 Reactive Oxygen Species
"Reactive Oxygen Species" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of SIGNAL TRANSDUCTION and GENE EXPRESSION, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
| Descriptor ID |
D017382
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| MeSH Number(s) |
D01.339.431 D01.650.775
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| Concept/Terms |
Reactive Oxygen Species- Reactive Oxygen Species
- Oxygen Species, Reactive
- Active Oxygen
- Oxygen, Active
- Oxygen Radicals
- Pro-Oxidants
- Pro Oxidants
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Below are MeSH descriptors whose meaning is more general than "Reactive Oxygen Species".
Below are MeSH descriptors whose meaning is more specific than "Reactive Oxygen Species".
This graph shows the total number of publications written about "Reactive Oxygen Species" by people in this website by year, and whether "Reactive Oxygen Species" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 3 | 4 | | 1997 | 0 | 3 | 3 | | 1998 | 0 | 1 | 1 | | 1999 | 1 | 2 | 3 | | 2000 | 1 | 2 | 3 | | 2001 | 0 | 3 | 3 | | 2002 | 4 | 7 | 11 | | 2003 | 7 | 6 | 13 | | 2004 | 5 | 10 | 15 | | 2005 | 7 | 7 | 14 | | 2006 | 4 | 10 | 14 | | 2007 | 1 | 8 | 9 | | 2008 | 6 | 10 | 16 | | 2009 | 5 | 11 | 16 | | 2010 | 2 | 15 | 17 | | 2011 | 8 | 14 | 22 | | 2012 | 4 | 20 | 24 | | 2013 | 4 | 24 | 28 | | 2014 | 0 | 20 | 20 | | 2015 | 6 | 7 | 13 | | 2016 | 3 | 15 | 18 | | 2017 | 5 | 16 | 21 | | 2018 | 0 | 12 | 12 | | 2019 | 1 | 21 | 22 | | 2020 | 4 | 11 | 15 | | 2021 | 2 | 18 | 20 | | 2022 | 0 | 15 | 15 | | 2023 | 1 | 15 | 16 | | 2024 | 2 | 12 | 14 | | 2025 | 4 | 13 | 17 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Reactive Oxygen Species" by people in Profiles.
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Murray KO, Gioscia-Ryan RA, Justice JN, Santos-Parker JR, Bispham NZ, Hutton DA, Darvish S, Miyamoto-Ditmon J, Clayton ZS, Chonchol M, Seals DR, Rossman MJ. Translational studies of chronic supplementation with a mitochondria-targeted antioxidant to improve physical function with ageing. J Physiol. 2026 04; 604(7):2898-2922.
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Saunders EF, Schultz KR, Lowe I, Anderson AL, Bikkumalla VS, Soto D, Tran NY, Baumel-Alterzon S, Knight JD, Shearn CT. Rapid protein carbonylation and decreased insulin secretion induced by inflammatory oxidative stress compounds. Free Radic Biol Med. 2026 Jan; 242:320-332.
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Affandi T, Ohm AM, Speidel JT, Caino MC, Boulton DP, Reyland ME. PKCd Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response. Mol Cancer Res. 2025 Sep 04; 23(9):779-791.
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Kumari N, Panja S, Kumar B, Ahmad R, Kollala SS, Siddhanta K, Islam F, Joshi V, Talmon GA, Murry DJ, Singh AB, Oupický D. Reactive Oxygen Species-Responsive Polymeric Chloroquine Nanogel for Targeted Oral Therapy of Ulcerative Colitis. ACS Appl Mater Interfaces. 2025 Sep 10; 17(36):50443-50463.
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Gong N, Kim D, Alameh MG, El-Mayta R, Han EL, Dwivedi G, Palanki R, Shi Q, Han X, Xue L, Xu J, Meng Z, Luo T, Figueroa-Espada CG, Weissman D, Li J, Mitchell MJ. Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity. Nat Biomed Eng. 2025 Dec; 9(12):2181-2195.
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Skuli SJ, Bakayoko A, Kruidenier M, Manning B, Pammer P, Salimov A, Riley O, Brake-Sillá G, Dopkin D, Bowman M, Martinez-Gutierrez LN, Anderson CC, Reisz JA, Buono R, Paul M, Saland E, Liccardo F, DeVine A, Wong S, Xu JP, Nee E, Hausler R, Boettcher S, Sebti SM, Lai C, Maxwell KN, Sarry JE, Fruman DA, D'Alessandro A, Mesaros C, Keith B, Simon MC, Sung PJ, Wertheim G, Skuli N, Bowman RL, Matthews A, Carroll M. Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response. Leukemia. 2025 Sep; 39(9):2087-2098.
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Heo J, Miller DL, Hoffman JR, Oberholtzer E, Castelli KM, Sparagna GC, Fisher-Wellman KH, Greising SM, Call JA. Acute mitochondrial reactive oxygen species emissions drive mitochondrial dysfunction after traumatic muscle injury in male mice. Am J Physiol Cell Physiol. 2025 Jul 01; 329(1):C235-C250.
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Berry AR, Ruzzene ST, Ostrander EI, Wegerson KN, Orozco-Fersiva NC, Stone MF, Valenti WB, Izaias JE, Holzer JP, Greiner JJ, Garcia VP, DeSouza CA. The non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function. J Appl Physiol (1985). 2025 Jun 01; 138(6):1571-1577.
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Elajaili H, Lyttle BD, Lewis CV, Bardill JR, Dee N, Seal S, Nozik ES, Liechty KW, Zgheib C. Increased ROS and Persistent Pro-Inflammatory Responses in a Diabetic Wound Healing Model (db/db): Implications for Delayed Wound Healing. Int J Mol Sci. 2025 May 20; 26(10).
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Lu X, Tang L, Wu Y, Hilton T, Chen X, Houck K, Fulton S, Han C, Romero S, Wang Y, Kozar R, Cardenas JC, Fu X, Zhang J, Zhao Z, Dong JF. Metabolically aberrant extracellular mitochondria induce oxidative endotheliopathy in traumatic brain injury. Blood Adv. 2025 May 13; 9(9):2079-2090.
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