Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Bruce H Appel

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-3465

    Collapse Research 
    Collapse research activities and funding
    R21MH140123     (APPEL, BRUCE H)Jun 1, 2025 - May 31, 2027
    NIH
    A synaptogenic adhesion code for myelin specificity
    Role: Principal Investigator
    R01NS124166     (FRANCO, SANTOS JOE)Jul 1, 2022 - May 31, 2027
    NIH
    Temporal and Spatial Control of Oligodendrocyte Fate Specification
    Role: Co-Principal Investigator
    T32GM141742     (MOORE, JEFFREY KYLE)Jul 1, 2021 - Jun 30, 2026
    NIH
    Predoctoral Training in the Genetics of Development, Disease and Regeneration
    Role: Co-Principal Investigator
    R35NS122191     (APPEL, BRUCE H)May 15, 2021 - Apr 30, 2029
    NIH
    Mechanisms of Developmental Myelination
    Role: Principal Investigator
    R21NS110213     (APPEL, BRUCE H)Sep 1, 2018 - Aug 31, 2020
    NIH
    Mechanisms of Neuron-Glia Synaptic Communication
    Role: Principal Investigator
    R01NS095679     (APPEL, BRUCE H)Sep 15, 2015 - Jun 30, 2024
    NIH
    Mechanisms guiding axon selection for myelination in vivo
    Role: Principal Investigator
    R01NS065788     (APPEL, BRUCE H)Aug 1, 2009 - Jul 31, 2015
    NIH
    Genetic Screen for Zebrafish Neural Defect Mutants
    Role: Principal Investigator
    R01NS062717     (APPEL, BRUCE H)May 1, 2009 - Apr 30, 2015
    NIH
    Genetic Analysis of Peripheral Nerve Development
    Role: Principal Investigator
    R03MH076346     (APPEL, BRUCE H)Sep 15, 2005 - Sep 14, 2006
    NIH
    A Screen For Drugs:Promote Oligodendrocyte Formatio(RMI)
    Role: Principal Investigator
    R01NS046668     (APPEL, BRUCE H)Jul 1, 2003 - Feb 29, 2020
    NIH
    Genetic Analysis of Oligodendrocyte Specification
    Role: Principal Investigator
    R01HD038118     (APPEL, BRUCE H)Jul 8, 1999 - Jun 30, 2005
    NIH
    GENETIC ANALYSIS OF MIDLINE CELL FATE SPECIFICATION
    Role: Principal Investigator
    F32HD007658     (APPEL, BRUCE H)Oct 20, 1993
    NIH
    SPECIFICATION OF MOTONEURON DEVELOPMENT IN ZEBRAFISH
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tran LN, Shinde A, Schuster KH, Sabaawy A, Dale E, Welch MJ, Isner TJ, Nunez SA, Garc?a-Moreno F, Sagerstr?m CG, Appel BH, Franco SJ. Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence. Genes Dev. 2025 May 22. PMID: 40404401.
      View in: PubMed
    2. Russell K, Kearns CA, Walker MB, Knoeckel CS, Ribera AB, Doll CA, Appel B. Bdnf-Ntrk2 Signaling Promotes but is not Essential for Spinal Cord Myelination in Larval Zebrafish. bioRxiv. 2025 Feb 21. PMID: 40027741.
      View in: PubMed
    3. Tran LN, Shinde A, Schuster KH, Sabaawy A, Dale E, Welch MJ, Isner TJ, Nunez SA, Garc?a-Moreno F, Sagerstr?m CG, Appel BH, Franco SJ. Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence. bioRxiv. 2025 Jan 21. PMID: 39896669.
      View in: PubMed
    4. Ranard KM, Appel B. Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment. J Lipid Res. 2025 Jan; 66(1):100716. PMID: 39608569.
      View in: PubMed
    5. Carey NJ, Doll CA, Appel B. Oligodendrocytes use postsynaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes. bioRxiv. 2024 Nov 09. PMID: 39574762.
      View in: PubMed
    6. Bromley-Coolidge S, Iruegas D, Appel B. Cspg4 sculpts oligodendrocyte precursor cell morphology. Differentiation. 2024 Nov-Dec; 140:100819. PMID: 39566199.
      View in: PubMed
    7. Bromley-Coolidge S, Iruegas D, Appel B. Cspg4 sculpts oligodendrocyte precursor cell morphology. bioRxiv. 2024 Aug 08. PMID: 39149260.
      View in: PubMed
    8. Miles KD, Barker CM, Russell KP, Appel BH, Doll CA. Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome. J Neurosci. 2024 Jul 31; 44(31). PMID: 38969506.
      View in: PubMed
    9. Ranard KM, Appel B. Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment. bioRxiv. 2024 Jul 30. PMID: 39131270.
      View in: PubMed
    10. Stenzel A, Mumme-Monheit A, Sucharov J, Walker M, Mitchell JM, Appel B, Nichols JT. Distinct and redundant roles for zebrafish her genes during mineralization and craniofacial patterning. Front Endocrinol (Lausanne). 2022; 13:1033843. PMID: 36578958.
      View in: PubMed
    11. Kearns CA, Walker M, Ravanelli AM, Scott K, Arzbecker MR, Appel B. Zebrafish spinal cord oligodendrocyte formation requires boc function. Genetics. 2021 08 09; 218(4). PMID: 34057474.
      View in: PubMed
    12. Doll CA, Scott K, Appel B. Fmrp regulates oligodendrocyte lineage cell specification and differentiation. Glia. 2021 10; 69(10):2349-2361. PMID: 34110049.
      View in: PubMed
    13. Terhune EA, Cuevas MT, Monley AM, Wethey CI, Chen X, Cattell MV, Bayrak MN, Bland MR, Sutphin B, Trahan GD, Taylor MRG, Niswander LA, Jones KL, Baschal EE, Antunes L, Dobbs M, Gurnett C, Appel B, Gray R, Hadley Miller N. Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish. Hum Mutat. 2021 04; 42(4):392-407. PMID: 33382518.
      View in: PubMed
    14. Yergert KM, Doll CA, O'Rouke R, Hines JH, Appel B. Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo. PLoS Biol. 2021 01; 19(1):e3001053. PMID: 33439856.
      View in: PubMed
    15. Jewett CE, Appel BH, Prekeris R. The Rab11 effectors Fip5 and Fip1 regulate zebrafish intestinal development. Biol Open. 2020 10 23; 9(10). PMID: 32973079.
      View in: PubMed
    16. Scott K, O'Rourke R, Gillen A, Appel B. Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating the Shh signaling response. Development. 2020 08 27; 147(16). PMID: 32680935.
      View in: PubMed
    17. Doll CA, Yergert KM, Appel BH. The RNA binding protein fragile X mental retardation protein promotes myelin sheath growth. Glia. 2020 03; 68(3):495-508. PMID: 31626382.
      View in: PubMed
    18. Hughes AN, Appel B. Oligodendrocytes express synaptic proteins that modulate myelin sheath formation. Nat Commun. 2019 09 11; 10(1):4125. PMID: 31511515.
      View in: PubMed
    19. Ravanelli AM, Kearns CA, Powers RK, Wang Y, Hines JH, Donaldson MJ, Appel B. Sequential specification of oligodendrocyte lineage cells by distinct levels of Hedgehog and Notch signaling. Dev Biol. 2018 12 15; 444(2):93-106. PMID: 30347186.
      View in: PubMed
    20. Mathews ES, Appel B. Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling. J Neurosci. 2016 07 20; 36(29):7628-39. PMID: 27445141.
      View in: PubMed
    21. Appel B. Myelination: Both Mindful and Mindless? Curr Biol. 2016 06 06; 26(11):R468-70. PMID: 27269724.
      View in: PubMed
    22. Hudish LI, Galati DF, Ravanelli AM, Pearson CG, Huang P, Appel B. miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development. 2016 07 01; 143(13):2292-304. PMID: 27226318.
      View in: PubMed
    23. Hughes EG, Appel B. The cell biology of CNS myelination. Curr Opin Neurobiol. 2016 08; 39:93-100. PMID: 27152449.
      View in: PubMed
    24. Mathews ES, Appel B. Oligodendrocyte differentiation. Methods Cell Biol. 2016; 134:69-96. PMID: 27312491.
      View in: PubMed
    25. Ravanelli AM, Appel B. Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitment. Genes Dev. 2015 Dec 01; 29(23):2504-15. PMID: 26584621.
      View in: PubMed
    26. Kearns CA, Ravanelli AM, Cooper K, Appel B. Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. J Neurosci. 2015 Nov 04; 35(44):14861-71. PMID: 26538655.
      View in: PubMed
    27. Hines JH, Ravanelli AM, Schwindt R, Scott EK, Appel B. Neuronal activity biases axon selection for myelination in vivo. Nat Neurosci. 2015 May; 18(5):683-9. PMID: 25849987.
      View in: PubMed
    28. Hudish LI, Appel B. microRNA regulation of neural precursor self-renewal and differentiation. Neurogenesis (Austin). 2014; 1(1):e976018. PMID: 27502270.
      View in: PubMed
    29. Quintana AM, Geiger EA, Achilly N, Rosenblatt DS, Maclean KN, Stabler SP, Artinger KB, Appel B, Shaikh TH. Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating mmachc expression. Dev Biol. 2014 Dec 01; 396(1):94-106. PMID: 25281006.
      View in: PubMed
    30. Blasky AJ, Pan L, Moens CB, Appel B. Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination. Dev Dyn. 2014 Dec; 243(12):1511-23. PMID: 25130183.
      View in: PubMed
    31. Mathews ES, Mawdsley DJ, Walker M, Hines JH, Pozzoli M, Appel B. Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression. J Neurosci. 2014 Feb 26; 34(9):3402-12. PMID: 24573296.
      View in: PubMed
    32. Wang Y, Pan L, Moens CB, Appel B. Notch3 establishes brain vascular integrity by regulating pericyte number. Development. 2014 Jan; 141(2):307-17. PMID: 24306108.
      View in: PubMed
    33. Hudish LI, Blasky AJ, Appel B. miR-219 regulates neural precursor differentiation by direct inhibition of apical par polarity proteins. Dev Cell. 2013 Nov 25; 27(4):387-98. PMID: 24239515.
      View in: PubMed
    34. Langworthy MM, Appel B. Schwann cell myelination requires Dynein function. Neural Dev. 2012 Nov 20; 7:37. PMID: 23167977.
      View in: PubMed
    35. Snyder JL, Kearns CA, Appel B. Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Dev. 2012 May 03; 7:15. PMID: 22554084.
      View in: PubMed
    36. Simmons T, Appel B. Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish. PLoS One. 2012; 7(2):e32317. PMID: 22384214.
      View in: PubMed
    37. Jao LE, Appel B, Wente SR. A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization. Development. 2012 Apr; 139(7):1316-26. PMID: 22357925.
      View in: PubMed
    38. Zannino DA, Sagerstr?m CG, Appel B. olig2-Expressing hindbrain cells are required for migrating facial motor neurons. Dev Dyn. 2012 Feb; 241(2):315-26. PMID: 22275004.
      View in: PubMed
    39. Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J Biol Chem. 2012 Jan 06; 287(2):1600-8. PMID: 22128191.
      View in: PubMed
    40. Takada N, Appel B. swap70 promotes neural precursor cell cycle exit and oligodendrocyte formation. Mol Cell Neurosci. 2011 Nov; 48(3):225-35. PMID: 21875669.
      View in: PubMed
    41. Takada N, Appel B. Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen. Dev Dyn. 2010 Jul; 239(7):2041-7. PMID: 20549738.
      View in: PubMed
    42. Takada N, Kucenas S, Appel B. Sox10 is necessary for oligodendrocyte survival following axon wrapping. Glia. 2010 Jun; 58(8):996-1006. PMID: 20229602.
      View in: PubMed
    43. Zhao X, He X, Han X, Yu Y, Ye F, Chen Y, Hoang T, Xu X, Mi QS, Xin M, Wang F, Appel B, Lu QR. MicroRNA-mediated control of oligodendrocyte differentiation. Neuron. 2010 Mar 11; 65(5):612-26. PMID: 20223198.
      View in: PubMed
    44. Kucenas S, Wang WD, Knapik EW, Appel B. A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord. J Neurosci. 2009 Dec 02; 29(48):15187-94. PMID: 19955371.
      View in: PubMed
    45. Roberts RK, Appel B. Apical polarity protein PrkCi is necessary for maintenance of spinal cord precursors in zebrafish. Dev Dyn. 2009 Jul; 238(7):1638-48. PMID: 19449304.
      View in: PubMed
    46. Zannino DA, Appel B. Olig2+ precursors produce abducens motor neurons and oligodendrocytes in the zebrafish hindbrain. J Neurosci. 2009 Feb 25; 29(8):2322-33. PMID: 19244509.
      View in: PubMed
    47. Kim H, Shin J, Kim S, Poling J, Park HC, Appel B. Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos. Dev Dyn. 2008 Aug; 237(8):2081-9. PMID: 18627107.
      View in: PubMed
    48. Kucenas S, Snell H, Appel B. nkx2.2a promotes specification and differentiation of a myelinating subset of oligodendrocyte lineage cells in zebrafish. Neuron Glia Biol. 2008 May; 4(2):71-81. PMID: 19737431.
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    49. McFarland KA, Topczewska JM, Weidinger G, Dorsky RI, Appel B. Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum. Dev Biol. 2008 Jun 01; 318(1):162-71. PMID: 18423594.
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    50. Qu X, Jia H, Garrity DM, Tompkins K, Batts L, Appel B, Zhong TP, Baldwin HS. Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Dev Biol. 2008 May 15; 317(2):486-96. PMID: 18407257.
      View in: PubMed
    51. Kucenas S, Takada N, Park HC, Woodruff E, Broadie K, Appel B. CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nat Neurosci. 2008 Feb; 11(2):143-51. PMID: 18176560.
      View in: PubMed
    52. Sarmah B, Winfrey VP, Olson GE, Appel B, Wente SR. A role for the inositol kinase Ipk1 in ciliary beating and length maintenance. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19843-8. PMID: 18056639.
      View in: PubMed
    53. Park HC, Shin J, Roberts RK, Appel B. An olig2 reporter gene marks oligodendrocyte precursors in the postembryonic spinal cord of zebrafish. Dev Dyn. 2007 Dec; 236(12):3402-7. PMID: 17969181.
      View in: PubMed
    54. Shin J, Poling J, Park HC, Appel B. Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development. 2007 May; 134(10):1911-20. PMID: 17442701.
      View in: PubMed
    55. Kirby BB, Takada N, Latimer AJ, Shin J, Carney TJ, Kelsh RN, Appel B. In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Nat Neurosci. 2006 Dec; 9(12):1506-11. PMID: 17099706.
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    56. Latimer AJ, Appel B. Notch signaling regulates midline cell specification and proliferation in zebrafish. Dev Biol. 2006 Oct 15; 298(2):392-402. PMID: 16876779.
      View in: PubMed
    57. Ng AN, de Jong-Curtain TA, Mawdsley DJ, White SJ, Shin J, Appel B, Dong PD, Stainier DY, Heath JK. Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Dev Biol. 2005 Oct 01; 286(1):114-35. PMID: 16125164.
      View in: PubMed
    58. Park HC, Boyce J, Shin J, Appel B. Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function. J Neurosci. 2005 Jul 20; 25(29):6836-44. PMID: 16033893.
      View in: PubMed
    59. Sarmah B, Latimer AJ, Appel B, Wente SR. Inositol polyphosphates regulate zebrafish left-right asymmetry. Dev Cell. 2005 Jul; 9(1):133-45. PMID: 15992547.
      View in: PubMed
    60. Latimer AJ, Shin J, Appel B. her9 promotes floor plate development in zebrafish. Dev Dyn. 2005 Apr; 232(4):1098-104. PMID: 15739223.
      View in: PubMed
    61. Park HC, Shin J, Appel B. Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development. 2004 Dec; 131(23):5959-69. PMID: 15539490.
      View in: PubMed
    62. Garg R, Geng CD, Miller JL, Callens S, Tang X, Appel B, Xu B. Molecular cloning and characterization of the catalytic domain of zebrafish homologue of the ataxia-telangiectasia mutated gene. Mol Cancer Res. 2004 Jun; 2(6):348-53. PMID: 15235110.
      View in: PubMed
    63. Appel B, Marasco P, McClung LE, Latimer AJ. lunatic fringe regulates Delta-Notch induction of hypochord in zebrafish. Dev Dyn. 2003 Oct; 228(2):281-6. PMID: 14518000.
      View in: PubMed
    64. Park HC, Appel B. Delta-Notch signaling regulates oligodendrocyte specification. Development. 2003 Aug; 130(16):3747-55. PMID: 12835391.
      View in: PubMed
    65. Shin J, Park HC, Topczewska JM, Mawdsley DJ, Appel B. Neural cell fate analysis in zebrafish using olig2 BAC transgenics. Methods Cell Sci. 2003; 25(1-2):7-14. PMID: 14739582.
      View in: PubMed
    66. Park HC, Mehta A, Richardson JS, Appel B. olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Dev Biol. 2002 Aug 15; 248(2):356-68. PMID: 12167410.
      View in: PubMed
    67. Latimer AJ, Dong X, Markov Y, Appel B. Delta-Notch signaling induces hypochord development in zebrafish. Development. 2002 Jun; 129(11):2555-63. PMID: 12015285.
      View in: PubMed
    68. Appel B, Chitnis A. Neurogenesis and specification of neuronal identity. Results Probl Cell Differ. 2002; 40:237-51. PMID: 12353479.
      View in: PubMed
    69. Appel B, Givan LA, Eisen JS. Delta-Notch signaling and lateral inhibition in zebrafish spinal cord development. BMC Dev Biol. 2001; 1:13. PMID: 11495630.
      View in: PubMed
    70. Appel B. Zebrafish neural induction and patterning. Dev Dyn. 2000 Oct; 219(2):155-68. PMID: 11002336.
      View in: PubMed
    71. Appel B, Fritz A, Westerfield M, Grunwald DJ, Eisen JS, Riley BB. Delta-mediated specification of midline cell fates in zebrafish embryos. Curr Biol. 1999 Mar 11; 9(5):247-56. PMID: 10074451.
      View in: PubMed
    72. Appel B, Eisen JS. Regulation of neuronal specification in the zebrafish spinal cord by Delta function. Development. 1998 Feb; 125(3):371-80. PMID: 9425133.
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    73. Moens CB, Yan YL, Appel B, Force AG, Kimmel CB. valentino: a zebrafish gene required for normal hindbrain segmentation. Development. 1996 Dec; 122(12):3981-90. PMID: 9012518.
      View in: PubMed
    74. Appel B, Korzh V, Glasgow E, Thor S, Edlund T, Dawid IB, Eisen JS. Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Development. 1995 Dec; 121(12):4117-25. PMID: 8575312.
      View in: PubMed
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