 NADPH-Ferrihemoprotein Reductase
"NADPH-Ferrihemoprotein Reductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.
| Descriptor ID |
D009251
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| MeSH Number(s) |
D08.811.682.608.191.500
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| Concept/Terms |
NADPH-Ferrihemoprotein Reductase- NADPH-Ferrihemoprotein Reductase
- NADPH Ferrihemoprotein Reductase
- Reductase, NADPH-Ferrihemoprotein
- Cytochrome P-450 Reductase
- Cytochrome P 450 Reductase
- Reductase, Cytochrome P-450
- Cytochrome P450 Reductase
- P450 Reductase, Cytochrome
- Reductase, Cytochrome P450
- Ferrihemoprotein P-450 Reductase
- Ferrihemoprotein P 450 Reductase
- Reductase, Ferrihemoprotein P-450
- Ferrihemoprotein P450 Reductase
- Reductase, Ferrihemoprotein P450
- NADPH-P450 Reductase
- NADPH P450 Reductase
- Reductase, NADPH-P450
- NADPH Cytochrome P-450 Oxidoreductase
- NADPH Cytochrome P 450 Oxidoreductase
- NADPH Cytochrome P-450 Reductase
- NADPH Cytochrome P 450 Reductase
- NADPH Cytochrome P450 Oxidoreductase
- NADPH Cytochrome P450 Reductase
- NADPH-Cytochrome P450 Reductase
- P450 Reductase, NADPH-Cytochrome
- Reductase, NADPH-Cytochrome P450
- Cytochrome P-450 Oxidase
- Cytochrome P 450 Oxidase
- Oxidase, Cytochrome P-450
- P-450 Oxidase, Cytochrome
- NADPH Cytochrome c Reductase
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Below are MeSH descriptors whose meaning is more general than "NADPH-Ferrihemoprotein Reductase".
Below are MeSH descriptors whose meaning is more specific than "NADPH-Ferrihemoprotein Reductase".
This graph shows the total number of publications written about "NADPH-Ferrihemoprotein Reductase" by people in this website by year, and whether "NADPH-Ferrihemoprotein Reductase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2016 | 0 | 2 | 2 |
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Below are the most recent publications written about "NADPH-Ferrihemoprotein Reductase" by people in Profiles.
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Tanner JA, Prasad B, Claw KG, Stapleton P, Chaudhry A, Schuetz EG, Thummel KE, Tyndale RF. Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors. J Pharmacol Exp Ther. 2017 Jan; 360(1):129-139.
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Tyagi V, Alwaseem H, O'Dwyer KM, Ponder J, Li QY, Jordan CT, Fasan R. Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs. Bioorg Med Chem. 2016 09 01; 24(17):3876-3886.
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Kandel SE, Lampe JN. Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicity. Chem Res Toxicol. 2014 Sep 15; 27(9):1474-86.
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Yan C, Kepa JK, Siegel D, Stratford IJ, Ross D. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). Mol Pharmacol. 2008 Dec; 74(6):1657-65.
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Guo W, Reigan P, Siegel D, Ross D. Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. Drug Metab Dispos. 2008 Oct; 36(10):2050-7.
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Wen B, Lampe JN, Roberts AG, Atkins WM, David Rodrigues A, Nelson SD. Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase. Arch Biochem Biophys. 2006 Oct 01; 454(1):42-54.
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Hidestrand M, Shankar K, Ronis MJ, Badger TM. Effects of light and dark beer on hepatic cytochrome P-450 expression in male rats receiving alcoholic beverages as part of total enteral nutrition. Alcohol Clin Exp Res. 2005 May; 29(5):888-95.
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Day BJ, Kariya C. A novel class of cytochrome P450 reductase redox cyclers: cationic manganoporphyrins. Toxicol Sci. 2005 May; 85(1):713-9.
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Kachadourian R, Flaherty MM, Crumbliss AL, Patel M, Day BJ. Synthesis and in vitro antioxidant properties of manganese(III) beta-octabromo-meso-tetrakis(4-carboxyphenyl)porphyrin. J Inorg Biochem. 2003 Jul 01; 95(4):240-8.
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Pink JJ, Planchon SM, Tagliarino C, Varnes ME, Siegel D, Boothman DA. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J Biol Chem. 2000 Feb 25; 275(8):5416-24.
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