 Gap Junctions
"Gap Junctions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of CONNEXINS, the family of proteins which form the junctions.
| Descriptor ID |
D017629
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| MeSH Number(s) |
A11.284.149.165.420.471
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| Concept/Terms |
Gap Junctions- Gap Junctions
- Gap Junction
- Junction, Gap
- Junctions, Gap
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Below are MeSH descriptors whose meaning is more general than "Gap Junctions".
Below are MeSH descriptors whose meaning is more specific than "Gap Junctions".
This graph shows the total number of publications written about "Gap Junctions" by people in this website by year, and whether "Gap Junctions" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 | | 2000 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 2 | 0 | 2 | | 2012 | 3 | 0 | 3 | | 2013 | 2 | 2 | 4 | | 2014 | 3 | 1 | 4 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 4 | 5 | | 2018 | 1 | 1 | 2 | | 2019 | 1 | 1 | 2 | | 2020 | 1 | 1 | 2 | | 2021 | 1 | 2 | 3 | | 2023 | 0 | 2 | 2 | | 2024 | 1 | 1 | 2 | | 2025 | 1 | 1 | 2 | | 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gap Junctions" by people in Profiles.
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Levitt CH, Isaacs D, Hansen MS, Kravets V, Briggs JK, Benninger RKP. Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional ß-cell subpopulations. J Gen Physiol. 2026 05 04; 158(3).
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Kuruppath P, Jones ST, Pouille F, Ramirez-Gordillo D, Restrepo D, Schoppa NE. Connexin 36-mediated gap junctions contribute to fine odour discrimination and late-phase excitation of mitral cells in the mouse olfactory bulb. J Physiol. 2026 02; 604(3):1282-1302.
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Mulkearns-Hubert EE, Hajdari N, Hong ES, Jacobs AP, Gaboriau A, Giltner S, Tannish G, Kay KE, Wang SZ, LaViolette PS, Silver DJ, Hubert CG, Dhawan A, Lathia JD. Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis. Cell Rep. 2025 Sep 23; 44(9):116303.
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Miles KD, Barker CM, Russell KP, Appel BH, Doll CA. Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome. J Neurosci. 2024 07 31; 44(31).
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Mickus R, Ra?kevicius V, Sarapiniene I, Mikalayeva V, Prekeris R, Skeberdis VA. Phosphorylation-dependent allosteric regulation of Cx43 gap junction inhibitor potency. Biomed Pharmacother. 2024 May; 174:116550.
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Briggs JK, Gresch A, Marinelli I, Dwulet JM, Albers DJ, Kravets V, Benninger RKP. ß-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network. Elife. 2023 11 29; 12.
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St Clair JR, Westacott MJ, Miranda J, Farnsworth NL, Kravets V, Schleicher WE, Dwulet JM, Levitt CH, Heintz A, Ludin NWF, Benninger RKP. Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction. J Physiol. 2023 09; 601(18):4053-4072.
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Miranda JG, Schleicher WE, Wells KL, Ramirez DG, Landgrave SP, Benninger RKP. Dynamic changes in ß-cell [Ca2+] regulate NFAT activation, gene transcription, and islet gap junction communication. Mol Metab. 2022 03; 57:101430.
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Adams MT, Dwulet JM, Briggs JK, Reissaus CA, Jin E, Szulczewski JM, Lyman MR, Sdao SM, Kravets V, Nimkulrat SD, Ponik SM, Merrins MJ, Mirmira RG, Linnemann AK, Benninger RK, Blum B. Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient ß cells. Elife. 2021 07 07; 10.
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Dwulet JM, Briggs JK, Benninger RKP. Small subpopulations of ß-cells do not drive islet oscillatory [Ca2+] dynamics via gap junction communication. PLoS Comput Biol. 2021 05; 17(5):e1008948.
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