Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Ethan G Hughes

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio

    Collapse Research 
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    R01NS134829     (ZUCHERO, JOHN B)Aug 15, 2024 - Jul 31, 2029
    NIH
    Does Learning Require Calcium-Dependent Myelin Remodeling?
    Role: Co-Principal Investigator
    R01NS132859     (HUGHES, ETHAN GARRETT)Jul 1, 2023 - May 31, 2028
    NIH
    In vivo three-photon microscopy of the cortical gray and white matter
    Role: Principal Investigator
    R01NS125230     (HUGHES, ETHAN GARRETT)Dec 1, 2021 - Nov 30, 2026
    NIH
    Precision of Myelin Plasticity in Health and Disease
    Role: Principal Investigator
    R01NS115975     (WELLE, CRISTIN G)Feb 1, 2020 - Dec 31, 2029
    NIH
    The role of myelination in cortical circuit function and motor behavior
    Role: Principal Investigator
    R21NS106432     (HUGHES, ETHAN GARRETT)May 15, 2018 - Apr 30, 2021
    NIH
    Oligodendrocytes and their Precursors in a Novel Model of Antibody-Mediated Cortical Demyelination
    Role: Principal Investigator
    F32NS076098     (HUGHES, ETHAN)Jul 1, 2011 - Jun 30, 2013
    NIH
    NG2 cell dynamics in the normal and injured adult central nervous system
    Role: Principal Investigator
    F31NS056549     (HUGHES, ETHAN G)Jul 1, 2007 - Jun 30, 2011
    NIH
    The role of astrocytes in inhibitory synaptogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Della-Flora Nunes G, Osso LA, Haynes JA, Conant L, Thornton MA, Stockton ME, Brassell KA, Morris A, Mancha Corchado YI, Gaynes JA, Chavez AR, Woerner MB, MacKenna DA, Alavi A, Danks A, Poleg-Polsky A, Gandhi R, Vivian JA, Denman DJ, Hughes EG. Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function. Nat Commun. 2025 Jan 16; 16(1):732. PMID: 39820244.
      View in: PubMed
    2. Poleg S, Li BZ, Sergison M, Ridenour M, Hughes EG, Tollin D, Klug A. Age-related myelin deficits in the auditory brain stem contribute to cocktail-party deficits. bioRxiv. 2024 Nov 18. PMID: 39211072.
      View in: PubMed
    3. Osso LA, Hughes EG. Dynamics of mature myelin. Nat Neurosci. 2024 Aug; 27(8):1449-1461. PMID: 38773349.
      View in: PubMed
    4. Huang R, Carter ER, Hughes EG, Welle CG. Paired vagus nerve stimulation drives precise remyelination and motor recovery after myelin loss. bioRxiv. 2024 May 12. PMID: 38766201.
      View in: PubMed
    5. Thornton MA, Futia GL, Stockton ME, Budoff SA, Ramirez AN, Ozbay B, Tzang O, Kilborn K, Poleg-Polsky A, Restrepo D, Gibson EA, Hughes EG. Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis. Nat Neurosci. 2024 May; 27(5):846-861. PMID: 38539013.
      View in: PubMed
    6. Hill RA, Nishiyama A, Hughes EG. Features, Fates, and Functions of Oligodendrocyte Precursor Cells. Cold Spring Harb Perspect Biol. 2024 03 01; 16(3). PMID: 38052500.
      View in: PubMed
    7. Nunes GD, Osso LA, Haynes JA, Morris A, Conant L, Stockton ME, Thornton MA, Vivian JA, Gandhi R, Denman DJ, Hughes EG. Incomplete remyelination via endogenous or therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function. bioRxiv. 2024 Feb 22. PMID: 39411163.
      View in: PubMed
    8. Thornton MA, Futia GL, Stockton ME, Budoff SA, Ramirez AN, Ozbay B, Tzang O, Kilborn K, Poleg-Polsky A, Restrepo D, Gibson EA, Hughes EG. Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis. bioRxiv. 2023 Nov 01. PMID: 37961298.
      View in: PubMed
    9. Owens GP, Fellin TJ, Matschulat A, Salas V, Schaller KL, Given KS, Ritchie AM, Navarro A, Blauth K, Hughes EG, Macklin WB, Bennett JL. Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1-anchored membrane domains. J Clin Invest. 2023 10 02; 133(19). PMID: 37561592.
      View in: PubMed
    10. Bacmeister CM, Huang R, Osso LA, Thornton MA, Conant L, Chavez AR, Poleg-Polsky A, Hughes EG. Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons. Nat Neurosci. 2022 10; 25(10):1300-1313. PMID: 36180791.
      View in: PubMed
    11. Thornton MA, Futia GL, Stockton ME, Ozbay BN, Kilborn K, Restrepo D, Gibson EA, Hughes EG. Characterization of red fluorescent reporters for dual-color in vivo three-photon microscopy. Neurophotonics. 2022 Jul; 9(3):031912. PMID: 35496497.
      View in: PubMed
    12. Supekar OD, Sias A, Hansen SR, Martinez G, Peet GC, Peng X, Bright VM, Hughes EG, Restrepo D, Shepherd DP, Welle CG, Gopinath JT, Gibson EA. Miniature structured illumination microscope for in vivo 3D imaging of brain structures with optical sectioning. Biomed Opt Express. 2022 Apr 01; 13(4):2530-2541. PMID: 35519247.
      View in: PubMed
    13. Majewska AK, Verkhratsky A, Hughes EG. Special issue editorial: Glial plasticity in health and disease. Eur J Neurosci. 2021 09; 54(5):5643-5648. PMID: 34363271.
      View in: PubMed
    14. Hughes EG, Stockton ME. Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration. Front Cell Dev Biol. 2021; 9:714169. PMID: 34368163.
      View in: PubMed
    15. Bacmeister CM, Barr HJ, McClain CR, Thornton MA, Nettles D, Welle CG, Hughes EG. Motor learning promotes remyelination via new and surviving oligodendrocytes. Nat Neurosci. 2020 07; 23(7):819-831. PMID: 32424285.
      View in: PubMed
    16. Thornton MA, Hughes EG. Neuron-oligodendroglia interactions: Activity-dependent regulation of cellular signaling. Neurosci Lett. 2020 05 14; 727:134916. PMID: 32194135.
      View in: PubMed
    17. Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD. Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nat Neurosci. 2019 05; 22(5):741-752. PMID: 30936556.
      View in: PubMed
    18. Ozbay BN, Futia GL, Ma M, Bright VM, Gopinath JT, Hughes EG, Restrepo D, Gibson EA. Three dimensional two-photon brain imaging in freely moving mice using a miniature fiber coupled microscope with active axial-scanning. Sci Rep. 2018 05 25; 8(1):8108. PMID: 29802371.
      View in: PubMed
    19. Hughes EG, Orthmann-Murphy JL, Langseth AJ, Bergles DE. Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat Neurosci. 2018 05; 21(5):696-706. PMID: 29556025.
      View in: PubMed
    20. Kim J, Hughes EG, Shetty AS, Arlotta P, Goff LA, Bergles DE, Brown SP. Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease. J Neurosci. 2017 09 13; 37(37):9037-9053. PMID: 28821643.
      View in: PubMed
    21. Agarwal A, Wu PH, Hughes EG, Fukaya M, Tischfield MA, Langseth AJ, Wirtz D, Bergles DE. Transient Opening of the Mitochondrial Permeability?Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017 Feb 08; 93(3):587-605.e7. PMID: 28132831.
      View in: PubMed
    22. Hughes EG, Appel B. The cell biology of CNS myelination. Curr Opin Neurobiol. 2016 08; 39:93-100. PMID: 27152449.
      View in: PubMed
    23. Peng X, Hughes EG, Moscato EH, Parsons TD, Dalmau J, Balice-Gordon RJ. Cellular plasticity induced by anti-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis antibodies. Ann Neurol. 2015 Mar; 77(3):381-98. PMID: 25369168.
      View in: PubMed
    24. Hughes EG, Bergles DE. Hidden progenitors replace microglia in the adult brain. Neuron. 2014 Apr 16; 82(2):253-5. PMID: 24742453.
      View in: PubMed
    25. Hughes EG, Kang SH, Fukaya M, Bergles DE. Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat Neurosci. 2013 Jun; 16(6):668-76. PMID: 23624515.
      View in: PubMed
    26. Moscato EH, Jain A, Peng X, Hughes EG, Dalmau J, Balice-Gordon RJ. Mechanisms underlying autoimmune synaptic encephalitis leading to disorders of memory, behavior and cognition: insights from molecular, cellular and synaptic studies. Eur J Neurosci. 2010 Jul; 32(2):298-309. PMID: 20646055; PMCID: PMC2955837.
      View in: PubMed, PubMed Central
    27. Hughes EG, Peng X, Gleichman AJ, Lai M, Zhou L, Tsou R, Parsons TD, Lynch DR, Dalmau J, Balice-Gordon RJ. Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci. 2010 Apr 28; 30(17):5866-75. PMID: 20427647.
      View in: PubMed
    28. Hughes EG, Elmariah SB, Balice-Gordon RJ. Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis. Mol Cell Neurosci. 2010 Jan; 43(1):136-45. PMID: 19850128.
      View in: PubMed
    29. Lai M, Hughes EG, Peng X, Zhou L, Gleichman AJ, Shu H, Mat? S, Kremens D, Vitaliani R, Geschwind MD, Bataller L, Kalb RG, Davis R, Graus F, Lynch DR, Balice-Gordon R, Dalmau J. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009 Apr; 65(4):424-34. PMID: 19338055.
      View in: PubMed
    30. Keene SD, Greco TM, Parastatidis I, Lee SH, Hughes EG, Balice-Gordon RJ, Speicher DW, Ischiropoulos H. Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome. Proteomics. 2009 Feb; 9(3):768-82. PMID: 19132682.
      View in: PubMed
    31. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, Dessain SK, Rosenfeld MR, Balice-Gordon R, Lynch DR. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008 Dec; 7(12):1091-8. PMID: 18851928.
      View in: PubMed
    32. Kayser MS, McClelland AC, Hughes EG, Dalva MB. Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors. J Neurosci. 2006 Nov 22; 26(47):12152-64. PMID: 17122040.
      View in: PubMed
    33. Elmariah SB, Oh EJ, Hughes EG, Balice-Gordon RJ. Astrocytes regulate inhibitory synapse formation via Trk-mediated modulation of postsynaptic GABAA receptors. J Neurosci. 2005 Apr 06; 25(14):3638-50. PMID: 15814795.
      View in: PubMed
    34. Elmariah SB, Hughes EG, Oh EJ, Balice-Gordon RJ. Neurotrophin signaling among neurons and glia during formation of tripartite synapses. Neuron Glia Biol. 2004 Nov; 1(4):1-11. PMID: 16528404.
      View in: PubMed
    35. Hughes EG, Maguire JL, McMinn MT, Scholz RE, Sutherland ML. Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking. Brain Res Mol Brain Res. 2004 May 19; 124(2):114-23. PMID: 15135219.
      View in: PubMed
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