 Ribosomal Protein S6 Kinases, 90-kDa
"Ribosomal Protein S6 Kinases, 90-kDa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
| Descriptor ID |
D038744
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| MeSH Number(s) |
D08.811.913.696.620.682.700.862.500 D12.644.360.600.500 D12.776.476.600.500
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| Concept/Terms |
Ribosomal Protein S6 Kinases, 90-kDa- Ribosomal Protein S6 Kinases, 90-kDa
- Ribosomal Protein S6 Kinases, 90 kDa
- p90(rsk)
- MAP-Kinase-Activated Protein Kinase 1
- MAP Kinase Activated Protein Kinase 1
- MAPKAP Kinase-1
- MAPKAP Kinase 1
- MAP-Kinase-Activated Kinase 1
- MAP Kinase Activated Kinase 1
- Ribosomal Protein S6 Kinase, 90-kDa
- Ribosomal Protein S6 Kinase, 90 kDa
- p90 Ribosomal S6 Kinase
- MAPKAP-K1
- pp90(rsk)
- MAPKAPK1
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Below are MeSH descriptors whose meaning is more general than "Ribosomal Protein S6 Kinases, 90-kDa".
Below are MeSH descriptors whose meaning is more specific than "Ribosomal Protein S6 Kinases, 90-kDa".
This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in this website by year, and whether "Ribosomal Protein S6 Kinases, 90-kDa" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2003 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2014 | 0 | 2 | 2 | | 2015 | 0 | 2 | 2 | | 2017 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in Profiles.
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Casalvieri KA, Matheson CJ, Warfield BM, Backos DS, Reigan P. N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors. Bioorg Med Chem. 2021 07 01; 41:116220.
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Casalvieri KA, Matheson CJ, Backos DS, Reigan P. Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study. Bioorg Med Chem. 2020 03 01; 28(5):115303.
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Ohm AM, Affandi T, Reyland ME. EGF receptor and PKCd kinase activate DNA damage-induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases. J Biol Chem. 2019 03 22; 294(12):4488-4497.
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Casalvieri KA, Matheson CJ, Backos DS, Reigan P. Selective Targeting of RSK Isoforms in Cancer. Trends Cancer. 2017 04; 3(4):302-312.
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Martinez EC, Passariello CL, Li J, Matheson CJ, Dodge-Kafka K, Reigan P, Kapiloff MS. RSK3: A regulator of pathological cardiac remodeling. IUBMB Life. 2015 May; 67(5):331-7.
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Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. J Biol Chem. 2015 Apr 10; 290(15):9363-76.
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Kroczynska B, Mehrotra S, Majchrzak-Kita B, Arslan AD, Altman JK, Stein BL, McMahon B, Kozlowski P, Kahle PJ, Eklund EA, Fish EN, Platanias LC. Regulatory effects of SKAR in interferon a signaling and its role in the generation of type I IFN responses. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):11377-82.
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Williamson DL, Li Z, Tuder RM, Feinstein E, Kimball SR, Dungan CM. Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency. J Appl Physiol (1985). 2014 Aug 01; 117(3):246-56.
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Adochio R, Leitner JW, Hedlund R, Draznin B. Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of phosphatidylinositol 3-kinase and S6K1 kinase. Endocrinology. 2009 Mar; 150(3):1165-73.
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Zhang HM, Li L, Papadopoulou N, Hodgson G, Evans E, Galbraith M, Dear M, Vougier S, Saxton J, Shaw PE. Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1. Nucleic Acids Res. 2008 May; 36(8):2594-607.
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