 Receptors, Notch
"Receptors, Notch" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.
| Descriptor ID |
D051880
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| MeSH Number(s) |
D12.776.543.750.725 D12.776.930.770
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Receptors, Notch".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Notch".
This graph shows the total number of publications written about "Receptors, Notch" by people in this website by year, and whether "Receptors, Notch" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 7 | 7 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 2 | 3 | | 2006 | 3 | 0 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 2 | 2 | 4 | | 2009 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2011 | 3 | 0 | 3 | | 2012 | 3 | 1 | 4 | | 2013 | 5 | 1 | 6 | | 2014 | 4 | 1 | 5 | | 2015 | 5 | 0 | 5 | | 2016 | 2 | 1 | 3 | | 2017 | 1 | 3 | 4 | | 2018 | 3 | 3 | 6 | | 2019 | 2 | 1 | 3 | | 2020 | 3 | 0 | 3 | | 2022 | 1 | 2 | 3 | | 2023 | 0 | 2 | 2 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, Notch" by people in Profiles.
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Como CN, O'Rourke R, Winkler C, Mitchell D, Tran L, Lorberbaum D, Sussel L, Franco S, Siegenthaler J. Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2. Cell Rep. 2025 May 27; 44(5):115637.
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Brinkley DM, Smith KC, Fink EC, Kwen W, Yoo NH, West Z, Sullivan NL, Farthing AS, Hale VA, Goutte C. Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells. Genetics. 2024 Jul 08; 227(3).
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Tran LN, Loew SK, Franco SJ. Notch Signaling Plays a Dual Role in Regulating the Neuron-to-Oligodendrocyte Switch in the Developing Dorsal Forebrain. J Neurosci. 2023 10 11; 43(41):6854-6871.
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Vladar EK, Kunimoto K, Rojas-Hernandez LS, Spano JM, Sellers ZM, Joo NS, Cooney RA, Axelrod JD, Milla CE. Notch signaling inactivation by small molecule ?-secretase inhibitors restores the multiciliated cell population in the airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2023 06 01; 324(6):L771-L782.
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Stenzel A, Mumme-Monheit A, Sucharov J, Walker M, Mitchell JM, Appel B, Nichols JT. Distinct and redundant roles for zebrafish her genes during mineralization and craniofacial patterning. Front Endocrinol (Lausanne). 2022; 13:1033843.
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Ojha R, Tantray I, Rimal S, Mitra S, Cheshier S, Lu B. Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells. Dev Cell. 2022 01 24; 57(2):260-276.e9.
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Gjorevski N, Nikolaev M, Brown TE, Mitrofanova O, Brandenberg N, DelRio FW, Yavitt FM, Liberali P, Anseth KS, Lutolf MP. Tissue geometry drives deterministic organoid patterning. Science. 2022 Jan 07; 375(6576):eaaw9021.
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Kobia FM, Preusse K, Dai Q, Weaver N, Hass MR, Chaturvedi P, Stein SJ, Pear WS, Yuan Z, Kovall RA, Kuang Y, Eafergen N, Sprinzak D, Gebelein B, Brunskill EW, Kopan R. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. PLoS Biol. 2020 10; 18(10):e3000850.
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Bohin N, Keeley TM, Carulli AJ, Walker EM, Carlson EA, Gao J, Aifantis I, Siebel CW, Rajala MW, Myers MG, Jones JC, Brindley CD, Dempsey PJ, Samuelson LC. Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition. Stem Cell Reports. 2020 07 14; 15(1):156-170.
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Lorberbaum DS, Sussel L. A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development. Dev Cell. 2020 03 23; 52(6):681-682.
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