 Alkylation
"Alkylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
| Descriptor ID |
D000478
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| MeSH Number(s) |
G02.111.035 G02.607.094 G03.059
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Alkylation".
Below are MeSH descriptors whose meaning is more specific than "Alkylation".
This graph shows the total number of publications written about "Alkylation" by people in this website by year, and whether "Alkylation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1997 | 0 | 3 | 3 | | 1999 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Alkylation" by people in Profiles.
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Ghazvini S, Alonso R, Alhakamy N, Dhar P. pH-Induced Changes in the Surface Viscosity of Unsaturated Phospholipids Monitored Using Active Interfacial Microrheology. Langmuir. 2018 01 23; 34(3):1159-1170.
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Thurlow SE, Kilgour DP, Campopiano DJ, Mackay CL, Langridge-Smith PR, Clarke DJ, Campbell CJ. Determination of Protein Thiol Reduction Potential by Isotope Labeling and Intact Mass Measurement. Anal Chem. 2016 Mar 01; 88(5):2727-33.
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Zambrano CA, Salamander RM, Collins AC, Grady SR, Marks MJ. Regulation of the distribution and function of [(125)I]epibatidine binding sites by chronic nicotine in mouse embryonic neuronal cultures. J Pharmacol Exp Ther. 2012 Aug; 342(2):245-54.
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Roede JR, Go YM, Jones DP. Redox equivalents and mitochondrial bioenergetics. Methods Mol Biol. 2012; 810:249-80.
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Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, Ross D. Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems. Biochemistry. 2011 Aug 09; 50(31):6678-88.
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Kaar JL, Basse N, Joerger AC, Stephens E, Rutherford TJ, Fersht AR. Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding. Protein Sci. 2010 Dec; 19(12):2267-78.
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Lambert JR, Eddy VJ, Young CD, Persons KS, Sarkar S, Kelly JA, Genova E, Lucia MS, Faller DV, Ray R. A vitamin D receptor-alkylating derivative of 1a,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth. Cancer Prev Res (Phila). 2010 Dec; 3(12):1596-607.
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Shearn CT, Fritz KS, Meier BW, Kirichenko OV, Thompson JA. Carbonyl reductase inactivation may contribute to mouse lung tumor promotion by electrophilic metabolites of butylated hydroxytoluene: protein alkylation in vivo and in vitro. Chem Res Toxicol. 2008 Aug; 21(8):1631-41.
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Ahn NG, Resing KA. Cell biology. Lessons in rational drug design for protein kinases. Science. 2005 May 27; 308(5726):1266-7.
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Arnold MA, Dur?n SG, Gin DY. Diastereoselective [4+2] annulation of vinyl carbodiimides with N-alkyl imines. Asymmetric synthetic access to the batzelladine alkaloids. J Am Chem Soc. 2005 May 18; 127(19):6924-5.
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