Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Bruce Appel

Concepts (305)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Zebrafish Proteins
52
2025
287
10.570
Why?
Zebrafish
69
2025
500
10.370
Why?
Oligodendroglia
36
2025
179
10.100
Why?
Myelin Sheath
23
2025
165
8.330
Why?
Spinal Cord
23
2025
373
4.640
Why?
Cell Differentiation
33
2025
2003
4.040
Why?
Axons
16
2025
198
3.990
Why?
Motor Neurons
18
2024
233
3.400
Why?
Gene Expression Regulation, Developmental
31
2025
874
2.970
Why?
Animals, Genetically Modified
31
2025
242
2.470
Why?
Hedgehog Proteins
10
2025
200
2.450
Why?
Nerve Tissue Proteins
18
2021
601
2.390
Why?
Neurogenesis
7
2021
154
2.350
Why?
Neural Stem Cells
6
2025
161
2.280
Why?
Stem Cells
15
2018
602
2.220
Why?
Signal Transduction
26
2025
5144
2.160
Why?
Basic Helix-Loop-Helix Transcription Factors
13
2021
245
1.670
Why?
Receptors, Notch
9
2025
87
1.650
Why?
Embryo, Nonmammalian
20
2021
169
1.630
Why?
Cell Lineage
15
2025
350
1.590
Why?
Cell Movement
10
2015
990
1.530
Why?
Oligodendrocyte Precursor Cells
2
2024
20
1.460
Why?
Body Patterning
13
2014
136
1.430
Why?
Neurons
15
2025
1619
1.390
Why?
Fragile X Mental Retardation Protein
3
2024
86
1.330
Why?
Animals
74
2025
37657
1.300
Why?
RNA-Binding Proteins
5
2021
440
1.300
Why?
Homeodomain Proteins
9
2015
511
1.140
Why?
Central Nervous System
5
2024
265
1.060
Why?
TOR Serine-Threonine Kinases
3
2021
423
1.040
Why?
Schwann Cells
4
2014
34
0.980
Why?
Brain-Derived Neurotrophic Factor
2
2025
141
0.950
Why?
Green Fluorescent Proteins
14
2016
400
0.930
Why?
Receptor, trkB
1
2025
33
0.920
Why?
Receptor, Notch1
5
2012
65
0.900
Why?
Cell Polarity
5
2016
140
0.900
Why?
Docosahexaenoic Acids
1
2024
86
0.850
Why?
Cytoplasmic Dyneins
2
2015
8
0.850
Why?
F-Box Proteins
2
2015
21
0.850
Why?
Oligodendrocyte Transcription Factor 2
11
2025
22
0.810
Why?
Cholesterol
2
2016
405
0.790
Why?
Maternal Nutritional Physiological Phenomena
1
2024
180
0.780
Why?
Mutation
17
2021
4013
0.770
Why?
Ubiquitin-Protein Ligases
2
2015
175
0.760
Why?
Membrane Proteins
8
2008
1154
0.750
Why?
Notochord
5
2006
14
0.720
Why?
Neural Cell Adhesion Molecules
1
2021
32
0.710
Why?
RNA Caps
1
2021
33
0.710
Why?
Rhombencephalon
3
2012
31
0.690
Why?
RNA Transport
1
2021
26
0.680
Why?
Transcription Factors
10
2021
1703
0.680
Why?
Cell Cycle Proteins
4
2015
624
0.660
Why?
3' Untranslated Regions
1
2021
149
0.650
Why?
MicroRNAs
3
2016
689
0.620
Why?
RNA, Messenger
8
2021
2828
0.610
Why?
Carrier Proteins
4
2020
740
0.600
Why?
Proto-Oncogene Proteins c-akt
1
2021
444
0.600
Why?
Protein Biosynthesis
1
2021
444
0.580
Why?
Phagocytosis
1
2020
388
0.560
Why?
Neuroglia
5
2018
173
0.510
Why?
Larva
5
2025
238
0.510
Why?
Myelin Proteins
1
2016
45
0.500
Why?
Cytogenetic Analysis
1
2016
34
0.490
Why?
Neural Crest
3
2014
121
0.490
Why?
Protein Kinase C
2
2025
252
0.480
Why?
Synapses
1
2019
428
0.470
Why?
Axonal Transport
1
2015
26
0.450
Why?
Brain
4
2018
2858
0.440
Why?
Trans-Activators
4
2004
388
0.440
Why?
Cell Cycle
3
2013
597
0.440
Why?
Hydroxymethylglutaryl-CoA Synthase
1
2014
3
0.430
Why?
Phosphatidylinositol 3-Kinases
1
2016
368
0.430
Why?
Pericytes
1
2013
35
0.410
Why?
DNA-Binding Proteins
3
2020
1478
0.410
Why?
SOXE Transcription Factors
2
2025
21
0.380
Why?
Demyelinating Diseases
1
2012
85
0.370
Why?
Peripheral Nerves
2
2012
71
0.360
Why?
Action Potentials
1
2015
499
0.360
Why?
Guanine Nucleotide Exchange Factors
1
2011
66
0.350
Why?
Fragile X Syndrome
2
2024
118
0.350
Why?
In Situ Hybridization
7
2013
320
0.330
Why?
Gene Expression Regulation
3
2017
2599
0.320
Why?
Cell Proliferation
7
2018
2504
0.300
Why?
Isoenzymes
1
2009
302
0.290
Why?
Genes, Reporter
4
2015
274
0.280
Why?
Organogenesis
2
2020
61
0.280
Why?
Adult Stem Cells
1
2007
40
0.270
Why?
Synaptic Vesicles
2
2019
41
0.270
Why?
Wnt Proteins
1
2008
136
0.260
Why?
Exocytosis
2
2019
88
0.260
Why?
Morphogenesis
3
2008
171
0.250
Why?
Cloning, Molecular
7
2008
533
0.250
Why?
Nuclear Proteins
1
2011
712
0.250
Why?
Cerebellum
1
2008
218
0.240
Why?
Cyclin-Dependent Kinase Inhibitor p57
1
2005
4
0.240
Why?
Myelin Basic Protein
3
2025
44
0.240
Why?
Cell Adhesion Molecules
2
2019
179
0.230
Why?
Chondroitin Sulfate Proteoglycans
1
2024
10
0.230
Why?
Morpholinos
2
2016
30
0.220
Why?
Time-Lapse Imaging
2
2015
22
0.220
Why?
Electrical Synapses
1
2024
11
0.220
Why?
F-Box-WD Repeat-Containing Protein 7
2
2015
6
0.220
Why?
Cell Count
2
2016
326
0.220
Why?
Ubiquitin-Protein Ligase Complexes
2
2015
7
0.220
Why?
Proteoglycans
1
2024
109
0.210
Why?
Intracellular Signaling Peptides and Proteins
6
2003
464
0.210
Why?
Bromodeoxyuridine
3
2010
80
0.210
Why?
Cilia
3
2021
172
0.210
Why?
Glycosyltransferases
1
2003
16
0.210
Why?
Retinoids
1
2003
34
0.210
Why?
Nervous System
2
2001
68
0.210
Why?
Models, Biological
6
2019
1828
0.200
Why?
Neuroepithelial Cells
2
2015
4
0.200
Why?
Veratrum Alkaloids
3
2008
20
0.200
Why?
Peripheral Nervous System
1
2003
20
0.200
Why?
Antigens
1
2024
362
0.190
Why?
Amyloid beta-Peptides
1
2025
233
0.190
Why?
Receptors, Cell Surface
2
2002
397
0.190
Why?
Purkinje Cells
1
2003
69
0.190
Why?
Intestines
2
2020
357
0.180
Why?
Microscopy, Confocal
2
2015
324
0.180
Why?
Spatio-Temporal Analysis
1
2021
34
0.180
Why?
Eukaryotic Initiation Factors
1
2021
12
0.170
Why?
Regulatory Sequences, Ribonucleic Acid
1
2021
18
0.170
Why?
Molecular Sequence Data
6
2012
2929
0.170
Why?
Molecular Imaging
1
2021
55
0.170
Why?
Epigenesis, Genetic
1
2025
660
0.160
Why?
Tissue Distribution
1
2021
330
0.160
Why?
Extracellular Matrix
1
2024
555
0.160
Why?
Microscopy, Electron, Transmission
2
2012
157
0.160
Why?
rab GTP-Binding Proteins
1
2020
77
0.160
Why?
Superior Colliculi
1
2020
44
0.160
Why?
Vitamin B 12
2
2017
125
0.150
Why?
Gastrula
3
2006
17
0.150
Why?
Immunohistochemistry
3
2010
1737
0.150
Why?
Embryonic Stem Cells
2
2010
129
0.150
Why?
Host Cell Factor C1
2
2017
15
0.140
Why?
Interneurons
3
2024
124
0.140
Why?
Female
8
2024
75515
0.140
Why?
Scoliosis
1
2021
217
0.140
Why?
Single-Cell Analysis
1
2021
338
0.140
Why?
Sequence Analysis, RNA
1
2021
450
0.140
Why?
Microglia
1
2020
255
0.140
Why?
Mice, Transgenic
2
2020
2180
0.130
Why?
Base Sequence
4
2017
2180
0.130
Why?
Neuronal Plasticity
1
2019
304
0.130
Why?
Phosphotransferases (Alcohol Group Acceptor)
2
2007
46
0.130
Why?
Nerve Fibers, Myelinated
1
2015
49
0.120
Why?
Genes, Homeobox
1
1995
51
0.120
Why?
Oligonucleotides, Antisense
2
2008
112
0.120
Why?
Pregnancy
2
2021
7070
0.120
Why?
Sequence Alignment
2
2012
363
0.120
Why?
Veratridine
1
2015
5
0.120
Why?
Tetrodotoxin
1
2015
41
0.110
Why?
Cell Division
2
2008
798
0.110
Why?
Potassium Channels, Inwardly Rectifying
1
2015
47
0.110
Why?
Transcriptome
1
2021
1003
0.110
Why?
Gene Expression
3
2014
1491
0.110
Why?
Sirolimus
1
2016
277
0.110
Why?
Gene Expression Profiling
1
2021
1764
0.110
Why?
Cell Communication
1
2016
318
0.110
Why?
Receptor, Notch3
1
2013
5
0.110
Why?
Repressor Proteins
1
2017
425
0.110
Why?
Receptor, Platelet-Derived Growth Factor beta
1
2013
29
0.100
Why?
Luciferases
1
2013
150
0.100
Why?
Immunoenzyme Techniques
1
2013
209
0.100
Why?
Protein Structure, Tertiary
1
2015
859
0.100
Why?
Colforsin
1
2012
48
0.100
Why?
Cerebral Hemorrhage
1
2013
117
0.100
Why?
Real-Time Polymerase Chain Reaction
1
2013
346
0.100
Why?
RNA
2
2012
930
0.100
Why?
Blood-Brain Barrier
1
2013
144
0.100
Why?
Cell Membrane
1
2016
724
0.090
Why?
Models, Genetic
2
2012
591
0.090
Why?
Nucleocytoplasmic Transport Proteins
1
2012
7
0.090
Why?
Recombinant Fusion Proteins
1
2015
672
0.090
Why?
Arthrogryposis
1
2012
15
0.090
Why?
Ligands
2
2004
667
0.090
Why?
Cyclic AMP
1
2012
219
0.090
Why?
rac GTP-Binding Proteins
1
2011
36
0.090
Why?
rac1 GTP-Binding Protein
1
2011
58
0.090
Why?
Phenotype
4
2020
3166
0.090
Why?
Neuropeptides
1
2011
76
0.090
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2013
987
0.090
Why?
Immunosuppressive Agents
1
2016
854
0.090
Why?
Mutagenesis
1
2012
182
0.090
Why?
Blotting, Western
1
2013
1234
0.090
Why?
Chromosome Mapping
1
2012
504
0.080
Why?
Enzyme Inhibitors
1
2014
854
0.080
Why?
Spinal Nerves
1
2009
7
0.080
Why?
Mice
4
2025
18048
0.080
Why?
Amino Acid Sequence
4
2005
2158
0.080
Why?
Adherens Junctions
1
2009
25
0.080
Why?
Oligodeoxyribonucleotides, Antisense
1
2009
8
0.080
Why?
T-Box Domain Proteins
2
2008
100
0.080
Why?
Caspase 3
1
2010
250
0.080
Why?
Microscopy, Electron
1
2009
441
0.080
Why?
Male
5
2021
69783
0.070
Why?
Sequence Homology, Amino Acid
3
2005
391
0.070
Why?
Smoothened Receptor
1
2008
6
0.070
Why?
S100 Calcium Binding Protein G
1
2008
8
0.070
Why?
Calbindin 2
1
2008
11
0.070
Why?
Oligonucleotide Array Sequence Analysis
1
2010
761
0.070
Why?
Zonula Occludens-1 Protein
1
2008
17
0.070
Why?
Glial Fibrillary Acidic Protein
1
2008
112
0.070
Why?
Time Factors
3
2010
6956
0.070
Why?
Fishes
1
2008
110
0.070
Why?
Morpholines
1
2008
126
0.070
Why?
Recombinant Proteins
2
2007
1357
0.070
Why?
Developmental Biology
1
2007
23
0.070
Why?
Cell Survival
1
2010
1129
0.060
Why?
Fetal Proteins
1
2006
14
0.060
Why?
Muscle Proteins
1
2008
240
0.060
Why?
Intercellular Signaling Peptides and Proteins
1
2008
388
0.060
Why?
Flow Cytometry
1
2010
1197
0.060
Why?
Branchial Region
2
2017
38
0.060
Why?
Humans
10
2021
141187
0.060
Why?
Receptors, G-Protein-Coupled
1
2008
226
0.060
Why?
Craniofacial Abnormalities
2
2017
75
0.060
Why?
Phosphoproteins
1
2008
338
0.060
Why?
Prosencephalon
1
2025
48
0.060
Why?
Models, Neurological
1
2007
251
0.060
Why?
Microscopy, Fluorescence
1
2006
417
0.060
Why?
Hyperkinesis
1
2024
17
0.060
Why?
Connexins
1
2024
52
0.050
Why?
Gap Junctions
1
2024
63
0.050
Why?
Helix-Loop-Helix Motifs
1
2003
12
0.050
Why?
Catalytic Domain
1
2004
224
0.050
Why?
Myocytes, Cardiac
1
2008
535
0.050
Why?
Microinjections
1
2003
86
0.050
Why?
Fibroblast Growth Factors
1
2003
180
0.050
Why?
Age Factors
1
2009
3292
0.050
Why?
Luminescent Proteins
1
2003
181
0.050
Why?
Embryonic and Fetal Development
1
2001
93
0.040
Why?
Genetic Vectors
1
2003
336
0.040
Why?
Mesoderm
1
2002
144
0.040
Why?
Mammals
1
2022
287
0.040
Why?
Microvilli
1
2020
75
0.040
Why?
Hot Temperature
1
2003
403
0.040
Why?
Bone and Bones
1
2022
317
0.040
Why?
Endosomes
1
2020
143
0.040
Why?
Disease Models, Animal
2
2024
4404
0.040
Why?
ELAV-Like Protein 3
1
1998
1
0.040
Why?
Evolution, Molecular
1
2002
510
0.040
Why?
ELAV Proteins
1
1998
14
0.040
Why?
Embryonic Induction
1
1998
31
0.040
Why?
Antigens, Surface
1
1998
156
0.030
Why?
Avian Proteins
1
1996
22
0.030
Why?
Primary Cell Culture
1
2017
171
0.030
Why?
Oncogene Proteins
1
1996
59
0.030
Why?
DNA Primers
1
1995
510
0.030
Why?
Protein Binding
1
2020
2239
0.030
Why?
Oxidoreductases
1
2014
96
0.030
Why?
Gene Knockdown Techniques
1
2014
330
0.030
Why?
Cells, Cultured
2
2011
4208
0.020
Why?
Chondrocytes
1
2014
229
0.020
Why?
Rats
2
2011
5629
0.020
Why?
Fibroblasts
1
2017
1020
0.020
Why?
Plasmids
1
2012
365
0.020
Why?
Transcription, Genetic
1
2017
1487
0.020
Why?
SOXD Transcription Factors
1
2010
5
0.020
Why?
Cell Line
2
2007
2885
0.020
Why?
Electroporation
1
2010
38
0.020
Why?
Chick Embryo
1
2010
133
0.020
Why?
Ribonuclease III
1
2010
44
0.020
Why?
Endoribonucleases
1
2010
79
0.020
Why?
DEAD-box RNA Helicases
1
2010
78
0.020
Why?
Embryo, Mammalian
1
2010
236
0.020
Why?
Adaptor Proteins, Signal Transducing
1
2011
429
0.020
Why?
Cell Nucleus
1
2012
609
0.020
Why?
Versicans
1
2008
5
0.020
Why?
Bone Morphogenetic Protein 4
1
2008
43
0.020
Why?
RNA, Small Interfering
1
2010
626
0.020
Why?
Centrosome
1
2007
71
0.020
Why?
Bone Morphogenetic Proteins
1
2008
139
0.020
Why?
Protozoan Proteins
1
2007
87
0.020
Why?
Oligonucleotides
1
2008
148
0.020
Why?
Genotype
1
2012
1859
0.020
Why?
Gene Expression Regulation, Enzymologic
1
2007
274
0.020
Why?
Biological Transport
1
2007
407
0.020
Why?
Cerebral Cortex
1
2010
461
0.020
Why?
DNA, Recombinant
1
2005
48
0.010
Why?
Endoderm
1
2005
20
0.010
Why?
Phytic Acid
1
2005
42
0.010
Why?
Microtubules
1
2007
285
0.010
Why?
Epithelium
1
2005
316
0.010
Why?
Genes, Dominant
1
2004
97
0.010
Why?
Ataxia Telangiectasia Mutated Proteins
1
2004
66
0.010
Why?
Hippocampus
1
2010
939
0.010
Why?
S Phase
1
2004
77
0.010
Why?
Heart
1
2008
620
0.010
Why?
Calcium Signaling
1
2005
250
0.010
Why?
Apoptosis
1
2012
2574
0.010
Why?
Mice, Knockout
1
2010
3068
0.010
Why?
Transfection
1
2004
943
0.010
Why?
Tumor Suppressor Proteins
1
2004
325
0.010
Why?
Intestinal Mucosa
1
2005
631
0.010
Why?
Epithelial Cells
1
2005
1110
0.010
Why?
Child
1
2017
22308
0.010
Why?
Maf Transcription Factors
1
1996
1
0.010
Why?
Cell Transplantation
1
1996
39
0.010
Why?
Mosaicism
1
1996
74
0.010
Why?
Genetic Markers
1
1996
343
0.010
Why?
Selection, Genetic
1
1996
264
0.010
Why?
Polymerase Chain Reaction
1
1996
1056
0.010
Why?
Appel's Networks
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