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Charles Greger Sagerstrom

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
ORCID ORCID Icon0000-0002-1509-5810 Additional info
    Other Positions
    TitleAssoc Chair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-PEDS
    DivisionGeneral Operations


    Collapse Biography 
    Collapse education and training
    Macalester College, St. Paul, MNBA05/1987Biology
    Stanford University, Stanford, CAPhD05/1993Immunology
    Whitehead Institute/MIT, Cambridge, MAPostdoc11/1997Developmental Biology

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R21NS137568     (SAGERSTROM, CHARLES G)Jun 1, 2024 - May 31, 2026
    NIH
    Molecular identification of the isthmic organizer
    Role: Principal Investigator
    R01NS124166     (FRANCO, SANTOS JOE)Jul 1, 2022 - May 31, 2027
    NIH
    Temporal and Spatial Control of Oligodendrocyte Fate Specification
    Role: Co-Principal Investigator
    R01GM142158     (SAGERSTROM, CHARLES G)May 1, 2021 - Mar 31, 2025
    NIH
    In vivo motif selectivity and functionality of TALE family TFs
    Role: Principal Investigator
    R01HD065081     (SAGERSTROM, CHARLES G)Feb 5, 2011 - Jan 31, 2017
    NIH
    Genetic Regulation of Rhombomere Formation
    Role: Principal Investigator
    R21DK068237     (SAGERSTROM, CHARLES G)Sep 1, 2004 - Jun 30, 2007
    NIH
    Specification and Positioning of the Pancreas
    Role: Principal Investigator
    R03HD039156     (SAGERSTROM, CHARLES G)Sep 1, 2000 - Jun 30, 2002
    NIH
    FUNCTIONAL ANALYSIS OF VERTEBRATE CAUDAL DEVELOPMENT
    Role: Principal Investigator
    R01NS038183     (SAGERSTROM, CHARLES G)Dec 3, 1998 - Nov 30, 2028
    NIH
    MOLECULAR ANALYSIS OF HINDBRAIN DEVELOPMENT
    Role: Principal Investigator
    R56NS038183     (SAGERSTROM, CHARLES G)Dec 3, 1998 - May 31, 2008
    NIH
    Molecular Analysis of Hindbrain Formation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kim YI, O'Rourke R, Sagerstr?m CG. scMultiome analysis identifies embryonic hindbrain progenitors with mixed rhombomere identities. Elife. 2023 Nov 10; 12. PMID: 37947350.
      View in: PubMed
    2. Bhandari S, Hong K, Miyawaki-Kuwakado A, Tomimatsu K, Kim YI, Nam IK, Sagerstr?m CG, Nakamura M, Choe SK. nudt7 gene depletion causes transcriptomic change in early development of zebrafish. J Biochem. 2022 Dec 27; 173(1):53-63. PMID: 36270274.
      View in: PubMed
    3. Bobola N, Sagerstr?m CG. TALE transcription factors: Cofactors no more. Semin Cell Dev Biol. 2024 Jan-Feb; 152-153:76-84. PMID: 36509674.
      View in: PubMed
    4. Bridoux L, Zarrineh P, Mallen J, Phuycharoen M, Latorre V, Ladam F, Losa M, Baker SM, Sagerstrom C, Mace KA, Rattray M, Bobola N. HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation. PLoS Genet. 2020 12; 16(12):e1009162. PMID: 33315856.
      View in: PubMed
    5. Stanney W, Ladam F, Donaldson IJ, Parsons TJ, Maehr R, Bobola N, Sagerstr?m CG. Combinatorial action of NF-Y and TALE at embryonic enhancers defines distinct gene expression programs during zygotic genome activation in zebrafish. Dev Biol. 2020 03 15; 459(2):161-180. PMID: 31862379.
      View in: PubMed
    6. Yildiz O, Downes GB, Sagerstr?m CG. Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain. Neural Dev. 2019 02 27; 14(1):5. PMID: 30813944.
      View in: PubMed
    7. Ghosh P, Maurer JM, Sagerstr?m CG. Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Dev. 2018 06 26; 13(1):13. PMID: 29945667.
      View in: PubMed
    8. Ladam F, Stanney W, Donaldson IJ, Yildiz O, Bobola N, Sagerstr?m CG. TALE factors use two distinct functional modes to control an essential zebrafish gene expression program. Elife. 2018 06 18; 7. PMID: 29911973.
      View in: PubMed
    9. Maurer JM, Sagerstr?m CG. A parental requirement for dual-specificity phosphatase 6 in zebrafish. BMC Dev Biol. 2018 03 15; 18(1):6. PMID: 29544468.
      View in: PubMed
    10. Ghosh P, Sagerstr?m CG. Developing roles for Hox proteins in hindbrain gene regulatory networks. Int J Dev Biol. 2018; 62(11-12):767-774. PMID: 30604846.
      View in: PubMed
    11. Losa M, Latorre V, Andrabi M, Ladam F, Sagerstr?m C, Novoa A, Zarrineh P, Bridoux L, Hanley NA, Mallo M, Bobola N. A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree. Elife. 2017 09 27; 6. PMID: 28952437.
      View in: PubMed
    12. Deplancke B, Sagerstr?m C. Editorial overview: Genome architecture and expression. Curr Opin Genet Dev. 2017 04; 43:iv-v. PMID: 28473185.
      View in: PubMed
    13. Zannino DA, Sagerstr?m CG. An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system. Neural Dev. 2015 Oct 24; 10:24. PMID: 26499851.
      View in: PubMed
    14. Amin S, Donaldson IJ, Zannino DA, Hensman J, Rattray M, Losa M, Spitz F, Ladam F, Sagerstr?m C, Bobola N. Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Dev Cell. 2015 Feb 09; 32(3):265-77. PMID: 25640223.
      View in: PubMed
    15. Weicksel SE, Gupta A, Zannino DA, Wolfe SA, Sagerstr?m CG. Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafish. BMC Dev Biol. 2014 Jun 05; 14:25. PMID: 24902847.
      View in: PubMed
    16. Zannino DA, Downes GB, Sagerstr?m CG. prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements. Dev Biol. 2014 Jun 15; 390(2):247-60. PMID: 24631215.
      View in: PubMed
    17. Choe SK, Ladam F, Sagerstr?m CG. TALE factors poise promoters for activation by Hox proteins. Dev Cell. 2014 Jan 27; 28(2):203-11. PMID: 24480644.
      View in: PubMed
    18. Ladam F, Sagerstr?m CG. Functional analysis of hox genes in zebrafish. Methods Mol Biol. 2014; 1196:133-44. PMID: 25151162.
      View in: PubMed
    19. Ladam F, Sagerstr?m CG. Hox regulation of transcription: more complex(es). Dev Dyn. 2014 Jan; 243(1):4-15. PMID: 23765878.
      View in: PubMed
    20. Weicksel SE, Xu J, Sagerstr?m CG. Dynamic nucleosome organization at hox promoters during zebrafish embryogenesis. PLoS One. 2013; 8(5):e63175. PMID: 23671670.
      View in: PubMed
    21. Choe SK, Nakamura M, Ladam F, Etheridge L, Sagerstr?m CG. A Gal4/UAS system for conditional transgene expression in rhombomere 4 of the zebrafish hindbrain. Dev Dyn. 2012 Jun; 241(6):1125-32. PMID: 22499412.
      View in: PubMed
    22. Zannino DA, Sagerstr?m CG, Appel B. olig2-Expressing hindbrain cells are required for migrating facial motor neurons. Dev Dyn. 2012 Feb; 241(2):315-26. PMID: 22275004.
      View in: PubMed
    23. Choe SK, Zhang X, Hirsch N, Straubhaar J, Sagerstr?m CG. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Dev Biol. 2011 Oct 15; 358(2):356-67. PMID: 21787765.
      View in: PubMed
    24. Mallappa C, Nasipak BT, Etheridge L, Androphy EJ, Jones SN, Sagerstr?m CG, Ohkawa Y, Imbalzano AN. Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function. Mol Cell Biol. 2010 Jul; 30(13):3176-86. PMID: 20421421.
      View in: PubMed
    25. Alexa K, Choe SK, Hirsch N, Etheridge L, Laver E, Sagerstr?m CG. Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish. PLoS One. 2009 Dec 11; 4(12):e8261. PMID: 20011517.
      View in: PubMed
    26. Choe SK, Lu P, Nakamura M, Lee J, Sagerstr?m CG. Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis. Dev Cell. 2009 Oct; 17(4):561-7. PMID: 19853569.
      View in: PubMed
    27. Nakamura M, Choe SK, Runko AP, Gardner PD, Sagerstr?m CG. Nlz1/Znf703 acts as a repressor of transcription. BMC Dev Biol. 2008 Nov 12; 8:108. PMID: 19014486.
      View in: PubMed
    28. Choe SK, Hirsch N, Zhang X, Sagerstr?m CG. hnf1b genes in zebrafish hindbrain development. Zebrafish. 2008 Sep; 5(3):179-87. PMID: 18945197.
      View in: PubMed
    29. diIorio P, Alexa K, Choe SK, Etheridge L, Sagerstr?m CG. TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm. Dev Biol. 2007 Apr 01; 304(1):221-31. PMID: 17289013.
      View in: PubMed
    30. Choe SK, Sagerstr?m CG. Variable Meis-dependence among paralog group-1 Hox proteins. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):1384-91. PMID: 15883028.
      View in: PubMed
    31. Sagerstr?m CG, Gammill LS, Veale R, Sive H. Specification of the enveloping layer and lack of autoneuralization in zebrafish embryonic explants. Dev Dyn. 2005 Jan; 232(1):85-97. PMID: 15543604.
      View in: PubMed
    32. Nakamura M, Runko AP, Sagerstr?m CG. A novel subfamily of zinc finger genes involved in embryonic development. J Cell Biochem. 2004 Nov 15; 93(5):887-95. PMID: 15449319.
      View in: PubMed
    33. Choe SK, Sagerstr?m CG. Paralog group 1 hox genes regulate rhombomere 5/6 expression of vhnf1, a repressor of rostral hindbrain fates, in a meis-dependent manner. Dev Biol. 2004 Jul 15; 271(2):350-61. PMID: 15223339.
      View in: PubMed
    34. Sagerstr?m CG. PbX marks the spot. Dev Cell. 2004 Jun; 6(6):737-8. PMID: 15177017.
      View in: PubMed
    35. Roy NM, Sagerstr?m CG. An early Fgf signal required for gene expression in the zebrafish hindbrain primordium. Brain Res Dev Brain Res. 2004 Jan 31; 148(1):27-42. PMID: 14757516.
      View in: PubMed
    36. Runko AP, Sagerstr?m CG. Isolation of nlz2 and characterization of essential domains in Nlz family proteins. J Biol Chem. 2004 Mar 19; 279(12):11917-25. PMID: 14709556.
      View in: PubMed
    37. Runko AP, Sagerstr?m CG. Nlz belongs to a family of zinc-finger-containing repressors and controls segmental gene expression in the zebrafish hindbrain. Dev Biol. 2003 Oct 15; 262(2):254-67. PMID: 14550789.
      View in: PubMed
    38. Lane ME, Runko AP, Roy NM, Sagerstr?m CG. Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4. Gene Expr Patterns. 2002 Dec; 2(3-4):207-11. PMID: 12617802.
      View in: PubMed
    39. Etheridge L, Diiorio P, Sagerstr?m CG. A zebrafish unc-45-related gene expressed during muscle development. Dev Dyn. 2002 Aug; 224(4):457-60. PMID: 12203738.
      View in: PubMed
    40. Choe SK, Vlachakis N, Sagerstr?m CG. Meis family proteins are required for hindbrain development in the zebrafish. Development. 2002 Feb; 129(3):585-95. PMID: 11830560.
      View in: PubMed
    41. Sagerstr?m CG, Kao BA, Lane ME, Sive H. Isolation and characterization of posteriorly restricted genes in the zebrafish gastrula. Dev Dyn. 2001 Apr; 220(4):402-8. PMID: 11307172.
      View in: PubMed
    42. Vlachakis N, Choe SK, Sagerstr?m CG. Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish. Development. 2001 Apr; 128(8):1299-312. PMID: 11262231.
      View in: PubMed
    43. Vlachakis N, Ellstrom DR, Sagerstr?m CG. A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b. Dev Dyn. 2000 Jan; 217(1):109-19. PMID: 10679934.
      View in: PubMed
    44. Grinblat Y, Lane ME, Sagerstr?m C, Sive H. Analysis of zebrafish development using explant culture assays. Methods Cell Biol. 1999; 59:127-56. PMID: 9891359.
      View in: PubMed
    45. Sagerstr?m CG. Slippery slopes: Understanding gradients and asymmetries in development. Trends Cell Biol. 1997 Nov; 7(11):463-5. PMID: 17709008.
      View in: PubMed
    46. Sagerstr?m CG, Sun BI, Sive HL. Subtractive cloning: past, present, and future. Annu Rev Biochem. 1997; 66:751-83. PMID: 9242923.
      View in: PubMed
    47. Sagerstr?m CG, Grinblat Y, Sive H. Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions. Development. 1996 06; 122(6):1873-83. PMID: 8674426.
      View in: PubMed
    48. Sagerstr?m CG, Kerr EM, Allison JP, Davis MM. Activation and differentiation requirements of primary T cells in vitro. Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):8987-91. PMID: 8415642.
      View in: PubMed
    49. Devaux B, Bjorkman PJ, Stevenson C, Greif W, Elliott JF, Sagerstr?m C, Clayberger C, Krensky AM, Davis MM. Generation of monoclonal antibodies against soluble human T cell receptor polypeptides. Eur J Immunol. 1991 Sep; 21(9):2111-9. PMID: 1832385.
      View in: PubMed
    50. Lin AY, Devaux B, Green A, Sagerstr?m C, Elliott JF, Davis MM. Expression of T cell antigen receptor heterodimers in a lipid-linked form. Science. 1990 Aug 10; 249(4969):677-9. PMID: 1696397.
      View in: PubMed
    51. Davis MM, Berg LJ, Lin AY, Fazekas de St Groth B, Devaux B, Sagerstrom CG, Bjorkman PJ, Elliott JF. TCR recognition and selection in vivo. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:119-28. PMID: 2700932.
      View in: PubMed
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