 Morpholinos
"Morpholinos" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Synthetic analogs of NUCLEIC ACIDS composed of morpholine ring derivatives (MORPHOLINES) linked by phosphorodimidates. One standard DNA nucleic acid base (ADENINE; GUANINE; CYTOSINE; OR THYMINE) is bound to each morpholine ring.
| Descriptor ID |
D060172
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| MeSH Number(s) |
D03.383.533.640.562 D13.695.578.424.337
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| Concept/Terms |
Morpholinos- Morpholinos
- Morpholino Oligonucleotides
- Oligonucleotides, Morpholino
- Phosphorodiamidate Morpholino Oligomers
- Morpholino Oligomers, Phosphorodiamidate
- Oligomers, Phosphorodiamidate Morpholino
- PMO Oligomers
- Oligomers, PMO
- Morpholino Oligos
- Oligos, Morpholino
- MORF Oligomers
- Oligomers, MORF
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Below are MeSH descriptors whose meaning is more general than "Morpholinos".
Below are MeSH descriptors whose meaning is more specific than "Morpholinos".
This graph shows the total number of publications written about "Morpholinos" by people in this website by year, and whether "Morpholinos" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 | | 2012 | 0 | 4 | 4 | | 2013 | 1 | 1 | 2 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 2 | 2 | | 2016 | 1 | 2 | 3 | | 2017 | 2 | 1 | 3 | | 2018 | 1 | 2 | 3 | | 2019 | 2 | 0 | 2 | | 2020 | 1 | 1 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Morpholinos" by people in Profiles.
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Paul S, Caruthers MH. Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry. Molecules. 2023 Jul 13; 28(14).
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Le BT, Paul S, Jastrzebska K, Langer H, Caruthers MH, Veedu RN. Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2207956119.
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Roffers-Agarwal J, Lidberg KA, Gammill LS. The lysine methyltransferase SETD2 is a dynamically expressed regulator of early neural crest development. Genesis. 2021 10; 59(10):e23448.
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Langner HK, Jastrzebska K, Caruthers MH. Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras. J Am Chem Soc. 2020 09 23; 142(38):16240-16253.
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Connaughton DM, Dai R, Owen DJ, Marquez J, Mann N, Graham-Paquin AL, Nakayama M, Coyaud E, Laurent EMN, St-Germain JR, Blok LS, Vino A, Kl?mbt V, Deutsch K, Wu CW, Kolvenbach CM, Kause F, Ottlewski I, Schneider R, Kitzler TM, Majmundar AJ, Buerger F, Onuchic-Whitford AC, Youying M, Kolb A, Salmanullah D, Chen E, van der Ven AT, Rao J, Ityel H, Seltzsam S, Rieke JM, Chen J, Vivante A, Hwang DY, Kohl S, Dworschak GC, Hermle T, Alders M, Bartolomaeus T, Bauer SB, Baum MA, Brilstra EH, Challman TD, Zyskind J, Costin CE, Dipple KM, Duijkers FA, Ferguson M, Fitzpatrick DR, Fick R, Glass IA, Hulick PJ, Kline AD, Krey I, Kumar S, Lu W, Marco EJ, Wentzensen IM, Mefford HC, Platzer K, Povolotskaya IS, Savatt JM, Shcherbakova NV, Senguttuvan P, Squire AE, Stein DR, Thiffault I, Voinova VY, Somers MJG, Ferguson MA, Traum AZ, Daouk GH, Daga A, Rodig NM, Terhal PA, van Binsbergen E, Eid LA, Tasic V, Rasouly HM, Lim TY, Ahram DF, Gharavi AG, Reutter HM, Rehm HL, MacArthur DG, Lek M, Laricchia KM, Lifton RP, Xu H, Mane SM, Sanna-Cherchi S, Sharrocks AD, Raught B, Fisher SE, Bouchard M, Khokha MK, Shril S, Hildebrandt F. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Am J Hum Genet. 2020 10 01; 107(4):727-742.
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Krishna H, Jastrzebska K, Caruthers M. Exploring site-specific activation of bis-N,N'-dialkylaminophosphordiamidites and the synthesis of morpholinophosphoramidate oligonucleotides. FEBS Lett. 2019 07; 593(13):1459-1467.
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Bouchard M, Vogel LF, Apkon SD. Restoration of Walking After Surgical Management of Equinus in a Non-ambulatory Child With Duchenne Muscular Dystrophy: A Case Presentation. PM R. 2019 11; 11(11):1240-1243.
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Julien C, Tomberlin C, Roberts CM, Akram A, Stein GH, Silverman MA, Link CD. In vivo induction of membrane damage by ?-amyloid peptide oligomers. Acta Neuropathol Commun. 2018 11 29; 6(1):131.
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Moreno RL, Williams K, Jones KL, Ribera AB. Investigation of Islet2a function in zebrafish embryos: Mutants and morphants differ in morphologic phenotypes and gene expression. PLoS One. 2018; 13(6):e0199233.
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Maurer JM, Sagerstr?m CG. A parental requirement for dual-specificity phosphatase 6 in zebrafish. BMC Dev Biol. 2018 03 15; 18(1):6.
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