 Tissue Distribution
"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
| Descriptor ID |
D014018
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| MeSH Number(s) |
G03.787.917 G07.690.725.949
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| Concept/Terms |
Tissue Distribution- Tissue Distribution
- Distribution, Tissue
- Distributions, Tissue
- Tissue Distributions
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Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".
Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".
This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 6 | 6 | | 1995 | 0 | 4 | 4 | | 1996 | 0 | 4 | 4 | | 1997 | 0 | 6 | 6 | | 1998 | 0 | 4 | 4 | | 1999 | 0 | 14 | 14 | | 2000 | 0 | 9 | 9 | | 2001 | 0 | 7 | 7 | | 2002 | 0 | 9 | 9 | | 2003 | 0 | 14 | 14 | | 2004 | 0 | 12 | 12 | | 2005 | 0 | 13 | 13 | | 2006 | 0 | 10 | 10 | | 2007 | 0 | 11 | 11 | | 2008 | 0 | 10 | 10 | | 2009 | 0 | 12 | 12 | | 2010 | 0 | 8 | 8 | | 2011 | 0 | 9 | 9 | | 2012 | 0 | 6 | 6 | | 2013 | 0 | 7 | 7 | | 2014 | 0 | 10 | 10 | | 2015 | 0 | 7 | 7 | | 2016 | 0 | 7 | 7 | | 2017 | 0 | 8 | 8 | | 2018 | 0 | 8 | 8 | | 2019 | 0 | 9 | 9 | | 2020 | 1 | 4 | 5 | | 2021 | 0 | 6 | 6 | | 2022 | 0 | 5 | 5 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tissue Distribution" by people in Profiles.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Effects of Polyethylene Glycol and 8-Aminooctanoic Acid Linkers on Melanoma Uptake of [99mTc]Tc-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized a-MSH Peptides. Bioconjug Chem. 2023 05 17; 34(5):934-940.
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McCollum CR, Courtney CM, O'Connor NJ, Aunins TR, Jordan TX, Rogers KL, Brindley S, Brown JM, Nagpal P, Chatterjee A. Safety and Biodistribution of Nanoligomers Targeting the SARS-CoV-2 Genome for the Treatment of COVID-19. ACS Biomater Sci Eng. 2023 03 13; 9(3):1656-1671.
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Datta-Mannan A, Molitoris BA, Feng Y, Martinez MM, Sandoval RM, Brown RM, Merkel D, Croy JE, Dunn KW. Intravital Microscopy Reveals Unforeseen Biodistribution Within the Liver and Kidney Mechanistically Connected to the Clearance of a Bifunctional Antibody. Drug Metab Dispos. 2023 03; 51(3):403-412.
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McCollum CR, Courtney CM, O'Connor NJ, Aunins TR, Ding Y, Jordan TX, Rogers KL, Brindley S, Brown JM, Nagpal P, Chatterjee A. Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice. ACS Biomater Sci Eng. 2022 07 11; 8(7):3087-3106.
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Banda NK, Deane KD, Bemis EA, Strickland C, Seifert J, Jordan K, Goldman K, Morgan BP, Moreland LW, Lewis MJ, Pitzalis C, Holers VM. Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features. J Immunol. 2022 06 01; 208(11):2482-2496.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Novel 64Cu-Labeled NOTA-Conjugated Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptides with Enhanced Tumor to Kidney Uptake Ratios. Mol Pharm. 2022 07 04; 19(7):2535-2541.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Novel Al18F-NOTA-Conjugated Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptides with Enhanced Melanoma Uptake. Bioconjug Chem. 2022 05 18; 33(5):982-990.
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Tang W, Panja S, Jogdeo CM, Tang S, Yu A, Oupick? D. Study of Renal Accumulation of Targeted Polycations in Acute Kidney Injury. Biomacromolecules. 2022 05 09; 23(5):2064-2074.
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Talkington AM, McSweeney MD, Wessler T, Rath MK, Li Z, Zhang T, Yuan H, Frank JE, Forest MG, Cao Y, Lai SK. A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes. J Control Release. 2022 03; 343:518-527.
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Maruggi G, Mallett CP, Westerbeck JW, Chen T, Lofano G, Friedrich K, Qu L, Sun JT, McAuliffe J, Kanitkar A, Arrildt KT, Wang KF, McBee I, McCoy D, Terry R, Rowles A, Abrahim MA, Ringenberg MA, Gains MJ, Spickler C, Xie X, Zou J, Shi PY, Dutt T, Henao-Tamayo M, Ragan I, Bowen RA, Johnson R, Nuti S, Luisi K, Ulmer JB, Steff AM, Jalah R, Bertholet S, Stokes AH, Yu D. A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models. Mol Ther. 2022 05 04; 30(5):1897-1912.
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