 CDC2 Protein Kinase
"CDC2 Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.
| Descriptor ID |
D016203
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| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.500.250 D08.811.913.696.620.682.700.646.500.984.500 D12.644.360.250.067.249 D12.644.360.250.580.500 D12.776.167.200.067.249 D12.776.167.200.580.500 D12.776.476.250.067.249 D12.776.476.250.580.500 D12.776.744.360
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| Concept/Terms |
CDC2 Protein Kinase- CDC2 Protein Kinase
- Protein Kinase, CDC2
- Cdk1 Protein Kinase
- Protein Kinase, Cdk1
- cdk1 Kinase
- cdc2+ Protein
- Cyclin-Dependent Kinase 1
- Cyclin Dependent Kinase 1
p34cdc2 Protein- p34cdc2 Protein
- Protein p34cdc2
- p34cdc2, Protein
- Histone Kinase p34(cdc2)
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Below are MeSH descriptors whose meaning is more general than "CDC2 Protein Kinase".
Below are MeSH descriptors whose meaning is more specific than "CDC2 Protein Kinase".
This graph shows the total number of publications written about "CDC2 Protein Kinase" by people in this website by year, and whether "CDC2 Protein Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2004 | 2 | 1 | 3 | | 2005 | 1 | 3 | 4 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2014 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "CDC2 Protein Kinase" by people in Profiles.
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Ravindran Menon D, Luo Y, Arcaroli JJ, Liu S, KrishnanKutty LN, Osborne DG, Li Y, Samson JM, Bagby S, Tan AC, Robinson WA, Messersmith WA, Fujita M. CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma. Cancer Res. 2018 12 01; 78(23):6561-6574.
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Matheson CJ, Casalvieri KA, Backos DS, Reigan P. Development of Potent Pyrazolopyrimidinone-Based WEE1 Inhibitors with Limited Single-Agent Cytotoxicity for Cancer Therapy. ChemMedChem. 2018 08 20; 13(16):1681-1694.
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Garcia TB, Fosmire SP, Porter CC. Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine. Leuk Res. 2018 01; 64:30-33.
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Brose L, Crest J, Tao L, Sullivan W. Polo kinase mediates the phosphorylation and cellular localization of Nuf/FIP3, a Rab11 effector. Mol Biol Cell. 2017 Jun 01; 28(11):1435-1443.
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Avena JS, Burns S, Yu Z, Ebmeier CC, Old WM, Jaspersen SL, Winey M. Licensing of yeast centrosome duplication requires phosphoregulation of sfi1. PLoS Genet. 2014 Oct; 10(10):e1004666.
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Brumbaugh J, Russell JD, Yu P, Westphall MS, Coon JJ, Thomson JA. NANOG is multiply phosphorylated and directly modified by ERK2 and CDK1 in vitro. Stem Cell Reports. 2014 Jan 14; 2(1):18-25.
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Box NF, Vukmer TO, Terzian T. Targeting p53 in melanoma. Pigment Cell Melanoma Res. 2014 Jan; 27(1):8-10.
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Nazarova E, O'Toole E, Kaitna S, Francois P, Winey M, Vogel J. Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly. Mol Biol Cell. 2013 Oct; 24(20):3238-50.
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Peng A, Yamamoto TM, Goldberg ML, Maller JL. A novel role for greatwall kinase in recovery from DNA damage. Cell Cycle. 2010 Nov 01; 9(21):4364-9.
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Royou A, McCusker D, Kellogg DR, Sullivan W. Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation. J Cell Biol. 2008 Oct 06; 183(1):63-75.
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