 Retinaldehyde
"Retinaldehyde" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration.
| Descriptor ID |
D012172
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| MeSH Number(s) |
D02.047.850 D02.455.326.271.665.202.495.690 D02.455.426.392.368.367.379.249.700.690 D02.455.849.131.495.690 D23.767.261.700.690
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| Concept/Terms |
Retinaldehyde- Retinaldehyde
- Vitamin A Aldehyde
- Aldehyde, Vitamin A
- Retinene
- Axerophthal
- Retinal
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Below are MeSH descriptors whose meaning is more general than "Retinaldehyde".
Below are MeSH descriptors whose meaning is more specific than "Retinaldehyde".
This graph shows the total number of publications written about "Retinaldehyde" by people in this website by year, and whether "Retinaldehyde" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Retinaldehyde" by people in Profiles.
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Singh S, Arcaroli J, Thompson DC, Messersmith W, Vasiliou V. Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers. Adv Exp Med Biol. 2015; 815:281-94.
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Jackson BC, Reigan P, Miller B, Thompson DC, Vasiliou V. Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde--in vitro studies and computational modeling. Pharm Res. 2015 May; 32(5):1648-62.
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Ruiz FX, Moro A, Gallego O, Ard?vol A, Rovira C, Petrash JM, Par?s X, Farr?s J. Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde. Chem Biol Interact. 2011 May 30; 191(1-3):199-205.
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Paik J, Blaner WS, Swisshelm K. Cis-retinol dehydrogenase: 9-cis-retinol metabolism and its effect on proliferation of human MCF7 breast cancer cells. Exp Cell Res. 2005 Feb 01; 303(1):183-96.
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Chen C, Tsina E, Cornwall MC, Crouch RK, Vijayaraghavan S, Koutalos Y. Reduction of all-trans retinal to all-trans retinol in the outer segments of frog and mouse rod photoreceptors. Biophys J. 2005 Mar; 88(3):2278-87.
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Han M, DeDecker BS, Smith SO. Localization of the retinal protonated Schiff base counterion in rhodopsin. Biophys J. 1993 Aug; 65(2):899-906.
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