 Catalytic Domain
"Catalytic Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
| Descriptor ID |
D020134
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| MeSH Number(s) |
G02.111.570.120.704 G02.111.570.820.709.275.750.188
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| Concept/Terms |
Catalytic Domain- Catalytic Domain
- Catalytic Domains
- Domain, Catalytic
- Domains, Catalytic
- Catalytic Subunit
- Catalytic Subunits
- Subunit, Catalytic
- Subunits, Catalytic
- Catalytic Region
- Catalytic Regions
- Region, Catalytic
- Regions, Catalytic
- Catalytic Core
- Catalytic Cores
- Core, Catalytic
- Cores, Catalytic
Active Site- Active Site
- Active Sites
- Site, Active
- Sites, Active
- Catalytic Site
- Catalytic Sites
- Site, Catalytic
- Sites, Catalytic
- Reactive Site
- Reactive Sites
- Site, Reactive
- Sites, Reactive
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Below are MeSH descriptors whose meaning is more general than "Catalytic Domain".
Below are MeSH descriptors whose meaning is more specific than "Catalytic Domain".
This graph shows the total number of publications written about "Catalytic Domain" by people in this website by year, and whether "Catalytic Domain" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 | | 1999 | 1 | 3 | 4 | | 2000 | 0 | 7 | 7 | | 2001 | 0 | 3 | 3 | | 2002 | 1 | 3 | 4 | | 2003 | 0 | 5 | 5 | | 2004 | 1 | 4 | 5 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 4 | 5 | | 2007 | 0 | 3 | 3 | | 2008 | 0 | 5 | 5 | | 2009 | 1 | 7 | 8 | | 2010 | 1 | 8 | 9 | | 2011 | 0 | 6 | 6 | | 2012 | 2 | 7 | 9 | | 2013 | 1 | 15 | 16 | | 2014 | 1 | 6 | 7 | | 2015 | 0 | 12 | 12 | | 2016 | 2 | 7 | 9 | | 2017 | 0 | 7 | 7 | | 2018 | 1 | 8 | 9 | | 2019 | 0 | 7 | 7 | | 2020 | 0 | 8 | 8 | | 2021 | 1 | 8 | 9 | | 2022 | 0 | 5 | 5 | | 2023 | 1 | 5 | 6 | | 2024 | 4 | 3 | 7 | | 2025 | 0 | 3 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Catalytic Domain" by people in Profiles.
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Lee E, Tran N, Redzic JS, Singh H, Alamillo L, Holyoak T, Hamelberg D, Eisenmesser EZ. Identifying and controlling inactive and active conformations of a serine protease. Sci Adv. 2025 Apr 11; 11(15):eadu7447.
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Tran N, Redzic JS, Eisenmesser EZ, Holyoak T. The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallogr F Struct Biol Commun. 2025 Apr 01; 81(Pt 4):124-129.
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Singh A, Jangid K, Nehul S, Dhaka P, Rani R, Pareek A, Sharma GK, Kumar P, Tomar S. Structural and Mechanistic Insights into the Main Protease (Mpro) Dimer Interface Destabilization Inhibitor: Unveiling New Therapeutic Avenues against SARS-CoV-2. Biochemistry. 2025 04 01; 64(7):1589-1605.
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Lee E, Redzic JS, Eisenmesser EZ. Evolutionary Adaptations in Biliverdin Reductase B: Insights into Coenzyme Dynamics and Catalytic Efficiency. Int J Mol Sci. 2024 Dec 10; 25(24).
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Newton MS, Azadeh AL, Morgenthaler AB, Copley SD. Challenging a decades-old paradigm: ProB and ProA do not channel the unstable intermediate in proline synthesis after all. Proc Natl Acad Sci U S A. 2024 Nov 12; 121(46):e2413673121.
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Miller LG, Kim W, Schowe S, Taylor K, Han R, Jain V, Park R, Sherman M, Fang J, Ramirez H, Ellington A, Tamamis P, Resendiz MJE, Zhang YJ, Contreras L. Selective 8-oxo-rG stalling occurs in the catalytic core of polynucleotide phosphorylase (PNPase) during degradation. Proc Natl Acad Sci U S A. 2024 Nov 12; 121(46):e2317865121.
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Chambers LR, Ye Q, Cai J, Gong M, Ledvina HE, Zhou H, Whiteley AT, Suhandynata RT, Corbett KD. A eukaryotic-like ubiquitination system in bacterial antiviral defence. Nature. 2024 Jul; 631(8022):843-849.
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Briganti L, Manzine LR, de Mello Capetti CC, de Ara?jo EA, de Oliveira Arnoldi Pellegrini V, Guimaraes FEG, de Oliveira Neto M, Polikarpov I. Unravelling biochemical and structural features of Bacillus licheniformis GH5 mannanase using site-directed mutagenesis and high-resolution protein crystallography studies. Int J Biol Macromol. 2024 Aug; 274(Pt 2):133182.
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Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA. Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun. 2024 May 06; 15(1):3775.
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Anderson JW, Vaisar D, Jones DN, Pegram LM, Vigers GP, Chen H, Moffat JG, Ahn NG. Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2. Elife. 2024 Mar 27; 12.
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