 Exoribonucleases
"Exoribonucleases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of enzymes that catalyze the exonucleolytic cleavage of RNA. It includes EC 3.1.13.-, EC 3.1.14.-, EC 3.1.15.-, and EC 3.1.16.-. EC 3.1.-
| Descriptor ID |
D005095
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| MeSH Number(s) |
D08.811.277.352.365.300 D08.811.277.352.700.375
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Exoribonucleases".
Below are MeSH descriptors whose meaning is more specific than "Exoribonucleases".
This graph shows the total number of publications written about "Exoribonucleases" by people in this website by year, and whether "Exoribonucleases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 2 | 2 | | 2010 | 0 | 1 | 1 | | 2012 | 3 | 0 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 3 | 0 | 3 | | 2016 | 3 | 0 | 3 | | 2018 | 3 | 0 | 3 | | 2019 | 1 | 2 | 3 | | 2020 | 3 | 1 | 4 | | 2021 | 2 | 1 | 3 | | 2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "Exoribonucleases" by people in Profiles.
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Huynh TN, Parker R. The PARN, TOE1, and USB1 RNA deadenylases and their roles in non-coding RNA regulation. J Biol Chem. 2023 09; 299(9):105139.
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Huynh TN, Shukla S, Reigan P, Parker R. Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening. Sci Rep. 2023 03 31; 13(1):5244.
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Canal B, McClure AW, Curran JF, Wu M, Ulferts R, Weissmann F, Zeng J, Bertolin AP, Milligan JC, Basu S, Drury LS, Deegan TD, Fujisawa R, Roberts EL, Basier C, Labib K, Beale R, Howell M, Diffley JFX. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease. Biochem J. 2021 07 16; 478(13):2445-2464.
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Basu S, Mak T, Ulferts R, Wu M, Deegan T, Fujisawa R, Tan KW, Lim CT, Basier C, Canal B, Curran JF, Drury LS, McClure AW, Roberts EL, Weissmann F, Zeisner TU, Beale R, Cowling VH, Howell M, Labib K, Diffley JFX. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. Biochem J. 2021 07 16; 478(13):2481-2497.
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Akiyama BM, Graham ME, O Donoghue Z, Beckham JD, Kieft JS. Three-dimensional structure of a flavivirus dumbbell RNA reveals molecular details of an RNA regulator of replication. Nucleic Acids Res. 2021 07 09; 49(12):7122-7138.
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Sparks H, Monogue B, Akiyama B, Kieft J, Beckham JD. Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication. Viruses. 2020 10 18; 12(10).
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Jones RA, Steckelberg AL, Vicens Q, Szucs MJ, Akiyama BM, Kieft JS. Different tertiary interactions create the same important 3D features in a distinct flavivirus xrRNA. RNA. 2021 01; 27(1):54-65.
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Szucs MJ, Nichols PJ, Jones RA, Vicens Q, Kieft JS. A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of Flaviviridae. mBio. 2020 09 29; 11(5).
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Steckelberg AL, Vicens Q, Costantino DA, Nix JC, Kieft JS. The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold. RNA. 2020 12; 26(12):1767-1776.
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Shukla S, Jeong HC, Sturgeon CM, Parker R, Batista LFZ. Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita. Blood Adv. 2020 06 23; 4(12):2717-2722.
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