 Neural Cell Adhesion Molecules
"Neural Cell Adhesion Molecules" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (CD56 ANTIGEN); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)
| Descriptor ID |
D019006
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| MeSH Number(s) |
D12.776.395.550.200.250.520 D12.776.543.550.200.250.520 D23.050.301.350.250.520
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| Concept/Terms |
Neural Cell Adhesion Molecules- Neural Cell Adhesion Molecules
- NCAM
- Neural Cell Adhesion Molecule
- Cell Adhesion Molecules, Neural
- Cell Adhesion Molecule, Neural
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Below are MeSH descriptors whose meaning is more general than "Neural Cell Adhesion Molecules".
Below are MeSH descriptors whose meaning is more specific than "Neural Cell Adhesion Molecules".
This graph shows the total number of publications written about "Neural Cell Adhesion Molecules" by people in this website by year, and whether "Neural Cell Adhesion Molecules" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1995 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 4 | 4 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 | | 2015 | 1 | 2 | 3 | | 2019 | 2 | 1 | 3 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 1 | 2 | | 2023 | 0 | 1 | 1 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neural Cell Adhesion Molecules" by people in Profiles.
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Whiteley AE, Ma D, Wang L, Yu SY, Yin C, Price TT, Simon BG, Xu KR, Marsh KA, Brockman ML, Prioleau TM, Zhou KI, Cui X, Fecci PE, Jeck WR, McCall CM, Neff JL, Sipkins DA. Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis. Science. 2024 06 21; 384(6702):eadh5548.
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Sah S, Keable R, Pfundstein G, Clemens KJ, Begg D, Schachner M, Leshchyns'ka I, Sytnyk V. Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits. Cereb Cortex. 2023 09 09; 33(18):10047-10065.
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Keable R, Hu S, Pfundstein G, Kozlova I, Su F, Du X, Yang H, Gunnersen J, Schachner M, Leshchyns'ka I, Sytnyk V. The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes. Cell Mol Life Sci. 2022 Oct 17; 79(11):555.
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Kim J, Kim S, Kim H, Hwang IW, Bae S, Karki S, Kim D, Ogelman R, Bang G, Kim JY, Kajander T, Um JW, Oh WC, Ko J. MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus. Proc Natl Acad Sci U S A. 2022 01 25; 119(4).
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Kearns CA, Walker M, Ravanelli AM, Scott K, Arzbecker MR, Appel B. Zebrafish spinal cord oligodendrocyte formation requires boc function. Genetics. 2021 08 09; 218(4).
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Alliey-Rodriguez N, Grey TA, Shafee R, Asif H, Lutz O, Bolo NR, Padmanabhan J, Tandon N, Klinger M, Reis K, Spring J, Coppes L, Zeng V, Hegde RR, Hoang DT, Bannai D, Nawaz U, Henson P, Liu S, Gage D, McCarroll S, Bishop JR, Hill S, Reilly JL, Lencer R, Clementz BA, Buckley P, Glahn DC, Meda SA, Narayanan B, Pearlson G, Keshavan MS, Ivleva EI, Tamminga C, Sweeney JA, Curtis D, Badner JA, Keedy S, Rapoport J, Liu C, Gershon ES. NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis. Transl Psychiatry. 2019 09 17; 9(1):230.
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Dai J, Aoto J, S?dhof TC. Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron. 2019 06 05; 102(5):993-1008.e5.
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Angione K, Eschbach K, Smith G, Joshi C, Demarest S. Genetic testing in a cohort of patients with potential epilepsy with myoclonic-atonic seizures. Epilepsy Res. 2019 02; 150:70-77.
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Pak C, Danko T, Zhang Y, Aoto J, Anderson G, Maxeiner S, Yi F, Wernig M, S?dhof TC. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell. 2015 Sep 03; 17(3):316-28.
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Jenkins AK, Paterson C, Wang Y, Hyde TM, Kleinman JE, Law AJ. Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging. Mol Psychiatry. 2016 May; 21(5):701-6.
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