Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Bruce Appel

Concepts (307)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Zebrafish Proteins
54
2026
311
11.000
Why?
Oligodendroglia
38
2026
187
10.710
Why?
Zebrafish
71
2026
528
10.690
Why?
Myelin Sheath
23
2025
168
8.050
Why?
Spinal Cord
25
2026
380
5.300
Why?
Cell Differentiation
35
2026
2050
4.050
Why?
Axons
16
2025
201
3.900
Why?
Motor Neurons
18
2024
234
3.330
Why?
Gene Expression Regulation, Developmental
33
2026
905
3.080
Why?
Neural Stem Cells
8
2026
166
2.490
Why?
Animals, Genetically Modified
31
2025
250
2.410
Why?
Hedgehog Proteins
10
2025
197
2.390
Why?
Nerve Tissue Proteins
18
2021
592
2.350
Why?
Neurogenesis
8
2026
156
2.350
Why?
Oligodendrocyte Precursor Cells
3
2026
23
2.320
Why?
Stem Cells
15
2018
626
2.150
Why?
Signal Transduction
27
2026
5226
2.110
Why?
Homeodomain Proteins
10
2026
523
1.810
Why?
Cell Lineage
17
2026
376
1.790
Why?
Receptors, Notch
9
2025
92
1.600
Why?
Embryo, Nonmammalian
20
2021
173
1.580
Why?
Cell Movement
10
2015
965
1.500
Why?
Body Patterning
13
2014
138
1.390
Why?
Neurons
15
2025
1640
1.340
Why?
Animals
76
2026
38058
1.310
Why?
RNA-Binding Proteins
5
2021
462
1.260
Why?
Central Nervous System
6
2026
281
1.210
Why?
TOR Serine-Threonine Kinases
3
2021
449
1.000
Why?
Schwann Cells
4
2014
33
0.950
Why?
Brain-Derived Neurotrophic Factor
2
2025
148
0.920
Why?
Green Fluorescent Proteins
14
2016
405
0.910
Why?
Receptor, trkB
1
2025
36
0.900
Why?
Receptor, Notch1
5
2012
64
0.880
Why?
Cell Polarity
5
2016
137
0.880
Why?
Docosahexaenoic Acids
1
2024
83
0.830
Why?
Cytoplasmic Dyneins
2
2015
8
0.830
Why?
Transcription Factors
12
2026
1741
0.820
Why?
F-Box Proteins
2
2015
23
0.820
Why?
Oligodendrocyte Transcription Factor 2
11
2025
23
0.790
Why?
Cholesterol
2
2016
406
0.780
Why?
Maternal Nutritional Physiological Phenomena
1
2024
181
0.760
Why?
Mutation
17
2021
4089
0.750
Why?
Ubiquitin-Protein Ligases
2
2015
192
0.730
Why?
Membrane Proteins
8
2008
1166
0.730
Why?
Notochord
5
2006
14
0.710
Why?
RNA Caps
1
2021
33
0.690
Why?
Neural Cell Adhesion Molecules
1
2021
38
0.690
Why?
Rhombencephalon
3
2012
31
0.670
Why?
RNA Transport
1
2021
27
0.670
Why?
Cell Cycle Proteins
4
2015
628
0.640
Why?
3' Untranslated Regions
1
2021
152
0.630
Why?
MicroRNAs
3
2016
701
0.610
Why?
Carrier Proteins
4
2020
737
0.590
Why?
Proto-Oncogene Proteins c-akt
1
2021
436
0.590
Why?
RNA, Messenger
8
2021
2832
0.580
Why?
Phagocytosis
1
2020
299
0.560
Why?
Protein Biosynthesis
1
2021
458
0.560
Why?
Neuroglia
5
2018
172
0.500
Why?
Larva
5
2025
242
0.490
Why?
Myelin Proteins
1
2016
45
0.490
Why?
Cytogenetic Analysis
1
2016
33
0.480
Why?
Neural Crest
3
2014
126
0.480
Why?
Protein Kinase C
2
2025
252
0.470
Why?
Synapses
1
2019
439
0.460
Why?
Axonal Transport
1
2015
26
0.440
Why?
Cell Cycle
3
2013
596
0.430
Why?
Brain
4
2018
2933
0.430
Why?
Trans-Activators
4
2004
405
0.430
Why?
Hydroxymethylglutaryl-CoA Synthase
1
2014
3
0.420
Why?
Phosphatidylinositol 3-Kinases
1
2016
380
0.410
Why?
Pericytes
1
2013
36
0.400
Why?
DNA-Binding Proteins
3
2020
1499
0.390
Why?
SOXE Transcription Factors
2
2025
22
0.370
Why?
Demyelinating Diseases
1
2012
84
0.360
Why?
Peripheral Nerves
2
2012
72
0.350
Why?
Action Potentials
1
2015
506
0.350
Why?
Fragile X Syndrome
2
2024
118
0.340
Why?
Guanine Nucleotide Exchange Factors
1
2011
64
0.340
Why?
In Situ Hybridization
7
2013
319
0.330
Why?
Gene Expression Regulation
3
2017
2608
0.320
Why?
Cell Proliferation
7
2018
2496
0.300
Why?
Isoenzymes
1
2009
299
0.280
Why?
Genes, Reporter
4
2015
275
0.280
Why?
Organogenesis
2
2020
65
0.270
Why?
Adult Stem Cells
1
2007
39
0.260
Why?
Synaptic Vesicles
2
2019
40
0.260
Why?
Wnt Proteins
1
2008
133
0.260
Why?
Exocytosis
2
2019
84
0.250
Why?
Morphogenesis
3
2008
173
0.250
Why?
Cloning, Molecular
7
2008
540
0.240
Why?
Nuclear Proteins
1
2011
748
0.240
Why?
Cerebellum
1
2008
223
0.240
Why?
Cyclin-Dependent Kinase Inhibitor p57
1
2005
5
0.230
Why?
Myelin Basic Protein
3
2025
44
0.230
Why?
Cell Adhesion Molecules
2
2019
178
0.220
Why?
Chondroitin Sulfate Proteoglycans
1
2024
10
0.220
Why?
Morpholinos
2
2016
29
0.210
Why?
Time-Lapse Imaging
2
2015
22
0.210
Why?
Electrical Synapses
1
2024
11
0.210
Why?
Cell Count
2
2016
320
0.210
Why?
F-Box-WD Repeat-Containing Protein 7
2
2015
6
0.210
Why?
Ubiquitin-Protein Ligase Complexes
2
2015
8
0.210
Why?
CRISPR-Cas Systems
1
2026
170
0.210
Why?
Proteoglycans
1
2024
110
0.210
Why?
Intracellular Signaling Peptides and Proteins
6
2003
459
0.210
Why?
Bromodeoxyuridine
3
2010
79
0.210
Why?
Cilia
3
2021
173
0.200
Why?
Glycosyltransferases
1
2003
16
0.200
Why?
Retinoids
1
2003
33
0.200
Why?
Nervous System
2
2001
70
0.200
Why?
Models, Biological
6
2019
1821
0.200
Why?
Gene Regulatory Networks
1
2026
318
0.190
Why?
Neuroepithelial Cells
2
2015
4
0.190
Why?
Veratrum Alkaloids
3
2008
20
0.190
Why?
Peripheral Nervous System
1
2003
20
0.190
Why?
Antigens
1
2024
347
0.190
Why?
Receptors, Cell Surface
2
2002
377
0.190
Why?
Amyloid beta-Peptides
1
2025
241
0.180
Why?
Purkinje Cells
1
2003
64
0.180
Why?
Intestines
2
2020
358
0.180
Why?
Microscopy, Confocal
2
2015
321
0.170
Why?
Spatio-Temporal Analysis
1
2021
39
0.170
Why?
Eukaryotic Initiation Factors
1
2021
12
0.170
Why?
Regulatory Sequences, Ribonucleic Acid
1
2021
18
0.170
Why?
Molecular Sequence Data
6
2012
2930
0.160
Why?
Molecular Imaging
1
2021
55
0.160
Why?
Extracellular Matrix
1
2024
553
0.160
Why?
Epigenesis, Genetic
1
2025
684
0.160
Why?
Tissue Distribution
1
2021
327
0.160
Why?
Microscopy, Electron, Transmission
2
2012
157
0.160
Why?
rab GTP-Binding Proteins
1
2020
76
0.160
Why?
Superior Colliculi
1
2020
44
0.150
Why?
Vitamin B 12
2
2017
127
0.150
Why?
Gastrula
3
2006
17
0.150
Why?
Immunohistochemistry
3
2010
1716
0.150
Why?
Embryonic Stem Cells
2
2010
130
0.150
Why?
Host Cell Factor C1
2
2017
15
0.140
Why?
Interneurons
3
2024
128
0.140
Why?
Sequence Analysis, RNA
1
2021
442
0.140
Why?
Female
8
2024
78271
0.140
Why?
Scoliosis
1
2021
223
0.140
Why?
Single-Cell Analysis
1
2021
358
0.130
Why?
Microglia
1
2020
268
0.130
Why?
Mice, Transgenic
2
2020
2182
0.130
Why?
Base Sequence
4
2017
2190
0.130
Why?
Neuronal Plasticity
1
2019
309
0.120
Why?
Phosphotransferases (Alcohol Group Acceptor)
2
2007
48
0.120
Why?
Nerve Fibers, Myelinated
1
2015
47
0.120
Why?
Genes, Homeobox
1
1995
50
0.120
Why?
Oligonucleotides, Antisense
2
2008
116
0.110
Why?
Pregnancy
2
2021
7190
0.110
Why?
Sequence Alignment
2
2012
366
0.110
Why?
Veratridine
1
2015
5
0.110
Why?
Tetrodotoxin
1
2015
40
0.110
Why?
Cell Division
2
2008
766
0.110
Why?
Potassium Channels, Inwardly Rectifying
1
2015
44
0.110
Why?
Gene Expression
3
2014
1490
0.110
Why?
Transcriptome
1
2021
1045
0.110
Why?
Sirolimus
1
2016
281
0.110
Why?
Gene Expression Profiling
1
2021
1782
0.100
Why?
Receptor, Notch3
1
2013
8
0.100
Why?
Repressor Proteins
1
2017
437
0.100
Why?
Cell Communication
1
2016
324
0.100
Why?
Receptor, Platelet-Derived Growth Factor beta
1
2013
31
0.100
Why?
Fibroblast Growth Factors
2
2026
188
0.100
Why?
Luciferases
1
2013
152
0.100
Why?
Immunoenzyme Techniques
1
2013
200
0.100
Why?
Protein Structure, Tertiary
1
2015
862
0.100
Why?
Colforsin
1
2012
48
0.100
Why?
Cerebral Hemorrhage
1
2013
120
0.090
Why?
Real-Time Polymerase Chain Reaction
1
2013
341
0.090
Why?
Mice
5
2026
18339
0.090
Why?
Models, Genetic
2
2012
536
0.090
Why?
Cell Membrane
1
2016
706
0.090
Why?
RNA
2
2012
940
0.090
Why?
Blood-Brain Barrier
1
2013
155
0.090
Why?
Nucleocytoplasmic Transport Proteins
1
2012
9
0.090
Why?
Recombinant Fusion Proteins
1
2015
675
0.090
Why?
Arthrogryposis
1
2012
16
0.090
Why?
Ligands
2
2004
673
0.090
Why?
Cyclic AMP
1
2012
209
0.090
Why?
rac GTP-Binding Proteins
1
2011
34
0.090
Why?
Phenotype
4
2020
3162
0.090
Why?
rac1 GTP-Binding Protein
1
2011
56
0.090
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2013
983
0.090
Why?
Neuropeptides
1
2011
77
0.090
Why?
Immunosuppressive Agents
1
2016
846
0.090
Why?
Blotting, Western
1
2013
1187
0.080
Why?
Mutagenesis
1
2012
192
0.080
Why?
Chromosome Mapping
1
2012
510
0.080
Why?
Enzyme Inhibitors
1
2014
824
0.080
Why?
Spinal Nerves
1
2009
7
0.080
Why?
Amino Acid Sequence
4
2005
2155
0.080
Why?
Adherens Junctions
1
2009
24
0.070
Why?
Oligodeoxyribonucleotides, Antisense
1
2009
8
0.070
Why?
Caspase 3
1
2010
238
0.070
Why?
T-Box Domain Proteins
2
2008
106
0.070
Why?
Microscopy, Electron
1
2009
415
0.070
Why?
Male
5
2021
72315
0.070
Why?
Sequence Homology, Amino Acid
3
2005
396
0.070
Why?
Smoothened Receptor
1
2008
5
0.070
Why?
S100 Calcium Binding Protein G
1
2008
8
0.070
Why?
Oligonucleotide Array Sequence Analysis
1
2010
758
0.070
Why?
Calbindin 2
1
2008
12
0.070
Why?
Zonula Occludens-1 Protein
1
2008
16
0.070
Why?
Glial Fibrillary Acidic Protein
1
2008
124
0.070
Why?
Time Factors
3
2010
7173
0.060
Why?
Fishes
1
2008
108
0.060
Why?
Morpholines
1
2008
128
0.060
Why?
Developmental Biology
1
2007
23
0.060
Why?
Recombinant Proteins
2
2007
1370
0.060
Why?
Cell Survival
1
2010
1098
0.060
Why?
Fetal Proteins
1
2006
15
0.060
Why?
Intercellular Signaling Peptides and Proteins
1
2008
381
0.060
Why?
Flow Cytometry
1
2010
1173
0.060
Why?
Muscle Proteins
1
2008
244
0.060
Why?
Branchial Region
2
2017
37
0.060
Why?
Humans
10
2021
144759
0.060
Why?
Receptors, G-Protein-Coupled
1
2008
233
0.060
Why?
Neocortex
1
2026
49
0.060
Why?
Craniofacial Abnormalities
2
2017
76
0.060
Why?
Phosphoproteins
1
2008
344
0.060
Why?
Prosencephalon
1
2025
53
0.060
Why?
Microscopy, Fluorescence
1
2006
416
0.060
Why?
Models, Neurological
1
2007
254
0.060
Why?
Hyperkinesis
1
2024
16
0.050
Why?
Connexins
1
2024
56
0.050
Why?
Helix-Loop-Helix Motifs
1
2003
12
0.050
Why?
Gap Junctions
1
2024
67
0.050
Why?
Catalytic Domain
1
2004
232
0.050
Why?
Myocytes, Cardiac
1
2008
556
0.050
Why?
Microinjections
1
2003
92
0.050
Why?
Age Factors
1
2009
3333
0.040
Why?
Luminescent Proteins
1
2003
185
0.040
Why?
Phosphorylation
1
2026
1732
0.040
Why?
Embryonic and Fetal Development
1
2001
93
0.040
Why?
Genetic Vectors
1
2003
337
0.040
Why?
Mesoderm
1
2002
150
0.040
Why?
Mammals
1
2022
293
0.040
Why?
Microvilli
1
2020
75
0.040
Why?
Hot Temperature
1
2003
407
0.040
Why?
Bone and Bones
1
2022
314
0.040
Why?
Endosomes
1
2020
140
0.040
Why?
Disease Models, Animal
2
2024
4557
0.040
Why?
ELAV-Like Protein 3
1
1998
1
0.030
Why?
Evolution, Molecular
1
2002
514
0.030
Why?
ELAV Proteins
1
1998
14
0.030
Why?
Embryonic Induction
1
1998
31
0.030
Why?
Antigens, Surface
1
1998
157
0.030
Why?
Avian Proteins
1
1996
21
0.030
Why?
Primary Cell Culture
1
2017
173
0.030
Why?
Oncogene Proteins
1
1996
61
0.030
Why?
DNA Primers
1
1995
512
0.030
Why?
Protein Binding
1
2020
2273
0.030
Why?
Oxidoreductases
1
2014
96
0.030
Why?
Gene Knockdown Techniques
1
2014
336
0.020
Why?
Cells, Cultured
2
2011
4154
0.020
Why?
Chondrocytes
1
2014
232
0.020
Why?
Rats
2
2011
5597
0.020
Why?
Fibroblasts
1
2017
1034
0.020
Why?
Plasmids
1
2012
379
0.020
Why?
Transcription, Genetic
1
2017
1496
0.020
Why?
SOXD Transcription Factors
1
2010
5
0.020
Why?
Cell Line
2
2007
2882
0.020
Why?
Chick Embryo
1
2010
132
0.020
Why?
Ribonuclease III
1
2010
44
0.020
Why?
Electroporation
1
2010
41
0.020
Why?
Endoribonucleases
1
2010
80
0.020
Why?
DEAD-box RNA Helicases
1
2010
90
0.020
Why?
Embryo, Mammalian
1
2010
232
0.020
Why?
Adaptor Proteins, Signal Transducing
1
2011
427
0.020
Why?
Cell Nucleus
1
2012
618
0.020
Why?
Versicans
1
2008
5
0.020
Why?
Bone Morphogenetic Protein 4
1
2008
43
0.020
Why?
RNA, Small Interfering
1
2010
635
0.020
Why?
Centrosome
1
2007
71
0.020
Why?
Bone Morphogenetic Proteins
1
2008
142
0.020
Why?
Protozoan Proteins
1
2007
93
0.020
Why?
Oligonucleotides
1
2008
151
0.020
Why?
Genotype
1
2012
1833
0.020
Why?
Gene Expression Regulation, Enzymologic
1
2007
269
0.020
Why?
Biological Transport
1
2007
417
0.020
Why?
Cerebral Cortex
1
2010
464
0.020
Why?
DNA, Recombinant
1
2005
48
0.010
Why?
Endoderm
1
2005
21
0.010
Why?
Phytic Acid
1
2005
35
0.010
Why?
Microtubules
1
2007
286
0.010
Why?
Epithelium
1
2005
314
0.010
Why?
Genes, Dominant
1
2004
101
0.010
Why?
Ataxia Telangiectasia Mutated Proteins
1
2004
69
0.010
Why?
S Phase
1
2004
80
0.010
Why?
Hippocampus
1
2010
965
0.010
Why?
Heart
1
2008
636
0.010
Why?
Calcium Signaling
1
2005
251
0.010
Why?
Apoptosis
1
2012
2430
0.010
Why?
Mice, Knockout
1
2010
3121
0.010
Why?
Transfection
1
2004
940
0.010
Why?
Tumor Suppressor Proteins
1
2004
321
0.010
Why?
Intestinal Mucosa
1
2005
676
0.010
Why?
Epithelial Cells
1
2005
1125
0.010
Why?
Child
1
2017
22633
0.010
Why?
Maf Transcription Factors
1
1996
1
0.010
Why?
Cell Transplantation
1
1996
39
0.010
Why?
Mosaicism
1
1996
73
0.010
Why?
Genetic Markers
1
1996
331
0.010
Why?
Selection, Genetic
1
1996
256
0.010
Why?
Polymerase Chain Reaction
1
1996
1054
0.010
Why?
Appel's Networks
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