 F-Box Proteins
"F-Box Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.
| Descriptor ID |
D044783
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| MeSH Number(s) |
D12.776.157.169
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| Concept/Terms |
F-Box Proteins- F-Box Proteins
- F Box Proteins
- F-Box Domain Protein
- Domain Protein, F-Box
- F Box Domain Protein
- Protein, F-Box Domain
- F-Box Protein Family
- F Box Protein Family
- Protein Family, F-Box
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Below are MeSH descriptors whose meaning is more general than "F-Box Proteins".
Below are MeSH descriptors whose meaning is more specific than "F-Box Proteins".
This graph shows the total number of publications written about "F-Box Proteins" by people in this website by year, and whether "F-Box Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 | | 2012 | 2 | 1 | 3 | | 2013 | 2 | 0 | 2 | | 2014 | 1 | 2 | 3 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 2 | 3 | | 2019 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "F-Box Proteins" by people in Profiles.
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Affandi T, Haas A, Ohm AM, Wright GM, Black JC, Reyland ME. PKCd Regulates Chromatin Remodeling and DNA Repair through SIRT6. Mol Cancer Res. 2024 02 01; 22(2):181-196.
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Gleason E, Malik K, Sannar E, Kamara D, Serrano V, Augustyn M. Challenging Case: A Multidisciplinary Approach to Demystifying Chronic Sleep Impairment in an Infant with a Complex Medical and Behavioral Profile. J Dev Behav Pediatr. 2024 Mar-Apr 01; 45(2):e176-e179.
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Mills CA, Wang X, Bhatt DP, Grimsrud PA, Matson JP, Lahiri D, Burke DJ, Cook JG, Hirschey MD, Emanuele MJ. Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control. Mol Cell Biol. 2021 01 25; 41(2).
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Ferdoush J, Sen R, Durairaj G, Barman P, Kaja A, Guha S, Bhaumik SR. An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function. Mol Cell Biol. 2020 03 16; 40(7).
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Jansen S, van der Werf IM, Innes AM, Afenjar A, Agrawal PB, Anderson IJ, Atwal PS, van Binsbergen E, van den Boogaard MJ, Castiglia L, Coban-Akdemir ZH, van Dijck A, Doummar D, van Eerde AM, van Essen AJ, van Gassen KL, Guillen Sacoto MJ, van Haelst MM, Iossifov I, Jackson JL, Judd E, Kaiwar C, Keren B, Klee EW, Klein Wassink-Ruiter JS, Meuwissen ME, Monaghan KG, de Munnik SA, Nava C, Ockeloen CW, Pettinato R, Racher H, Rinne T, Romano C, Sanders VR, Schnur RE, Smeets EJ, Stegmann APA, Stray-Pedersen A, Sweetser DA, Terhal PA, Tveten K, VanNoy GE, de Vries PF, Waxler JL, Willing M, Pfundt R, Veltman JA, Kooy RF, Vissers LELM, de Vries BBA. De novo variants in FBXO11 cause a syndromic form of intellectual disability with behavioral problems and dysmorphisms. Eur J Hum Genet. 2019 05; 27(5):738-746.
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Li Y, Jin K, Bunker E, Zhang X, Luo X, Liu X, Hao B. Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCFFBXO31 ubiquitin ligase. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):319-324.
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Sheikh MO, Thieker D, Chalmers G, Schafer CM, Ishihara M, Azadi P, Woods RJ, Glushka JN, Bendiak B, Prestegard JH, West CM. O2 sensing-associated glycosylation exposes the F-box-combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases. J Biol Chem. 2017 11 17; 292(46):18897-18915.
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Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016 Oct 14; 44(18):8855-8869.
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Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T. Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry. Cell. 2016 Jun 30; 166(1):167-80.
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Zhu L, Li Q, Wong SH, Huang M, Klein BJ, Shen J, Ikenouye L, Onishi M, Schneidawind D, Buechele C, Hansen L, Duque-Afonso J, Zhu F, Martin GM, Gozani O, Majeti R, Kutateladze TG, Cleary ML. ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. Cancer Discov. 2016 07; 6(7):770-83.
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