Quantitative Structure-Activity Relationship
"Quantitative Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.
Descriptor ID |
D021281
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MeSH Number(s) |
G02.111.830.500 G07.690.773.997.500
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Concept/Terms |
Quantitative Structure-Activity Relationship- Quantitative Structure-Activity Relationship
- Quantitative Structure Activity Relationship
- Quantitative Structure-Activity Relationships
- Relationship, Quantitative Structure-Activity
- Relationships, Quantitative Structure-Activity
- Structure-Activity Relationship, Quantitative
- Structure-Activity Relationships, Quantitative
- Structure Activity Relationship, Quantitative
- QSAR
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Below are MeSH descriptors whose meaning is more general than "Quantitative Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Quantitative Structure-Activity Relationship".
This graph shows the total number of publications written about "Quantitative Structure-Activity Relationship" by people in this website by year, and whether "Quantitative Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 1 | 1 | 2004 | 1 | 0 | 1 | 2005 | 2 | 0 | 2 | 2008 | 1 | 0 | 1 | 2011 | 0 | 2 | 2 | 2012 | 0 | 1 | 1 | 2015 | 2 | 0 | 2 |
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Below are the most recent publications written about "Quantitative Structure-Activity Relationship" by people in Profiles.
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Xiong W, Matheson CJ, Xu M, Backos DS, Mills TS, Salian-Mehta S, Kiseljak-Vassiliades K, Reigan P, Wierman ME. Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors. Mol Cancer Ther. 2016 Mar; 15(3):412-20.
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Liao Z, Gu L, Vergalli J, Mariani SA, De Dominici M, Lokareddy RK, Dagvadorj A, Purushottamachar P, McCue PA, Trabulsi E, Lallas CD, Gupta S, Ellsworth E, Blackmon S, Ertel A, Fortina P, Leiby B, Xia G, Rui H, Hoang DT, Gomella LG, Cingolani G, Njar V, Pattabiraman N, Calabretta B, Nevalainen MT. Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia. Mol Cancer Ther. 2015 Aug; 14(8):1777-93.
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Valdameri G, Gauthier C, Terreux R, Kachadourian R, Day BJ, Winnischofer SM, Rocha ME, Frachet V, Ronot X, Di Pietro A, Boumendjel A. Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity. J Med Chem. 2012 Apr 12; 55(7):3193-200.
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Rasulev B, Turabekova M, Gorska M, Kulig K, Bielejewska A, Lipkowski J, Leszczynski J. Use of quantitative structure-enantioselective retention relationship for the liquid chromatography chiral separation prediction of the series of pyrrolidin-2-one compounds. Chirality. 2012 Jan; 24(1):72-7.
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Morrill JA, Biggs JH, Bowman CN, Stansbury JW. Development of quantitative structure-activity relationships for explanatory modeling of fast reacting (meth)acrylate monomers bearing novel functionality. J Mol Graph Model. 2011 Feb; 29(5):763-72.
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Nolan KA, Doncaster JR, Dunstan MS, Scott KA, Frenkel AD, Siegel D, Ross D, Barnes J, Levy C, Leys D, Whitehead RC, Stratford IJ, Bryce RA. Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26; 52(22):7142-56.
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Moss N, Choi Y, Cogan D, Flegg A, Kahrs A, Loke P, Meyn O, Nagaraja R, Napier S, Parker A, Thomas Peterson J, Ramsden P, Sarko C, Skow D, Tomlinson J, Tye H, Whitaker M. A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties. Bioorg Med Chem Lett. 2009 Apr 15; 19(8):2206-10.
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Durairaj C, Shah JC, Senapati S, Kompella UB. Prediction of vitreal half-life based on drug physicochemical properties: quantitative structure-pharmacokinetic relationships (QSPKR). Pharm Res. 2009 May; 26(5):1236-60.
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Collnot EM, Baldes C, Wempe MF, Hyatt J, Navarro L, Edgar KJ, Schaefer UF, Lehr CM. Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. J Control Release. 2006 Mar 10; 111(1-2):35-40.
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Seth PP, Miyaji A, Jefferson EA, Sannes-Lowery KA, Osgood SA, Propp SS, Ranken R, Massire C, Sampath R, Ecker DJ, Swayze EE, Griffey RH. SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain. J Med Chem. 2005 Nov 17; 48(23):7099-102.
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