocha SM, McDermott CP, Reigan P, Slayden RA, Tjalkens RB. Neuroprotective efficacy of the glucocorticoid receptor modulator PT150 in the rotenone mouse model of Parkinson's disease. Neurotoxicology. 2024 Jul; 103:320-334.
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Tanner MK, Hohorst AA, Westerman JD, Mendoza CS, Han R, Moya NA, Jaime J, Alvarez LM, Dryden MQ, Balolia A, Abdul RA, Loetz EC, Greenwood BN. Pharmacological manipulations of the dorsomedial and dorsolateral striatum during fear extinction reveal opposing roles in fear renewal. Neurobiol Learn Mem. 2024 07; 212:107937.
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Bayram E, Coughlin DG, Rajmohan R, Litvan I. Sex differences for clinical correlates of substantia nigra neuron loss in people with Lewy body pathology. Biol Sex Differ. 2024 Jan 19; 15(1):8.
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Barcomb K, Ford CP. Alterations in neurotransmitter co-release in Parkinson's disease. Exp Neurol. 2023 12; 370:114562.
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Bortz DM, Feistritzer CM, Power CC, Grace AA. Medial septum activation improves strategy switching once strategies are well-learned via bidirectional regulation of dopamine neuron population activity. Neuropsychopharmacology. 2022 11; 47(12):2090-2100.
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Zych SM, Ford CP. Divergent properties and independent regulation of striatal dopamine and GABA co-transmission. Cell Rep. 2022 05 17; 39(7):110823.
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Tekriwal A, Felsen G, Ojemann SG, Abosch A, Thompson JA. Motor context modulates substantia nigra pars reticulata spike activity in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 2022 04; 93(4):386-394.
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Gordi?n-V?lez WJ, Chouhan D, Espa?a RA, Chen HI, Burdick JA, Duda JE, Cullen DK. Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria. Brain Res Bull. 2021 10; 175:168-185.
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