 DEAD-box RNA Helicases
"DEAD-box RNA Helicases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large family of RNA helicases that share a common protein motif with the single letter amino acid sequence D-E-A-D (Asp-Glu-Ala-Asp). In addition to RNA helicase activity, members of the DEAD-box family participate in other aspects of RNA metabolism and regulation of RNA function.
| Descriptor ID |
D053487
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| MeSH Number(s) |
D08.811.913.696.445.735.720.249
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| Concept/Terms |
DEAD-box RNA Helicases- DEAD-box RNA Helicases
- DEAD box RNA Helicases
- Helicases, DEAD-box RNA
- RNA Helicases, DEAD-box
DEAD Box Helicase p68- DEAD Box Helicase p68
- p68 RNA Helicase
- Helicase, p68 RNA
- RNA Helicase, p68
- p68 DEAD Box Protein
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Below are MeSH descriptors whose meaning is more general than "DEAD-box RNA Helicases".
Below are MeSH descriptors whose meaning is more specific than "DEAD-box RNA Helicases".
This graph shows the total number of publications written about "DEAD-box RNA Helicases" by people in this website by year, and whether "DEAD-box RNA Helicases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 1 | 0 | 1 | | 2009 | 2 | 0 | 2 | | 2010 | 3 | 2 | 5 | | 2011 | 1 | 1 | 2 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2014 | 3 | 0 | 3 | | 2015 | 4 | 0 | 4 | | 2016 | 1 | 0 | 1 | | 2017 | 5 | 1 | 6 | | 2018 | 4 | 0 | 4 | | 2019 | 2 | 0 | 2 | | 2020 | 1 | 1 | 2 | | 2021 | 2 | 1 | 3 | | 2022 | 1 | 0 | 1 | | 2024 | 3 | 1 | 4 | | 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "DEAD-box RNA Helicases" by people in Profiles.
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Briney CA, Henriksen JC, Lin C, Jones LA, Benner L, Rains AB, Gutierrez R, Gafken PR, Rissland OS. Muskelin is a substrate adaptor of the highly regulated Drosophila embryonic CTLH E3 ligase. EMBO Rep. 2025 Mar; 26(6):1647-1669.
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Schultz KAP, MacFarland SP, Perrino MR, Mitchell SG, Kamihara J, Nelson AT, Mallinger PHR, Brzezinski JJ, Maxwell KN, Woodward ER, Gallinger B, Kim SY, Greer MC, Schneider KW, Scollon SR, Das A, Wasserman JD, Eng C, Malkin D, Foulkes WD, Michaeli O, Bauer AJ, Stewart DR. Update on Pediatric Surveillance Recommendations for PTEN Hamartoma Tumor Syndrome, DICER1-Related Tumor Predisposition, and Tuberous Sclerosis Complex. Clin Cancer Res. 2025 Jan 17; 31(2):234-244.
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Nakajima R, Zhou Y, Shirasawa M, Nishimura N, Zhao L, Fikriyanti M, Kamiya Y, Iwanaga R, Bradford AP, Shinmyozu K, Nishibuchi G, Nakayama JI, Kurayoshi K, Araki K, Ohtani K. DEAD/H Box 5 (DDX5) Augments E2F1-Induced Cell Death Independent of the Tumor Suppressor p53. Int J Mol Sci. 2024 Dec 10; 25(24).
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Yanas A, Shweta H, Owens MC, Liu KF, Goldman YE. RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity. Curr Biol. 2024 Dec 16; 34(24):5714-5727.e6.
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Owens MC, Shen H, Yanas A, Mendoza-Figueroa MS, Lavorando E, Wei X, Shweta H, Tang HY, Goldman YE, Liu KF. Specific catalytically impaired DDX3X mutants form sexually dimorphic hollow condensates. Nat Commun. 2024 11 05; 15(1):9553.
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Alsina FC, Lupan BM, Lin LJ, Musso CM, Mosti F, Newman CR, Wood LM, Suzuki A, Agostino M, Moore JK, Silver DL. The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton. Cell Rep. 2024 09 24; 43(9):114666.
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Shen H, Yanas A, Owens MC, Zhang C, Fritsch C, Fare CM, Copley KE, Shorter J, Goldman YE, Liu KF. Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. Mol Cell. 2022 07 21; 82(14):2588-2603.e9.
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Golmard L, Vasta LM, Duflos V, Corsini C, Dubois d'Enghien C, McMaster ML, Harney LA, Carr AG, Ling A, Dijoud F, Gauthier A, Miettinen M, Cost NG, Gauthier-Villars M, Orbach D, Irtan S, Haouy S, Schultz KA, Stoppa-Lyonnet D, Coupier I, Stewart DR, Sirvent N. Testicular Sertoli cell tumour and potentially testicular Leydig cell tumour are features of DICER1 syndrome. J Med Genet. 2022 04; 59(4):346-350.
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Han DS, Chalmers DJ, Greffe B, Garrington T, Partrick D, Lovell M, Schneider KW, Cost NG. A Cystic Renal Mass in the Setting of a Pneumothorax: More Than Meets the Eye? Urology. 2021 08; 154:275-277.
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Liu APY, Kelsey MM, Sabbaghian N, Park SH, Deal CL, Esbenshade AJ, Ploner O, Peet A, Traunecker H, Ahmed YHE, Zacharin M, Tiulpakov A, Lapshina AM, Walter AW, Dutta P, Rai A, Korbonits M, de Kock L, Nichols KE, Foulkes WD, Priest JR. Clinical Outcomes and Complications of Pituitary Blastoma. J Clin Endocrinol Metab. 2021 01 23; 106(2):351-363.
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