 alpha-Synuclein
"alpha-Synuclein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.
| Descriptor ID |
D051844
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| MeSH Number(s) |
D12.776.631.860.500 D12.776.637.500
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| Concept/Terms |
alpha-Synuclein- alpha-Synuclein
- alpha Synuclein
- Non-AB Component of AD Amyloid Protein
- Non AB Component of AD Amyloid Protein
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Below are MeSH descriptors whose meaning is more general than "alpha-Synuclein".
Below are MeSH descriptors whose meaning is more specific than "alpha-Synuclein".
This graph shows the total number of publications written about "alpha-Synuclein" by people in this website by year, and whether "alpha-Synuclein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 | | 2003 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 2 | 1 | 3 | | 2019 | 0 | 1 | 1 | | 2022 | 1 | 0 | 1 | | 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "alpha-Synuclein" by people in Profiles.
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Amo-Aparicio J, Daly J, H?jen JF, Dinarello CA. Pharmacologic inhibition of NLRP3 reduces the levels of a-synuclein and protects dopaminergic neurons in a model of Parkinson's disease. J Neuroinflammation. 2023 Jun 22; 20(1):147.
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Heiden DL, Monogue B, Ali MDH, Beckham JD. A functional role for alpha-synuclein in neuroimmune responses. J Neuroimmunol. 2023 03 15; 376:578047.
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Gibbons C, Wang N, Rajan S, Kern D, Palma JA, Kaufmann H, Freeman R. Cutaneous a-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease. Neurology. 2023 04 11; 100(15):e1529-e1539.
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Monogue B, Chen Y, Sparks H, Behbehani R, Chai A, Rajic AJ, Massey A, Kleinschmidt-Demasters BK, Vermeren M, Kunath T, Beckham JD. Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue. Brain. 2022 10 21; 145(10):3622-3636.
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Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, Angelova PR, Esteras N, Vinokurov AY, Morris K, Jeacock K, Tosatto L, Little D, Gissen P, Clarke DJ, Kunath T, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S. Pathological structural conversion of a-synuclein at the mitochondria induces neuronal toxicity. Nat Neurosci. 2022 09; 25(9):1134-1148.
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Ahmed J, Fitch TC, Donnelly CM, Joseph JA, Ball TD, Bassil MM, Son A, Zhang C, Ledreux A, Horowitz S, Qin Y, Paredes D, Kumar S. Foldamers reveal and validate therapeutic targets associated with toxic a-synuclein self-assembly. Nat Commun. 2022 04 27; 13(1):2273.
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Bantle CM, Rocha SM, French CT, Phillips AT, Tran K, Olson KE, Bass TA, Aboellail T, Smeyne RJ, Tjalkens RB. Astrocyte inflammatory signaling mediates a-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis. Exp Neurol. 2021 12; 346:113845.
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Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, Pavlov EV, Klenerman D, Abramov AY, Gandhi S. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell Death Differ. 2020 10; 27(10):2781-2796.
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Guerrero-G?mez D, Mora-Lorca JA, S?enz-Narciso B, Naranjo-Galindo FJ, Mu?oz-Lobato F, Parrado-Fern?ndez C, Goikolea J, Cedazo-Minguez ?, Link CD, Neri C, Sequedo MD, V?zquez-Manrique RP, Fern?ndez-Su?rez E, Goder V, Pan? R, Cabiscol E, Askjaer P, Cabello J, Miranda-Vizuete A. Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation. Cell Death Differ. 2019 09; 26(9):1545-1565.
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Hughes CD, Choi ML, Ryten M, Hopkins L, Drews A, Bot?a JA, Iljina M, Rodrigues M, Gagliano SA, Gandhi S, Bryant C, Klenerman D. Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis. Acta Neuropathol. 2019 01; 137(1):103-120.
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