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Santos J. Franco

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-3124

    Collapse Biography 
    Collapse education and training
    Colorado State University, Fort Collins, COB.S.05/2000Biological Sciences
    University of Wisconsin, Madison, WIPh.D.08/2005Cellular and Molecular Biology
    The Scripps Research Institute, La Jolla, CAPostdoctoral07/2013Developmental Neuroscience

    Collapse Research 
    Collapse research activities and funding
    R01NS124166     (FRANCO, SANTOS JOE)Jul 1, 2022 - May 31, 2027
    NIH
    Temporal and Spatial Control of Oligodendrocyte Fate Specification
    Role: Principal Investigator
    R01NS109239     (FRANCO, SANTOS JOE)Feb 1, 2020 - Nov 30, 2023
    NIH
    Mechanisms of Oligodendrocyte Fate Specification in the Developing Neocortex
    Role: Principal Investigator
    R56NS109239     (FRANCO, SANTOS JOE)Dec 15, 2018 - Nov 30, 2019
    NIH
    Mechanisms of Oligodendrocyte Fate Specification in the Developing Neocortex
    Role: Principal Investigator
    F32NS060355     (FRANCO, SANTOS JOE)Aug 1, 2009 - Jul 31, 2012
    NIH
    Mechanisms of Reelin Action on neuronal Migration During Neocortical Lamination
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Tran LN, Loew SK, Franco SJ. Notch Signaling Plays a Dual Role in Regulating the Neuron-to-Oligodendrocyte Switch in the Developing Dorsal Forebrain. J Neurosci. 2023 10 11; 43(41):6854-6871. PMID: 37640551.
      View in: PubMed
    2. Kleinjan MS, Buchta WC, Ogelman R, Hwang IW, Kuwajima M, Hubbard DD, Kareemo DJ, Prikhodko O, Olah SL, Gomez Wulschner LE, Abraham WC, Franco SJ, Harris KM, Chan Oh W, Kennedy MJ. Dually innervated dendritic spines develop in the absence of excitatory activity and resist plasticity through tonic inhibitory crosstalk. Neuron. 2023 May 03; 111(9):1517. PMID: 37141861.
      View in: PubMed
    3. Kleinjan MS, Buchta WC, Ogelman R, Hwang IW, Kuwajima M, Hubbard DD, Kareemo DJ, Prikhodko O, Olah SL, Gomez Wulschner LE, Abraham WC, Franco SJ, Harris KM, Oh WC, Kennedy MJ. Dually innervated dendritic spines develop in the absence of excitatory activity and resist plasticity through tonic inhibitory crosstalk. Neuron. 2023 02 01; 111(3):362-371.e6. PMID: 36395772.
      View in: PubMed
    4. Hoff KJ, Aiken JE, Gutierrez MA, Franco SJ, Moore JK. TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics. Elife. 2022 05 05; 11. PMID: 35511030.
      View in: PubMed
    5. Gutierrez MA, Dwyer BE, Franco SJ. Csmd2 Is a Synaptic Transmembrane Protein that Interacts with PSD-95 and Is Required for Neuronal Maturation. eNeuro. 2019 Mar/Apr; 6(2). PMID: 31068362.
      View in: PubMed
    6. Winkler CC, Franco SJ. Loss of Shh signaling in the neocortex reveals heterogeneous cell recovery responses from distinct oligodendrocyte populations. Dev Biol. 2019 08 01; 452(1):55-65. PMID: 31071314.
      View in: PubMed
    7. Fregoso SP, Dwyer BE, Franco SJ. Lmx1a drives Cux2 expression in the cortical hem through activation of a conserved intronic enhancer. Development. 2019 03 07; 146(5). PMID: 30770393.
      View in: PubMed
    8. Winkler CC, Yabut OR, Fregoso SP, Gomez HG, Dwyer BE, Pleasure SJ, Franco SJ. The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog. J Neurosci. 2018 06 06; 38(23):5237-5250. PMID: 29739868.
      View in: PubMed
    9. Kazmierczak M, Kazmierczak P, Peng AW, Harris SL, Shah P, Puel JL, Lenoir M, Franco SJ, Schwander M. Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner. J Neurosci. 2017 03 29; 37(13):3447-3464. PMID: 28209736.
      View in: PubMed
    10. Martinez-Garay I, Gil-Sanz C, Franco SJ, Espinosa A, Moln?r Z, Mueller U. Cadherin 2/4 signaling via PTP1B and catenins is crucial for nucleokinesis during radial neuronal migration in the neocortex. Development. 2016 06 15; 143(12):2121-34. PMID: 27151949.
      View in: PubMed
    11. Gil-Sanz C, Espinosa A, Fregoso SP, Bluske KK, Cunningham CL, Martinez-Garay I, Zeng H, Franco SJ, M?ller U. Lineage Tracing Using Cux2-Cre and Cux2-CreERT2 Mice. Neuron. 2015 May 20; 86(4):1091-1099. PMID: 25996136.
      View in: PubMed
    12. Trotter J, Lee GH, Kazdoba TM, Crowell B, Domogauer J, Mahoney HM, Franco SJ, M?ller U, Weeber EJ, D'Arcangelo G. Dab1 is required for synaptic plasticity and associative learning. J Neurosci. 2013 Sep 25; 33(39):15652-68. PMID: 24068831.
      View in: PubMed
    13. Gil-Sanz C, Franco SJ, Martinez-Garay I, Espinosa A, Harkins-Perry S, M?ller U. Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues. Neuron. 2013 Aug 07; 79(3):461-77. PMID: 23931996.
      View in: PubMed
    14. Brunne B, Franco S, Bouch? E, Herz J, Howell BW, Pahle J, M?ller U, May P, Frotscher M, Bock HH. Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice. Glia. 2013 Aug; 61(8):1347-63. PMID: 23828756.
      View in: PubMed
    15. Franco SJ, M?ller U. Shaping our minds: stem and progenitor cell diversity in the mammalian neocortex. Neuron. 2013 Jan 09; 77(1):19-34. PMID: 23312513.
      View in: PubMed
    16. Franco SJ, Gil-Sanz C, Martinez-Garay I, Espinosa A, Harkins-Perry SR, Ramos C, M?ller U. Fate-restricted neural progenitors in the mammalian cerebral cortex. Science. 2012 Aug 10; 337(6095):746-9. PMID: 22879516.
      View in: PubMed
    17. Franco SJ, M?ller U. Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system. Dev Neurobiol. 2011 Nov; 71(11):889-900. PMID: 21739613.
      View in: PubMed
    18. Franco SJ, Martinez-Garay I, Gil-Sanz C, Harkins-Perry SR, M?ller U. Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex. Neuron. 2011 Feb 10; 69(3):482-97. PMID: 21315259.
      View in: PubMed
    19. Barros CS, Franco SJ, M?ller U. Extracellular matrix: functions in the nervous system. Cold Spring Harb Perspect Biol. 2011 Jan 01; 3(1):a005108. PMID: 21123393.
      View in: PubMed
    20. Simonson WT, Franco SJ, Huttenlocher A. Talin1 regulates TCR-mediated LFA-1 function. J Immunol. 2006 Dec 01; 177(11):7707-14. PMID: 17114441.
      View in: PubMed
    21. Franco SJ, Senetar MA, Simonson WT, Huttenlocher A, McCann RO. The conserved C-terminal I/LWEQ module targets Talin1 to focal adhesions. Cell Motil Cytoskeleton. 2006 Sep; 63(9):563-81. PMID: 16830345.
      View in: PubMed
    22. Franco SJ, Huttenlocher A. Regulating cell migration: calpains make the cut. J Cell Sci. 2005 Sep 01; 118(Pt 17):3829-38. PMID: 16129881.
      View in: PubMed
    23. Franco SJ, Rodgers MA, Perrin BJ, Han J, Bennin DA, Critchley DR, Huttenlocher A. Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol. 2004 Oct; 6(10):977-83. PMID: 15448700.
      View in: PubMed
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