 Hypoxanthine Phosphoribosyltransferase
"Hypoxanthine Phosphoribosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
| Descriptor ID |
D007041
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| MeSH Number(s) |
D08.811.913.400.725.450
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| Concept/Terms |
Hypoxanthine Phosphoribosyltransferase- Hypoxanthine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine
- IMP Pyrophosphorylase
- Pyrophosphorylase, IMP
- HGPRT
- HPRT
- HPRTase
- Hypoxanthine-Guanine Phosphoribosyltransferase
- Hypoxanthine Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine-Guanine
- Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Guanine
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Below are MeSH descriptors whose meaning is more general than "Hypoxanthine Phosphoribosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Hypoxanthine Phosphoribosyltransferase".
This graph shows the total number of publications written about "Hypoxanthine Phosphoribosyltransferase" by people in this website by year, and whether "Hypoxanthine Phosphoribosyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2013 | 2 | 0 | 2 |
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Below are the most recent publications written about "Hypoxanthine Phosphoribosyltransferase" by people in Profiles.
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Champagne DP, Shockett PE. Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing. Mutat Res. 2014 Mar; 761:34-48.
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Choudhary R, Baturin D, Fosmire S, Freed B, Porter CC. Knockdown of HPRT for selection of genetically modified human hematopoietic progenitor cells. PLoS One. 2013; 8(3):e59594.
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Vasiliou V, Sandoval M, Backos DS, Jackson BC, Chen Y, Reigan P, Lanaspa MA, Johnson RJ, Koppaka V, Thompson DC. ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1. Chem Biol Interact. 2013 Feb 25; 202(1-3):22-31.
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Li M, Scott DE, Shandas R, Stenmark KR, Tan W. High pulsatility flow induces adhesion molecule and cytokine mRNA expression in distal pulmonary artery endothelial cells. Ann Biomed Eng. 2009 Jun; 37(6):1082-92.
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Porter CC, DeGregori J. Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection. Blood. 2008 Dec 01; 112(12):4466-74.
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Chaudhary K, Darling JA, Fohl LM, Sullivan WJ, Donald RG, Pfefferkorn ER, Ullman B, Roos DS. Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii. J Biol Chem. 2004 Jul 23; 279(30):31221-7.
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Ruttenber AJ, Harrison LT, Baron A, McClure D, Glanz J, Quillin R, O'Neill JP, Sullivan L, Campbell J, Nicklas JA. hprt mutant frequencies, nonpulmonary malignancies, and domestic radon exposure: "postmortem" analysis of an interesting hypothesis. Environ Mol Mutagen. 2001; 37(1):7-16.
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Falta MT, Atkinson MA, Allegretta M, Vacek PM, Albertini RJ. Azathioprine associated T-cell mutations in insulin-dependent diabetes mellitus. Scand J Immunol. 2000 Jun; 51(6):626-33.
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Falta MT, Magin GK, Allegretta M, Steinman L, Atkinson MA, Brostoff SW, Albertini RJ. Selection of hprt mutant T cells as surrogates for dividing cells reveals a restricted T cell receptor BV repertoire in insulin-dependent diabetes mellitus. Clin Immunol. 1999 Mar; 90(3):340-51.
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Roos DS, Sullivan WJ, Striepen B, Bohne W, Donald RG. Tagging genes and trapping promoters in Toxoplasma gondii by insertional mutagenesis. Methods. 1997 Oct; 13(2):112-22.
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