 Synapses
"Synapses" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
| Descriptor ID |
D013569
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| MeSH Number(s) |
A08.850 A11.284.149.165.420.780
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Synapses".
Below are MeSH descriptors whose meaning is more specific than "Synapses".
This graph shows the total number of publications written about "Synapses" by people in this website by year, and whether "Synapses" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 4 | 4 | | 1996 | 1 | 2 | 3 | | 1997 | 1 | 1 | 2 | | 1998 | 2 | 1 | 3 | | 1999 | 1 | 2 | 3 | | 2000 | 4 | 1 | 5 | | 2001 | 3 | 2 | 5 | | 2002 | 3 | 2 | 5 | | 2003 | 4 | 6 | 10 | | 2004 | 6 | 2 | 8 | | 2005 | 6 | 0 | 6 | | 2006 | 14 | 5 | 19 | | 2007 | 7 | 3 | 10 | | 2008 | 5 | 4 | 9 | | 2009 | 7 | 3 | 10 | | 2010 | 14 | 1 | 15 | | 2011 | 8 | 4 | 12 | | 2012 | 7 | 2 | 9 | | 2013 | 1 | 5 | 6 | | 2014 | 7 | 5 | 12 | | 2015 | 5 | 11 | 16 | | 2016 | 8 | 7 | 15 | | 2017 | 5 | 5 | 10 | | 2018 | 12 | 5 | 17 | | 2019 | 9 | 5 | 14 | | 2020 | 2 | 6 | 8 | | 2021 | 3 | 8 | 11 | | 2022 | 6 | 5 | 11 | | 2023 | 2 | 4 | 6 | | 2024 | 6 | 11 | 17 | | 2025 | 4 | 4 | 8 |
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Below are the most recent publications written about "Synapses" by people in Profiles.
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Tamura S, Nelson AD, Spratt PWE, Hamada EC, Zhou X, Kyoung H, Li Z, Arnould C, Barskyi V, Krupkin B, Young K, Zhao J, Holden SS, Sahagun A, Keeshen CM, Lu C, Ben-Shalom R, Taloma SE, Schamiloglu S, Li YC, Min L, Jenkins PM, Pan JQ, Paz JT, Sanders SJ, Matharu N, Ahituv N, Bender KJ. CRISPR activation for SCN2A-related neurodevelopmental disorders. Nature. 2025 Oct; 646(8086):983-991.
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Savchuk S, Gentry KM, Wang W, Carleton E, Biagi-Junior CAO, Luthria K, Yalçin B, Ni L, Farnsworth HC, Davis RA, Drexler R, Melms JC, Liu Y, Acosta-Alvarez L, Hartmann GG, Pavarino EC, LaBelle J, Woo PJ, Toland AM, Qu F, Kim YS, Filbin MG, Krasnow MA, Ligon KL, Izar B, Sage J, Sabatini BL, Monje M, Venkatesh HS. Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis. Nature. 2025 Oct; 646(8087):1232-1242.
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Miller CN, Li Y, Beier KT, Aoto J. Acute stress causes sex-specific changes to ventral subiculum synapses, circuitry, and anxiety-like behavior. Nat Commun. 2025 Jul 01; 16(1):5604.
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Morabito A, Zerlaut Y, Dhanasobhon D, Berthaux E, Pinho CM, Tzilivaki A, Moneron G, Cathala L, Poirazi P, Bacci A, DiGregorio DA, Lourenço J, Rebola N. Distinct dendritic integration strategies control dynamics of inhibition in the neocortex. Neuron. 2025 Sep 17; 113(18):2962-2978.e10.
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Bourne JN, Schoppa NE. Ultrastructural Contributions to Extrasynaptic Glutamatergic Signaling in Olfactory Bulb Glomeruli. J Comp Neurol. 2025 Mar; 533(3):e70034.
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Zent KH, Dell'Acqua ML. Synapse-to-Nucleus ERK?CREB Transcriptional Signaling Requires Dendrite-to-Soma Ca2+ Propagation Mediated by L-Type Voltage-Gated Ca2+ Channels. J Neurosci. 2025 Jan 22; 45(4).
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Stokes EG, Vasquez JJ, Azouz G, Nguyen M, Tierno A, Zhuang Y, Galinato VM, Hui M, Toledano M, Tyler I, Shi X, Hunt RF, Aoto J, Beier KT. Cationic peptides cause memory loss through endophilin-mediated endocytosis. Nature. 2025 Feb; 638(8050):479-489.
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Su F, Pfundstein G, Sah S, Zhang S, Keable R, Hagan DW, Sharpe LJ, Clemens KJ, Begg D, Phelps EA, Brown AJ, Leshchyns'ka I, Sytnyk V. Neuronal growth regulator 1 (NEGR1) promotes the synaptic targeting of glutamic acid decarboxylase 65 (GAD65). J Neurochem. 2025 Jan; 169(1):e16279.
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Hansen N, Dischler A, Dias C. Beyond the Synapse: FMR1 and FMRP Molecular Mechanisms in the Nucleus. Int J Mol Sci. 2024 Dec 30; 26(1).
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Bosquez Huerta NA, Lee ZF, Christine Song EA, Woo J, Cheng YT, Sardar D, Sert O, Maleki E, Yu K, Akdemir ES, Sanchez K, Jo J, Rasband MN, Lee HK, Harmanci AS, Deneen B. Sex-specific astrocyte regulation of spinal motor circuits by Nkx6.1. Cell Rep. 2025 01 28; 44(1):115121.
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