Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Colin Shearn

Concepts (302)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Protein Carbonylation
12
2025
57
3.590
Why?
Cholestasis
10
2023
213
3.530
Why?
Aldehydes
16
2025
141
3.400
Why?
Liver
22
2025
1895
2.770
Why?
PTEN Phosphohydrolase
7
2018
164
2.450
Why?
Liver Diseases, Alcoholic
12
2019
98
2.380
Why?
Bile Acids and Salts
7
2024
163
2.130
Why?
Oxidative Stress
16
2025
1350
1.870
Why?
Ethanol
12
2019
632
1.750
Why?
Antioxidants
7
2023
549
1.620
Why?
Glutathione Transferase
8
2019
96
1.620
Why?
Cholangitis, Sclerosing
4
2024
61
1.580
Why?
Parenteral Nutrition
5
2024
102
1.340
Why?
Proto-Oncogene Proteins c-akt
6
2016
436
1.320
Why?
Ileum
2
2024
112
1.000
Why?
Fatty Liver
3
2014
254
0.990
Why?
Mice
38
2025
18338
0.920
Why?
Tumor Necrosis Factor-alpha
5
2024
1212
0.920
Why?
Mice, Inbred C57BL
17
2025
5989
0.910
Why?
Inflammatory Bowel Diseases
3
2020
366
0.890
Why?
Fatty Liver, Alcoholic
2
2016
14
0.880
Why?
Insulin-Secreting Cells
3
2025
392
0.860
Why?
Signal Transduction
11
2024
5202
0.840
Why?
Thioredoxins
3
2018
31
0.810
Why?
Carcinoma, Hepatocellular
3
2019
372
0.720
Why?
Abdominal Injuries
1
2023
130
0.710
Why?
AMP-Activated Protein Kinases
2
2014
191
0.710
Why?
Animals
41
2025
38141
0.700
Why?
Protein Processing, Post-Translational
4
2016
468
0.660
Why?
Circadian Rhythm
1
2024
512
0.610
Why?
Butylated Hydroxytoluene
2
2011
37
0.610
Why?
Hepatocytes
5
2021
224
0.590
Why?
Peroxiredoxins
2
2018
26
0.580
Why?
Disease Models, Animal
13
2025
4559
0.580
Why?
Thioredoxin-Disulfide Reductase
1
2018
14
0.560
Why?
NF-E2-Related Factor 2
2
2019
100
0.550
Why?
Non-alcoholic Fatty Liver Disease
3
2017
265
0.540
Why?
Gene Knockout Techniques
1
2018
117
0.530
Why?
Hepatitis
1
2017
43
0.520
Why?
Liver Diseases
2
2021
304
0.510
Why?
Liver Cirrhosis
3
2024
287
0.500
Why?
Receptors, Cytoplasmic and Nuclear
3
2024
207
0.500
Why?
Superoxide Dismutase
5
2019
303
0.500
Why?
Mitochondrial Proteins
2
2015
262
0.490
Why?
Liver Neoplasms
4
2019
779
0.480
Why?
Chemical and Drug Induced Liver Injury, Chronic
1
2016
11
0.480
Why?
End Stage Liver Disease
1
2017
95
0.470
Why?
Thioredoxin Reductase 1
3
2023
8
0.470
Why?
Liver Cirrhosis, Alcoholic
1
2015
19
0.460
Why?
Tandem Mass Spectrometry
5
2022
566
0.440
Why?
Insulin
1
2025
2506
0.420
Why?
Alcoholism
3
2018
821
0.420
Why?
Oxidants
2
2012
103
0.410
Why?
ARNTL Transcription Factors
2
2024
17
0.410
Why?
Diet, High-Fat
2
2016
264
0.400
Why?
Mice, Knockout
8
2020
3125
0.380
Why?
Inflammation
6
2025
2883
0.380
Why?
Male
30
2025
72817
0.370
Why?
Dietary Fats
2
2018
308
0.360
Why?
Lipid Peroxidation
4
2016
163
0.350
Why?
Proteomics
5
2025
1191
0.340
Why?
RNA, Messenger
6
2023
2820
0.340
Why?
Xenobiotics
1
2011
31
0.330
Why?
Hydrogen Peroxide
1
2012
338
0.320
Why?
Chromatography, Liquid
4
2017
445
0.320
Why?
Reactive Oxygen Species
3
2025
602
0.320
Why?
Oxidoreductases Acting on CH-CH Group Donors
1
2010
27
0.310
Why?
Cell Proliferation
3
2018
2499
0.310
Why?
Glutathione Reductase
3
2019
24
0.310
Why?
Alcohol Drinking
1
2016
837
0.290
Why?
Down-Regulation
1
2011
616
0.280
Why?
Mitochondria
4
2019
990
0.280
Why?
Blotting, Western
4
2016
1162
0.280
Why?
Carcinoma
1
2010
224
0.270
Why?
Autophagy
2
2022
288
0.270
Why?
Alcohol Oxidoreductases
1
2008
62
0.270
Why?
Colonic Neoplasms
1
2010
257
0.260
Why?
Carcinogens
1
2008
123
0.260
Why?
Catalase
2
2017
133
0.260
Why?
Phosphoric Monoester Hydrolases
1
2007
56
0.250
Why?
NF-kappa B
2
2021
660
0.250
Why?
Glutathione
4
2019
366
0.230
Why?
Alanine Transaminase
3
2016
151
0.230
Why?
Hep G2 Cells
3
2021
75
0.230
Why?
Up-Regulation
2
2019
848
0.230
Why?
Case-Control Studies
3
2018
3619
0.220
Why?
Gene Expression Regulation
5
2021
2594
0.220
Why?
Recombinant Proteins
4
2020
1367
0.220
Why?
Enzyme Inhibitors
1
2008
821
0.210
Why?
Macrophage Activation
2
2023
186
0.210
Why?
Humans
28
2025
145491
0.210
Why?
Protein Kinase Inhibitors
1
2011
980
0.210
Why?
Ileitis
1
2024
33
0.210
Why?
Biomarkers
1
2015
4283
0.210
Why?
Phosphorylation
3
2014
1707
0.200
Why?
Epithelial Cells
1
2010
1112
0.200
Why?
Mice, Inbred NOD
1
2025
613
0.200
Why?
Genes, Regulator
1
2023
35
0.200
Why?
Lipoproteins
2
2021
166
0.200
Why?
Cysteine Proteinase Inhibitors
2
2014
49
0.190
Why?
Fibroblast Growth Factors
1
2024
188
0.190
Why?
Biliary Atresia
1
2025
158
0.190
Why?
Sulfhydryl Compounds
2
2018
188
0.190
Why?
Prostatic Neoplasms
1
2010
978
0.190
Why?
Insulin Resistance
1
2011
1244
0.180
Why?
Enzyme Activation
3
2013
762
0.180
Why?
Triglycerides
2
2016
518
0.180
Why?
Fatty Acid-Binding Proteins
2
2013
79
0.180
Why?
Mitochondria, Liver
2
2013
70
0.180
Why?
Dioxanes
1
2021
11
0.170
Why?
Phytosterols
1
2021
10
0.170
Why?
Isoxazoles
1
2021
55
0.170
Why?
NLR Family, Pyrin Domain-Containing 3 Protein
1
2023
168
0.170
Why?
Oxidation-Reduction
3
2019
1080
0.170
Why?
Mucoproteins
1
2020
8
0.160
Why?
Female
11
2025
78763
0.160
Why?
Models, Molecular
4
2014
1614
0.160
Why?
Phosphatidylinositol 4,5-Diphosphate
1
2020
33
0.160
Why?
Cholesterol
2
2020
405
0.160
Why?
Vesicular Transport Proteins
1
2020
85
0.160
Why?
Phosphatidylcholines
1
2020
130
0.150
Why?
Gene Expression
2
2021
1478
0.150
Why?
Macrophages
2
2025
1509
0.150
Why?
Cell Adhesion Molecules
1
2020
181
0.150
Why?
Cytokines
2
2025
2054
0.150
Why?
Acylation
1
2019
30
0.140
Why?
Chromatography, High Pressure Liquid
2
2013
581
0.140
Why?
Lysosomes
1
2019
128
0.140
Why?
Liposomes
1
2020
259
0.140
Why?
PPAR alpha
2
2016
54
0.140
Why?
Mice, 129 Strain
1
2018
84
0.140
Why?
Sulfinic Acids
1
2018
6
0.140
Why?
Heme Oxygenase-1
1
2018
74
0.130
Why?
Colon
1
2020
308
0.130
Why?
Ribosomes
1
2019
196
0.130
Why?
Aminobutyrates
1
2018
31
0.130
Why?
Pyruvaldehyde
1
2018
20
0.130
Why?
Lung
1
2011
4103
0.130
Why?
Azo Compounds
1
2017
30
0.130
Why?
Taurine
1
2018
41
0.130
Why?
Organ Specificity
1
2018
312
0.130
Why?
Colitis
1
2020
280
0.130
Why?
HSP70 Heat-Shock Proteins
1
2017
76
0.130
Why?
Protein Structure, Secondary
1
2018
366
0.130
Why?
Gene Deletion
2
2015
392
0.130
Why?
Homocystinuria
1
2018
62
0.130
Why?
Diabetes Mellitus
1
2025
1076
0.120
Why?
Mice, Inbred BALB C
2
2011
1261
0.120
Why?
Malnutrition
1
2018
86
0.120
Why?
Amino Acid Sequence
4
2015
2137
0.120
Why?
Lipogenesis
1
2016
62
0.120
Why?
Cell Line, Tumor
3
2020
3537
0.120
Why?
Fatty Acids, Unsaturated
1
2016
96
0.110
Why?
Sirtuin 3
2
2019
58
0.110
Why?
Lysine
1
2017
272
0.110
Why?
Middle Aged
4
2019
36176
0.110
Why?
Acetylation
4
2017
250
0.110
Why?
Cytochrome P-450 CYP4A
1
2014
4
0.110
Why?
CD36 Antigens
1
2014
32
0.100
Why?
Protein Isoforms
1
2015
396
0.100
Why?
Adult
4
2019
40707
0.100
Why?
Proteome
1
2019
517
0.100
Why?
Central Nervous System Depressants
1
2014
84
0.100
Why?
Heat-Shock Proteins
1
2014
134
0.100
Why?
DNA Primers
2
2012
507
0.100
Why?
Phosphatidylinositol 3-Kinases
2
2013
380
0.100
Why?
Protein Binding
4
2020
2250
0.100
Why?
Endoplasmic Reticulum Stress
1
2014
118
0.100
Why?
Adenosine Triphosphatases
1
2014
161
0.100
Why?
Carrier Proteins
1
2017
733
0.100
Why?
Acetyl-CoA Carboxylase
1
2013
32
0.100
Why?
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
1
2013
26
0.100
Why?
Molecular Sequence Data
3
2015
2910
0.100
Why?
Sterol Regulatory Element Binding Protein 1
1
2013
56
0.100
Why?
Endoplasmic Reticulum
2
2014
264
0.090
Why?
Models, Chemical
1
2014
264
0.090
Why?
Computational Biology
1
2017
687
0.090
Why?
Polymerase Chain Reaction
2
2016
1049
0.090
Why?
Organ Size
1
2013
461
0.090
Why?
Reactive Nitrogen Species
1
2011
16
0.080
Why?
Peptide Mapping
1
2011
62
0.080
Why?
Adiponectin
1
2013
240
0.080
Why?
Diabetes Mellitus, Type 2
1
2025
2582
0.080
Why?
Glycogen Synthase Kinase 3 beta
1
2011
73
0.080
Why?
Glycogen Synthase Kinase 3
1
2011
82
0.080
Why?
Binding Sites
2
2020
1313
0.080
Why?
Fenretinide
1
2010
3
0.080
Why?
Crotonates
1
2010
7
0.080
Why?
Receptors, Estrogen
1
2013
400
0.080
Why?
Tumor Cells, Cultured
1
2012
883
0.080
Why?
Toluidines
1
2010
10
0.080
Why?
Hydroxybutyrates
1
2010
15
0.080
Why?
Oxygen Consumption
1
2013
718
0.080
Why?
Cell Line, Transformed
1
2010
138
0.080
Why?
Microscopy, Confocal
1
2011
318
0.080
Why?
Fluorescence Resonance Energy Transfer
1
2011
177
0.080
Why?
Protein Conformation
1
2012
935
0.070
Why?
Glycoproteins
1
2011
353
0.070
Why?
Nitriles
1
2010
205
0.070
Why?
Cell Survival
1
2012
1094
0.070
Why?
Alkylation
1
2008
26
0.070
Why?
Diabetes Mellitus, Type 1
1
2025
3917
0.070
Why?
Nuclear Proteins
1
2013
743
0.070
Why?
RNA, Small Interfering
1
2010
632
0.070
Why?
Spectrometry, Mass, Electrospray Ionization
1
2008
179
0.070
Why?
Cytosol
1
2008
214
0.070
Why?
DNA Damage
2
2021
434
0.060
Why?
Base Sequence
1
2011
2180
0.060
Why?
Kidney
1
2015
1498
0.060
Why?
Cells, Cultured
2
2013
4127
0.060
Why?
Phosphatidylinositol Phosphates
1
2007
41
0.060
Why?
Immunohistochemistry
1
2011
1710
0.060
Why?
Static Electricity
1
2007
114
0.060
Why?
Hydrolysis
1
2007
199
0.060
Why?
Lung Neoplasms
2
2011
2664
0.060
Why?
Cloning, Molecular
2
2020
535
0.060
Why?
Amino Acid Substitution
1
2007
303
0.060
Why?
Phospholipids
1
2007
216
0.060
Why?
Rats, Sprague-Dawley
1
2011
2526
0.060
Why?
Peptides
1
2011
993
0.060
Why?
Skin
1
2010
766
0.050
Why?
Metabolome
2
2019
387
0.050
Why?
Kupffer Cells
1
2025
52
0.050
Why?
Transcription Factors
1
2013
1733
0.050
Why?
Biomarkers, Tumor
1
2011
1321
0.050
Why?
Glycosylation
2
2016
161
0.050
Why?
Amino Acids
2
2018
521
0.050
Why?
Rats
1
2011
5581
0.050
Why?
Sterols
1
2021
20
0.040
Why?
Systems Analysis
1
2021
22
0.040
Why?
Receptors, Tumor Necrosis Factor, Type I
1
2021
80
0.040
Why?
Electrophoresis, Gel, Two-Dimensional
2
2012
110
0.040
Why?
Intestinal Diseases
1
2021
43
0.040
Why?
Apoptosis
1
2010
2411
0.040
Why?
Bilirubin
1
2021
99
0.040
Why?
Fatty Acids
2
2016
459
0.040
Why?
Gas Chromatography-Mass Spectrometry
1
2021
127
0.040
Why?
Infliximab
1
2021
111
0.040
Why?
Chromatin Immunoprecipitation
1
2021
139
0.040
Why?
Protein Conformation, beta-Strand
1
2020
19
0.040
Why?
Sphingomyelins
1
2020
22
0.040
Why?
Ursodeoxycholic Acid
1
2020
17
0.040
Why?
Calcium
1
2007
1190
0.040
Why?
Phosphatidylinositols
1
2020
57
0.040
Why?
Phosphatidylserines
1
2020
61
0.040
Why?
Phosphatidylethanolamines
1
2020
76
0.040
Why?
Gene Knockdown Techniques
1
2021
335
0.040
Why?
Dextran Sulfate
1
2020
93
0.040
Why?
Molecular Docking Simulation
1
2020
123
0.040
Why?
Protein Interaction Domains and Motifs
1
2020
146
0.040
Why?
Lipid Bilayers
1
2020
101
0.040
Why?
Interleukin-1beta
1
2021
390
0.040
Why?
Genetic Vectors
1
2020
335
0.040
Why?
Crystallography, X-Ray
1
2020
491
0.040
Why?
Disease Susceptibility
1
2020
343
0.040
Why?
Sirtuins
1
2019
48
0.040
Why?
Molecular Dynamics Simulation
1
2020
266
0.030
Why?
gamma-Glutamyltransferase
1
2018
42
0.030
Why?
Gene Expression Profiling
1
2025
1769
0.030
Why?
Metabolic Networks and Pathways
1
2019
187
0.030
Why?
Cystathionine beta-Synthase
1
2018
65
0.030
Why?
Aged
1
2017
26125
0.030
Why?
F2-Isoprostanes
1
2016
20
0.030
Why?
Protein D-Aspartate-L-Isoaspartate Methyltransferase
1
2016
5
0.030
Why?
Sumoylation
1
2016
16
0.030
Why?
Oxides
1
2016
49
0.030
Why?
Escherichia coli
1
2020
857
0.030
Why?
Methylation
1
2016
242
0.030
Why?
Mutation
1
2007
4093
0.030
Why?
Chemokine CXCL2
1
2014
41
0.030
Why?
Receptor, Platelet-Derived Growth Factor beta
1
2014
31
0.030
Why?
Lipopolysaccharide Receptors
1
2014
87
0.030
Why?
Matrix Metalloproteinases
1
2014
95
0.030
Why?
Oxidative Phosphorylation
1
2015
209
0.030
Why?
Unfolded Protein Response
1
2014
58
0.030
Why?
Protein Folding
1
2014
279
0.020
Why?
Cyclic AMP Response Element-Binding Protein
1
2013
145
0.020
Why?
Anilino Naphthalenesulfonates
1
2012
9
0.020
Why?
Antibodies
1
2014
398
0.020
Why?
Actins
1
2014
421
0.020
Why?
Gene Expression Regulation, Enzymologic
1
2013
268
0.020
Why?
Fibrosis
1
2014
551
0.020
Why?
Immunoprecipitation
1
2012
147
0.020
Why?
Transforming Growth Factor beta
1
2014
475
0.020
Why?
Protein Structure, Tertiary
1
2014
850
0.020
Why?
Ubiquitination
1
2012
118
0.020
Why?
Lipid Metabolism
1
2015
529
0.020
Why?
Disease Progression
1
2019
2862
0.020
Why?
Microsomes, Liver
1
2011
85
0.020
Why?
NAD
1
2011
82
0.020
Why?
Sequence Alignment
1
2011
371
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2012
975
0.020
Why?
Transcriptome
1
2016
1038
0.020
Why?
Computer Simulation
1
2014
1026
0.020
Why?
Mass Spectrometry
1
2012
744
0.020
Why?
Hypoxia
1
2016
1199
0.020
Why?
Lipids
1
2013
709
0.020
Why?
Mice, Transgenic
1
2013
2189
0.020
Why?
Gene Expression Regulation, Neoplastic
1
2013
1439
0.020
Why?
Genetic Predisposition to Disease
1
2013
2355
0.010
Why?
Adolescent
1
2016
22485
0.010
Why?
Child
1
2016
22680
0.010
Why?
Shearn's Networks
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