 Tissue Distribution
"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
| Descriptor ID |
D014018
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| MeSH Number(s) |
G03.787.917 G07.690.725.949
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| Concept/Terms |
Tissue Distribution- Tissue Distribution
- Distribution, Tissue
- Distributions, Tissue
- Tissue Distributions
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Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".
Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".
This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 5 | 5 | | 1996 | 0 | 4 | 4 | | 1997 | 0 | 7 | 7 | | 1998 | 0 | 4 | 4 | | 1999 | 0 | 13 | 13 | | 2000 | 0 | 11 | 11 | | 2001 | 0 | 7 | 7 | | 2002 | 0 | 8 | 8 | | 2003 | 0 | 15 | 15 | | 2004 | 0 | 11 | 11 | | 2005 | 0 | 12 | 12 | | 2006 | 0 | 10 | 10 | | 2007 | 0 | 10 | 10 | | 2008 | 0 | 9 | 9 | | 2009 | 0 | 8 | 8 | | 2010 | 0 | 8 | 8 | | 2011 | 0 | 7 | 7 | | 2012 | 0 | 6 | 6 | | 2013 | 0 | 4 | 4 | | 2014 | 1 | 7 | 8 | | 2015 | 0 | 7 | 7 | | 2016 | 0 | 7 | 7 | | 2017 | 0 | 6 | 6 | | 2018 | 0 | 8 | 8 | | 2019 | 0 | 8 | 8 | | 2020 | 1 | 6 | 7 | | 2021 | 0 | 6 | 6 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 1 | 1 | | 2024 | 0 | 6 | 6 | | 2025 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Tissue Distribution" by people in Profiles.
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Lu S, Khan MA, Setua S, O'Boyle Q, Thangaraju K, Cabrales P, Swindle DC, Irwin DC, Buehler PW, Palmer AF. Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice. Biotechnol Bioeng. 2025 Oct; 122(10):2709-2723.
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Vadovics M, Zhao W, Daley EF, Lam K, Daly O, Rashid K, Lee HR, Schreiner P, Lundgreen KA, Gaudette BT, Shuvaev VV, Arguiri E, Muramatsu H, Sárközy A, Mdluli T, Xu J, Han X, De Luna N, Castaño D, Bettini E, Ábrahám E, Lipinszki Z, Carlucci G, Bansode AH, Nguyen K, Le TM, Luu T, Muzykantov VR, Bates P, Allman D, Mitchell MJ, Locci M, Radu CG, Heyes J, Pardi N. Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications. Nat Nanotechnol. 2025 Sep; 20(9):1312-1322.
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Qiao Z, Xu J, Gallazzi F, Fisher DR, Gonzalez R, Kwak J, Miao Y. Effect of Ibuprofen as an Albumin Binder on Melanoma-Targeting Properties of 177Lu-Labeled Ibuprofen-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides. Mol Pharm. 2024 Aug 05; 21(8):4004-4011.
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Burmakin M, Gilmour PS, Gram M, Shushakova N, Sandoval RM, Molitoris BA, Larsson TE. Therapeutic a-1-microglobulin ameliorates kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2024 Jul 01; 327(1):F103-F112.
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Atsavapranee E, Haley RM, Billingsley MM, Chan A, Ruan B, Figueroa-Espada CG, Gong N, Mukalel AJ, Bryan PN, Mitchell MJ. Ionizable lipid nanoparticles for RAS protease delivery to inhibit cancer cell proliferation. J Control Release. 2024 Jun; 370:614-625.
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Zhang X, Heo GS, Li A, Lahad D, Detering L, Tao J, Gao X, Zhang X, Luehmann H, Sultan D, Lou L, Venkatesan R, Li R, Zheng J, Amrute J, Lin CY, Kopecky BJ, Gropler RJ, Bredemeyer A, Lavine K, Liu Y. Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis. J Nucl Med. 2024 May 01; 65(5):775-780.
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Carmès L, Bort G, Lux F, Seban L, Rocchi P, Muradova Z, Hagège A, Heinrich-Balard L, Delolme F, Gueguen-Chaignon V, Truillet C, Crowley S, Bello E, Doussineau T, Dougan M, Tillement O, Schoenfeld JD, Brown N, Berbeco R. AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors. Nanoscale. 2024 Feb 01; 16(5):2347-2360.
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Natarajan P, Horak K, Rowe J, Yoon S, Lingo J, Tomich JM, Fleming SD. Biodistribution Analysis of Peptide-Coated Magnetic Iron Nanoparticles: A Simple and Quantitative Method. Mol Pharm. 2024 Feb 05; 21(2):970-981.
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Costa PAC, da Silva WN, Moura Prazeres PHD, Ferreira HAS, da Silva NJA, Figueiredo MM, da Silva Oliveira B, Scalzo Júnior SRA, Silva Santos FRD, Fernandes RA, Palanki R, Hamilton AG, Birbrair A, Santos VR, de Miranda AS, Mitchell MJ, Teixeira MM, Costa VV, Guimarães PPG. siRNA lipid nanoparticles for CXCL12 silencing modulate brain immune response during Zika infection. Biomed Pharmacother. 2024 Jan; 170:115981.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Effects of Polyethylene Glycol and 8-Aminooctanoic Acid Linkers on Melanoma Uptake of [99mTc]Tc-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized a-MSH Peptides. Bioconjug Chem. 2023 05 17; 34(5):934-940.
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