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Lori Gail Sussel

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BDC Basic Research
Phone303/724-9119
    Other Positions
    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-BDC Basic Research


    Collapse Research 
    Collapse research activities and funding
    U01DK127505     (NAKAYASU, ERNESTO SATOSHI;SUSSEL, LORI)Sep 15, 2020 - Jun 30, 2024
    NIH
    Alternative RNA splicing events contribute to the onset of islet dysfunction in T1D
    Role: Principal Investigator
    R01DK125360     (SUSSEL, LORI)Jul 1, 2020 - Apr 30, 2024
    NIH
    PTPN2 mutations affect islet beta cell susceptibility in T1D
    Role: Principal Investigator
    P30DK116073     (SUSSEL, LORI)Apr 1, 2020 - Mar 31, 2025
    NIH
    UC Denver Diabetes Research Center
    Role: Principal Investigator
    R01DK118155     (GADUE, PAUL J)Jul 1, 2018 - May 31, 2022
    NIH
    Intersection of signaling pathways and transcription factors regulating islet development
    Role: Co-Principal Investigator
    R01DK111405     (SUSSEL, LORI)Jul 1, 2017 - Jun 30, 2021
    NIH
    Long non-coding RNAs in Islet Cell Biology
    Role: Principal Investigator
    UC4DK108101     (ANSONG, CHARLES K)Sep 22, 2015 - Sep 21, 2019
    NIH
    Single Cell Resolution Omics Analysis of T1D islets
    Role: Co-Principal Investigator
    R21CA188059     (SUSSEL, LORI)Sep 1, 2014 - Aug 31, 2016
    NIH
    Long non-coding RNAs in pancreatic cancer
    Role: Principal Investigator
    DP3DK094400     (CLYNES, RAPHAEL A)Sep 20, 2011 - Aug 31, 2015
    NIH
    Epigenetic events underlying Type I diabetes
    Role: Co-Principal Investigator
    R01DK087711     (SUSSEL, LORI)Sep 20, 2010 - Jun 30, 2016
    NIH
    Regulation of exocrine pancreas formation
    Role: Principal Investigator
    R01DK082590     (SUSSEL, LORI)Jan 1, 2009 - Jul 31, 2027
    NIH
    Regulation of pancreatic islet cell fate
    Role: Principal Investigator
    U01DK072504     (SUSSEL, LORI)Aug 1, 2005 - Jul 31, 2010
    NIH
    Defining the roles of Nkx2.2 and NeuroD in regulating islet cell fate
    Role: Principal Investigator
    R01DK064146     (SUSSEL, LORI)Jun 1, 2003 - Mar 31, 2009
    NIH
    The role of Gata 4 in exocrine pancreas development
    Role: Principal Investigator
    R21DK061422     (SUSSEL, LORI)May 15, 2002 - Apr 30, 2004
    NIH
    Nkx2.2 and Gata6: regulation of islet development
    Role: Principal Investigator
    R21DK061151     (SUSSEL, LORI)Sep 30, 2001 - Aug 31, 2003
    NIH
    Transcriptional regulation of exocrine development
    Role: Principal Investigator
    F32NS010184     (SUSSEL, LORI)Dec 1, 1996
    NIH
    GENETIC ANALYSIS OF MOUSE NKX-21 AND NKX-22 GENES
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim YK, Kim YR, Wells KL, Sarbaugh D, Guney M, Tsai CF, Zee T, Karsenty G, Nakayasu ES, Sussel L. PTPN2 Regulates Metabolic Flux to Affect ?-Cell Susceptibility to Inflammatory Stress. Diabetes. 2024 Mar 01; 73(3):434-447. PMID: 38015772.
      View in: PubMed
    2. Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L. Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nat Commun. 2023 Nov 25; 14(1):7732. PMID: 38007492.
      View in: PubMed
    3. Brooks EP, Sussel L. Not the second fiddle: a cell development, identity, and function in health and diabetes. J Endocrinol. 2023 08 01; 258(2). PMID: 37171828.
      View in: PubMed
    4. Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L. Major ? cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 06 01; 37(11-12):490-504. PMID: 37364986.
      View in: PubMed
    5. Putman MS, Norris AW, Hull RL, Rickels MR, Sussel L, Blackman SM, Chan CL, Ode KL, Daley T, Stecenko AA, Moran A, Helmick MJ, Cray S, Alvarez JA, Stallings VA, Tuggle KL, Clancy JP, Eggerman TL, Engelhardt JF, Kelly A. Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes. Diabetes Care. 2023 06 01; 46(6):1112-1123. PMID: 37125948.
      View in: PubMed
    6. Putman MS, Norris AW, Hull RL, Rickels MR, Sussel L, Blackman SM, Chan CL, Ode KL, Daley T, Stecenko AA, Moran A, Helmick MJ, Cray S, Alvarez JA, Stallings VA, Tuggle KL, Clancy JP, Eggerman TL, Engelhardt JF, Kelly A. Cystic Fibrosis-Related Diabetes Workshop: Research Priorities Spanning Disease Pathophysiology, Diagnosis, and Outcomes. Diabetes. 2023 06 01; 72(6):677-689. PMID: 37125945.
      View in: PubMed
    7. Kim YK, Walters JA, Moss ND, Wells KL, Sheridan R, Miranda JG, Benninger RKP, Pyle LL, O'Brien RM, Sussel L, Davidson HW. Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration. Mol Metab. 2022 12; 66:101632. PMID: 36347424.
      View in: PubMed
    8. Lorberbaum DS, Sarbaugh D, Sussel L. Leveraging the strengths of mice, human stem cells, and organoids to model pancreas development and diabetes. Front Endocrinol (Lausanne). 2022; 13:1042611. PMID: 36339450.
      View in: PubMed
    9. Russ HA, Shilleh AH, Sussel L. From the dish to humans: A stem cell recipe for success. Cell Metab. 2022 02 01; 34(2):193-196. PMID: 35108510.
      View in: PubMed
    10. Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes. 2021 08 01; 70(8):1634-1637. PMID: 35381060.
      View in: PubMed
    11. Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes Care. 2021 08; 44(8):1744-1747. PMID: 34131046.
      View in: PubMed
    12. Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Stem Cell Reports. 2021 Apr 13; 16(4):1009. PMID: 33852882.
      View in: PubMed
    13. Kim YK, Sussel L, Davidson HW. Inherent Beta Cell Dysfunction Contributes to Autoimmune Susceptibility. Biomolecules. 2021 03 30; 11(4). PMID: 33808310.
      View in: PubMed
    14. Theis A, Singer RA, Garofalo D, Paul A, Narayana A, Sussel L. Groucho co-repressor proteins regulate ? cell development and proliferation by repressing Foxa1 in the developing mouse pancreas. Development. 2021 03 24; 148(6). PMID: 33658226.
      View in: PubMed
    15. Docherty FM, Sussel L. Islet Regeneration: Endogenous and Exogenous Approaches. Int J Mol Sci. 2021 Mar 24; 22(7). PMID: 33804882.
      View in: PubMed
    16. Li F, Hu D, Dieter C, Ansong C, Sussel L, Orr G. Single Molecule-Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet ?-Cells. Diabetes. 2021 05; 70(5):1117-1122. PMID: 33685924.
      View in: PubMed
    17. Moss ND, Sussel L. mRNA Processing: An Emerging Frontier in the Regulation of Pancreatic ? Cell Function. Front Genet. 2020; 11:983. PMID: 33088281.
      View in: PubMed
    18. Pajvani UB, Sussel L. An Ultradian Notch in Beta-Cell Development. N Engl J Med. 2020 07 02; 383(1):80-82. PMID: 32609988.
      View in: PubMed
    19. Lorberbaum DS, Kishore S, Rosselot C, Sarbaugh D, Brooks EP, Aragon E, Xuan S, Simon O, Ghosh D, Mendelsohn C, Gadue P, Sussel L. Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human ? cell specification. Development. 2020 06 22; 147(12). PMID: 32467243.
      View in: PubMed
    20. Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Stem Cell Reports. 2020 06 09; 14(6):1033-1043. PMID: 32386561.
      View in: PubMed
    21. Lorberbaum DS, Sussel L. A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development. Dev Cell. 2020 03 23; 52(6):681-682. PMID: 32208161.
      View in: PubMed
    22. Lorberbaum DS, Docherty FM, Sussel L. Animal Models of Pancreas Development, Developmental Disorders, and Disease. Adv Exp Med Biol. 2020; 1236:65-85. PMID: 32304069.
      View in: PubMed
    23. Guney MA, Lorberbaum DS, Sussel L. Pancreatic ? cell regeneration: To ? or not to ?. Curr Opin Physiol. 2020 Apr; 14:13-20. PMID: 32864533.
      View in: PubMed
    24. Singer RA, Arnes L, Cui Y, Wang J, Gao Y, Guney MA, Burnum-Johnson KE, Rabadan R, Ansong C, Orr G, Sussel L. The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function. Cell Metab. 2019 12 03; 30(6):1091-1106.e8. PMID: 31607563.
      View in: PubMed
    25. Hudish LI, Reusch JE, Sussel L. ? Cell dysfunction during progression of metabolic syndrome to type 2 diabetes. J Clin Invest. 2019 10 01; 129(10):4001-4008. PMID: 31424428.
      View in: PubMed
    26. Romer AI, Singer RA, Sui L, Egli D, Sussel L. Murine Perinatal ?-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1. Diabetes. 2019 12; 68(12):2259-2271. PMID: 31519700.
      View in: PubMed
    27. Hudish LI, Lorberbaum DS, Sussel L. FISHing for ? Cells. Dev Cell. 2019 01 07; 48(1):7-8. PMID: 30620904.
      View in: PubMed
    28. Bartolome A, Zhu C, Sussel L, Pajvani UB. Notch signaling dynamically regulates adult ? cell proliferation and maturity. J Clin Invest. 2019 01 02; 129(1):268-280. PMID: 30375986.
      View in: PubMed
    29. Font-Cunill B, Arnes L, Ferrer J, Sussel L, Beucher A. Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes. Front Genet. 2018; 9:524. PMID: 30459811.
      View in: PubMed
    30. Singer RA, Sussel L. Islet Long Noncoding RNAs: A Playbook for Discovery and Characterization. Diabetes. 2018 08; 67(8):1461-1470. PMID: 29937433.
      View in: PubMed
    31. Yin R, Kyle J, Burnum-Johnson K, Bloodsworth KJ, Sussel L, Ansong C, Laskin J. High Spatial Resolution Imaging of Mouse Pancreatic Islets Using Nanospray Desorption Electrospray Ionization Mass Spectrometry. Anal Chem. 2018 06 05; 90(11):6548-6555. PMID: 29718662.
      View in: PubMed
    32. Arnes L, Liu Z, Wang J, Maurer C, Sagalovskiy I, Sanchez-Martin M, Bommakanti N, Garofalo DC, Balderes DA, Sussel L, Olive KP, Rabadan R. Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma. Gut. 2019 03; 68(3):499-511. PMID: 29440233.
      View in: PubMed
    33. Cui Y, Hu D, Markillie LM, Chrisler WB, Gaffrey MJ, Ansong C, Sussel L, Orr G. Fluctuation localization imaging-based fluorescence in situ hybridization (fliFISH) for accurate detection and counting of RNA copies in single cells. Nucleic Acids Res. 2018 01 25; 46(2):e7. PMID: 29040675.
      View in: PubMed
    34. Lorberbaum DS, Sussel L. Gotta Have GATA for Human Pancreas Development. Cell Stem Cell. 2017 05 04; 20(5):577-579. PMID: 28475878.
      View in: PubMed
    35. Gutierrez GD, Gromada J, Sussel L. Heterogeneity of the Pancreatic Beta Cell. Front Genet. 2017; 8:22. PMID: 28321233.
      View in: PubMed
    36. Churchill AJ, Guti?rrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L. Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife. 2017 01 10; 6. PMID: 28071588.
      View in: PubMed
    37. Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ? cells. J Clin Invest. 2017 01 03; 127(1):215-229. PMID: 27941246.
      View in: PubMed
    38. Guti?rrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L. Pancreatic ? cell identity requires continual repression of non-? cell programs. J Clin Invest. 2017 01 03; 127(1):244-259. PMID: 27941248.
      View in: PubMed
    39. Gross S, Garofalo DC, Balderes DA, Mastracci TL, Dias JM, Perlmann T, Ericson J, Sussel L. The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2. Development. 2016 07 15; 143(14):2616-28. PMID: 27287799.
      View in: PubMed
    40. Xuan S, Sussel L. GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling. Development. 2016 Mar 01; 143(5):780-6. PMID: 26932670.
      View in: PubMed
    41. Arnes L, Akerman I, Balderes DA, Ferrer J, Sussel L. ?linc1 encodes a long noncoding RNA that regulates islet ?-cell formation and function. Genes Dev. 2016 Mar 01; 30(5):502-7. PMID: 26944677.
      View in: PubMed
    42. Borok MJ, Papaioannou VE, Sussel L. Unique functions of Gata4 in mouse liver induction and heart development. Dev Biol. 2016 Feb 15; 410(2):213-222. PMID: 26687508.
      View in: PubMed
    43. Gross S, Balderes D, Liu J, Asfaha S, Gu G, Wang TC, Sussel L. Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 15; 309(12):G975-87. PMID: 26492922.
      View in: PubMed
    44. Romer AI, Sussel L. Pancreatic islet cell development and regeneration. Curr Opin Endocrinol Diabetes Obes. 2015 Aug; 22(4):255-64. PMID: 26087337.
      View in: PubMed
    45. Roybon L, Mastracci TL, Li J, Stott SR, Leiter AB, Sussel L, Brundin P, Li JY. The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1. PLoS One. 2015; 10(6):e0128035. PMID: 26030886.
      View in: PubMed
    46. Singer RA, Arnes L, Sussel L. Noncoding RNAs in ? cell biology. Curr Opin Endocrinol Diabetes Obes. 2015 Apr; 22(2):77-85. PMID: 25692923.
      View in: PubMed
    47. Arnes L, Sussel L. Epigenetic modifications and long noncoding RNAs influence pancreas development and function. Trends Genet. 2015 Jun; 31(6):290-9. PMID: 25812926.
      View in: PubMed
    48. M?ller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Di?guez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferr?re B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tsch?p MH. Ghrelin. Mol Metab. 2015 Jun; 4(6):437-60. PMID: 26042199.
      View in: PubMed
    49. Clark JK, O'keefe A, Mastracci TL, Sussel L, Matise MP, Kucenas S. Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development. Dev Dyn. 2014 Sep; 243(9):1116-29. PMID: 24979729.
      View in: PubMed
    50. Sussel L, Niswander L. Editorial overview: developmental mechanisms, patterning and evolution. Curr Opin Genet Dev. 2014 Aug; 27:v-vii. PMID: 24998023.
      View in: PubMed
    51. Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC. ?-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care. 2014 Jun; 37(6):1751-8. PMID: 24812433.
      View in: PubMed
    52. Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC. ?-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab. 2014 Jun; 99(6):1983-92. PMID: 24712577.
      View in: PubMed
    53. Nair KS, Abel ED, Adler SG, Dyck PJ, Gardner TW, Haskins KM, Hotamisligil G, Jensen MD, Krook A, Mandarino LJ, Mitchell BD, Pessin JE, Sowers JR, Sussel L, Wareham N, Vella A. Time to look back and to look forward. Diabetes. 2014 Apr; 63(4):1169-70. PMID: 24651796.
      View in: PubMed
    54. Zhu Q, Zhao X, Zheng K, Li H, Huang H, Zhang Z, Mastracci T, Wegner M, Chen Y, Sussel L, Qiu M. Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS. Development. 2014 Feb; 141(3):548-55. PMID: 24449836.
      View in: PubMed
    55. Balderes DA, Magnuson MA, Sussel L. Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion. Genesis. 2013 Dec; 51(12):844-51. PMID: 23996959.
      View in: PubMed
    56. Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, McCracken K, Wells JM, Heller RS, Dor Y, Glaser B. Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One. 2013; 8(8):e70397. PMID: 23940571.
      View in: PubMed
    57. Mastracci TL, Lin CS, Sussel L. Generation of mice encoding a conditional allele of Nkx2.2. Transgenic Res. 2013 Oct; 22(5):965-72. PMID: 23494546.
      View in: PubMed
    58. Lugani F, Arora R, Papeta N, Patel A, Zheng Z, Sterken R, Singer RA, Caridi G, Mendelsohn C, Sussel L, Papaioannou VE, Gharavi AG. A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. PLoS Genet. 2013; 9(2):e1003206. PMID: 23437001.
      View in: PubMed
    59. Mastracci TL, Anderson KR, Papizan JB, Sussel L. Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas. PLoS Genet. 2013; 9(2):e1003278. PMID: 23408910.
      View in: PubMed
    60. Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L. Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS One. 2012; 7(12):e52026. PMID: 23251675.
      View in: PubMed
    61. Ioannou M, Serafimidis I, Arnes L, Sussel L, Singh S, Vasiliou V, Gavalas A. ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol. 2013 Feb 01; 374(1):153-63. PMID: 23142317.
      View in: PubMed
    62. Mor?n I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakic N, Garc?a-Hurtado J, Rodr?guez-Segu? S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J. Human ? cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 2012 Oct 03; 16(4):435-48. PMID: 23040067.
      View in: PubMed
    63. Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest. 2012 Oct; 122(10):3516-28. PMID: 23006325.
      View in: PubMed
    64. Talchai C, Xuan S, Lin HV, Sussel L, Accili D. Pancreatic ? cell dedifferentiation as a mechanism of diabetic ? cell failure. Cell. 2012 Sep 14; 150(6):1223-34. PMID: 22980982.
      View in: PubMed
    65. Sussel L. Advances in pancreas development: generation informs regeneration. Semin Cell Dev Biol. 2012 Aug; 23(6):655. PMID: 22749955.
      View in: PubMed
    66. Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L. Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis. 2012 Aug; 50(8):612-24. PMID: 22539496.
      View in: PubMed
    67. Mastracci TL, Sussel L. The endocrine pancreas: insights into development, differentiation, and diabetes. Wiley Interdiscip Rev Dev Biol. 2012 Sep-Oct; 1(5):609-28. PMID: 23799564.
      View in: PubMed
    68. Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L. Nkx2.2 repressor complex regulates islet ?-cell specification and prevents ?-to-a-cell reprogramming. Genes Dev. 2011 Nov 01; 25(21):2291-305. PMID: 22056672.
      View in: PubMed
    69. Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL, Sussel L. Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 01; 359(1):1-11. PMID: 21856296.
      View in: PubMed
    70. Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L. The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development. 2011 Aug; 138(15):3213-24. PMID: 21750032.
      View in: PubMed
    71. Hill JT, Anderson KR, Mastracci TL, Kaestner KH, Sussel L. Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas. BMC Bioinformatics. 2011 Feb 25; 12:62. PMID: 21352540.
      View in: PubMed
    72. Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ. Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development. 2011 Feb; 138(3):531-41. PMID: 21205797.
      View in: PubMed
    73. Lek M, Dias JM, Marklund U, Uhde CW, Kurdija S, Lei Q, Sussel L, Rubenstein JL, Matise MP, Arnold HH, Jessell TM, Ericson J. A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development. 2010 Dec; 137(23):4051-60. PMID: 21062862.
      View in: PubMed
    74. Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, Stein R. Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol. 2010 Sep; 30(17):4234-44. PMID: 20584984.
      View in: PubMed
    75. Gu C, Stein GH, Pan N, Goebbels S, H?rnberg H, Nave KA, Herrera P, White P, Kaestner KH, Sussel L, Lee JE. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab. 2010 Apr 07; 11(4):298-310. PMID: 20374962.
      View in: PubMed
    76. Anderson KR, White P, Kaestner KH, Sussel L. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol. 2009 Dec 10; 9:65. PMID: 20003319.
      View in: PubMed
    77. Hill JT, Chao CS, Anderson KR, Kaufman F, Johnson CW, Sussel L. Nkx2.2 activates the ghrelin promoter in pancreatic islet cells. Mol Endocrinol. 2010 Feb; 24(2):381-90. PMID: 19965928.
      View in: PubMed
    78. Roybon L, Mastracci TL, Ribeiro D, Sussel L, Brundin P, Li JY. GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2. Cereb Cortex. 2010 May; 20(5):1234-44. PMID: 19767311.
      View in: PubMed
    79. Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 06; 284(45):31236-48. PMID: 19759004.
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    80. Prakash N, Puelles E, Freude K, Tr?mbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development. 2009 Aug; 136(15):2545-55. PMID: 19592574.
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    81. Hill JT, Mastracci TL, Vinton C, Doyle ML, Anderson KR, Loomis ZL, Schrunk JM, Minic AD, Prabakar KR, Pugliese A, Sun Y, Smith RG, Sussel L. Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regul Pept. 2009 Oct 09; 157(1-3):51-6. PMID: 19268691.
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    82. Jedlicka P, Sui X, Sussel L, Gutierrez-Hartmann A. Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine. Am J Pathol. 2009 Apr; 174(4):1280-90. PMID: 19264912.
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    83. Chao CS, Loomis ZL, Lee JE, Sussel L. Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007 Dec 15; 312(2):523-32. PMID: 17988662.
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    84. Desai S, Loomis Z, Pugh-Bernard A, Schrunk J, Doyle MJ, Minic A, McCoy E, Sussel L. Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol. 2008 Jan 01; 313(1):58-66. PMID: 18022152.
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    85. Doyle MJ, Sussel L. Nkx2.2 regulates beta-cell function in the mature islet. Diabetes. 2007 Aug; 56(8):1999-2007. PMID: 17456846.
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    86. Doyle MJ, Loomis ZL, Sussel L. Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development. 2007 Feb; 134(3):515-23. PMID: 17202186.
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    87. Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R. FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol. 2006 Aug; 26(15):5735-43. PMID: 16847327.
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    88. Decker K, Goldman DC, Grasch CL, Sussel L. Gata6 is an important regulator of mouse pancreas development. Dev Biol. 2006 Oct 15; 298(2):415-29. PMID: 16887115.
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    89. Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development. 2006 Jan; 133(1):89-98. PMID: 16339193.
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    90. Doyle MJ, Sussel L. Engineering islets: lessons from stem cells and embryonic development. Endocrinol Metab Clin North Am. 2004 Mar; 33(1):149-62, x. PMID: 15053900.
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    91. Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):2924-9. PMID: 14970313.
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    92. Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B. The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol. 2004 Feb 01; 266(1):178-89. PMID: 14729487.
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    93. Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development. 2000 Dec; 127(24):5533-40. PMID: 11076772.
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    94. Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development. 2000 Aug; 127(16):3533-42. PMID: 10903178.
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    95. Sussel L, Marin O, Kimura S, Rubenstein JL. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999 Aug; 126(15):3359-70. PMID: 10393115.
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    96. Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15; 398(6728):622-7. PMID: 10217145.
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    97. Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI. Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese. Diabetes. 1998 Aug; 47(8):1356-8. PMID: 9703340.
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    98. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun; 125(12):2213-21. PMID: 9584121.
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    99. Qiu M, Shimamura K, Sussel L, Chen S, Rubenstein JL. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. Mech Dev. 1998 Mar; 72(1-2):77-88. PMID: 9533954.
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    100. Sussel L, Vannier D, Shore D. Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics. 1995 Nov; 141(3):873-88. PMID: 8582633.
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    101. Sussel L, Vannier D, Shore D. Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae. Mol Cell Biol. 1993 Jul; 13(7):3919-28. PMID: 8321199.
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    102. Hardy CF, Sussel L, Shore D. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 1992 May; 6(5):801-14. PMID: 1577274.
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    103. Sussel L, Shore D. Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7749-53. PMID: 1881914.
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