 Glutamate-Cysteine Ligase
"Glutamate-Cysteine Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
| Descriptor ID |
D005721
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| MeSH Number(s) |
D08.811.464.259.850.400
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| Concept/Terms |
Glutamate-Cysteine Ligase- Glutamate-Cysteine Ligase
- Glutamate Cysteine Ligase
- Ligase, Glutamate-Cysteine
- gamma-Glutamyl-Cysteine Synthetase
- Synthetase, gamma-Glutamyl-Cysteine
- gamma Glutamyl Cysteine Synthetase
- Glutamylcysteine Synthetase
- Synthetase, Glutamylcysteine
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Below are MeSH descriptors whose meaning is more general than "Glutamate-Cysteine Ligase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate-Cysteine Ligase".
This graph shows the total number of publications written about "Glutamate-Cysteine Ligase" by people in this website by year, and whether "Glutamate-Cysteine Ligase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2006 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2019 | 0 | 2 | 2 | | 2022 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutamate-Cysteine Ligase" by people in Profiles.
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Sri Hari A, Banerji R, Liang LP, Fulton RE, Huynh CQ, Fabisiak T, McElroy PB, Roede JR, Patel M. Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability. Redox Biol. 2023 11; 67:102895.
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Thompson B, Davidson EA, Chen Y, Orlicky DJ, Thompson DC, Vasiliou V. Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues. Chem Biol Interact. 2022 Mar 01; 355:109804.
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Chen Y, Manna SK, Golla S, Krausz KW, Cai Y, Garcia-Milian R, Chakraborty T, Chakraborty J, Chatterjee R, Thompson DC, Gonzalez FJ, Vasiliou V. Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosis. Free Radic Biol Med. 2019 11 01; 143:127-139.
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Chen Y, Golla S, Garcia-Milian R, Thompson DC, Gonzalez FJ, Vasiliou V. Hepatic metabolic adaptation in a murine model of glutathione deficiency. Chem Biol Interact. 2019 Apr 25; 303:1-6.
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McElroy PB, Sri Hari A, Day BJ, Patel M. Post-translational Activation of Glutamate Cysteine Ligase with Dimercaprol: A NOVEL MECHANISM OF INHIBITING NEUROINFLAMMATION IN VITRO. J Biol Chem. 2017 03 31; 292(13):5532-5545.
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Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT. Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. J Biol Chem. 2013 Nov 22; 288(47):33542-33558.
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Backos DS, Fritz KS, McArthur DG, Kepa JK, Donson AM, Petersen DR, Foreman NK, Franklin CC, Reigan P. Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma. Neurochem Res. 2013 Sep; 38(9):1838-49.
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Kachadourian R, Day BJ, Pugazhenti S, Franklin CC, Genoux-Bastide E, Mahaffey G, Gauthier C, Di Pietro A, Boumendjel A. A synthetic chalcone as a potent inducer of glutathione biosynthesis. J Med Chem. 2012 Feb 09; 55(3):1382-8.
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Backos DS, Franklin CC, Reigan P. The role of glutathione in brain tumor drug resistance. Biochem Pharmacol. 2012 Apr 15; 83(8):1005-12.
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Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC. Posttranslational modification and regulation of glutamate-cysteine ligase by the a,?-unsaturated aldehyde 4-hydroxy-2-nonenal. Free Radic Biol Med. 2011 Jan 01; 50(1):14-26.
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