 Caspases
"Caspases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
| Descriptor ID |
D020169
|
| MeSH Number(s) |
D08.811.277.656.262.500.126 D08.811.277.656.300.200.126 D12.644.360.075.405 D12.776.476.075.405
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Caspases".
Below are MeSH descriptors whose meaning is more specific than "Caspases".
This graph shows the total number of publications written about "Caspases" by people in this website by year, and whether "Caspases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 5 | 6 | | 2000 | 2 | 7 | 9 | | 2001 | 1 | 3 | 4 | | 2002 | 2 | 2 | 4 | | 2003 | 5 | 13 | 18 | | 2004 | 5 | 13 | 18 | | 2005 | 4 | 21 | 25 | | 2006 | 5 | 13 | 18 | | 2007 | 2 | 6 | 8 | | 2008 | 5 | 2 | 7 | | 2009 | 3 | 7 | 10 | | 2010 | 1 | 2 | 3 | | 2011 | 0 | 9 | 9 | | 2012 | 0 | 4 | 4 | | 2013 | 1 | 6 | 7 | | 2014 | 1 | 4 | 5 | | 2015 | 1 | 6 | 7 | | 2016 | 1 | 0 | 1 | | 2017 | 3 | 3 | 6 | | 2018 | 2 | 1 | 3 | | 2019 | 0 | 1 | 1 | | 2020 | 1 | 1 | 2 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 1 | 2 | | 2024 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Caspases" by people in Profiles.
-
Yadav M, Kandhari K, Mathan SV, Ali M, Singh RP. Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC. Mol Carcinog. 2024 Sep; 63(9):1697-1711.
-
Muro I, Qualman AC, Kovacs EJ, Idrovo JP. Burn-Induced Apoptosis in the Livers of Aged Mice Is Associated With Caspase Cleavage of Bcl-xL. J Surg Res. 2023 10; 290:147-155.
-
Keestra-Gounder AM, Nagao PE. Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation. Front Immunol. 2023; 14:1075834.
-
The E, de Graaf DM, Zhai Y, Yao Q, Ao L, Fullerton DA, Dinarello CA, Meng X. Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2202577119.
-
Su TT. Non-apoptotic roles of apoptotic proteases: new tricks for an old dog. Open Biol. 2020 08; 10(8):200130.
-
Weaver BP, Weaver YM, Omi S, Yuan W, Ewbank JJ, Han M. Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development. Dev Cell. 2020 05 04; 53(3):358-369.e6.
-
Das D, Fayazzadeh E, Li X, Koirala N, Wadera A, Lang M, Zernic M, Panick C, Nesbitt P, McLennan G. Quiescent hepatic stellate cells induce toxicity and sensitivity to doxorubicin in cancer cells through a caspase-independent cell death pathway: Central role of apoptosis-inducing factor. J Cell Physiol. 2020 09; 235(9):6167-6182.
-
Nowak KL, Edelstein CL. Apoptosis and autophagy in polycystic kidney disease (PKD). Cell Signal. 2020 04; 68:109518.
-
Su TT. Cellular plasticity, caspases and autophagy; that which does not kill us, well, makes us different. Open Biol. 2018 11 28; 8(11).
-
Verghese S, Su TT. Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila. PLoS Genet. 2018 11; 14(11):e1007659.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|